| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiro Sato, Setsu Sawai, Naokazu Shimad. Comparison of the ability of different quantitative indices in Japanese journal of radiology. 2024-09-05. PMID:39235674. |
comparison of the ability of different quantitative indices in by imaging dopamine transporter (dat) uptake in the striatum, |
2024-09-05 |
2024-09-08 |
Not clear |
| Paul C Omaliko, Peter R Ferket, Tunde E Ogundare, Oluwabunmi O Apalowo, Ikenna G Enenya, Odinaka C Iwuozo, Jian Han, Yewande O Fasin. Impact of dietary fat types on expression levels of dopamine and serotonin transporters in the ileum of broiler chickens. Poultry science. vol 103. issue 11. 2024-08-30. PMID:39214056. |
a broiler chicken trial was conducted to evaluate the influence of dietary fat types on protein expression of 2 neurotransmitter transporters, dopamine (dat) and serotonin (5-htt). |
2024-08-30 |
2024-09-04 |
chicken |
| Laurent Galineau, Emmanuelle Claude, Zuhal Gulhan, Sylvie Bodard, Sophie Sérrière, Camille Dupuy, Jérémy Monteiro, Adeline Oury, Priscila Bertevello, Gabrielle Chicheri, Johnny Vercouillie, Lydie Nadal-Desbarats, Sylvie Chalon, Antoine Lefèvre, Patrick Emon. DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT). EJNMMI radiopharmacy and chemistry. vol 9. issue 1. 2024-08-27. PMID:39192050. |
desi-tq-ms imaging for ex vivo brain biodistribution assessment: evaluation of lbt-999, a ligand of the dopamine transporter (dat). |
2024-08-27 |
2024-08-30 |
Not clear |
| Seunghyeon Shin, Hyun-Yeol Nam, Keunyoung Kim, Jihyun Kim, Myung Jun Lee, Kyoungjune Pa. Clinical assessment and striatal dopaminergic activity in healthy controls and patients with Parkinson's disease: a Bayesian approach. Annals of nuclear medicine. 2024-08-27. PMID:39190111. |
we aimed to evaluate correlations between striatal dopamine transporter (dat) uptake and clinical assessments in both patients with parkinson's disease (pd) and healthy controls. |
2024-08-27 |
2024-08-30 |
Not clear |
| Alfonso Mata-Bermudez, Ricardo Trejo-Chávez, Marina Martínez-Vargas, Adán Pérez-Arredondo, Maria de Los Ángeles Martínez-Cardenas, Araceli Diaz-Ruiz, Camilo Rios, Luz Navarr. Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders. Frontiers in neuroscience. vol 18. 2024-08-23. PMID:39176379. |
in this work, we summarize the studies carried out in patients who have suffered tbi and describe alterations in the dopaminergic system, highlighting (1) dysfunction of the dopaminergic neuronal circuits caused by tbi, where modifications are shown in the dopamine transporter (dat) and alterations in the expression of dopamine receptor 2 (d2r) in brain areas with dopaminergic innervation, thus establishing a hypodopaminergic state and (2) variations in the concentration of dopamine and its metabolites in biological fluids of post-tbi patients, such as elevated dopamine (da) and alterations in homovanillic acid (hva). |
2024-08-23 |
2024-08-25 |
Not clear |
| Takato Hiranita, Su-Min Li, Jonathan L Kat. Effects of Dual Inhibition at Dopamine Transporter and σ Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats. The Journal of pharmacology and experimental therapeutics. 2024-08-23. PMID:39179413. |
however, σr antagonists when combined with dopamine transporter (dat) inhibitors substantially decrease cocaine self-administration. |
2024-08-23 |
2024-08-27 |
rat |
| Nirosen Vijiaratnam, Christine Girges, Dilan Athauda, Alexa King, Grace Auld, Rachel McComish, Kashfia Chowdhury, Simon Skene, Kate Maclagan, Kallol Ray Chaudhuri, Vincenzo Libri, John Dickson, Thomas Foltyni. Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early- to Mid-Stage Parkinson's Disease Modification Trials. Movement disorders clinical practice. 2024-08-22. PMID:39169806. |
