| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Charles Paterna, Andreas Leng, Elisabeth Weber, Joram Feldon, Hansruedi Büele. DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 15. issue 4. 2007-05-22. PMID:17299411. |
after mptp lesioning, significantly more dopamine neurons survived in the virus-injected substantia nigra of the aav-dj-1 and aav-parkin mice when compared with aav-enhanced green fluorescent protein injected controls. |
2007-05-22 |
2023-08-12 |
mouse |
| M Schirmer, J N Nobrega, S J Harrison, W Lösche. Alterations in dopamine D3 receptors in the circling (ci3) rat mutant. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17187934. |
neurochemical determination of dopamine and dopamine metabolite levels in striatum, nucleus accumbens and substantia nigra showed that ci3 rats have a significant asymmetry in striatal dopamine in that dopamine levels were significantly lower in the hemisphere contralateral to the preferred direction of turning. |
2007-05-21 |
2023-08-12 |
rat |
| E Ch Wolter. PD-related psychosis: pathophysiology with therapeutical strategies. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447413. |
parkinson's disease (pd) is a chronic, neurodegenerative disease with degeneration of the central dopaminergic neurons in the substantia nigra, leading to a depletion of dopamine (da) in the striatum. |
2007-05-17 |
2023-08-12 |
Not clear |
| Zhihua Xie, Gregory M Mille. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234899. |
recent studies demonstrated wide distribution of taar1 in brain, coexpression of taar1 with dopamine transporter (dat) in a subset of dopamine neurons in both mouse and rhesus monkey substantia nigra, and monoamine transporter-modulated activation. |
2007-05-14 |
2023-08-12 |
mouse |
| Zhihua Xie, Susan V Westmoreland, Mary E Bahn, Guo-Lin Chen, Hong Yang, Eric J Vallender, Wei-Dong Yao, Bertha K Madras, Gregory M Mille. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234900. |
in the present study, we demonstrate taar1 mrna and protein expression in rhesus monkey brain regions associated with monoaminergic systems, variable cellular distribution of taar1 in rhesus monkey brain, and taar1 coexpression with the dopamine transporter (dat) in a subset of dopamine neurons in both rhesus monkey and mouse substantia nigra. |
2007-05-14 |
2023-08-12 |
mouse |
| Renee M Miller, Gretchen L Kiser, Tamma Kaysser-Kranich, Cindy Casaceli, Emanuela Colla, Michael K Lee, Chockalingham Palaniappan, Howard J Federof. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17254569. |
the pathophysiological processes that cause parkinson's disease (pd) affect dopamine neurons residing in the substantia nigra with devastating consequences for normal movement. |
2007-05-10 |
2023-08-12 |
mouse |
| Chaohui Zhao, Zaodung Ling, Mary B Newman, Ankush Bhatia, Paul M Carve. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17234424. |
following intraparenchymal injection of the dopamine (da) neurotoxin 6-hydroxydopamine, we previously demonstrated passage of fluoresceinisothiocyanate-labeled albumin (fitc-la) from blood into the substantia nigra (sn) and striatum suggesting damage to the blood-brain barrier (bbb). |
2007-05-08 |
2023-08-12 |
mouse |
| Toshi Nagatsu, Makoto Sawad. Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16823625. |
parkinson's disease (pd) is considered to be an aging-related neurodegeneration of catecholamine (ca) systems [typically a9 dopamine (da) neurons in the substantia nigra and a6 noradrenaline (na) neurons in the locus coeruleus]. |
2007-04-24 |
2023-08-12 |
Not clear |
| Marie Westerlund, Andrea Carmine Belin, Michael R Felder, Lars Olson, Dagmar Galte. High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease. The FEBS journal. vol 274. issue 5. 2007-04-12. PMID:17257171. |
parkinson's disease (pd) is a heterogeneous movement disorder characterized by progressive degeneration of dopamine neurons in substantia nigra. |
2007-04-12 |
2023-08-12 |
mouse |
| M P Smith, W A Cas. Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson's disease. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17110046. |
