| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B M Prasad, S G Amar. The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567046. |
dopamine uptake in these cultures was saturable with a k(m) of approximately 560 +/- 60 nm and a dat turnover rate of 0.74 +/- 0.07 dopamine molecules per second. |
2001-10-11 |
2023-08-12 |
human |
| B M Prasad, S G Amar. The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567046. |
thus, dopamine neurons fire approximately three action potentials in the time taken for dat to go through one transport cycle. |
2001-10-11 |
2023-08-12 |
human |
| H Hastrup, A Karlin, J A Javitc. Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 18. 2001-10-04. PMID:11526230. |
we found that cross-linking the human dopamine transporter (dat), which is heterologously expressed in human embryonic kidney 293 cells, either with copper phenanthroline (cup) or the bifunctional reagent bis-(2-methanethiosulfonatoethyl)amine hydrochloride (bis-ea) increased the apparent molecular mass determined with nonreducing sds/page from approximately 85 to approximately 195 kda. |
2001-10-04 |
2023-08-12 |
human |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, W A Zaman, K M Johnso. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425577. |
we previously disclosed the discovery of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3) as a novel class of dopamine transporter (dat) inhibitors and showed that (+/-)-3 has a significant functional antagonism against cocaine in vitro. |
2001-09-20 |
2023-08-12 |
Not clear |
| P Emond, J Helfenbein, S Chalon, L Garreau, J Vercouillie, Y Frangin, J C Besnard, D Guillotea. Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425587. |
the effects of structural modifications of 2 beta-carbomethoxy-3 beta-phenyl tropane analogues were evaluated on in vitro affinity to the dopamine (dat) and serotonin (5-htt) transporters in rat brain tissue. |
2001-09-20 |
2023-08-12 |
rat |
| B M Tyler-McMahon, J A Stewart, J Jackson, M D Bitner, A Fauq, D J McCormick, E Richelso. Altering behavioral responses and dopamine transporter protein with antisense peptide nucleic acids. Biochemical pharmacology. vol 62. issue 7. 2001-09-20. PMID:11543728. |
the dopamine transporter (dat) plays a role in locomotion and is an obligatory target for amphetamines. |
2001-09-20 |
2023-08-12 |
rat |
| M E Reith, J L Berfield, L C Wang, J V Ferrer, J A Javitc. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of biological chemistry. vol 276. issue 31. 2001-09-13. PMID:11395483. |
the binding affinity of the cocaine analog [(3)h]2 beta-carbomethoxy-3beta-(4-fluorophenyl) tropane (win) for the dopamine transporter (dat) is increased by the reaction of cys-90, at the extracellular end of the first transmembrane segment, with methanethiosulfonate (mts) reagents. |
2001-09-13 |
2023-08-12 |
human |
| M Suzuki, T J Desmond, R L Albin, K A Fre. Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494403. |
autoradiography was used to quantify radioligand binding to vmat2, vacht, the dopamine plasmalemmal transporter (dat), benzodiazepine (bz) binding sites, and d2-type dopamine receptors. |
2001-09-13 |
2023-08-12 |
human |
| C Roubert, C Sagné, M Kapsimali, P Vernier, F Bourrat, B Giro. A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Molecular pharmacology. vol 60. issue 3. 2001-09-06. PMID:11502876. |
this carrier is very similar to the human neuronal norepinephrine transporter (net) and the human neuronal dopamine transporter (dat), showing 70 and 64% amino acid identity, respectively. |
2001-09-06 |
2023-08-12 |
human |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
these included the dopamine transporter (dat) and polyspecific organic cation transporters oct-1 and oct-3. |
2001-08-30 |
2023-08-12 |
mouse |
| T P Laine, A Ahonen, P Räsänen, T Pohjalainen, J Tiihonen, J Hietal. The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics. Alcohol and alcoholism (Oxford, Oxfordshire). vol 36. issue 3. 2001-08-23. PMID:11373265. |
striatal dopamine transporter (dat) densities were studied with [(123)i]2-beta-carbometoxy-3beta(4-iodophenyl)tropane and single-photon emission tomography in 29 detoxified alcoholics, who were also genotyped for the two alleles of taqi a rflp at the drd2 receptor gene locus. |
2001-08-23 |
2023-08-12 |
human |
| S Callier, M Morissette, M Grandbois, D Pélaprat, T Di Paol. Neuroprotective properties of 17beta-estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice. Synapse (New York, N.Y.). vol 41. issue 2. 2001-08-23. PMID:11400179. |
the hormonal effect on the dopamine transporter (dat) was examined to probe the integrity of dopamine neurons and glutamate receptors in order to find a possible excitotoxic mechanism. |
2001-08-23 |
2023-08-12 |
mouse |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
plasma membrane dopamine transporter (dat), vesicular monoamine transporters (vmat) type-1 and -2 and the expression of the dopaminergic markers dopamine and tyrosine hydroxylase were assessed in membranes and/or in cytospin centrifuged human peripheral blood lymphocytes. |
2001-08-23 |
2023-08-12 |
human |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
the radiolabeled dat ligand [3h]gbr12935 was bound to peripheral lymphocytes in a manner consistent with the specific binding to a dopamine uptake system, with a dissociation constant similar to that found in striatum, but with a lower density of binding sites. |
2001-08-23 |
2023-08-12 |
human |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
lymphocyte dat characterized in this study has probably functional relevance as [3h]dopamine was taken up by intact lymphocytes and uptake was inhibited specifically by compounds known to affect dopamine transport. |
2001-08-23 |
2023-08-12 |
human |
| N Sakuragawa, M A Elwan, S Uchida, T Fujii, K Kawashim. Non-neuronal neurotransmitters and neurotrophic factors in amniotic epithelial cells: expression and function in humans and monkey. Japanese journal of pharmacology. vol 85. issue 1. 2001-08-16. PMID:11243569. |
we have provided evidence that haec have multiple functions such as synthesis and release of acetylcholine (ach) and catecholamine (ca) as well as expressing mrna coding for dopamine receptors and dopamine (da) transporter (dat). |
2001-08-16 |
2023-08-12 |
human |
| P C Meltzer, B Wang, Z Chen, P Blundell, M Jayaraman, M D Gonzalez, C George, B K Madra. Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Journal of medicinal chemistry. vol 44. issue 16. 2001-08-16. PMID:11472216. |
its reinforcing and stimulant effects are related to its ability to inhibit the membrane bound dopamine transporter (dat). |
2001-08-16 |
2023-08-12 |
Not clear |
| P C Meltzer, B Wang, Z Chen, P Blundell, M Jayaraman, M D Gonzalez, C George, B K Madra. Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Journal of medicinal chemistry. vol 44. issue 16. 2001-08-16. PMID:11472216. |
inhibition of the dat causes an increase of dopamine in the synapse with a resultant activation of postsynaptic receptors. |
2001-08-16 |
2023-08-12 |
Not clear |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
we used rt-pcr to clone monoamine transporters from macaca mulatta, macaca fasicularis and saimiri sciureus (dopamine transporter; dat) and macaca mulatta (norepinephrine transporter; net and serotonin transporter; sert). |
2001-08-09 |
2023-08-12 |
human |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
variant i displayed dopamine transport kinetics and binding affinities for various dat blockers (including cocaine) versus [3h] cft (win 35, 428) that were identical to wild-type dat (n=7 drugs; r(2)=0.991). |
2001-08-09 |
2023-08-12 |
human |