the dopamine transporter striatal binding ratio (dat sbr) has been used as an outcome measure in parkinson's disease (pd) trials of potential disease-modifying therapies; however, both patient characteristics and analysis approach potentially complicate its interpretation. |
2024-08-22 |
2024-08-24 |
Not clear |
| Jacqueline Saenz, Elnaz Khezerlou, Meha Aggarwal, Amina Shaikh, Naga Ganti, Freja Herborg, Ping-Yue Pa. Parkinson's disease gene, Synaptojanin1, dysregulates the surface maintenance of the dopamine transporter. NPJ Parkinson's disease. vol 10. issue 1. 2024-08-08. PMID:39117637. |
we now report a fast depletion of evoked dopamine and impaired maintenance of the axonal dopamine transporter (dat) in the synj1 haploinsufficient (synj1+/-) neurons. |
2024-08-08 |
2024-08-12 |
Not clear |
| Jeppe C Nielsen, Kristine Salomon, Iris E Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J Lolan. Structure of the human dopamine transporter in complex with cocaine. Nature. 2024-08-07. PMID:39112703. |
the dopamine transporter (dat) is crucial for regulating dopamine signalling and is the prime mediator for the rewarding and addictive effects of cocaine |
2024-08-07 |
2024-08-10 |
human |
| Peng Huang, Zhiting Wan, Shaogang Q. Targeting the RUNX3-miR-186-3p-DAT-IGF1R axis as a therapeutic strategy in a Parkinson's disease model. Journal of translational medicine. vol 22. issue 1. 2024-08-06. PMID:39103832. |
furthermore, the high mir-186-3p expression in pd can be targeted to inhibit the dat expression, resulting in a decrease in the dopamine content of dopaminergic neurons. |
2024-08-06 |
2024-08-08 |
mouse |
| Xiaoyu Zhong, Jisui Li, Xiaohong X. Adolescent exposure to bisphenol-a antagonizes androgen regulation of social behavior in male mice. Neurotoxicology and teratology. 2024-08-03. PMID:39097242. |
in addition, bpa removed down-regulation in the levels of dopamine (da) transporter (dat) and da receptor 1 (dr1) in the nac of tp-gdx mice. |
2024-08-03 |
2024-08-06 |
mouse |
| Ma Chengcheng, An Panpan, Yan Yalong, Su Mingyu, Xu Wei, Chen Jing, Tang Chuanx. GDNF improves the cognitive ability of PD mice by promoting glycosylation and membrane distribution of DAT. Scientific reports. vol 14. issue 1. 2024-08-01. PMID:39090173. |
the regulation of dopamine transporter (dat) is integral to this process. |
2024-08-01 |
2024-08-05 |
mouse |
| Ma Chengcheng, An Panpan, Yan Yalong, Su Mingyu, Xu Wei, Chen Jing, Tang Chuanx. GDNF improves the cognitive ability of PD mice by promoting glycosylation and membrane distribution of DAT. Scientific reports. vol 14. issue 1. 2024-08-01. PMID:39090173. |
additionally, gdnf potentiated the reutilization of neurotransmitters by the pfc presynaptic membrane, boosting the effective release of dopamine following a single electrical stimulation, ultimately ameliorating the cognitive impairments in pd mice.therefore, we propose that gdnf enhances the glycosylation and membrane trafficking of dat by facilitating the re-aggregation of the golgi apparatus, thereby amplifying the utilization of da signals. |
2024-08-01 |
2024-08-05 |
mouse |
| Felipe Arriva Pitella, Leonardo Alexandre-Santos, Kleython José Coriolano Cavalcanti de Lacerda, Ana Carolina Trevisan, Mery Kato, Fernando Eduardo Padovan-Neto, Vitor Tumas, Lauro Wichert-An. Parkinson's disease and levodopa-induced dyskinesias: a quantitative analysis through Radiologia brasileira. vol 57. 2024-07-31. PMID:39077067. |
