| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995853. |
these results suggested that the inhibition of muscarinic cholinergic neuronal activity modulates dopamine turnover in the striatum by simultaneous enhancement of the dynamics of dopamine synthesis and dat availability, resulting in no significant changes in apparent "static" ecf dopamine level but showing a decrease in [(11)c]raclopride binding in vivo attributable to the reduction of affinity of dopamine d(2) receptors. |
2000-10-18 |
2023-08-12 |
monkey |
| D C Harvey, G Lacan, S P Tanious, W P Meleg. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain research. vol 871. issue 2. 2000-10-04. PMID:10899292. |
longitudinal studies using positron emission tomography (pet) with the dopamine transporter (dat)-binding ligand, [11c]win 35,428 (win), were used to show decreases in striatal win binding of 80% at 1 week and only 10% at 1.5 years. |
2000-10-04 |
2023-08-12 |
human |
| D C Harvey, G Lacan, S P Tanious, W P Meleg. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain research. vol 871. issue 2. 2000-10-04. PMID:10899292. |
a post-mortem characterization of other meth subjects at 1 month showed extensive decreases in immunoreactivity (ir) profiles of tyrosine hydroxylase (th), dat and vesicular monoamine transporter-2 (vmat) in the striatum, medial forebrain bundle and the ventral midbrain dopamine (vmd) cell region. |
2000-10-04 |
2023-08-12 |
human |
| S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kun. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nuclear medicine and biology. vol 27. issue 3. 2000-09-26. PMID:10832081. |
adam(7) also showed more than 1,000-fold selectivity for sert over norepinephrine transporter (net) and dopamine transporter (dat) ( k(i)=699 and 840 nm, for net and dat, respectively). |
2000-09-26 |
2023-08-12 |
human |
| T Zigova, L F Barroso, A E Willing, S Saporta, M P McGrogan, T B Freeman, P R Sanber. Dopaminergic phenotype of hNT cells in vitro. Brain research. Developmental brain research. vol 122. issue 1. 2000-09-26. PMID:10915908. |
furthermore, numerous th-positive hnt cells were also immunoreactive to dopamine transporter (dat), dopamine receptor (d2) and aldehyde dehydrogenase (ahd-2), an enzyme exclusively expressed by dopaminergic (da) ventral mesencephalic (vm) precursors. |
2000-09-26 |
2023-08-12 |
Not clear |
| L Zhao, K M Johnson, M Zhang, J Flippen-Anderson, A P Kozikowsk. Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects. Journal of medicinal chemistry. vol 43. issue 17. 2000-09-21. PMID:10966747. |
some of these compounds were found to retain considerable affinity as inhibitors of the dopamine transporter (dat) and the norepinephrine transporter (net), but they were less potent inhibitors of the serotonin transporter (sert). |
2000-09-21 |
2023-08-12 |
rat |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |
| F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus, M Borrmann-Hassenbach, M Knapp, S Cichon, W Maier, M Rietschel, P Propping, M M Nöthe. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1). Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889530. |
the dopamine transporter (dat) plays a central role in dopaminergic neurotransmission in the human brain. |
2000-09-12 |
2023-08-12 |
human |
| F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus, M Borrmann-Hassenbach, M Knapp, S Cichon, W Maier, M Rietschel, P Propping, M M Nöthe. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1). Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889530. |
genetic association studies have used a variable number of tandem repeat (vntr) polymorphism in the 3'-flanking region of the dopamine transporter gene (dat1) to implicate the dat in the development of various neuropsychiatric disorders. |
2000-09-12 |
2023-08-12 |
human |
| D J Vandenbergh, M D Thompson, E H Cook, E Bendahhou, T Nguyen, M D Krasowski, D Zarrabian, D Comings, E M Sellers, R F Tyndale, S R George, B F O'Dowd, G R Uh. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889531. |
the dopamine transporter (dat) provides major regulation of the synaptic levels of dopamine and is a principal target of psychostimulant drugs. |
