| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Van Kampen, H A Robertso. A possible role for dopamine D3 receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra. Neuroscience. vol 136. issue 2. 2006-03-17. PMID:16216425. |
dopamine d3 receptors have also been found in the substantia nigra [diaz j, pilon c, le foll b, gross c, triller a, schwartz jc, sokoloff p (2000) dopamine d3 receptors expressed by all mesencephalic dopamine neurons. |
2006-03-17 |
2023-08-12 |
rat |
| Matteo Marti, Flora Mela, Martina Fantin, Silvia Zucchini, Jeffrey M Brown, Jassir Witta, Manuela Di Benedetto, Beata Buzas, Rainer K Reinscheid, Severo Salvadori, Remo Guerrini, Patrizia Romualdi, Sanzio Candeletti, Michele Simonato, Brian M Cox, Michele Morar. Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 42. 2006-03-15. PMID:16237164. |
the opioid-like neuropeptide nociceptin/orphanin fq (n/ofq) and its receptor (nop) are expressed in the substantia nigra (sn), a brain area containing dopamine neurons that degenerate in parkinson's disease. |
2006-03-15 |
2023-08-12 |
mouse |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
dopamine (da) has been postulated to play a role in the loss of dopaminergic substantia nigra (sn) neurons in parkinson's disease because of its propensity to oxidize and form quinones and other reactive oxygen species that can alter cellular function. |
2006-03-13 |
2023-08-12 |
mouse |
| Marat V Avshalumov, Billy T Chen, Tibor Koós, James M Tepper, Margaret E Ric. Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858048. |
here, we examined regulation of k(atp) channels in substantia nigra dopamine neurons by hydrogen peroxide (h2o2), which is produced in all cells during aerobic metabolism. |
2006-03-09 |
2023-08-12 |
Not clear |
| Marat V Avshalumov, Billy T Chen, Tibor Koós, James M Tepper, Margaret E Ric. Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858048. |
in contrast, when endogenous h2o2 levels were increased after inhibition of catalase, the predominant peroxidase in the substantia nigra, with 3-amino-1,2,4-triazole (1 mm), all dopamine neurons responded with glibenclamide-reversible hyperpolarization. |
2006-03-09 |
2023-08-12 |
Not clear |
| Mar Cuadrado-Tejedor, M Teresa Sesma, José Manuel Giménez-Amaya, Lourdes Orti. Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:16005240. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (da) levels in the striatum. |
2006-03-09 |
2023-08-12 |
mouse |
| Ana Saavedra, Graça Baltazar, Caetana M Carvalho, Emília P Duart. GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures. Free radical biology & medicine. vol 39. issue 12. 2006-03-07. PMID:16298686. |
in this work we investigated ho-1 expression in rat substantia nigra postnatal cell cultures under conditions mimicking dopamine toxicity and its modulation by glial cell line-derived neurotrophic factor (gdnf), a potent neuroprotective factor for dopaminergic neurons. |
2006-03-07 |
2023-08-12 |
rat |
| Xia Li, Kinzo Matsumoto, Yukihisa Murakami, Yasuhiro Tezuka, Yingliang Wu, Shigetoshi Kadot. Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice. Pharmacology, biochemistry, and behavior. vol 82. issue 2. 2006-03-02. PMID:16214209. |
this combination caused a reduction of spontaneous locomotor activity, motor incoordination, and declines of dopamine level in the striatum and tyrosine hydroxylase-positive neurons in the substantia nigra. |
2006-03-02 |
2023-08-12 |
mouse |
| Tomoki Kuwahara, Akihiko Koyama, Keiko Gengyo-Ando, Mayumi Masuda, Hisatomo Kowa, Makoto Tsunoda, Shohei Mitani, Takeshi Iwatsub. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. The Journal of biological chemistry. vol 281. issue 1. 2006-02-28. PMID:16260788. |
dopamine neurons in substantia nigra are the major site of neurodegeneration associated with alpha-synuclein deposition in parkinson disease. |
2006-02-28 |
2023-08-12 |
human |
| Taizo Nakazat. Striatal dopamine release in the rat during a cued lever-press task for food reward and the development of changes over time measured using high-speed voltammetry. Experimental brain research. vol 166. issue 1. 2006-02-24. PMID:16028033. |
substantia nigra dopamine neuronal activity in the primate is thought to be related to the error in predicting reward delivery. |
