| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H L Kimmel, F I Carroll, M J Kuha. Locomotor stimulant effects of novel phenyltropanes in the mouse. Drug and alcohol dependence. vol 65. issue 1. 2002-01-04. PMID:11714587. |
based on their affinities to the transporters in this earlier study, the analogs were classified as nonselective (cocaine, rti-51, rti-55, rti-108, rti-112, rti-116, rti-126, and rti-139) or dopamine transporter (dat) selective (rti-113, rti-120, rti-121, rti-141, rti-150, rti-171, rti-177, rti-199, rti-204, and rti-219). |
2002-01-04 |
2023-08-12 |
mouse |
| K M Wilcox, I A Paul, G A Ordway, W L Woolverto. Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in rats. Psychopharmacology. vol 157. issue 3. 2001-12-20. PMID:11605081. |
local anesthetics bind to the dopamine transporter (dat), inhibit dopamine (da) uptake and have been reported to have cocaine-like discriminative stimulus effects. |
2001-12-20 |
2023-08-12 |
rat |
| G Eisenhofe. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacology & therapeutics. vol 91. issue 1. 2001-12-19. PMID:11707293. |
in mammals, neuronal uptake of catecholamines involves the dopamine transporter (dat) at dopaminergic neurons and the norepinephrine transporter (net) at noradrenergic neurons. |
2001-12-19 |
2023-08-12 |
Not clear |
| A Laakso, J Bergman, M Haaparanta, H Vilkman, O Solin, E Syvälahti, J Hietal. Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophrenia research. vol 52. issue 1-2. 2001-12-18. PMID:11595398. |
we have previously reported that average striatal dopamine transporter (dat) binding in vivo is unaltered in neuroleptic-naive first-episode schizophrenic patients [laakso et al., am. |
2001-12-18 |
2023-08-12 |
Not clear |
| A Laakso, J Bergman, M Haaparanta, H Vilkman, O Solin, E Syvälahti, J Hietal. Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophrenia research. vol 52. issue 1-2. 2001-12-18. PMID:11595398. |
however, as it has been suggested that some of the brain changes in schizophrenia may vary depending on the illness phase, we studied dat density in eight stable, medicated chronic schizophrenic patients and eight matched controls using positron emission tomography and [18f]cft, a marker of dopamine nerve terminals. |
2001-12-18 |
2023-08-12 |
Not clear |
| A Laakso, J Bergman, M Haaparanta, H Vilkman, O Solin, E Syvälahti, J Hietal. Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophrenia research. vol 52. issue 1-2. 2001-12-18. PMID:11595398. |
together with the finding of unchanged average striatal dat levels in first-episode patients and relative insensitivity of striatal [18f]cft binding to endogenous dopamine and neuroleptic drugs, the result is in line with a relative loss of striatal dopaminergic nerve terminals and/or decreased expression of dat in a subset of chronic schizophrenic patients. |
2001-12-18 |
2023-08-12 |
Not clear |
| A Antonini, R M Moresco, C Gobbo, R De Notaris, A Panzacchi, P Barone, S Calzetti, A Negrotti, G Pezzoli, F Fazi. The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487195. |
neuroimaging studies of the striatal dopamine transporter (dat) are useful in the assessment of the dopaminergic system in parkinson's disease (pd). |
2001-12-13 |
2023-08-12 |
human |
| E Tupala, J T Kuikka, H Hall, K Bergström, T Särkioja, P Räsänen, T Mantere, J Hiltunen, J Vepsäläinen, J Tiihone. Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography. NeuroImage. vol 14. issue 1 Pt 1. 2001-12-07. PMID:11525341. |
positron emission tomography (pet) and single photon emission tomography (spet) studies have indicated alterations in striatal dopamine transporters (dat) and in presynaptic dopamine (da) function in alcoholics, although also contradictory results have been reported. |
2001-12-07 |
2023-08-12 |
human |
| K Yoshimoto, B Kato, S Ueda, K Noritake, K Sakai, M Shibata, M Hori, H Kawano, Y Takeuchi, Y Wakabayashi, M Yasuhar. Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats. Mechanisms of ageing and development. vol 122. issue 15. 2001-12-07. PMID:11557275. |
nucleus accumbens (acc) of young (4 months old) and aged (24 months old) wistar rats were perfused with dopamine (da) uptake blocker, cocaine, or the serotonin (5-ht) selective reuptake inhibitor, fluoxetine, through the microdialysis probe membrane, used to assess the dopamine transporter (dat) or serotonin transporter (sert) modulation. |
