| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edson Bor-Seng-Shu, Andre C Felicio, Pedro Braga-Neto, Ilza Rosa Batista, Wellingson Silva Paiva, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Luis Augusto Franco de Andrade, Orlando Graziani Povoas Barsottini, Ming Chi Shih, Rodrigo A Bressan, Henrique Ballalai Ferra. Dopamine transporter imaging using 99mTc-TRODAT-1 SPECT in Parkinson's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 20. 2015-03-09. PMID:25109468. |
although the decrease in striatal dopamine transporter (dat) density has been described in north american, european, and asian parkinson's disease (pd) patients, studies on this issue are required in the rest of the world. |
2015-03-09 |
2023-08-13 |
Not clear |
| Steven J O'dell, John F Marshal. Running wheel exercise before a binge regimen of methamphetamine does not protect against striatal dopaminergic damage. Synapse (New York, N.Y.). vol 68. issue 9. 2015-03-06. PMID:24899064. |
repeated administration of methamphetamine (mamph) to rodents in a single-day "binge" dosing regimen produces long-lasting damage to forebrain dopaminergic nerve terminals as measured by decreases in tissue dopamine (da) content and levels of the plasmalemmal da transporter (dat). |
2015-03-06 |
2023-08-13 |
rat |
| J R Gugusheff, Z Y Ong, B S Muhlhausle. Naloxone treatment alters gene expression in the mesolimbic reward system in 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood. Physiology & behavior. vol 133. 2015-02-19. PMID:24727340. |
we measured mrna expression of key components of the reward pathway (mu-opioid receptor, proenkephalin, tyrosine hydroxylase, d1 and d2 receptors and the dopamine active transporter (dat)) in the nucleus accumbens (nac) and ventral tegmental area (vta) of the offspring of control and cafeteria fed (jf) dams at weaning and after a 10-day naloxone treatment post-weaning and determined food preferences in adulthood in the remaining offspring. |
2015-02-19 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
the primary target of psychostimulants such as amphetamine and methamphetamine is the dopamine transporter (dat), the major regulator of extracellular dopamine levels in the brain. |
2015-02-19 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
we further examined the unique mechanisms by which amphetamine and methamphetamine regulate dat function and dopamine neurotransmission; in the present study we examined the impact of extracellular and intracellular amphetamine and methamphetamine on the spontaneous firing of cultured midbrain dopaminergic neurons and isolated dat-mediated current. |
2015-02-19 |
2023-08-13 |
Not clear |
| Lars Borre, Thorvald F Andreassen, Lei Shi, Harel Weinstein, Ulrik Gethe. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of biological chemistry. vol 289. issue 37. 2015-02-19. PMID:25063810. |
the dopamine transporter (dat) belongs to the family of neurotransmitter:sodium symporters and controls dopamine (da) homeostasis by mediating na(+)- and cl(-)-dependent reuptake of da. |
2015-02-19 |
2023-08-13 |
xenopus_laevis |
| Yu-Wen Li, Shaun Langdon, Rick Pieschl, Todd Strong, Robert N Wright, Kenneth Rohrbach, Snjezana Lelas, Nicholas J Lodg. Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats. European journal of pharmacology. vol 737. 2015-02-13. PMID:24821570. |
at higher doses, sibutramine produces thermogenesis; dat inhibition and activation of dopamine d1 receptors are required for this effect. |
2015-02-13 |
2023-08-13 |
rat |
| John D Robinson, Christopher D Howard, Elissa D Pastuzyn, Diane L Byers, Kristen A Keefe, Paul A Garri. Methamphetamine-induced neurotoxicity disrupts pharmacologically evoked dopamine transients in the dorsomedial and dorsolateral striatum. Neurotoxicity research. vol 26. issue 2. 2015-02-12. PMID:24562969. |
here, we further investigated this disruption by assessing effects of meth pretreatment on da transients elicited by a drug cocktail of raclopride, a d2 da receptor antagonist, and nomifensine, an inhibitor of the dopamine transporter (dat). |
2015-02-12 |
2023-08-12 |
rat |
| Rejwi Acharya Dahal, Akula Bala Pramod, Babita Sharma, Danielle Krout, James D Foster, Joo Hwan Cha, Jianjing Cao, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henr. Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. The Journal of biological chemistry. vol 289. issue 43. 2015-02-12. PMID:25179220. |
