| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronald L Klein, Robert D Dayton, Karen M Henderson, Leonard Petrucell. Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16554120. |
while there was significant loss of dopamine neurons in the tau/control group relative to uninjected substantia nigra, there was no cell loss in the tau/parkin group. |
2006-09-28 |
2023-08-12 |
mouse |
| Satoshi Ohashi, Atsushi Mori, Naoki Kurihara, Yasuhide Mitsumoto, Masami Naka. Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16581184. |
an extensive dopaminergic cell loss was found in both the striatum and substantia nigra of older mice given one and two injections of mptp with marked decrease in striatal dopamine (da) levels, but not young mice. |
2006-09-28 |
2023-08-12 |
mouse |
| H Ji, P D Shepar. SK Ca2+-activated K+ channel ligands alter the firing pattern of dopamine-containing neurons in vivo. Neuroscience. vol 140. issue 2. 2006-09-25. PMID:16564639. |
in the present series of experiments, extracellular single unit recording techniques were used to assess the central effects of prototypical sk channel ligands on the firing pattern of dopamine neurons in the substantia nigra of the chloral hydrate anesthetized rat. |
2006-09-25 |
2023-08-12 |
rat |
| Yong Yang, Xing Liu, Yan Long, Fang Wang, Jian-Hua Ding, Su-Yi Liu, Ye-Hong Sun, Hong-Hong Yao, Hai Wang, Jie Wu, Gang H. Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats. The international journal of neuropsychopharmacology. vol 9. issue 1. 2006-09-19. PMID:15927086. |
this treatment caused a depletion of dopamine in the striatum and substantia nigra. |
2006-09-19 |
2023-08-12 |
rat |
| Yong Yang, Xing Liu, Yan Long, Fang Wang, Jian-Hua Ding, Su-Yi Liu, Ye-Hong Sun, Hong-Hong Yao, Hai Wang, Jie Wu, Gang H. Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats. The international journal of neuropsychopharmacology. vol 9. issue 1. 2006-09-19. PMID:15927086. |
for 2 wk improved behavioural dysfunction and elevated dopamine contents in the striatum and substantia nigra of rotenone-treated rats. |
2006-09-19 |
2023-08-12 |
rat |
| M Shamoto-Nagai, W Maruyama, H Yi, Y Akao, F Tribl, M Gerlach, T Osawa, P Riederer, M Nao. Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 5. 2006-09-19. PMID:16362626. |
parkinson's disease is characterized by the selective depletion of dopamine neurons in the substantia nigra, particular those containing neuromelanin. |
2006-09-19 |
2023-08-12 |
human |
| Monte A Gates, Eduardo M Torres, Anna White, Rosemary A Fricker-Gates, Stephen B Dunnet. Re-examining the ontogeny of substantia nigra dopamine neurons. The European journal of neuroscience. vol 23. issue 5. 2006-09-18. PMID:16553799. |
re-examining the ontogeny of substantia nigra dopamine neurons. |
2006-09-18 |
2023-08-12 |
rat |
| Luciana Mosca, Eugenio Lendaro, Maria d'Erme, Sonia Marcellini, Sonia Moretti, Maria Anna Rose. 5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y. Neurochemistry international. vol 49. issue 3. 2006-09-15. PMID:16549224. |
in recent years a catechol-thioether metabolite of dopamine, 5-s-cysteinyl-dopamine, has been identified in certain dopaminergic regions of the brain, notably the substantia nigra. |
2006-09-15 |
2023-08-12 |
human |
| Jeffrey H Kordower, Nicholas M Kanaan, Yaping Chu, Rangasamy Suresh Babu, James Stansell, Brian T Terpstra, Caryl E Sortwell, Kathy Steece-Collier, Timothy J Collie. Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys. Annals of neurology. vol 60. issue 2. 2006-09-15. PMID:16862579. |
mcnaught and colleagues reported recently that systemic administration of proteasome inhibitors psi (z-ileu-glu(otbu)-ala-leu-cho) or epoxomicin recapitulated many of the degenerative changes seen in parkinson's disease including loss of striatal dopamine and cell loss in the substantia nigra, locus ceruleus, dorsal motor nucleus of the x cranial nerve, and nucleus basalis of meynert. |
2006-09-15 |
2023-08-12 |
rat |
| Fumiaki Mori, Makoto Nishie, Akiyoshi Kakita, Makoto Yoshimoto, Hitoshi Takahashi, Koichi Wakabayash. Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. Journal of neuropathology and experimental neurology. vol 65. issue 8. 2006-09-15. PMID:16896314. |
relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in parkinson disease substantia nigra. |
2006-09-15 |
2023-08-12 |
human |
| Cristina M Bäckman, Lufei Shan, Ya Jun Zhang, Barry J Hoffer, Sherry Leonard, Juan C Troncoso, Paul Vonsatel, Andreas C Toma. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Molecular and cellular endocrinology. vol 252. issue 1-2. 2006-09-12. PMID:16644101. |
