| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Kirby, R L Barlow, J R Bloomquis. Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 61. issue 1. 2001-07-12. PMID:11294980. |
significant increase in v(max) of striatal dat was not observed at doses > 12 mg/kg, which suggested that toxic effects of heptachlor epoxide may be responsible for loss of maximal dopamine uptake observed at higher doses of heptachlor. |
2001-07-12 |
2023-08-12 |
mouse |
| M Guttman, D Stewart, D Hussey, A Wilson, S Houle, S Kis. Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD. Neurology. vol 56. issue 11. 2001-07-12. PMID:11402115. |
animal data indicate that chronic exposure to dopaminergic drugs can alter levels of the dopamine transporter (dat), which is critically involved in regulation of synaptic dopamine levels. |
2001-07-12 |
2023-08-12 |
Not clear |
| T Hayashi, H Hirata, M Asanuma, B Ladenheim, L I Tsao, J L Cadet, T P S. Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53. Synapse (New York, N.Y.). vol 39. issue 4. 2001-07-05. PMID:11169780. |
the levels of dopamine transporter (dat), tyrosine hydroxylase (th), major biogenic amines including da, 5-hydroxytryptamine (5-ht), and their metabolites were examined. |
2001-07-05 |
2023-08-12 |
mouse |
| J Holzschuh, S Ryu, F Aberger, W Drieve. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of development. vol 101. issue 1-2. 2001-07-05. PMID:11231083. |
to characterize the formation of the dopaminergic system in the developing zebrafish cns, we cloned cdnas encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat), a membrane transport protein which terminates dopamine action by re-uptake. |
2001-07-05 |
2023-08-12 |
zebrafish |
| J Samochowiec, F Rybakowski, P Czerski, M Zakrzewska, G Stepień, J Pełka-Wysiecka, J Horodnicki, J K Rybakowski, J Hause. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology. vol 43. issue 4. 2001-07-05. PMID:11340364. |
we studied the association between temperamental personality dimensions measured with the temperament and character inventory (tci) and polymorphisms of the dopamine (dat), norepinephrine (net) and serotonin (5-htt) transporter genes in 127 healthy polish volunteers. |
2001-07-05 |
2023-08-12 |
human |
| P Semwal, S Prasad, T Bhatia, S N Deshpande, J Wood, V L Nimgaonkar, B K Thelm. Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia. Molecular psychiatry. vol 6. issue 2. 2001-06-28. PMID:11317226. |
polymorphisms within the genes encoding the serotonin 2a receptor (ht2a), tryptophan hydroxylase (tph), catechol-o-methyl transferase (comt) and dopamine transporter (dat) were thus investigated. |
2001-06-28 |
2023-08-12 |
Not clear |
| M Y Chang, S H Lee, J H Kim, K H Lee, Y S Kim, H Son, Y S Le. Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331404. |
dopaminergic neurotransmission is terminated by the action of the presynaptic dopamine transporter (dat). |
2001-06-28 |
2023-08-12 |
Not clear |
| C Roubert, P J Cox, M Bruss, M Hamon, H Bönisch, B Giro. Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11092898. |
the norepinephrine (net) and dopamine (dat) transporters are highly homologous proteins, displaying many pharmacological similarities. |
2001-06-21 |
2023-08-12 |
human |
| H L Kimmel, F I Carroll, M J Kuha. RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282369. |
an earlier study in our laboratory showed that 24 h after intracerebroventricular administration of the irreversible dopamine transporter inhibitor rti-76, [3h]gbr12935 binding to the dopamine transporter (dat) protein was inhibited in both the striatum and nucleus accumbens of the rat in a dose-dependent fashion (0.05-5.0 micromol). |
2001-06-21 |
2023-08-12 |
rat |
| E Isovich, M Engelmann, R Landgraf, E Fuch. Social isolation after a single defeat reduces striatal dopamine transporter binding in rats. The European journal of neuroscience. vol 13. issue 6. 2001-06-21. PMID:11285023. |
because the dopaminergic system is thought to be altered in depressive illness, we investigated the impact of individual and group housing on the temporal development of changes of dopamine transporter (dat) binding in male rats after a single social defeat. |
2001-06-21 |
2023-08-12 |
rat |
| A Tidjane Corera, J C Do-Régo, J Costentin, J J Bonne. Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes. Neuroscience research. vol 39. issue 3. 2001-06-14. PMID:11248372. |
