| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng She. PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. European journal of nuclear medicine and molecular imaging. 2024-04-08. PMID:38587645. |
despite the in vitro evidence that toludesvenlafaxine inhibits the reuptake of serotonin (5-ht), norepinephrine (ne) and dopamine (da), there is no in vivo evidence that toludesvenlafaxine binds to dat and increases da level, a mechanism thought to contribute to its favorable clinical performance. |
2024-04-08 |
2024-04-10 |
rat |
| Kuo Hao Lee, Sung Joon Won, Precious Oyinloye, Lei Sh. Unlocking the Potential of High-Quality Dopamine Transporter Pharmacological Data: Advancing Robust Machine Learning-Based QSAR Modeling. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38558976. |
the dopamine transporter (dat) plays a critical role in the central nervous system and has been implicated in numerous psychiatric disorders. |
2024-04-01 |
2024-04-04 |
Not clear |
| Ping-Yue Pan, Jacqueline Saenz, Elnaz Khezerlou, Meha Aggarwal, Amina Shaikh, Naga Ganti, Freja Herbor. Parkinson's disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter. Research square. 2024-04-01. PMID:38559229. |
we now report fast depletion of evoked dopamine (da) and altered maintenance of the axonal dopamine transporter (dat) in the synj1+/- neurons. |
2024-04-01 |
2024-04-04 |
Not clear |
| Robert Goldsmith, Amal Aburahma, Jon E Spragu. Dopamine Concentration Changes Associated with the Retrodialysis of Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) into the Caudate Putamen. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539653. |
structural modifications to synthetic psychoactive cathinones (spcs), a class of drugs that contain a β-keto modification of the phenethylamine pharmacophore of amphetamine, induce differences in dopamine transporter (dat) activity. |
2024-03-28 |
2024-03-30 |
rat |
| Filip L H Fredensborg, Kasper Thilsing-Hansen, Jane A Simonsen, Peter Grupe, Ziba A Farahani, Christian W Andersen, Albert Gjedde, Svend Hvidste. Dynamic multi-pinhole collimated brain SPECT of Parkinson's disease by [ Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38503852. |
dynamic multi-pinhole collimated brain spect of parkinson's disease by [ we investigated the feasibility of using a dopamine transporter (dat) tracer ligand ([ |
2024-03-20 |
2024-03-23 |
Not clear |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
single treatment therapies have not been successful for cocaine use disorder; therefore, this study focuses on a combination therapy targeting the dopamine transporter (dat) and kor. |
2024-03-19 |
2024-03-21 |
rat |
| Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot, Adam MacDonald, Moein Yaqubi, Samantha Gruenheid, Louis-Eric Trudeau, Jo Anne Stratto. Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. The European journal of neuroscience. 2024-03-15. PMID:38487941. |
characterizing enteric neurons in dopamine transporter (dat)-cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. |
2024-03-15 |
2024-03-17 |
mouse |
| Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D Sach. Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice. Frontiers in molecular neuroscience. vol 17. 2024-03-15. PMID:38486964. |
although the dopamine transporter (dat) is known to play a key role in maintaining dopamine (da) homeostasis, its importance for the regulation of stress susceptibility remains largely unknown. |
2024-03-15 |
2024-03-17 |
mouse |
| Emily J Miller, Habibeh Khoshboue. Immunity on ice: The impact of methamphetamine on peripheral immunity. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467482. |
methamphetamine (meth) regulation of the dopamine transporter (dat) and central nervous system (cns) dopamine transmission have been extensively studied. |
2024-03-11 |
2024-03-14 |
Not clear |
| Emily J Miller, Habibeh Khoshboue. Immunity on ice: The impact of methamphetamine on peripheral immunity. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467482. |
akin to dopamine neurons in the cns, a majority of peripheral immune cells also express dat, implying that in addition to their effect in the cns, dat ligands such as methamphetamine may have a role in modulating peripheral immunity. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
the dopamine transporter (dat) is a key site of action for cocaine and amphetamines. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
dysfunctional dat is associated with aberrant synaptic dopamine transmission and enhanced drug-seeking and taking behavior. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
lastly, we discuss the therapeutic potential of cholesterol-modifying drugs as a new avenue to normalize dat function and dopamine transmission in patients with psychostimulant use disorder. |
2024-03-11 |
2024-03-14 |
Not clear |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
dual dat and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. |
2024-03-06 |
2024-03-08 |
rat |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
previous studies have shown that dual inhibitors of the dopamine transporter (dat) and sigma receptors significantly reduce the behavioral/reinforcing effects of cocaine, which have been associated with stimulation of extracellular dopamine (da) levels resulting from dat inhibition. |
2024-03-06 |
2024-03-08 |
rat |
| Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newma. Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes. JACS Au. vol 4. issue 2. 2024-03-01. PMID:38425927. |
the dopamine transporter (dat) is one of the key regulators of dopamine (da) signaling in the central nervous system (cns) and in the periphery. |
2024-03-01 |
2024-03-03 |
mouse |
| Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newma. Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes. JACS Au. vol 4. issue 2. 2024-03-01. PMID:38425927. |
recent reports in a model of parkinson's disease (pd) have shown that dopamine neuronal loss in the cns impacts the expression of dat in peripheral immune cells. |
2024-03-01 |
2024-03-03 |
mouse |
| Alev Ecevitoglu, Nicolette Meka, Renee A Rotolo, Gayle A Edelstein, Sonya Srinath, Kathryn R Beard, Carla Carratala-Ros, Rose E Presby, Jianjing Cao, Amarachi Okorom, Amy H Newman, Mercè Correa, John D Salamon. Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-01. PMID:38429498. |
preclinical data indicate that dopamine transport (dat) inhibitors can reverse pharmacologically-induced low-effort biases and increase selection of high-effort options in effort-based choice tasks. |
2024-03-01 |
2024-03-04 |
rat |
| Fabio Bellia, Antonio Girella, Eugenia Annunzi, Beatrice Benatti, Matteo Vismara, Alberto Priori, Fabiana Festucci, Federico Fanti, Dario Compagnone, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addari. Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder. Translational psychiatry. vol 14. issue 1. 2024-02-28. PMID:38409080. |
we found reduced daglα and nape-pld in blood samples of individuals with ocd (when compared to healthy controls) as well as in the amygdala complex and prefrontal cortex of dopamine transporter (dat) heterozygous rats, manifesting compulsive behaviours. |
2024-02-28 |
2024-03-01 |
human |
| Jie Liu, Jing Kang, Meihui Qi, Jie Tang, Yi Fang, Chunyi Liu, Jingjing Hong, Jiaojiao Zuo, Zhengping Che. Synthesis and initial evaluation of radioiodine-labelled deuterated tropane derivatives targeting dopamine transporter. Bioorganic & medicinal chemistry letters. 2024-02-26. PMID:38408514. |
the dopamine transporter (dat) is closely related to a variety of neurological disorders including parkinson's disease (pd) and other neurodegenerative diseases. |
2024-02-26 |
2024-03-02 |
Not clear |