2001-12-07 |
2023-08-12 |
rat |
| H F Kun. Development of Tc-99m labeled tropanes: TRODAT-1, as a dopamine transporter imaging agent. Nuclear medicine and biology. vol 28. issue 5. 2001-12-05. PMID:11516695. |
the success in developing tc-99m trodat-1 for cns dopamine transporters (dat) serves as the first example of tc-99m site-specific imaging of human brain. |
2001-12-05 |
2023-08-12 |
human |
| J S Fowler, N D Volkow, G J Wang, S J Gatley, J Loga. [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy. Nuclear medicine and biology. vol 28. issue 5. 2001-12-05. PMID:11516700. |
it was soon discovered that [(11)c]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that it is also a sensitive radiotracer for dopamine transporter (dat) availability. |
2001-12-05 |
2023-08-12 |
human |
| R R Gainetdinov, A R Mohn, L M Bohn, M G Caro. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 20. 2001-12-04. PMID:11572967. |
the dopamine transporter (dat), which reuptakes the released neurotransmitter into presynaptic terminals, is a major determinant of the intensity and duration of the dopaminergic signal. |
2001-12-04 |
2023-08-12 |
mouse |
| T F el-Moselhy, K S Avor, G P Basmadjia. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie. vol 334. issue 8-9. 2001-12-04. PMID:11688137. |
a series of 2'-substituted cocaine analogs (4-8) was prepared and evaluated in an in vitro dopamine transporter (dat) binding assay. |
2001-12-04 |
2023-08-12 |
Not clear |
| Z Liu, Y Wang, W Zhao, J Ding, Z Mei, L Guo, D Cui, J Fe. Peptide derived from insulin with regulatory activity of dopamine transporter. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543766. |
a nonapeptide derived from the c terminus of the insulin b chain, h(2)n-arg-gly-phe-phe-tyr-thr-pro-lys-ala-cooh, was found to strongly inhibit dopamine (da) uptake by rat dopamine transporter (dat) stably expressed in cho cells (designated d8 cells). |
2001-11-01 |
2023-08-12 |
rat |
| A R Galeeva, E B Iur'ev, E K Khusnutdinov. [The evaluation of VNTR-polymorphism in the gene of dopamine transporter in men of different nationalities with acute alcoholic psychosis]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 101. issue 5. 2001-10-25. PMID:11505915. |
vntr-polymorphism of the gene of dopamine transporter (dat) in men of the russian and tatar nationalities with acute alcoholic psychoses was analyzed by method of the polymerase chain reaction. |
2001-10-25 |
2023-08-12 |
Not clear |
| M L Mundorf, J D Joseph, C M Austin, M G Caron, R M Wightma. Catecholamine release and uptake in the mouse prefrontal cortex. Journal of neurochemistry. vol 79. issue 1. 2001-10-25. PMID:11595765. |
in the prefrontal cortex (pfc), immunohistochemical fluorescence of the plap along with staining for dopamine transporter (dat) and norepinephrine transporter (net) revealed that all three exhibit remarkable spatial overlap. |
2001-10-25 |
2023-08-12 |
mouse |
| M Sas. [Function of monoamine neurotransmitter transporters]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 8. 2001-10-18. PMID:11519142. |
antiepileptic drugs such as ssri and tricyclic antidepressants bind with serotonin transporter(sert), noradrenaline transporter(net) and/or dopamine transporters(dat) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft. |
2001-10-18 |
2023-08-12 |
Not clear |
| D S Rothblat, J A Schroeder, J S Schneide. Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: potential contributors to spontaneous recovery from experimental Parkinsonism. Journal of neuroscience research. vol 65. issue 3. 2001-10-11. PMID:11494360. |
the present study examined the extent to which compensatory changes in tyrosine hydroxylase (th) and dopamine transporter (dat) gene and protein expression may underlie this behavioral recovery. |
2001-10-11 |
2023-08-12 |
Not clear |
| B M Prasad, S G Amar. The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567046. |
the dopamine transporter (dat) plays a crucial role in the clearance of extracellular dopamine in brain. |
2001-10-11 |
2023-08-12 |
human |
| B M Prasad, S G Amar. The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567046. |
uptake of dopamine by the cloned human dat has been shown to be electrogenic and voltage-dependent, with greater uptake observed at hyperpolarized potentials. |
2001-10-11 |
2023-08-12 |
human |