this same lesion paradigm produced dopamine depletions of 90-95% in the striatum and 63-80% in the substantia nigra by 14-28 days post-6-ohda. |
2007-04-11 |
2023-08-12 |
rat |
| S J O'Dell, N B Gross, A N Fricks, B D Casiano, T B Nguyen, J F Marshal. Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17157992. |
after killing, dopaminergic damage was assessed by both quantifying 3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester ([(125)i]rti-55) binding to striatal dopamine transporters and counting tyrosine hydroxylase-positive cells in the substantia nigra. |
2007-04-11 |
2023-08-12 |
rat |
| Yasuko Kitao, Yuzuru Imai, Kentaro Ozawa, Ayane Kataoka, Toshio Ikeda, Mariko Soda, Kazuhiko Nakimawa, Hiroshi Kiyama, David M Stern, Osamu Hori, Kazumasa Wakamatsu, Shosuke Ito, Shigeyoshi Itohara, Ryosuke Takahashi, Satoshi Ogaw. Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Human molecular genetics. vol 16. issue 1. 2007-04-03. PMID:17116640. |
pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. |
2007-04-03 |
2023-08-12 |
mouse |
| Kazuhiko Nakadate, Takahiro Noda, Shin-Ichi Sakakibara, Kenzo Kumamoto, Tadao Matsuura, Jeffery N Joyce, Shuichi Ued. Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. Acta neuropathologica. vol 112. issue 1. 2007-03-29. PMID:16609850. |
zitter mutant rats exhibit abnormal metabolism of superoxide species and demonstrate progressive degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2007-03-29 |
2023-08-12 |
rat |
| J R Walters, D Hu, C A Itoga, L C Parr-Brownlie, D A Bergstro. Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17112675. |
spike train recordings from striatum, subthalamic nucleus (stn), globus pallidus (gp), and substantia nigra pars reticulata (snpr) were paired with simultaneous local field potential (lfp) recordings from snpr or motor cortex ipsilateral to a unilateral lesion of substantia nigra dopamine neurons in urethane-anesthetized rats. |
2007-03-28 |
2023-08-12 |
rat |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
to meet this challenge, we applied laser pressure catapult microdissection (lcm) of the substantia nigra in combination with quantitative western blot to provide an index of dopamine neurodegeneration in mice treated with mptp. |
2007-03-27 |
2023-08-12 |
mouse |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
seven days following initiation of mptp treatment, striatal dopamine depletion was maximal and there was histological evidence of neuronal degeneration in the substantia nigra. |
2007-03-27 |
2023-08-12 |
mouse |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
this reduction corresponded to decreases in striatal dopamine and loss of immunocytochemically detected th but not beta-actin in the substantia nigra (sn). |
2007-03-27 |
2023-08-12 |
mouse |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
thus, this method provides a quantitative means to measure dopamine neuron toxicity in the substantia nigra and, as such has potential application in evaluating regimens that may be neuroprotective or neurorestorative for dopaminergic neurons. |
2007-03-27 |
2023-08-12 |
mouse |
| Przemysław Nowak, Grazyna Szczerbak, Joanna Dabrowska, Aleksandra Bortel, Izabela Biedka, Richard M Kostrzew. [Molecular mechanisms of levodopa action in animal models of Parkinson's disease]. Neurologia i neurochirurgia polska. vol 40. issue 6. 2007-03-27. PMID:17199178. |
one of the most important hallmarks of parkinson's disease is the loss of neuronal cell bodies containing neuromelanin in the substantia nigra zona compacta, and subsequently, loss of dopamine terminals in basal ganglia nuclei of the brain. |
2007-03-27 |
2023-08-12 |
Not clear |
| Rieko Setsuie, Yu-Lai Wang, Hideki Mochizuki, Hitoshi Osaka, Hideki Hayakawa, Nobutsune Ichihara, Hang Li, Akiko Furuta, Yae Sano, Ying-Jie Sun, Jungkee Kwon, Tomohiro Kabuta, Kenji Yoshimi, Shunsuke Aoki, Yoshikuni Mizuno, Mami Noda, Keiji Wad. Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16965839. |
we found a significant reduction in the dopaminergic neurons in the substantia nigra and the dopamine content in the striatum in the high-expressing i93m tg mice as compared with non-tg mice at 20 weeks of age. |
2007-03-20 |
2023-08-12 |
mouse |