| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deborah A Cory-Slechta, Mona Thiruchelvam, Brian K Barlow, Eric K Richfiel. Developmental pesticide models of the Parkinson disease phenotype. Environmental health perspectives. vol 113. issue 9. 2006-02-17. PMID:16140639. |
in a second model, exposure to mb from gestational days 10-17 markedly increased vulnerability to pq exposures during adulthood, with reductions in dopamine and metabolites and numbers of dopamine neurons in the substantia nigra. |
2006-02-17 |
2023-08-12 |
mouse |
| Carrie E John, Evgeny A Budygin, Yolanda Mateo, Sara R Jone. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16300629. |
neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. |
2006-02-14 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |
| V I Mel'nikova, A V Lavrent'eva, V S Kudrin, K S Raevskii, M V Ugryumo. Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses. Neuroscience and behavioral physiology. vol 35. issue 8. 2006-02-06. PMID:16132261. |
in addition, l-tyrosine increased dopamine synthesis in the substantia nigra and decreased dopamine synthesis in the mediobasal hypothalamus. |
2006-02-06 |
2023-08-12 |
rat |
| Saga Johansson, I-Hui Lee, Lars Olson, Christian Spenge. Olfactory ensheathing glial co-grafts improve functional recovery in rats with 6-OHDA lesions. Brain : a journal of neurology. vol 128. issue Pt 12. 2006-01-26. PMID:16251218. |
cell type analysis of fetal vm grafts suggested that dopamine neurons of the substantia nigra rather than of the ventral tegmental area were increased in the presence of oec co-grafts. |
2006-01-26 |
2023-08-12 |
rat |
| Robert M Silva, Vincent Ries, Tinmarla Frances Oo, Olga Yarygina, Vernice Jackson-Lewis, Elizabeth J Ryu, Phoebe D Lu, Stefan J Marciniak, David Ron, Serge Przedborski, Nikolai Kholodilov, Lloyd A Greene, Robert E Burk. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of neurochemistry. vol 95. issue 4. 2006-01-20. PMID:16135078. |
chop/gadd153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. |
2006-01-20 |
2023-08-12 |
Not clear |
| Thomas D Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S Gambino, John Nayda, Timothy Buckley, Ewa K Stachowiak, Earl J Bergey, Haridas Pudavar, Purnendu Dutta, David C Bloom, William J Bowers, Michal K Stachowia. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16039006. |
transfection of tyrosine kinase deleted fgf receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. |
2006-01-17 |
2023-08-12 |
rat |
| Abesh Kumar Bhattacharjee, Lisa Chang, Ho-Joo Lee, Richard P Bazinet, Ruth Seemann, Stanley I Rapopor. D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats. Psychopharmacology. vol 180. issue 4. 2006-01-17. PMID:16163535. |
signal transduction involving the activation of phospholipase a2 (pla2) to release arachidonic acid (aa) from membrane phospholipids, when coupled to dopamine d1- and d2-type receptors, can be imaged in rats having a chronic unilateral lesion of the substantia nigra. |
2006-01-17 |
2023-08-12 |
rat |
| Ismael Santa-María, Félix Hernández, Mark A Smith, George Perry, Jesús Avila, Francisco J Moren. Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers. Molecular and cellular biochemistry. vol 278. issue 1-2. 2006-01-17. PMID:16180106. |
curiously, neurons expressing dopamine (substantia nigra) show a low content of tau protein and seldom have tau aggregation in tauopathies. |
2006-01-17 |
2023-08-12 |
Not clear |
| Paul S Frankel, Amanda J Hoonakker, Glen R Hanson, Lloyd Bush, Kristen A Keefe, Mario E Alburge. Differential neurotensin responses to low and high doses of methamphetamine in the terminal regions of striatal efferents. European journal of pharmacology. vol 522. issue 1-3. 2006-01-10. PMID:16199030. |
these findings suggest that low and high doses of methamphetamine differentially affect the release of neurotensin from the terminals of striatonigral neurons and that both dopamine d1 and d2 receptor activation contributes to the low-dose methamphetamine effects in the substantia nigra. |
2006-01-10 |
2023-08-12 |
Not clear |
| Virginia Zbarsky, Krishna P Datla, Shabnam Parkar, