All Relations between dopamine and dat

Publication Sentence Publish Date Extraction Date Species
Therese C Ku, Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela A Camacho-Hernandez, Amarachi V Okorom, Kristine Walloe Salomon, Kuo Hao Lee, Claus J Loland, Henry J Duff, Lei Shi, Amy Hauck Newma. Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity. ACS pharmacology & translational science. vol 7. issue 2. 2024-02-15. PMID:38357284. we have previously discovered "atypical" dopamine transporter (dat) inhibitors that do not display psychostimulant-like behaviors and may be useful as medications to treat psud. 2024-02-15 2024-02-17 Not clear
Ashley Centner, Isabella Del Priore, Nicole Chambers, Sophie R Cohen, Michelle L Terry, Michael Coyle, John Glinski, Anna C Stoll, Joseph R Patterson, Christopher J Kemp, Kathryn M Miller, Michael Kubik, Nathan Kuhn, Kelvin C Luk, Caryl E Sortwell, Christopher Bisho. Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study. The European journal of neuroscience. 2024-02-15. PMID:38356120. compared with reduction in striatal th, reduction in striatal dopamine transporter (dat) was more pronounced and progressed between the 4- and 8-month p.i. 2024-02-15 2024-02-17 rat
Christopher J Bergin, Aïcha Zouggar, Amanda Mendes da Silva, Tanguy Fenouil, Joshua R Haebe, Angelique N Masibag, Gautam Agrawal, Muhammad S Shah, Tamara Sandouka, Mario Tiberi, Rebecca C Auer, Michele Ardolino, Yannick D Benoi. The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors. Nature cancer. 2024-02-13. PMID:38351181. using a stem cell-based phenotypic drug-screening pipeline, we identified the dopamine transporter (dat) antagonist vanoxerine, a compound with previously demonstrated clinical safety, as a cancer-specific downregulator of g9a expression. 2024-02-13 2024-02-16 Not clear
Julia Canzian, João V Borba, Jaíne Ames, Rossano M Silva, Cássio M Resmim, Camilla W Pretzel, Maria Cecília F Duarte, Tamiris R Storck, Khadija A Mohammed, Isaac A Adedara, Vania L Loro, Robert Gerlai, Denis B Rosember. The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes and brain oxidative status in adult zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 2024-02-07. PMID:38325745. functional changes in dopamine transporter (dat) are related to various psychiatric conditions, including bipolar disorder (bd) symptoms. 2024-02-07 2024-02-10 zebrafish
Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. generation of dopamine transporter (dat)-mcherry knock-in rats by crispr-cas9 genome editing. 2024-02-07 2024-02-10 rat
Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. since dopamine transporter (dat) gene is known as a marker for dopaminergic neurons, we inserted chr2-mcherry into the downstream of the dat gene locus of the rat genome by clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (crispr-cas9) genome editing and created dat-chr2-mcherry knock-in rats. 2024-02-07 2024-02-10 rat
David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. following viral transfection, we found an increase in the surface expression of the dopamine transporter (dat), a protein associated with the regulation of dopamine signaling, dopamine transmission, and cocaine-associated behavior. 2024-01-31 2024-02-03 rat
Margherita Tassan Mazzocco, Marcello Serra, Marco Maspero, Angela Coliva, Luca Presotto, Maria Antonietta Casu, Micaela Morelli, Rosa Maria Moresco, Sara Belloli, Annalisa Pinn. Positive relation between dopamine neuron degeneration and metabolic connectivity disruption in the MPTP plus probenecid mouse model of Parkinson's disease. Experimental neurology. 2024-01-28. PMID:38281587. longitudinal pet imaging of the dopamine transporter (dat) by [ 2024-01-28 2024-01-31 mouse
Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. we studied the dopamine transporter (dat) protein, which is responsible for regulating dopamine levels through the reuptake of dopamine in neuronal cells. 2024-01-28 2024-01-31 human
Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. taken together, we can deduce that glycosylation changes in dat lead to dysfunction of dat to regulate dopamine levels, which in turn alters behavior in larval zebrafish. 2024-01-28 2024-01-31 human
Efthalia Angelopoulou, Anastasia Bougea, Alexandros Hatzimanolis, Leonidas Stefanis, Nikolaos Scarmeas, Sokratis Papageorgio. Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects. Medicina (Kaunas, Lithuania). vol 60. issue 1. 2024-01-23. PMID:38256375. neuroimaging studies have revealed that mbi in patients with pd may be related todistinct patterns of brain atrophy, altered neuronal connectivity, and distribution of dopamine transporter (dat) depletion, shedding more light on its pathophysiological background. 2024-01-23 2024-01-25 Not clear
Ralph Buchert, Balazs Szabo, Akos Kovacs, Thomas Buddenkotte, Franziska Mathies, Amir Karimzadeh, Wencke Lehnert, Susanne Klutmann, Attila Forgacs, Ivayla Apostolov. Dopamine Transporter SPECT with 12-Minute Scan Duration Using Multiple-Pinhole Collimators. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-01-18. PMID:38238040. this study evaluated the potential to reduce the scan duration in dopamine transporter (dat) spect when using a second-generation multiple-pinhole (mph) collimator designed for brain spect with improved count sensitivity and improved spatial resolution compared with parallel-hole and fanbeam collimators. 2024-01-18 2024-01-21 Not clear
Jose Medina-Luque, Patrick Piechocinski, Paul Feyen, Carmelo Sgobio, Jochen Herm. Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson's disease transgenic mouse. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167878. structurally, dopamine transporter (dat) was found to be redistributed in larger dat-positive clumps only in the dls of 3- and 12-month-old mice. 2024-01-03 2024-01-06 mouse
Maggy Yu Hei Lau, Sana Gadiwalla, Susan Jones, Elisa Gallian. Different electrophysiological profiles of genetically labelled dopaminergic neurons in the mouse midbrain and olfactory bulb. The European journal of neuroscience. 2024-01-03. PMID:38169095. after confirming the penetrance and specificity of the dopamine transporter (dat) cre line, we compared soma shape, passive membrane properties, voltage sags and action potential (ap) firing across midbrain and forebrain bulbar da subtypes. 2024-01-03 2024-01-06 mouse
Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. dopamine transporter (dat) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. 2024-01-02 2024-01-05 mouse
Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. acute amph administration leads to transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. 2024-01-02 2024-01-05 mouse
Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. 2023-12-28 2023-12-31 mouse
Duncan J Noble, Aida Mohammadkhani, Min Qiao, Stephanie L Borglan. Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex. The European journal of neuroscience. 2023-12-28. PMID:38155094. male and female adult dopamine transporter (dat) 2023-12-28 2023-12-31 Not clear
Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. 2023-12-23 2023-12-25 mouse
Thomas Budenkotte, Ivayla Apostolova, Roland Opfer, Julia Krüger, Susanne Klutmann, Ralph Bucher. Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance. European journal of nuclear medicine and molecular imaging. 2023-12-22. PMID:38133688. deep convolutional neural networks (cnn) are promising for automatic classification of dopamine transporter (dat)-spect images. 2023-12-22 2023-12-24 Not clear