| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heli Chauhan, Bryan A Killinger, Cheryl V Miller, Anna Moszczynsk. Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24717411. |
dopamine d2 receptor antagonists and dopamine transporter (dat) inhibitors protect against neurotoxicity of the drug by decreasing intracellular dopamine content and, consequently, dopamine autoxidation and production of reactive oxygen species. |
2015-01-19 |
2023-08-13 |
rat |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. vol 82. 2015-01-09. PMID:24447715. |
uwa-101, a dual, equipotent inhibitor of dopamine (dat) and serotonin (sert) transporters, has previously been shown to successfully extend duration of anti-parkinsonian benefit of l-dopa (on-time), without exacerbating dyskinesia, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmoset. |
2015-01-09 |
2023-08-12 |
marmoset |
| Susanne Nikolaus, Markus Beu, Angelica Maria De Souza Silva, Joseph P Huston, Hubertus Hautzel, Owen Y Chao, Christina Antke, Hans-Wilhelm Mülle. Relationship between L-DOPA-induced reduction in motor and exploratory activity and degree of DAT binding in the rat. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566000. |
the present study assessed the influence of l-dopa administration on neostriatal dopamine (da) transporter (dat) binding in relation to motor and exploratory behaviors in the rat. |
2015-01-08 |
2023-08-13 |
rat |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
the hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, glua2 and glun2b; dopamine markers, dopamine 1 receptor (d1), dopamine transporter (dat) and tyrosine hydroxylase (th); and memory markers, protein kinase m zeta (pkmζ) and protein kinase c zeta (pkcζ). |
2015-01-08 |
2023-08-13 |
mouse |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
in the striatum, ma treatment increased cytosolic dat and th levels associated with dopamine hyperfunction. |
2015-01-08 |
2023-08-13 |
mouse |
| Barbara Cagniard, Tatyana D Sotnikova, Raul R Gainetdinov, Xiaoxi Zhuan. The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. Journal of neurogenetics. vol 28. issue 1-2. 2015-01-07. PMID:24673634. |
although both cocaine and amphetamine mainly target the dopamine transporter (dat) and cause psychomotor effects, they have very different mechanisms of actions. |
2015-01-07 |
2023-08-12 |
mouse |
| Barbara Cagniard, Tatyana D Sotnikova, Raul R Gainetdinov, Xiaoxi Zhuan. The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. Journal of neurogenetics. vol 28. issue 1-2. 2015-01-07. PMID:24673634. |
whereas amphetamine-induced increase in extracellular dopamine was drastically diminished in constitutive dat knockdown mice, cocaine-induced increase in extracellular dopamine had a faster onset in knockdown mice compared with wild-type controls. |
2015-01-07 |
2023-08-12 |
mouse |
| Danna Jennings, Andrew Siderowf, Matthew Stern, John Seibyl, Shirley Eberly, David Oakes, Kenneth Mare. Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology. vol 83. issue 19. 2014-12-30. PMID:25298306. |
the purpose of this study is to evaluate the relative risk of abnormal dopamine transporter (dat) imaging for subjects with and without hyposmia and the feasibility of acquiring a large, community-based, 2-tiered biomarker assessment strategy to detect prodromal parkinson disease (pd). |
2014-12-30 |
2023-08-13 |
human |
| Ajit S Shinto, Joppy Antony, Koramadai Kamaleshwaran, Krishnan Vijayan, Arul Selvan, Aruna Korde, Mythili Kameshwaran, Grace Samue. Correlative (99m)tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of Parkinson disease. World journal of nuclear medicine. vol 13. issue 3. 2014-12-24. PMID:25538489. |
the imaging of dopamine transporter (dat) with (99m)tc-labeled tropane derivative (trodat-1) single photon emission computer tomography/computer tomography (spect/ct) has been proposed to be a valuable and feasible means of assessment of the integrity of dopamine neurons. |
2014-12-24 |
2023-08-13 |
human |
| Josiane W Bortolotto, Giana P Cognato, Raissa R Christoff, Laura N Roesler, Carlos E Leite, Luiza W Kist, Mauricio R Bogo, Monica R Vianna, Carla D Bona. Long-term exposure to paraquat alters behavioral parameters and dopamine levels in adult zebrafish (Danio rerio). Zebrafish. vol 11. issue 2. 2014-12-18. PMID:24568596. |
this study evaluated the effect of the systemic administration of pq on locomotion, learning and memory, social interaction, tyrosine hydroxylase (th) expression, dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels, and dopamine transporter (dat) gene expression in zebrafish. |
2014-12-18 |
2023-08-12 |
zebrafish |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
recent literature has shown that genetic and drug-induced elevations in dopamine transporter (dat) expression augment the neurochemical and behavioral potency of psychostimulant releasers. |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
dat levels and dopamine uptake rates have been shown to follow a gradient in the striatum, with the highest levels in the dorsal regions and lowest levels in the nucleus accumbens shell; thus, we hypothesized that amphetamine potency would follow this gradient. |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
using fast scan cyclic voltammetry in mouse brain slices, we examined dat inhibition and changes in exocytotic dopamine release by amphetamine across four striatal regions (dorsal and ventral caudate-putamen, nucleus accumbens core and shell). |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
consistent with our hypothesis, amphetamine effects at the dat and on release decreased across regions from dorsal to ventral, and both measures of potency were highly correlated with dopamine uptake rates. |
2014-12-18 |
2023-08-13 |
mouse |
| D Leo, L Mus, S Espinoza, M C Hoener, T D Sotnikova, R R Gainetdino. Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology. vol 81. 2014-12-15. PMID:24565640. |
in vivo evidence has indicated an inhibitory influence of taar1 on dopamine (da) neurotransmission, presumably via modulation of dopamine transporter (dat) or interaction with the d2 da receptor and/or activation of inwardly rectifying k(+) channels. |
2014-12-15 |
2023-08-12 |
mouse |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
methamphetamine interacts with the dopamine transporter (dat) and increases extracellular concentrations of dopamine that, in turn, binds to a number of dopamine receptor subtypes. |
2014-12-09 |
2023-08-12 |
rat |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
results indicate that the dopamine d3 receptor selective antagonist, pg01037, attenuated methamphetamine-induced decreases in striatal dat, but not hippocampal serotonin (5ht) transporter (sert), function, as assessed 7 days after treatment. |
2014-12-09 |
2023-08-12 |
rat |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
taken together, the present study demonstrates that dopamine d3 receptors mediate, in part, the long-term deficits in dat function caused by methamphetamine, and that this effect likely involves an attenuation of methamphetamine-induced hyperthermia. |
2014-12-09 |
2023-08-12 |
rat |
| Nadia O Postupna, C Dirk Keene, Caitlin Latimer, Emily E Sherfield, Rachel D Van Gelder, Jeffrey G Ojemann, Thomas J Montine, Martin Darva. Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 10. 2014-12-09. PMID:25068655. |
we observed that the fraction of synaptosomal particles with reactivity for dopamine transporter (dat) was significantly reduced in the pt and vm caudate of patients with neuropathological diagnosis of lbd. |
2014-12-09 |
2023-08-13 |
mouse |
| Kenji Ishibashi, Keiichi Oda, Kiichi Ishiwata, Kenji Ishi. Comparison of dopamine transporter decline in a patient with Parkinson's disease and normal aging effect. Journal of the neurological sciences. vol 339. issue 1-2. 2014-12-08. PMID:24462123. |
we report serial dopamine transporter (dat) positron emission tomography (pet) scanning in a patient with parkinson's disease (pd). |
2014-12-08 |
2023-08-12 |
human |