| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
tryptophan residues lying in putative dat transmembrane domains could contribute to both aromatic and cationic interactions between dat and dopamine or cocaine. |
2001-01-18 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, G R Uh. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Molecular pharmacology. vol 58. issue 6. 2001-01-18. PMID:11093799. |
these data, current provisional dat structural models, and results from parallel studies of other mutants identify candidate dopamine-selective dat domains for transmembrane dopamine permeation and regions in which mutations selectively lower cft affinities. |
2001-01-18 |
2023-08-12 |
Not clear |
| Y Zhang, R B Rothman, C M Dersch, B R de Costa, A E Jacobson, K C Ric. Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909). Journal of medicinal chemistry. vol 43. issue 25. 2001-01-18. PMID:11123994. |
a series of analogues related to 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2) and 1-¿2-[bis(4-fluorophenyl)methoxy]ethyl¿-4-(3-phenylpropyl)piperazine (3) (gbr 12935 and gbr 12909, respectively), in which the piperazine moiety was replaced by bridged piperazines for structural rigidity, has been designed, synthesized, and evaluated for their ability to bind to the dopamine transporter (dat) and to inhibit the uptake of (3)h-labeled dopamine (da). |
2001-01-18 |
2023-08-12 |
Not clear |
| E Donnemiller, C Brenneis, J Wissel, C Scherfler, W Poewe, G Riccabona, G K Wennin. Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPECT study using 123I-beta-CIT and 123I-IBZM. European journal of nuclear medicine. vol 27. issue 9. 2001-01-11. PMID:11007526. |
the activity ratios of striatal to cerebellar uptake were used as a semiquantitative parameter of striatal dopamine transporter (dat) and d2 receptor (d2r) binding. |
2001-01-11 |
2023-08-12 |
Not clear |
| A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPECT in parkinsonism. Parkinson Study Group. Neurology. vol 55. issue 10. 2001-01-04. PMID:11094111. |
in vivo imaging of the dopamine transporter (dat) with spect is a quantitative biomarker for pd onset and severity. |
2001-01-04 |
2023-08-12 |
Not clear |
| D C Harvey, G Laćan, W P Melega. Regional heterogeneity of dopaminergic deficits in vervet monkey striatum and substantia nigra after methamphetamine exposure. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958525. |
decreases in ir for tyrosine hydroxylase (th), dopamine transporter (dat), and the vesicular monoamine transporter (vmat2) were observed 1 week after meth hci (2x2 mg/kg; 24 h apart). |
2000-12-28 |
2023-08-12 |
monkey |
| R R Metzger, H M Haughey, D G Wilkins, J W Gibb, G R Hanson, A E Fleckenstei. Methamphetamine-induced rapid decrease in dopamine transporter function: role of dopamine and hyperthermia. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082443. |
single and multiple high-dose administrations of methamphetamine (meth) differentially decrease dopamine (da) transporter (dat) function, as assessed by measuring [(3)h]da uptake into rat striatal synaptosomes prepared 1 h after treatment. |
2000-12-20 |
2023-08-12 |
rat |
| C Spielewoy, C Roubert, M Hamon, M Nosten-Bertrand, C Betancur, B Giro. Behavioural disturbances associated with hyperdopaminergia in dopamine-transporter knockout mice. Behavioural pharmacology. vol 11. issue 3-4. 2000-12-14. PMID:11103882. |
these results emphasize the role of dopamine regulation in locomotion, exploration and maternal behaviours and suggest that mice with a genetic deletion of dat may represent a useful model to elucidate the altered behavioural processes accompanying pathological conditions associated with hyperdopaminergic function. |
2000-12-14 |
2023-08-12 |
mouse |
| B T Hoffman, T Kopajtic, J L Katz, A H Newma. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. Journal of medicinal chemistry. vol 43. issue 22. 2000-12-07. PMID:11063611. |
in light of the chronic problem of abuse of the controlled substance cocaine, we have investigated novel approaches toward both understanding the activity of inhibitors of the dopamine transporter (dat) and identifying novel inhibitors that may be of therapeutic potential. |
2000-12-07 |
2023-08-12 |
Not clear |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
the aim of these studies was to establish a rapid in vivo assay for evaluating potential "cocaine antagonists," i.e., drugs postulated to block cocaine binding to the dopamine transporter (dat) without corresponding blockade of dopamine reuptake. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
we next evaluated gbr12909, a piperazine analog promoted as a "cocaine antagonist" because of its ability to bind with high affinity to the dat, while only modestly elevating extracellular dopamine levels. |
2000-11-28 |
2023-08-12 |
rat |
| T Sander, W Berlin, A Ostapowicz, J Samochowiec, N Gscheidel, M R Hoeh. Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy. Epilepsy research. vol 41. issue 1. 2000-11-20. PMID:10924870. |
the genotypes of 133 german ige subjects and 223 ethnically matched controls were assessed for dna polymorphisms of genes encoding the glutamate (eaat2), the serotonin (sert), and dopamine (dat) transporters. |
2000-11-20 |
2023-08-12 |
human |
| G Page, M Peeters, J M Maloteaux, E Herman. Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. European journal of pharmacology. vol 403. issue 1-2. 2000-10-31. PMID:10969146. |
the aim of the present study was to investigate the effect of short- and long-term treatments with amantadine on the activity of the neuronal dopamine transporter (dat) in the rat striatum. |
2000-10-31 |
2023-08-12 |
rat |
| G Page, M Peeters, J M Maloteaux, E Herman. Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. European journal of pharmacology. vol 403. issue 1-2. 2000-10-31. PMID:10969146. |
this indicates that the increased dopamine uptake was not reflecting a modification at the level of the dat expression. |
2000-10-31 |
2023-08-12 |
rat |
| G Page, M Peeters, J M Maloteaux, E Herman. Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. European journal of pharmacology. vol 403. issue 1-2. 2000-10-31. PMID:10969146. |
an indirect mechanism would involve presynaptic dopamine receptors that control the activity of the dat in response to the increased dopamine concentration in the synaptic cleft. |
2000-10-31 |
2023-08-12 |
rat |
| M Benoit-Marand, M Jaber, F Gono. Release and elimination of dopamine in vivo in mice lacking the dopamine transporter: functional consequences. The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971639. |
in mice lacking the dopamine transporter (dat), the amplitude of dopamine (da) release and the kinetics of dopamine elimination were measured in vivo using carbon fibre electrodes combined with amperometry. |
2000-10-19 |
2023-08-12 |
mouse |
| A Heinz, D Goldma. Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems. Neurochemistry international. vol 37. issue 5-6. 2000-10-18. PMID:10871694. |
chronic alcohol intake induces neuroadaptive reductions in striatal dopamine transporter (dat) and d2 receptor availability, which were reversible during early abstinence. |
2000-10-18 |
2023-08-12 |
human |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995853. |
l-3,4-dihydroxyphenylalanine (l-[beta-(11)c]dopa) and 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane ([beta-(11)c]cft) were used to measure dopamine synthesis rate and dopamine transporter (dat) availability, respectively. |
2000-10-18 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995853. |
systemic administration of scopolamine at doses of 10 and 100 microg/kg dose-dependently increased both dopamine synthesis and dat availability as measured by l-[beta-(11)c]dopa and [beta-(11)c]cft, respectively. |
2000-10-18 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995853. |
however, scopolamine dose-dependently facilitated the striatal ecf dopamine induced by the dat inhibitor gbr12909 at a dose of 0.5 mg/kg. |
2000-10-18 |
2023-08-12 |
monkey |