| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Janowsky, C Mah, R A Johnson, C L Cunningham, T J Phillips, J C Crabbe, A J Eshleman, J K Belkna. Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. The Journal of pharmacology and experimental therapeutics. vol 298. issue 2. 2001-08-09. PMID:11454925. |
binding of 3beta-(4-iodophenyl) tropane-2beta-carboxylic acid methyl ester ([125i]rti-55) to the dopamine transporter (dat) in neostriatum from c57bl/6j, dba/2j, and 21 bxd recombinant inbred (ri) mouse strains indicated highly significant strain differences in dat density (bmax) but no significant differences in affinity (kd) for this radioligand. |
2001-08-09 |
2023-08-12 |
mouse |
| T Poyot, F Condé, M C Grégoire, V Frouin, C Coulon, C Fuseau, F Hinnen, F Dollé, P Hantraye, M Bottlaende. Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 7. 2001-07-26. PMID:11435790. |
the use of ligands of the dopamine transporters (dat) is an attractive alternative target; consequently, the current aim was to validate one of them, 11c-pe2i, using a multiinjection modeling approach allowing accurate quantitation of dat densities in the striatum. |
2001-07-26 |
2023-08-12 |
Not clear |
| N Kubota, Y Kiuchi, M Nemoto, H Oyamada, M Ohno, H Funahashi, S Shioda, K Oguch. Regulation of serotonin transporter gene expression in human glial cells by growth factors. European journal of pharmacology. vol 417. issue 1-2. 2001-07-19. PMID:11301061. |
the expression of serotonin transporter mrna was detected by reverse transcriptase-polymerase chain reaction in normal human astrocytes, whereas the dopamine transporter (dat) and the norepinephrine transporter (net) were not detected. |
2001-07-19 |
2023-08-12 |
human |
| H L Kimmel, A R Joyce, F I Carroll, M J Kuha. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408534. |
utilizing a technique for measuring the kinetics (synthesis, degradation, and half-life) of the dopamine transporter (dat) protein in the rat striatum and nucleus accumbens, we have investigated the effects of systemic administration of dopamine receptor agonists and antagonists upon dat kinetics in these brain regions. |
2001-07-19 |
2023-08-12 |
rat |
| H L Kimmel, A R Joyce, F I Carroll, M J Kuha. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408534. |
however, the dopamine d2 receptor agonists r-(-)-propylnorapomorphine hydrochloride (npa) and quinpirole decreased the half-life of dat. |
2001-07-19 |
2023-08-12 |
rat |
| H L Kimmel, A R Joyce, F I Carroll, M J Kuha. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408534. |
this effect was blocked by the dopamine d2 antagonist eticlopride, which, by itself, increased the half-life of dat. |
2001-07-19 |
2023-08-12 |
rat |
| H L Kimmel, A R Joyce, F I Carroll, M J Kuha. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408534. |
the results of the present study suggest that, through dopamine receptors, dopamine indirectly influences dat protein turnover in the striatum and in the nucleus accumbens, but in different ways. |
2001-07-19 |
2023-08-12 |
rat |
| D Martinez, J Gelernter, A Abi-Dargham, C H van Dyck, L Kegeles, R B Innis, M Laruell. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282255. |
a 40 base polymorphism of a variable number of tandem repeats (vntr) has been described in the 3' untranslated region of the gene (slc6a3) coding for the dopamine transporter (dat). |
2001-07-12 |
2023-08-12 |
human |
| D Martinez, J Gelernter, A Abi-Dargham, C H van Dyck, L Kegeles, R B Innis, M Laruell. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282255. |
to examine the neurochemical phenotype associated with this polymorphism, we compared amphetamine-induced dopamine release (measured as displacement of the radiotracer [123i]ibzm) and dat expression (measured with [123i]beta-cit) in the striatum with single photon computerized emission tomography (spect). |
2001-07-12 |
2023-08-12 |
human |
| D Martinez, J Gelernter, A Abi-Dargham, C H van Dyck, L Kegeles, R B Innis, M Laruell. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282255. |