the dopamine transporter (dat) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (da). |
2015-02-12 |
2023-08-13 |
rat |
| Anders V Pedersen, Thorvald F Andreassen, Claus J Lolan. A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter. The Journal of biological chemistry. vol 289. issue 50. 2015-02-12. PMID:25339174. |
in the human dopamine transporter (dat), the corresponding residues are arg-85 and asp-476. |
2015-02-12 |
2023-08-13 |
human |
| Tanuja Bordia, Matthew McGregor, Roger L Papke, Michael W Decker, J Michael McIntosh, Maryka Qui. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental neurology. vol 263. 2015-02-09. PMID:25261754. |
the striatal dopamine transporter (dat), a marker of dopaminergic integrity, was reduced ~70% with lesioning. |
2015-02-09 |
2023-08-13 |
rat |
| Murad Hossain, Rochelle N Wickramasekara, Lucia Carvell. β-Phenylethylamine requires the dopamine transporter to increase extracellular dopamine in Caenorhabditis elegans dopaminergic neurons. Neurochemistry international. vol 73. 2015-02-02. PMID:24161617. |
a number of in vitro and behavioral studies suggest the dopamine transporter (dat) plays a role in the effects generated by βpea, however the mechanism through which βpea affects dat has not yet been elucidated. |
2015-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| Jon D Gaffaney, Madhur Shetty, Bruce Felts, Akula-Bala Pramod, James D Foster, L Keith Henry, Roxanne A Vaugha. Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. Neurochemistry international. vol 73. 2015-02-02. PMID:24269640. |
ligand-induced changes in the conformation of extracellular loop (el) 2 in the rat (r) dopamine transporter (dat) were examined using limited proteolysis with endoproteinase asp-n and detection of cleavage products by epitope-specific immunoblotting. |
2015-02-02 |
2023-08-12 |
human |
| Yvette Dehnes, Jufang Shan, Thijs Beuming, Lei Shi, Harel Weinstein, Jonathan A Javitc. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry international. vol 73. 2015-02-02. PMID:24576496. |
the dopamine transporter (dat), a member of the neurotransmitter:sodium symporter family, mediates the reuptake of dopamine at the synaptic cleft. |
2015-02-02 |
2023-08-12 |
Not clear |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we determined axon integrity by measuring fiber length density with tyrosine hydroxylase (th) immunohistology and dopamine transporter (dat) density with dat immunohistology. |
2015-02-02 |
2023-08-13 |
Not clear |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we then calculated the terminal arbor size and compared these measures with previously published data of quantified in vivo positron emission tomography (pet) measures of presynaptic dopaminergic neurons, autoradiographic measures of dat and vesicular monoamine transporter type 2 (vmat2), striatal dopamine, nigral cell counts, and parkinsonian motor ratings in the same animals. |
2015-02-02 |
2023-08-13 |
Not clear |
| Wen-Ting Hsieh, Been-Huang Chian. A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease. Journal of agricultural and food chemistry. vol 62. issue 27. 2015-02-02. PMID:24933592. |
the derived cells expressed many mda markers including tyrosine hydroxylase (th), β-iii tubulin, and dopamine transporter (dat). |
2015-02-02 |
2023-08-13 |
human |
| Amandine Valomon, Sebastian C Holst, Valérie Bachmann, Antoine U Viola, Christina Schmidt, Jurian Zürcher, Wolfgang Berger, Christian Cajochen, Hans-Peter Landol. Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Chronobiology international. vol 31. issue 5. 2015-01-30. PMID:24625311. |
cerebral dopamine levels are regulated primarily by the dopamine transporter (dat) in the striatum and by catechol-o-methyl-transferase (comt) in the prefrontal cortex. |
2015-01-30 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| Walter Adriani, Francesca Zoratto, Giovanni Laviol. Brain processes in discounting: consequences of adolescent methylphenidate exposure. Current topics in behavioral neurosciences. vol 9. 2015-01-20. PMID:21956611. |
an "impulsive" behavioral profile appears to emerge more extremely in rats when forebrain dopamine (da) systems undergo remodeling, as in adolescence, or with experimental manipulation tapping onto the dopamine transporter (dat). |
2015-01-20 |
2023-08-12 |
human |