parkinson's disease and levodopa-induced dyskinesias: a quantitative analysis through to compare the dopamine transporter (dat) density with other risk factors for l-dopa-induced dyskinesia (lid) in patients with parkinson's disease (pd), with and without lid. |
2024-07-31 |
2024-08-02 |
Not clear |
| Ana Catya Jiménez-Torres, Katherine D Porter, Jamison A Hastie, Charles Adeniran, Omar Moukha-Chafiq, Theresa H Nguyen, Subramaniam Ananthan, Corinne E Augelli-Szafran, Chang-Guo Zhan, Jun Zh. Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063123. |
we have demonstrated that in vivo expression of tat in tat transgenic mice decreases dopamine uptake through both dopamine transporter (dat) and norepinephrine transporter (net) in the prefrontal cortex. |
2024-07-27 |
2024-07-29 |
mouse |
| Ana Catya Jiménez-Torres, Katherine D Porter, Jamison A Hastie, Charles Adeniran, Omar Moukha-Chafiq, Theresa H Nguyen, Subramaniam Ananthan, Corinne E Augelli-Szafran, Chang-Guo Zhan, Jun Zh. Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063123. |
further, our novel allosteric inhibitor of monoamine transporters, sri-32743, has been shown to attenuate tat-inhibited dopamine transport through dat and alleviates tat-potentiated cognitive impairments. |
2024-07-27 |
2024-07-29 |
mouse |
| Clara Nautrup Pedersen, Fuyu Yang, Samantha Ita, Yibin Xu, Ravikumar Akunuri, Sofia Trampari, Caroline Marie Teresa Neumann, Lasse Messell Desdorf, Birgit Schiøtt, Joseph M Salvino, Ole Valente Mortensen, Poul Nissen, Azadeh Shahsava. Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. Journal of neurochemistry. 2024-07-16. PMID:39010681. |
the regulation of dopamine (da) removal from the synaptic cleft is a crucial process in neurotransmission and is facilitated by the sodium- and chloride-coupled dopamine transporter dat. |
2024-07-16 |
2024-07-18 |
drosophila_melanogaster |
| Miguel Ribeiro, Jonas Campos, Tiffany S Pinho, Belém Sampaio-Marques, Sandra Barata-Antunes, Jorge Ribeiro Cibrão, Ricardo Araújo, Sara Duarte-Silva, Elsa Moreira, Rui A Sousa, Pedro M Costa, António J Salgad. Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions. Biotechnology journal. vol 19. issue 7. 2024-07-10. PMID:38987218. |
furthermore, following treatment with retinoic acid (ra) and further stimulation with brain-derived neurotrophic factor (bdnf) and nerve growth factor beta (ngf-β), the percentage of sh-sy5y cells stained positive for dopaminergic neuronal differentiation markers (tyrosine hydroxylase [th] and dopamine transporter [dat]) was higher in hpl or fd-hpl than in fbs, and gene expression of dopaminergic markers th, dat, and dr2 was also detected. |
2024-07-10 |
2024-07-13 |
human |
| Takahide Wada, Keizo Sugaya, Yuri Asano, Yasuhiro Nakata, Rie Naito, Tomoya Kawazoe, Yuji Saitoh, Kota Bokuda, Shinsuke Tobisawa, Toshio Shimizu, Kazushi Takahash. Association of dysphagia severity in multiple system atrophy with the specific binding ratio on dopamine transporter SPECT. Journal of the neurological sciences. vol 463. 2024-07-09. PMID:38981418. |
the present study investigated the relationship between dysphagia severity in msa and the specific binding ratio (sbr) on dopamine transporter (dat) spect using the hyodo score, a qualitative scale for use with fiberoptic endoscopic evaluation of swallowing (fees). |
2024-07-09 |
2024-07-12 |
Not clear |
| Arnav Paul, Diwakar Shukl. Oligomerization of Monoamine Transporters. Sub-cellular biochemistry. vol 104. 2024-07-04. PMID:38963486. |
the mat family functions using the electrochemical gradient of ions across the membrane and comprises three transporters, dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2024-07-04 |
2024-07-10 |
Not clear |