| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norihiro Harada, Shingo Nishiyama, Kengo Satoh, Dai Fukumoto, Takeharu Kakiuchi, Hideo Tsukad. Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys. Synapse (New York, N.Y.). vol 45. issue 1. 2002-08-06. PMID:12112412. |
l-[beta-(11)c]dopa and [(11)c]beta-cft were applied to determine dopamine presynaptic functions such as synthesis rate and transporter (dat) availability, respectively. |
2002-08-06 |
2023-08-12 |
monkey |
| Norihiro Harada, Shingo Nishiyama, Kengo Satoh, Dai Fukumoto, Takeharu Kakiuchi, Hideo Tsukad. Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys. Synapse (New York, N.Y.). vol 45. issue 1. 2002-08-06. PMID:12112412. |
although the markers of presynaptic terminals showed parallel age-related declines, the reduction of dopamine synthesis rate measured with l-[beta-(11)c]dopa was slightly smaller than that of dat determined with [(11)c]beta-cft. |
2002-08-06 |
2023-08-12 |
monkey |
| Norihiro Harada, Shingo Nishiyama, Kengo Satoh, Dai Fukumoto, Takeharu Kakiuchi, Hideo Tsukad. Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys. Synapse (New York, N.Y.). vol 45. issue 1. 2002-08-06. PMID:12112412. |
when the dat inhibitor gbr12909 (0.5 and 5 mg/kg) was administered, dat availability, dopamine synthesis, and d(2)r binding were significantly decreased in a dose-dependent manner in both age groups; however, the degrees of the decreases in these parameters were significantly higher in young rather than in aged animals. |
2002-08-06 |
2023-08-12 |
monkey |
| Servet M Yatin, Gregory M Miller, Courtney Norton, Bertha K Madra. Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse (New York, N.Y.). vol 45. issue 1. 2002-08-06. PMID:12112414. |
in hdat cells, dat substrates (dopamine, amphetamine) increased c-fos immunoreactivity 6- and 3-fold (respectively). |
2002-08-06 |
2023-08-12 |
human |
| Yossef Itzhak, Syed F Al. Behavioral consequences of methamphetamine-induced neurotoxicity in mice: relevance to the psychopathology of methamphetamine addiction. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105090. |
a high dose of meth given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (da), and da-transporter (dat) binding sites in the striatum. |
2002-08-02 |
2023-08-12 |
mouse |
| P-A H Noailles, J A Angul. Neurokinin receptors modulate the neurochemical actions of cocaine. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105102. |
the psychostimulant cocaine is an indirect agonist that increases synaptic dopamine (da) by binding with high affinity to the da transporter (dat) and blocking the active transport of synaptic da back into the terminal. |
2002-08-02 |
2023-08-12 |
rat |
| William F Maragos, Jun Zhu, M Dathan Chesnut, Linda P Dwoski. Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes. Biochemical pharmacology. vol 63. issue 8. 2002-07-15. PMID:11996892. |
the purpose of this study was to determine whether mitochondrial inhibition alters dopamine transporter (dat) function. |
2002-07-15 |
2023-08-12 |
rat |
| Lucia Carvelli, José A Morón, Kristopher M Kahlig, Jasmine V Ferrer, Namita Sen, James D Lechleiter, L M Fredrik Leeb-Lundberg, Gerald Merrill, Eileen M Lafer, Lisa M Ballou, Toni S Shippenberg, Jonathan A Javitch, Richard Z Lin, Aurelio Gall. PI 3-kinase regulation of dopamine uptake. Journal of neurochemistry. vol 81. issue 4. 2002-07-12. PMID:12065645. |
the magnitude and duration of dopamine (da) signaling is defined by the amount of vesicular release, da receptor sensitivity, and the efficiency of da clearance, which is largely determined by the da transporter (dat). |
2002-07-12 |
2023-08-12 |
human |
| Deborah C Mash, John Pablo, Qinjie Ouyang, W Lee Hearn, Sari Izenwasse. Dopamine transport function is elevated in cocaine users. Journal of neurochemistry. vol 81. issue 2. 2002-06-26. PMID:12064476. |
pyscho-stimulants attenuate dopamine transporter (dat) clearance efficiency, resulting in a net increase in synaptic dopamine levels. |
2002-06-26 |
2023-08-12 |
human |
| Christelle Gouhier, Sylvie Chalon, Anne Aubert-Pouessel, Marie-Claire Venier-Julienne, Christophe Jollivet, Jean-Pierre Benoit, Denis Guillotea. Protection of dopaminergic nigrostriatal afferents by GDNF delivered by microspheres in a rodent model of Parkinson's disease. Synapse (New York, N.Y.). vol 44. issue 3. 2002-06-20. PMID:11954043. |