2006-02-24 |
2023-08-12 |
rat |
| Byung P Cho, Dae Y Song, Shuei Sugama, Dong H Shin, Yoshinori Shimizu, Sung S Kim, Yoon S Kim, Tong H Jo. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia. vol 53. issue 1. 2006-02-24. PMID:16206155. |
phagocytic microglia, characterized by ed1-immunoreactivity or ed1- and ox6-immunoreactivity, appeared in the mfb and substantia nigra (sn) as early as 1-3 days post-lesion (dpl), when there was no apparent loss of sn dopamine (da) neurons. |
2006-02-24 |
2023-08-12 |
rat |
| Mario van der Stelt, Susan H Fox, Michael Hill, Alan R Crossman, Stefania Petrosino, Vincenzo Di Marzo, Jonathan M Brotchi. A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 9. 2006-02-23. PMID:15894565. |
in the untreated, mptp-lesioned primate, parkinsonism was associated with increases in both 2-ag (+88%) and anandamide (+49%) in the striatum, and of 2-ag (+97%) in the substantia nigra, changes that are consistent with the previously suggested role for endocannabinoids in mechanisms attempting to compensate for loss of dopamine in untreated parkinsonism. |
2006-02-23 |
2023-08-12 |
monkey |
| David M Dietz, Jenica Tapocik, Meriem Gaval-Cruz, Mohamed Kabba. Dopamine transporter, but not tyrosine hydroxylase, may be implicated in determining individual differences in behavioral sensitization to amphetamine. Physiology & behavior. vol 86. issue 3. 2006-02-21. PMID:16126238. |
furthermore, only hr rats pretreated with amphetamine exhibited an increase in dopamine transporter mrna in the ventral tegmental area (vta) and substantia nigra (sn). |
2006-02-21 |
2023-08-12 |
rat |
| Deborah A Cory-Slechta, Mona Thiruchelvam, Brian K Barlow, Eric K Richfiel. Developmental pesticide models of the Parkinson disease phenotype. Environmental health perspectives. vol 113. issue 9. 2006-02-17. PMID:16140639. |
combined exposures to the herbicide paraquat (pq) and the fungicide maneb (mb), both of which adversely affect dopamine systems, administered from postnatal days 5-19, produced selective losses of dopamine and metabolites and reduced numbers of dopamine neurons in the substantia nigra. |
2006-02-17 |
2023-08-12 |
mouse |
| Deborah A Cory-Slechta, Mona Thiruchelvam, Brian K Barlow, Eric K Richfiel. Developmental pesticide models of the Parkinson disease phenotype. Environmental health perspectives. vol 113. issue 9. 2006-02-17. PMID:16140639. |
in a second model, exposure to mb from gestational days 10-17 markedly increased vulnerability to pq exposures during adulthood, with reductions in dopamine and metabolites and numbers of dopamine neurons in the substantia nigra. |
2006-02-17 |
2023-08-12 |
mouse |
| Carrie E John, Evgeny A Budygin, Yolanda Mateo, Sara R Jone. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16300629. |
neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. |
2006-02-14 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |
| V I Mel'nikova, A V Lavrent'eva, V S Kudrin, K S Raevskii, M V Ugryumo. Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses. Neuroscience and behavioral physiology. vol 35. issue 8. 2006-02-06. PMID:16132261. |
in addition, l-tyrosine increased dopamine synthesis in the substantia nigra and decreased dopamine synthesis in the mediobasal hypothalamus. |
2006-02-06 |
2023-08-12 |
rat |
| Saga Johansson, I-Hui Lee, Lars Olson, Christian Spenge. Olfactory ensheathing glial co-grafts improve functional recovery in rats with 6-OHDA lesions. Brain : a journal of neurology. vol 128. issue Pt 12. 2006-01-26. PMID:16251218. |
cell type analysis of fetal vm grafts suggested that dopamine neurons of the substantia nigra rather than of the ventral tegmental area were increased in the presence of oec co-grafts. |
2006-01-26 |
2023-08-12 |
rat |
| Robert M Silva, Vincent Ries, Tinmarla Frances Oo, Olga Yarygina, Vernice Jackson-Lewis, Elizabeth J Ryu, Phoebe D Lu, Stefan J Marciniak, David Ron, Serge Przedborski, Nikolai Kholodilov, Lloyd A Greene, Robert E Burk. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of neurochemistry. vol 95. issue 4. 2006-01-20. PMID:16135078. |
chop/gadd153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. |
2006-01-20 |
2023-08-12 |
Not clear |