| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
the present experiments tested the hypothesis that [(3)h]win 35428 binding and [(3)h]dopamine uptake would be increased by exposure to cocaine through alterations in dat cellular trafficking, rather than increased protein synthesis. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
experiments were conducted in stably hdat-transfected n2a cells and assessed the dose response and time course of cocaine effects on [(3)h]win 35428 binding to the dat, [(3)h]dopamine uptake, measures of dat protein and mrna, as well as dat subcellular location. |
2002-02-07 |
2023-08-12 |
human |
| A L Svingos, C Chavkin, E E Colago, V M Picke. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746715. |
the behavioral effects of psychostimulants, which are produced at least in part through inhibition of the dopamine transporter (dat), are modulated by kappa-opioid receptors (kor) in the nucleus accumbens (acb). |
2002-02-05 |
2023-08-12 |
Not clear |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
we have tested this hypothesis by comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3h-dopamine into synaptosomes from frontal cortex, caudate nucleus, and nucleus accumbens from wild-type, net, and dopamine transporter (dat) knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
dopamine uptake was inhibited by cocaine and nisoxetine, but not by gbr12909, in frontal cortex synaptosomes from wild-type or dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
nisoxetine inhibited dopamine uptake by 20% in caudate and nucleus accumbens synaptosomes from wild-type and dat knock-out mice but had no effect in those from net knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
cocaine failed to block dopamine uptake into caudate or nucleus accumbens synaptosomes from dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
thus, whereas dopamine uptake in caudate and nucleus accumbens depends primarily on the dat, dopamine uptake in frontal cortex depends primarily on the net. |
2002-01-30 |
2023-08-12 |
mouse |
| A Varrone, K L Marek, D Jennings, R B Innis, J P Seiby. [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 6. 2002-01-25. PMID:11748733. |
in vivo imaging of the dopamine transporter (dat) with single photon emission computed tomography (spect) is a quantitative biomarker for parkinson's disease (pd) onset and severity. |
2002-01-25 |
2023-08-12 |
Not clear |
| K M Wilcox, K P Lindsey, J R Votaw, M M Goodman, L Martarello, F I Carroll, L L Howel. Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse (New York, N.Y.). vol 43. issue 1. 2002-01-24. PMID:11746736. |
drug effects on behavior were related to dopamine transporter (dat) occupancy in monkey striatum during neuroimaging with positron emission tomography. |
2002-01-24 |
2023-08-12 |
monkey |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
the dopamine (dat) and serotonin (sert) transporter genes both contain variable number of tandem repeats (vntr) in non-coding gene regions which have been correlated with a predisposition to a variety of cns disorders. |
2002-01-17 |
2023-08-12 |
human |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
this study demonstrates by lipid transfection into an immortalized dopaminergic cell line and biolistic transfection into dopamine neurons in neonatal rat midbrain slices that the human nine-repeat dat vntr can enhance transcription. |
2002-01-17 |
2023-08-12 |
human |
| R D Mayfield, R Maiya, D Keller, N R Zahnise. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739621. |
recent studies suggest that ethanol's action on central dopamine systems may also involve modulation of dopamine transporter (dat) activity. |
2002-01-17 |
2023-08-12 |
human |
| R D Mayfield, R Maiya, D Keller, N R Zahnise. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739621. |
thus, the increase in dopamine uptake was associated with a parallel increase in the number of dat molecules expressed at the cell surface. |
2002-01-17 |
2023-08-12 |
human |
| A M Allan, R Galindo, J Chynoweth, S R Engel, D D Savag. Conditioned place preference for cocaine is attenuated in mice over-expressing the 5-HT(3) receptor. Psychopharmacology. vol 158. issue 1. 2002-01-15. PMID:11685380. |
no changes in either the dopamine receptors (d1, d2, d3, and d4) or in the dopamine transporter (dat) were found over a wide range of brain regions. |
2002-01-15 |
2023-08-12 |
mouse |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harad. Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain. Synapse (New York, N.Y.). vol 42. issue 4. 2002-01-10. PMID:11746726. |
the effects of ketamine anesthesia on the binding of [(11)c]-labeled cocaine analogs, [(11)c]beta-cft (2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane) and [(11)c]beta-cit-fe (n-(2-fluoroethyl)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane), to the striatal dopamine transporter (dat) were evaluated in the monkey brain using positron emission tomography (pet). |
2002-01-10 |
2023-08-12 |
monkey |
| S Barc, G Page, L Barrier, A Piriou, B Fauconnea. Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698152. |
an intranigral injection of 10 microg mpp(+) in rat induced a decrease of about 30% of the neuronal dopamine transporter (dat) activity 21 days after lesion. |
2002-01-07 |
2023-08-12 |
rat |
| M F Zou, T Kopajtic, J L Katz, S Wirtz, J B Justice, A H Newma. Novel tropane-based irreversible ligands for the dopamine transporter. Journal of medicinal chemistry. vol 44. issue 25. 2002-01-07. PMID:11728190. |
we previously prepared a benztropine-based photoaffinity label [125i]-(n-[4-(4'-azido-3'-iodophenyl)butyl]-3alpha-[bis(4'-fluorophenyl)methoxy]tropane, [125i]1, that covalently attached to the 1-2 transmembrane spanning region of the dopamine transporter (dat). |
2002-01-07 |
2023-08-12 |
rat |
| M F Zou, T Kopajtic, J L Katz, S Wirtz, J B Justice, A H Newma. Novel tropane-based irreversible ligands for the dopamine transporter. Journal of medicinal chemistry. vol 44. issue 25. 2002-01-07. PMID:11728190. |
these ligands will provide important tools for further characterizing the binding domains for tropane-based dopamine uptake inhibitors at the dat. |
2002-01-07 |
2023-08-12 |
rat |
| R A González-Polo, A Mora, N Clemente, G Sabio, F Centeno, G Soler, J M Fuente. Mechanisms of MPP(+) incorporation into cerebellar granule cells. Brain research bulletin. vol 56. issue 2. 2002-01-04. PMID:11704348. |
we have studied the implication of various membrane transporter systems on mpp(+) neurotoxicity, including the dopamine transporter system (dat) and cationic amino acid transporters (cat). |
2002-01-04 |
2023-08-12 |
cat |