| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun J Kim, Masanori Ichise, James R Ballinger, Douglas Vines, Sean S Erami, Tatsuro Tatschida, Anthony E Lan. Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 2. 2002-05-17. PMID:11921116. |
spect scans using [123i]beta-cit (for dat) and [123i]ibf (for d2) were performed in 18 patients with pd (12 dopa-naïve and 6 on levodopa and/or dopamine agonists), 7 with msa of the striatonigral degeneration type, 6 with psp, and 29 normal controls. |
2002-05-17 |
2023-08-12 |
Not clear |
| T A Greenwood, M Alexander, P E Keck, S McElroy, A D Sadovnick, R A Remick, S H Shaw, J R Kelso. Segmental linkage disequilibrium within the dopamine transporter gene. Molecular psychiatry. vol 7. issue 2. 2002-05-14. PMID:11840309. |
the dopamine transporter gene (dat) has been implicated in a variety of disorders, including bipolar disorder, attention-deficit hyperactivity disorder, cocaine-induced paranoia, tourette's syndrome, and parkinson's disease. |
2002-05-14 |
2023-08-12 |
Not clear |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
substantial evidence has accumulated that the dopamine transporter (dat) is a key target for cocaine regarding its reinforcing effects. |
2002-05-06 |
2023-08-12 |
Not clear |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
the aim of the study is to gain insight into the structural requirements that determine the affinity of the data set molecules to the dat and the serotonin transporter (sert) as well as their inhibitory potency on dopamine uptake. |
2002-05-06 |
2023-08-12 |
Not clear |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
in the first part of the work, the selectivity of the database molecules for dat binding vs dopamine reuptake inhibition is investigated. |
2002-05-06 |
2023-08-12 |
Not clear |
| Tarek F El-Moselhy, Kwasi S Avor, Garo P Basmadjia. Synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. European journal of medicinal chemistry. vol 37. issue 2. 2002-05-02. PMID:11858849. |
a series of 2beta-isopropyl ester analogs of cocaine (7-11) was synthesised and evaluated in an in vitro dopamine transporter (dat) binding assays. |
2002-05-02 |
2023-08-12 |
Not clear |
| Richard Nass, David H Hall, David M Miller, Randy D Blakel. Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 5. 2002-04-26. PMID:11867711. |
in mammals, dopamine neuronal degeneration can be triggered through exposure to neurotoxins accumulated by the presynaptic dopamine transporter (dat), including 6-hydroxydopamine (6-ohda) and 1-methyl-4-phenylpyridinium. |
2002-04-26 |
2023-08-12 |
caenorhabditis_elegans |
| Lifen Xu, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Cheryl Klein-Stevens, Naiju Zhu, Stacey A Lomenzo, Leyte Winfield, Mark L Trudel. Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881989. |
from the in vitro structure-activity data, it is apparent that a tolyl group in the 2-position, independent of the stereochemical attachment to the tropane ring system, provided compounds (9-12, 14) that exhibit high-affinity binding at the dopamine transporter (dat). |
2002-04-26 |
2023-08-12 |
Not clear |
| Lifen Xu, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Cheryl Klein-Stevens, Naiju Zhu, Stacey A Lomenzo, Leyte Winfield, Mark L Trudel. Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881989. |
furthermore, despite a relatively low potency of 10 for the inhibition of dopamine uptake compared to its affinity for the dat, its behavioral profile did not vary significantly from cocaine. |
2002-04-26 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Christina M Dersch, Michael H Baumann, David Stafford, John R Glowa, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11882001. |
the s enantiomers displayed higher dopamine transporter (dat) affinity and the r enantiomers were found to interact at the serotonin transporter (sert) with higher affinity. |
2002-04-26 |
2023-08-12 |
monkey |
| Richard B Rothman, Christina M Dersch, F Ivy Carroll, Subramaniam Anantha. Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835522. |
using [125i]rti-55 to label the dopamine transporter (dat), our laboratory has consistently detected one binding site as well as one component of [3h]da uptake. |
2002-04-23 |
2023-08-12 |
mouse |
| Bassem F El-Khodor, Patricia Boks. Birth insult and stress interact to alter dopamine transporter binding in rat brain. Neuroreport. vol 13. issue 2. 2002-04-22. PMID:11893910. |
this study investigated whether mild birth complications (c-section birth, c-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3h]win 35428 binding to dopamine transporters (dat) in rat brain. |
2002-04-22 |
2023-08-12 |
rat |
| G M Miller, B K Madra. Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803445. |
dopamine transporter (dat) levels vary in normal subjects and deviate from the normal range in pathological states. |
2002-04-19 |
2023-08-12 |
human |
| D Martinez, A Broft, M Laruell. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. vol 2. issue 3. 2002-04-18. PMID:11535111. |
this paper reviews brain imaging studies designed to evaluate the significance of polymorphisms in genes coding for important drug targets (e.g., the serotonin transporter [sert], the dopamine transporter [dat] and the dopamine d(2) receptor) in terms of expression or function. |
2002-04-18 |
2023-08-12 |
human |
| Alicia E Derbez, Rupal M Mody, Linda L Werlin. Sigma(2)-receptor regulation of dopamine transporter via activation of protein kinase C. The Journal of pharmacology and experimental therapeutics. vol 301. issue 1. 2002-04-18. PMID:11907188. |
previous studies in our laboratory have demonstrated sigma(2)-receptor-mediated regulation of the dopamine transporter (dat) as measured by amphetamine-stimulated release of [(3)h]dopamine (da) from both rat striatal slices and pc12 cells. |
2002-04-18 |
2023-08-12 |
rat |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
cocaine's blockade of dopamine reuptake by brain dopamine transporters (dat) is a central feature of current understanding of cocaine reward and addiction. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
we have approached this problem by assessing expression, dopamine uptake, and cocaine analog affinities of 56 dat mutants in residues located in or near transmembrane domains likely to play significant roles in cocaine recognition and dopamine uptake. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
a phenylalanine-to-alanine mutant in putative dat transmembrane domain 3, f154a, retains normal dopamine uptake, lowers cocaine affinity 10-fold, and reduces cocaine stereospecificity. |
2002-04-11 |
2023-08-12 |
Not clear |
| Richard R Cesati, Gilles Tamagnan, Ronald M Baldwin, Sami S Zoghbi, Robert B Innis, Nora S Kula, Ross J Baldessarini, John A Katzenellenboge. Synthesis of cyclopentadienyltricarbonyl rhenium phenyltropanes by double ligand transfer: organometallic ligands for the dopamine transporter. Bioconjugate chemistry. vol 13. issue 1. 2002-04-05. PMID:11792176. |
such agents, when labeled with technetium-99m, might function as imaging agents for the dopamine transporter (dat) system that would be useful for assessing the onset and severity of parkinson's disease. |
2002-04-05 |
2023-08-12 |
Not clear |
| Stéphanie Barc, Guylène Page, Laurence Barrier, Lucette Garreau, Denis Guilloteau, Bernard Fauconneau, Sylvie Chalo. Relevance of different striatal markers in assessment of the MPP+-induced dopaminergic nigrostriatal injury in rat. Journal of neurochemistry. vol 80. issue 3. 2002-04-04. PMID:11905985. |
the in vivo binding of (e)-n-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (pe2i), a selective and potent inhibitor of the neuronal dopamine transporter (dat) was considered as the reference index of injury of striatal dopaminergic nerve-endings. |
2002-04-04 |
2023-08-12 |
rat |