| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bassem F El-Khodor, Patricia Boks. Birth insult and stress interact to alter dopamine transporter binding in rat brain. Neuroreport. vol 13. issue 2. 2002-04-22. PMID:11893910. |
this study investigated whether mild birth complications (c-section birth, c-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3h]win 35428 binding to dopamine transporters (dat) in rat brain. |
2002-04-22 |
2023-08-12 |
rat |
| G M Miller, B K Madra. Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803445. |
dopamine transporter (dat) levels vary in normal subjects and deviate from the normal range in pathological states. |
2002-04-19 |
2023-08-12 |
human |
| D Martinez, A Broft, M Laruell. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. vol 2. issue 3. 2002-04-18. PMID:11535111. |
this paper reviews brain imaging studies designed to evaluate the significance of polymorphisms in genes coding for important drug targets (e.g., the serotonin transporter [sert], the dopamine transporter [dat] and the dopamine d(2) receptor) in terms of expression or function. |
2002-04-18 |
2023-08-12 |
human |
| Alicia E Derbez, Rupal M Mody, Linda L Werlin. Sigma(2)-receptor regulation of dopamine transporter via activation of protein kinase C. The Journal of pharmacology and experimental therapeutics. vol 301. issue 1. 2002-04-18. PMID:11907188. |
previous studies in our laboratory have demonstrated sigma(2)-receptor-mediated regulation of the dopamine transporter (dat) as measured by amphetamine-stimulated release of [(3)h]dopamine (da) from both rat striatal slices and pc12 cells. |
2002-04-18 |
2023-08-12 |
rat |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
cocaine's blockade of dopamine reuptake by brain dopamine transporters (dat) is a central feature of current understanding of cocaine reward and addiction. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
we have approached this problem by assessing expression, dopamine uptake, and cocaine analog affinities of 56 dat mutants in residues located in or near transmembrane domains likely to play significant roles in cocaine recognition and dopamine uptake. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
a phenylalanine-to-alanine mutant in putative dat transmembrane domain 3, f154a, retains normal dopamine uptake, lowers cocaine affinity 10-fold, and reduces cocaine stereospecificity. |
2002-04-11 |
2023-08-12 |
Not clear |
| Richard R Cesati, Gilles Tamagnan, Ronald M Baldwin, Sami S Zoghbi, Robert B Innis, Nora S Kula, Ross J Baldessarini, John A Katzenellenboge. Synthesis of cyclopentadienyltricarbonyl rhenium phenyltropanes by double ligand transfer: organometallic ligands for the dopamine transporter. Bioconjugate chemistry. vol 13. issue 1. 2002-04-05. PMID:11792176. |
such agents, when labeled with technetium-99m, might function as imaging agents for the dopamine transporter (dat) system that would be useful for assessing the onset and severity of parkinson's disease. |
2002-04-05 |
2023-08-12 |
Not clear |
| Stéphanie Barc, Guylène Page, Laurence Barrier, Lucette Garreau, Denis Guilloteau, Bernard Fauconneau, Sylvie Chalo. Relevance of different striatal markers in assessment of the MPP+-induced dopaminergic nigrostriatal injury in rat. Journal of neurochemistry. vol 80. issue 3. 2002-04-04. PMID:11905985. |
the in vivo binding of (e)-n-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (pe2i), a selective and potent inhibitor of the neuronal dopamine transporter (dat) was considered as the reference index of injury of striatal dopaminergic nerve-endings. |
2002-04-04 |
2023-08-12 |
rat |
| S Purkerson-Parker, K L McDaniel, V C Mose. Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 2. 2002-04-01. PMID:11719704. |
recent reports indicate that heptachlor exposure also alters dopamine transporter (dat) expression and function in adult mice. |
2002-04-01 |
2023-08-12 |
mouse |
| Nora D Volkow, Gene-Jack Wang, Joanna S Fowler, Jean Logan, Dinko Franceschi, Laurence Maynard, Yu-Shin Ding, Samuel J Gatley, Andrew Gifford, Wei Zhu, James M Swanso. Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications. Synapse (New York, N.Y.). vol 43. issue 3. 2002-03-21. PMID:11793423. |
since methylphenidate's therapeutic effects are in part due to increases in extracellular da secondary to blockade of dopamine transporters (dat), the variability could reflect differences in levels of dat blockade. |
2002-03-21 |
2023-08-12 |
human |
| J H Meyer, S Krüger, A A Wilson, B K Christensen, V S Goulding, A Schaffer, C Minifie, S Houle, D Hussey, S H Kenned. Lower dopamine transporter binding potential in striatum during depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742250. |
to investigate this, we measured the dopamine transporter binding potential (dat bp) in the striatum of depressed and healthy subjects using [(11)c]rti-32 pet. |
2002-03-18 |
2023-08-12 |
human |
| J H Meyer, S Krüger, A A Wilson, B K Christensen, V S Goulding, A Schaffer, C Minifie, S Houle, D Hussey, S H Kenned. Lower dopamine transporter binding potential in striatum during depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742250. |
the dat, a predominantly presynaptic receptor, decreases in density after chronic dopamine depletion and the bp is proportional to receptor density. |
2002-03-18 |
2023-08-12 |
human |
| J H Meyer, S Krüger, A A Wilson, B K Christensen, V S Goulding, A Schaffer, C Minifie, S Houle, D Hussey, S H Kenned. Lower dopamine transporter binding potential in striatum during depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742250. |
low striatal dat bp in mde is consistent with a downregulation of dat in response to a dopamine lowering process. |
2002-03-18 |
2023-08-12 |
human |
| J H Meyer, S Krüger, A A Wilson, B K Christensen, V S Goulding, A Schaffer, C Minifie, S Houle, D Hussey, S H Kenned. Lower dopamine transporter binding potential in striatum during depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742250. |
lower dat bp itself reduces extracellular clearance of dopamine. |
2002-03-18 |
2023-08-12 |
human |
| J H Meyer, S Krüger, A A Wilson, B K Christensen, V S Goulding, A Schaffer, C Minifie, S Houle, D Hussey, S H Kenned. Lower dopamine transporter binding potential in striatum during depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742250. |
patients who did not decrease their striatal dat bp failed to compensate for low dopamine and showed greater impairment on dopamine related tests. |
2002-03-18 |
2023-08-12 |
human |
| Lynette C Daws, Paul D Callaghan, José A Morón, Kris M Kahlig, Toni S Shippenberg, Jonathan A Javitch, Aurelio Gall. Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820798. |
in hek 293 cells expressing the human dopamine transporter (dat), a 10-min incubation with 10 microm cocaine followed by extensive washing resulted in a 30% increase in [3h]dopamine (da) uptake as well as an increase in cell surface dat in biotinylation experiments. |
2002-03-15 |
2023-08-12 |
human |
| C Spielewoy, G Biala, C Roubert, M Hamon, C Betancur, B Giro. Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797063. |
mice lacking the dopamine transporter (dat(-/-)) exhibit high extracellular dopamine levels and marked hyperactivity. |
2002-03-13 |
2023-08-12 |
mouse |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| Tzu-Chen Yen, Kai-Yuan Tzen, Min-Chi Chen, Yah-Huei Wu Chou, Rou-Shayn Chen, Chi-Jen Chen, Shiaw-Pyng Wey, Gann Ting, Chin-Song L. Dopamine transporter concentration is reduced in asymptomatic Machado-Joseph disease gene carriers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 43. issue 2. 2002-03-12. PMID:11850478. |
dopamine transporter (dat) binding is decreased in machado-joseph disease (mjd) patients. |
2002-03-12 |
2023-08-12 |
human |