| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian O'Neill, Michael R Tilley, Dawn D Han, Keerthi Thirtamara-Rajamani, Erik R Hill, Georgia A Bishop, Fu-Ming Zhou, Matthew J During, Howard H G. Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum. Neuropharmacology. vol 79. 2014-12-03. PMID:24412674. |
using knock-in mice with a cocaine-insensitive dopamine transporter (dat-ci mice) we have shown previously that inhibition of the dopamine transporter (dat) is necessary for both of these behaviors. |
2014-12-03 |
2023-08-12 |
mouse |
| J Pijarowska-Kruszyna, A W Jaron, A Kachniarz, K Kasprzak, A Kowalska, B Malkowski, S Demphel, F Dollé, R Mikolajcza. Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one-step synthesis of the dopamine transporter PET ligand [(18)F]FECNT. Journal of labelled compounds & radiopharmaceuticals. vol 57. issue 3. 2014-12-03. PMID:24497079. |
the fluorine-18 labeled nortropane derivative 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane (fecnt) is a dopamine transporter (dat) ligand. |
2014-12-03 |
2023-08-12 |
Not clear |
| A Ferragud, C Velázquez-Sánchez, J J Canale. Modulation of methamphetamine's locomotor stimulation and self-administration by JHW 007, an atypical dopamine reuptake blocker. European journal of pharmacology. vol 731. 2014-12-03. PMID:24675149. |
jhw 007 [n-(n-butil)-3α-[bis(4'-fluorophenil)methoxi]-tropane] belongs to the family of n-substituted benztropine (bzt) analogs, atypical dopamine transporter (dat) blockers that are able to strongly modulate cocaine- and amphetamine-related behavior. |
2014-12-03 |
2023-08-12 |
rat |
| Xuefeng Tan, Lei Zhang, Huixia Zhu, Jianbing Qin, Meiling Tian, Chuanming Dong, Haoming Li, Guohua Ji. Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons. Neuroscience letters. vol 571. 2014-12-03. PMID:24769320. |
however, these da neurons were morphologically immature and seldom expressed dopamine transporter (dat), a late marker of mature da neurons. |
2014-12-03 |
2023-08-13 |
Not clear |
| WooChan Kim, Amane Tateno, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okub. In vivo activity of modafinil on dopamine transporter measured with positron emission tomography and [¹⁸F]FE-PE2I. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24451483. |
we conducted a dopamine transporter (dat) occupancy study with modafinil (200 or 300 mg) in ten healthy volunteers using positron emission tomography (pet) with [¹⁸f]fe-pe2i, a new pet radioligand with high affinity and selectivity for the dopamine transporter, to characterize its relation to abuse liability. |
2014-12-01 |
2023-08-12 |
human |
| Marta Marquie, Joseph J Locascio, Dorene M Rentz, J Alex Becker, Trey Hedden, Keith A Johnson, John H Growdon, Stephen N Gompert. Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an (11)C altropane positron emission tomography study. Alzheimer's research & therapy. vol 6. issue 5-8. 2014-11-27. PMID:25429309. |
we investigated the contribution of dopamine deficiency to cognition in parkinson disease (pd) and dementia with lewy bodies (dlb) with dopamine transporter (dat) imaging. |
2014-11-27 |
2023-08-13 |
Not clear |
| Erin S Calipari, Mark J Ferris, James R Melchior, Kristel Bermejo, Ali Salahpour, David C S Roberts, Sara R Jone. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addiction biology. vol 19. issue 2. 2014-11-25. PMID:22458761. |
mph has a mechanism of action similar to cocaine (coc) and is commonly characterized as a dopamine transporter (dat) blocker. |
2014-11-25 |
2023-08-12 |
Not clear |
| Vanessa Nieratschker, Martin Grosshans, Josef Frank, Jana Strohmaier, Christoph von der Goltz, Osman El-Maarri, Stephanie H Witt, Sven Cichon, Markus M Nöthen, Falk Kiefer, Marcella Rietsche. Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age. Addiction biology. vol 19. issue 2. 2014-11-25. PMID:22506971. |
a recent study found that hypermethylation of the promoter of the dopamine transporter (dat) gene was positively correlated with alcohol dependence and negatively correlated with alcohol craving. |
2014-11-25 |
2023-08-12 |
Not clear |
| Reagan R Wetherill, Kanchana Jagannathan, Falk W Lohoff, Ronald Ehrman, Charles P O'Brien, Anna Rose Childress, Teresa R Frankli. Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene. Addiction biology. vol 19. issue 2. 2014-11-25. PMID:23061530. |
our previous studies show that the dopamine transporter (dat) slc6a3 genotype exerts profound effects on limbic responses to scs. |
2014-11-25 |
2023-08-12 |
human |
| John R Lever, Dennis K Miller, Emily A Fergason-Cantrell, Caroline L Green, Lisa D Watkinson, Terry L Carmack, Susan Z Leve. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. The Journal of pharmacology and experimental therapeutics. vol 351. issue 1. 2014-11-25. PMID:25100754. |