no significant association was found between vntr polymorphism and amphetamine-induced dopamine release or dat density in the total sample, nor when each diagnostic group was considered separately. |
2001-07-12 |
2023-08-12 |
human |
| M L Kirby, R L Barlow, J R Bloomquis. Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 61. issue 1. 2001-07-12. PMID:11294980. |
increases in maximal rate of striatal dopamine uptake were attributed to induction of the dopamine transporter (dat) and a compensatory response to elevated synaptic levels of dopamine. |
2001-07-12 |
2023-08-12 |
mouse |
| M L Kirby, R L Barlow, J R Bloomquis. Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 61. issue 1. 2001-07-12. PMID:11294980. |
significant increase in v(max) of striatal dat was not observed at doses > 12 mg/kg, which suggested that toxic effects of heptachlor epoxide may be responsible for loss of maximal dopamine uptake observed at higher doses of heptachlor. |
2001-07-12 |
2023-08-12 |
mouse |
| M Guttman, D Stewart, D Hussey, A Wilson, S Houle, S Kis. Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD. Neurology. vol 56. issue 11. 2001-07-12. PMID:11402115. |
animal data indicate that chronic exposure to dopaminergic drugs can alter levels of the dopamine transporter (dat), which is critically involved in regulation of synaptic dopamine levels. |
2001-07-12 |
2023-08-12 |
Not clear |
| T Hayashi, H Hirata, M Asanuma, B Ladenheim, L I Tsao, J L Cadet, T P S. Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53. Synapse (New York, N.Y.). vol 39. issue 4. 2001-07-05. PMID:11169780. |
the levels of dopamine transporter (dat), tyrosine hydroxylase (th), major biogenic amines including da, 5-hydroxytryptamine (5-ht), and their metabolites were examined. |
2001-07-05 |
2023-08-12 |
mouse |
| J Holzschuh, S Ryu, F Aberger, W Drieve. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of development. vol 101. issue 1-2. 2001-07-05. PMID:11231083. |
to characterize the formation of the dopaminergic system in the developing zebrafish cns, we cloned cdnas encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat), a membrane transport protein which terminates dopamine action by re-uptake. |
2001-07-05 |
2023-08-12 |
zebrafish |
| J Samochowiec, F Rybakowski, P Czerski, M Zakrzewska, G Stepień, J Pełka-Wysiecka, J Horodnicki, J K Rybakowski, J Hause. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology. vol 43. issue 4. 2001-07-05. PMID:11340364. |
we studied the association between temperamental personality dimensions measured with the temperament and character inventory (tci) and polymorphisms of the dopamine (dat), norepinephrine (net) and serotonin (5-htt) transporter genes in 127 healthy polish volunteers. |
2001-07-05 |
2023-08-12 |
human |
| P Semwal, S Prasad, T Bhatia, S N Deshpande, J Wood, V L Nimgaonkar, B K Thelm. Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia. Molecular psychiatry. vol 6. issue 2. 2001-06-28. PMID:11317226. |
polymorphisms within the genes encoding the serotonin 2a receptor (ht2a), tryptophan hydroxylase (tph), catechol-o-methyl transferase (comt) and dopamine transporter (dat) were thus investigated. |
2001-06-28 |
2023-08-12 |
Not clear |
| M Y Chang, S H Lee, J H Kim, K H Lee, Y S Kim, H Son, Y S Le. Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331404. |
dopaminergic neurotransmission is terminated by the action of the presynaptic dopamine transporter (dat). |
2001-06-28 |
2023-08-12 |
Not clear |
| C Roubert, P J Cox, M Bruss, M Hamon, H Bönisch, B Giro. Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11092898. |
the norepinephrine (net) and dopamine (dat) transporters are highly homologous proteins, displaying many pharmacological similarities. |
2001-06-21 |
2023-08-12 |
human |
| H L Kimmel, F I Carroll, M J Kuha. RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282369. |
an earlier study in our laboratory showed that 24 h after intracerebroventricular administration of the irreversible dopamine transporter inhibitor rti-76, [3h]gbr12935 binding to the dopamine transporter (dat) protein was inhibited in both the striatum and nucleus accumbens of the rat in a dose-dependent fashion (0.05-5.0 micromol). |
2001-06-21 |
2023-08-12 |
rat |