| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. |
automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. |
2023-12-28 |
2023-12-31 |
mouse |
| Duncan J Noble, Aida Mohammadkhani, Min Qiao, Stephanie L Borglan. Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex. The European journal of neuroscience. 2023-12-28. PMID:38155094. |
male and female adult dopamine transporter (dat) |
2023-12-28 |
2023-12-31 |
Not clear |
| Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. |
furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. |
2023-12-23 |
2023-12-25 |
mouse |
| Thomas Budenkotte, Ivayla Apostolova, Roland Opfer, Julia Krüger, Susanne Klutmann, Ralph Bucher. Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance. European journal of nuclear medicine and molecular imaging. 2023-12-22. PMID:38133688. |
deep convolutional neural networks (cnn) are promising for automatic classification of dopamine transporter (dat)-spect images. |
2023-12-22 |
2023-12-24 |
Not clear |
| Amarachi V Okorom, Gisela Andrea Camacho-Hernandez, Kristine Salomon, Kuo Hao Lee, Therese C Ku, Jianjing Cao, Sung Joon Won, Jacob Friedman, Jenny Lam, James Paule, Rana Rais, Benjamin Klein, Zheng-Xiong Xi, Lei Shi, Claus J Loland, Amy Hauck Newma. Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile. Journal of medicinal chemistry. 2023-12-20. PMID:38117239. |
atypical dopamine transporter (dat) inhibitors have shown therapeutic potential in the preclinical models of psychostimulant use disorders (psud). |
2023-12-20 |
2023-12-23 |
rat |
| Madhur Shetty, Danielle E Bolland, Joshua Morrell, Bryon D Grove, James D Foster, Roxanne A Vaugha. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. Current research in physiology. vol 6. 2023-12-19. PMID:38107792. |
the primary regulator of dopamine availability in the brain is the dopamine transporter (dat), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the presynaptic neuron. |
2023-12-19 |
2023-12-21 |
Not clear |
| Yuliya Piatkova, Matthieu Doyen, Sébastien Heyer, Ayaz Tahmazov, Solene Frismand, Lucie Hopes, Laetitia Imbert, Antoine Verge. Effects of medication on dopamine transporter imaging using [ European journal of nuclear medicine and molecular imaging. 2023-12-19. PMID:38114618. |
effects of medication on dopamine transporter imaging using [ dopamine transporter (dat) imaging is used to support the diagnosis of neurodegenerative parkinsonian disorders. |
2023-12-19 |
2023-12-23 |
Not clear |
| Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S Moehle, Habibeh Khoshbouei, Matthew J Farre. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. NPJ Parkinson's disease. vol 9. issue 1. 2023-12-18. PMID:38110354. |
while striatal dopamine transporter (dat) expression and function is similarly impaired in both vki and haplo mice, that physiology is normalized in vki by treatment with the lrrk2 kinase inhibitor, mli-2. |
2023-12-18 |
2023-12-21 |
mouse |
| Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S Moehle, Habibeh Khoshbouei, Matthew J Farre. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. NPJ Parkinson's disease. vol 9. issue 1. 2023-12-18. PMID:38110354. |
taken together, these data show vps35 p.d620n confers a gain-of-function with respect to lrrk2 kinase activity, and that vps35 and lrrk2 functionally interact to regulate dat function and striatal dopamine transmission. |
2023-12-18 |
2023-12-21 |
mouse |
| Aleksandr Veshchitskii, Polina Shkorbatova, Aleksandr Mikhalkin, Zoja Fesenko, Evgeniya V Efimova, Raul R Gainetdinov, Natalia Merkulyev. Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter. Frontiers in molecular neuroscience. vol 16. 2023-12-11. PMID:38076209. |
extracellular dopamine levels are controlled by the membrane dopamine transporter (dat), and animals lacking dat (dat-ko) are characterized by hyperdopaminergia and several alterations of locomotion including hyperactivity. |
2023-12-11 |
2023-12-17 |
rat |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). |
2023-12-01 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. |
2023-12-01 |
2023-12-10 |
mouse |
| Min Seung Kim, Dong Gueu Park, In Ja Shin, Young Sil An, Jung Han Yoo. The Role of Dual-Phase 18F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome. Clinical nuclear medicine. 2023-11-28. PMID:38015725. |
this study was performed to delineate the specific patterns of cortical hypoperfusion, dopamine transporter (dat) uptake using dual-phase fp-cit pet in discriminating between cbs and ipd at early stage. |
2023-11-28 |
2023-12-07 |
Not clear |
| Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. |
in this article we showed that knockout of the gene encoding dat leads not only to a profound dysregulation of dopamine neurotransmission in the striatum but also in the midbrain, prefrontal cortex, hippocampus, medulla oblongata and spinal cord. |
2023-11-25 |
2023-11-28 |
rat |
| Felix P Mayer, Adele Stewart, Randy D Blakel. Leaky lessons learned: Efflux prone dopamine transporter variant DAT Val559 reveals sex and circuit specific contributions of D2 receptor signaling to neuropsychiatric disease. Basic & clinical pharmacology & toxicology. 2023-11-21. PMID:37987120. |
leaky lessons learned: efflux prone dopamine transporter variant dat val559 reveals sex and circuit specific contributions of d2 receptor signaling to neuropsychiatric disease. |
2023-11-21 |
2023-11-29 |
mouse |
| Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yu. Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948992. |
we determined dopamine transporter (dat) availability in the medial prefrontal cortex (mpfc), striatum, and nucleus accumbens (nac) after drug treatment. |
2023-11-10 |
2023-11-20 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
using dlap, we identified a small subpopulation of th-positive neurons (~5%), mainly located in the very lateral substantia nigra (sn), that was immunofluorescence-negative for the plasmalemmal dopamine transporter (dat), with ~40% smaller cell bodies. |
2023-11-10 |
2023-11-20 |
mouse |
| Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Son. Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893219. |
monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively), are important therapeutic targets due to their essential roles in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A Mennigen, Michael G Jon. A role for dopamine in control of the hypoxic ventilatory response via D The Journal of comparative neurology. 2023-10-14. PMID:37837632. |
we further identified dopamine active transporter (dat) and vesicular monoamine transporter (vmat2) expression in neurons of the gill filaments using transgenic lines. |
2023-10-14 |
2023-11-08 |
zebrafish |
| Romain Geelhand de Merxem, Sandrine Launay, Catherine Hana. Association Between Bipolar Disorder and Parkinson's Disease. Psychiatria Danubina. vol 35. issue Suppl 2. 2023-10-06. PMID:37800205. |
dopamine transporter (dat) scans can aid in making a differential diagnosis. |
2023-10-06 |
2023-10-07 |
Not clear |