the effects of gdnf released from microspheres were assessed by classical methods such as amphetamine-induced rotating behavior and tyrosine hydroxylase (th) immunoreactivity, as well as by quantitative autoradiography using pe2i, a dopamine transporter (dat) radiotracer, which is also suitable for spet imaging in humans. |
2002-06-20 |
2023-08-12 |
rat |
| Petrise Runnels Miles, Michelle L Mundorf, R Mark Wightma. Release and uptake of catecholamines in the bed nucleus of the stria terminalis measured in the mouse brain slice. Synapse (New York, N.Y.). vol 44. issue 3. 2002-06-20. PMID:11954051. |
clearance rates were reduced in the bstv in both norepinephrine transporter knockout (net ko) and dopamine transporter knockout (dat ko) mice when compared to results in wild-type (wt) mice. |
2002-06-20 |
2023-08-12 |
mouse |
| Michael J Bannon, Barb Pruetz, Amy B Manning-Bog, Christopher J Whitty, Sharon K Michelhaugh, Paola Sacchetti, James G Granneman, Deborah C Mash, Carl J Schmid. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959923. |
nurr1 is known to regulate transcription of the gene encoding the cocaine-sensitive dopamine transporter (dat). |
2002-06-11 |
2023-08-12 |
human |
| Michael J Bannon, Barb Pruetz, Amy B Manning-Bog, Christopher J Whitty, Sharon K Michelhaugh, Paola Sacchetti, James G Granneman, Deborah C Mash, Carl J Schmid. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959923. |
we show here that dat gene expression also is reduced markedly in the dopamine neurons of nurr1-deficient cocaine abusers, suggesting that nurr1 plays a critical role in vivo in controlling human dat gene expression and adaptation to repeated exposure to cocaine. |
2002-06-11 |
2023-08-12 |
human |
| H H Gu, X Wu, B Giros, M G Caron, M J Caplan, G Rudnic. The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Molecular biology of the cell. vol 12. issue 12. 2002-05-29. PMID:11739781. |
when expressed in epithelial cells, dopamine transporter (dat) was detected predominantly in the apical plasma membrane, whereas norepinephrine transporter (net) was found in the basolateral membrane, despite 67% overall amino acid sequence identity. |
2002-05-29 |
2023-08-12 |
Not clear |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter (dat) at the level of presynaptic terminals and increasing extracellular levels of dopamine (da). |
2002-05-29 |
2023-08-12 |
mouse |
| Ercem Kodas, Guylène Page, Luc Zimmer, Sylvie Vancassel, Denis Guilloteau, Georges Durand, Sylvie Chalo. Neither the density nor function of striatal dopamine transporters were influenced by chronic n-3 polyunsaturated fatty acid deficiency in rodents. Neuroscience letters. vol 321. issue 1-2. 2002-05-23. PMID:11872265. |
we hypothesized that the chronic dietary deficiency of n-3 polyunsaturated fatty acids (n-3 pufas) might affect the density and/or function of dopamine transporters (dat), which have a major role in regulating the synaptic level of dopamine. |
2002-05-23 |
2023-08-12 |
rat |
| Suzanne Doolen, Nancy R Zahnise. Conventional protein kinase C isoforms regulate human dopamine transporter activity in Xenopus oocytes. FEBS letters. vol 516. issue 1-3. 2002-05-23. PMID:11959130. |
the hypothesis that specific protein kinase c (pkc) isoforms regulate dopamine transporter (dat) function was tested in xenopus laevis oocytes expressing human (h)dat. |
2002-05-23 |
2023-08-12 |
human |
| José L Venero, El-Hadi Absi, Josefina Cano, Alberto Machad. Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. Journal of pineal research. vol 32. issue 1. 2002-05-20. PMID:11841594. |
we have evaluated the effect of chronic administration of melatonin in terms of mrna expression for tyrosine hydroxylase (th), the rate-limiting enzyme in catecholamine biosynthesis, and in the terms of dopamine (da) transporter (dat) by means of in situ hybridization. |
2002-05-20 |
2023-08-12 |
rat |
| W J Chen, C H Chen, J Huang, Y P Hsu, S V Seow, C C Chen, A T Chen. Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan. Psychiatric genetics. vol 11. issue 4. 2002-05-17. PMID:11807408. |
-141c ins/del) and variable number of tandem repeat polymorphism at the 3' untranslated region of the dopamine transporter (dat) gene (slc6a3) with alcoholism in a case-control study. |
2002-05-17 |
2023-08-12 |
human |
| Yun J Kim, Masanori Ichise, James R Ballinger, Douglas Vines, Sean S Erami, Tatsuro Tatschida, Anthony E Lan. Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 2. 2002-05-17. PMID:11921116. |
we performed spect evaluation of the dopamine transporter (dat) and dopamine d2 receptors (d2). |
2002-05-17 |
2023-08-12 |
Not clear |