to address this apparent paradox, we evaluated aspects of pd144418 binding in vitro, investigated σ1 receptor and dopamine transporter (dat) occupancy in vivo, and re-examined effects on locomotor activity. |
2014-11-25 |
2023-08-13 |
mouse |
| Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agunde. Genomic and pharmacogenomic biomarkers of Parkinson's disease. Current drug metabolism. vol 15. issue 2. 2014-11-24. PMID:24694231. |
nor did polymorphisms in genes related to dopamine or serotonin drd, dat, th, ddc, dbh, mao, comt, slc6a4, mtr, mthfr, oxidative stress noq1, noq2, mephx, hfe, gpx, cat, mnsod, hfe, ho-1, ho-2, nfe2l2, keap1, inflammatory processes, ils, tnf, act, nos, hnmt, abp1, hrhs, trophic and growth factors bdnf, fgf, or mitochondrial metabolism and function. |
2014-11-24 |
2023-08-13 |
cat |
| Chang Soon Choi, Minha Hong, Ki Chan Kim, Ji-Woon Kim, Sung Min Yang, Hana Seung, Mee Jung Ko, Dong-Hee Choi, Jueng Soo You, Chan Young Shin, Geon Ho Bah. Effects of atomoxetine on hyper-locomotive activity of the prenatally valproate-exposed rat offspring. Biomolecules & therapeutics. vol 22. issue 5. 2014-11-21. PMID:25414770. |
in this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (adhd) medications, methylphenidate (mph) and atomoxetine (atx) targeting dopamine and norepinephrine transporters (dat and net), respectively, on hyperactive behavior of prenatally vpa-exposed rat offspring. |
2014-11-21 |
2023-08-13 |
human |
| Horrick Sharma, Soumava Santra, Joy Debnath, Tamara Antonio, Maarten Reith, Aloke Dutt. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315194. |
the model revealed features important for inhibitors to exhibit a balanced activity against dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2014-11-06 |
2023-08-12 |
Not clear |
| Justin R Nickell, Kiran B Siripurapu, Ashish Vartak, Peter A Crooks, Linda P Dwoski. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Advances in pharmacology (San Diego, Calif.). vol 69. 2014-11-06. PMID:24484975. |
methamphetamine increases extracellular dopamine in reward-relevant pathways by interacting at vesicular monoamine transporter-2 (vmat2) to inhibit dopamine uptake and promote dopamine release from synaptic vesicles, increasing cytosolic dopamine available for reverse transport by the dopamine transporter (dat). |
2014-11-06 |
2023-08-12 |
rat |
| Justin R Nickell, Kiran B Siripurapu, Ashish Vartak, Peter A Crooks, Linda P Dwoski. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Advances in pharmacology (San Diego, Calif.). vol 69. 2014-11-06. PMID:24484975. |
the 2,4-dicholorophenyl mtd analog, ukmh-106, exhibited selectivity for vmat2 over dat, inhibited methamphetamine-evoked dopamine release, but required a difficult synthetic approach. |
2014-11-06 |
2023-08-12 |
rat |
| Pitna Kim, Chang Soon Choi, Jin Hee Park, So Hyun Joo, Soo Young Kim, Hyun Myung Ko, Ki Chan Kim, Se Jin Jeon, Seung Hwa Park, Seol-Heui Han, Jong Hoon Ryu, Jae Hoon Cheong, Jung Yeol Han, Ki Narm Ko, Chan Young Shi. Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring. Journal of neuroscience research. vol 92. issue 5. 2014-11-04. PMID:24510599. |
as a mechanistic link, both protein and mrna expression of dopamine transporter (dat), a key determinant of adhd-like phenotypes in experimental animals and humans, were significantly decreased by paternal etoh exposure in cerebral cortex and striatum of offspring mice along with increased methylation of a cpg region of the dat gene promoter. |
2014-11-04 |
2023-08-12 |
mouse |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
combined with the well-documented involvement of dopamine transporters (dats) in the regulation of pfc-dependent cognitive processes, it is important to test whether this form of plasticity can be modulated by dat activity in the pfc. |
2014-10-29 |
2023-08-12 |
rat |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
the excess amount of extracellular dopamine caused by dat inhibition acted critically on d1-like receptors to impair depression. |
2014-10-29 |
2023-08-12 |
rat |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
we suggest that abnormal increases of the extracellular dopamine level by dat inhibition impair synaptic depression in the pfc through over-stimulation of d1-like receptors. |
2014-10-29 |
2023-08-12 |
rat |
| Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Ki. YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24394491. |
furthermore, yy162 attenuated reductions in p-trkb, bdnf, dopamine transporter (dat) and norepinephrine transporter (net) expression. |
2014-10-28 |
2023-08-12 |
mouse |