addition of nacl (90--290 mm) to a 10 mm na(+) medium did not significantly modify b(max) and k(d) values for [3h]mazindol binding to the dopamine neuronal transporter (dat) studied on rat striatal membranes at 20 degrees c. addition of nacl differentially affected the ability of other uptake inhibitors and substrates to block the [3h]mazindol binding. |
2001-06-14 |
2023-08-12 |
rat |
| F Rothhammer, P Rothhammer, E Llo. [Genetics of addictive disorders]. Revista medica de Chile. vol 128. issue 11. 2001-06-14. PMID:11347517. |
more than 80% of alcoholics smoke cigarettes in the u.s.a. other genetic methods such as linkage analysis, allele sharing methods, association studies and analysis of inbred, transgenic and gene-knockout rodents, have partially agreed in showing that the 5ht-1b serotonin receptor and the drd1, drd2 and drd4 dopamine receptors, as well as the dopamine transporter dat, play an important role in behaviors related to alcoholism and substance abuse. |
2001-06-14 |
2023-08-12 |
human |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
recent studies reveal that dopamine (da), norepinephrine (ne), and serotonin (5-ht) transporters (dat, net, and sert, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase c (pkc). |
2001-06-07 |
2023-08-12 |
human |
| V Sandoval, E L Riddle, Y V Ugarte, G R Hanson, A E Fleckenstei. Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 4. 2001-06-07. PMID:11160413. |
this laboratory has demonstrated that a single methamphetamine (meth) injection rapidly and reversibly decreases the activity of the dopamine transporter (dat), as assessed ex vivo in synaptosomes prepared from treated rats. |
2001-06-07 |
2023-08-12 |
rat |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the present study examined the time course of alterations in levels of dopamine transporter (dat) binding sites that accompany cocaine self-administration using quantitative in vitro receptor autoradiography with [(3)h]win 35,428. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the density of dopamine transporter binding sites in the striatum of rhesus monkeys with 5 d, 3.3 months, or 1.5 years of cocaine self-administration experience was compared with dat levels in cocaine-naive control monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the similarity of these findings to previous studies in human cocaine addicts strongly suggest that the increased density of dopamine transporters observed in studies of human drug abusers are the result of the neurobiological effects of cocaine, ruling out confounds such as polydrug abuse, preexisting differences in dat levels, or comorbid psychiatric conditions. |
2001-06-07 |
2023-08-12 |
human |
| P D Acton, P T Meyer, P D Mozley, K Plössl, H F Kun. Simplified quantification of dopamine transporters in humans using [99mTc]TRODAT-1 and single-photon emission tomography. European journal of nuclear medicine. vol 27. issue 11. 2001-05-31. PMID:11105829. |
quantification of dopamine transporters (dat) using [99mtc]trodat-1 and single-photon emission tomography (spet) requires full kinetic modeling of the data, using complex and invasive arterial blood sampling to provide an input function to the model. |
2001-05-31 |
2023-08-12 |
human |
| M Stamenkovic, S D Schindler, S Asenbaum, A Neumeister, M Willeit, U Willinger, M de Zwaan, F Riederer, H N Aschauer, S Kaspe. No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette's disorder patients: a [(123)I]-beta-CIT SPECt-study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 1. 2001-05-31. PMID:11226814. |
there is evidence that tourette's disorder (td) is associated with abnormalities in the dopaminergic system involving the dopamine transporter (dat). |
2001-05-31 |
2023-08-12 |
Not clear |
| T A Greenwood, M Alexander, P E Keck, S McElroy, A D Sadovnick, R A Remick, J R Kelso. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. American journal of medical genetics. vol 105. issue 2. 2001-05-31. PMID:11304827. |
a role for the dopamine transporter (dat) in bipolar disorder is implicated by several lines of pharmacological evidence, as well as suggestive evidence of linkage at this locus, which we have reported previously. |
2001-05-31 |
2023-08-12 |
Not clear |