2000-09-12 |
2023-08-12 |
human |
| P C Meltzer, P Blundell, Y F Yong, Z Chen, C George, M D Gonzalez, B K Madra. 2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. Journal of medicinal chemistry. vol 43. issue 16. 2000-09-08. PMID:10956207. |
its reinforcing and stimulant properties derive from inhibition of monoamine transport systems, in particular the dopamine transporter (dat). |
2000-09-08 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
furthermore, gbr 12909, a potent dopamine transporter (dat) inhibitor, yielded similar effects. |
2000-08-25 |
2023-08-12 |
Not clear |
| H Tsukada, N Harada, S Nishiyama, H Ohba, K Sato, D Fukumoto, T Kakiuch. Ketamine decreased striatal [(11)C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881030. |
in contrast, ketamine increased both dopamine synthesis and dat availability as measured by l-[beta-(11)c]dopa and [(11)c]beta-cft, respectively, in a dose-dependent manner. |
2000-08-24 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, K Sato, D Fukumoto, T Kakiuch. Ketamine decreased striatal [(11)C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881030. |
these results suggest that the inhibition of glutamatergic neuronal activity modulates dopamine turnover in the striatum by simultaneous enhancement of the dynamics of dopamine synthesis and dat availability to the same extent, resulting in no apparent changes in ecf dopamine concentration as measured by microdialysis. |
2000-08-24 |
2023-08-12 |
monkey |
| R H Mach, M A Nader, R L Ehrenkaufer, H D Gage, S R Childers, L M Hodges, M M Hodges, H M Davie. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881032. |
both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (dat) than the cerebellum, a reference region devoid of dopaminergic terminals. |
2000-08-24 |
2023-08-12 |
Not clear |
| K H Krause, S H Dresel, J Krause, H F Kung, K Tatsc. Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neuroscience letters. vol 285. issue 2. 2000-08-23. PMID:10793238. |
ten previously untreated adults with attention deficit hyperactivity disorder (adhd) were investigated before and after 4 weeks of treatment with a dose of 3x5 mg methylphenidate/d by single photon emission computed tomography (spect) with [tc-99m]trodat-1, the first tc-99m labelled spect ligand specifically binding to the dopamine transporter (dat). |
2000-08-23 |
2023-08-12 |
Not clear |
| F I Tarazi, K Zhang, R J Baldessarin. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854717. |
we compared labeling of dopamine (dat) and serotonin (sert) transporter proteins in subregions of rat corpus striatum by quantitative autoradiography with [(3)h]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane ([(3)h]beta-cit) and [(3)h]paroxetine after 28 days of continuous subcutaneous infusion of olanzapine, quetiapine, risperidone, or vehicle controls. |
2000-08-17 |
2023-08-12 |
rat |
| S P Hamilton, F Haghighi, G A Heiman, D F Klein, S E Hodge, A J Fyer, M M Weissman, J A Knowle. Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898909. |
investigation of dopamine receptor (drd4) and dopamine transporter (dat) polymorphisms for genetic linkage or association to panic disorder. |
2000-08-10 |
2023-08-12 |
human |
| S P Hamilton, F Haghighi, G A Heiman, D F Klein, S E Hodge, A J Fyer, M M Weissman, J A Knowle. Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898909. |
in this study, we examined the genes for the d4 dopamine receptor (drd4) and the dopamine transporter (dat) using three common sequence polymorphisms. |
2000-08-10 |
2023-08-12 |
human |
| U Müller, T Wächter, H Barthel, M Reuter, D Y von Cramo. Striatal [123I]beta-CIT SPECT and prefrontal cognitive functions in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 3. 2000-08-02. PMID:10821439. |
significant (p < 0.05) correlations were observed between dopamine transporter (dat) density in the putamen and motor deficits as well as between dat density in both striatal compartments (head of the caudate nucleus and putamen) and prefrontal functioning. |
2000-08-02 |
2023-08-12 |
Not clear |