these data suggest that the extensive loss of dopaminergic neurons in the substantia nigra, and concomitant loss of striatal dopamine, may induce compensatory changes in the expression of target derived gdnf, but not its receptor system. |
2006-09-12 |
2023-08-12 |
human |
| Yoshitsugu Oiwa, Kunio Nakai, Toru Itakur. Histological effects of intraputaminal infusion of glial cell line-derived neurotrophic factor in Parkinson disease model macaque monkeys. Neurologia medico-chirurgica. vol 46. issue 6. 2006-09-08. PMID:16794346. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neuroprotection and regeneration molecule for dopamine neurons in the substantia nigra. |
2006-09-08 |
2023-08-12 |
monkey |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
no other alterations in the levels of dopamine and its metabolites were found in the caudate-putamen and substantia nigra. |
2006-09-07 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Karuppagounder S Senthilkumar, Kochupurackal P Mohanakuma. L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochemistry international. vol 49. issue 1. 2006-08-24. PMID:16490285. |
unilateral stereotaxic intranigral infusion of rotenone caused significant decrease of striatal dopamine levels as measured employing hplc-electrochemistry, and loss of tyrosine hydroxylase immunoreactivity in the perikarya of ipsilateral substantia nigra (sn) neurons and their terminals in the striatum. |
2006-08-24 |
2023-08-12 |
rat |
| Janelle M Silvers, Michael Y Aksenov, Marina V Aksenova, Jacob Beckley, Petra Olton, Charles F Mactutus, Rosemarie M Booz. Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. Journal of neurovirology. vol 12. issue 2. 2006-08-11. PMID:16798675. |
in this study, protein levels of tyrosine hydroxylase (th) and dopamine transporter (dat) in the substantia nigra of hiv-infected brains and -seronegative controls were determined by immunoblotting. |
2006-08-11 |
2023-08-12 |
human |
| Maria G Cersosimo, William C Kolle. The diagnosis of manganese-induced parkinsonism. Neurotoxicology. vol 27. issue 3. 2006-08-10. PMID:16325915. |
there is degeneration of the substantia nigra, pars compacta, which results in loss of striatal dopamine. |
2006-08-10 |
2023-08-12 |
Not clear |
| Marie-Eve Tremblay, Martine Saint-Pierre, Emmanuelle Bourhis, Daniel Lévesque, Claude Rouillard, Francesca Cicchett. Neuroprotective effects of cystamine in aged parkinsonian mice. Neurobiology of aging. vol 27. issue 6. 2006-07-26. PMID:15913845. |
pre-treatment with lower doses of cystamine (10 mg/kg) revealed increased levels of tyrosine hydroxylase (th) positive striatal fiber (p<0.01), increased density of th-immunoreactive cells (p<0.01), increased substantia nigra nurr1 mrna levels (p<0.001), and increased density of substantia nigra cells expressing the dopamine transporter (p<0.001) as compared to mptp treated mice. |
2006-07-26 |
2023-08-12 |
mouse |
| S Pavlovic, G Schulze, C Wernicke, R Bonnet, G Gille, L Badiali, A Kaminska, E Lorenc-Koci, K Ossowska, H Rommelspache. 2,9-Dimethyl-beta-carbolinium, a neurotoxin occurring in human brain, is a potent inducer of apoptosis as 1-methyl-4-phenylpyridinium. Neuroscience. vol 139. issue 4. 2006-07-26. PMID:16517085. |
three weeks after injection of 2,9-dimethyl-beta-carbolinium ion in the substantia nigra we found a dose-dependent decrease of dopamine and its metabolites in the striatum of rats. |
2006-07-26 |
2023-08-12 |
mouse |
| Jantarima Pandaranandaka, Sutthasinee Poonyachoti, Sarinee Kalandakanond-Thongson. Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats. Physiology & behavior. vol 87. issue 4. 2006-07-26. PMID:16545402. |
the concentrations of norepinephrine in caudate putamen, of dopamine in nucleus accumbens, of serotonin in frontal cortex, hippocampus, caudate putamen, nucleus accumbens, and substantia nigra and of the serotonin metabolite, the 5-hydroxyindolacetic acid in substantia nigra of ovx+e(2) rats were significantly lower than those of ovx rats. |
2006-07-26 |
2023-08-12 |
rat |
| Mariana Angoa-Pérez, Hao Jiang, Alba I Rodríguez, Cristina Lemini, Robert A Levine, Selva Rivas-Arancibi. Estrogen counteracts ozone-induced oxidative stress and nigral neuronal death. Neuroreport. vol 17. issue 6. 2006-07-26. PMID:16603924. |
oxidative stress is implicated in the premature death of dopamine neurons in substantia nigra in parkinson's disease. |
2006-07-26 |
2023-08-12 |
rat |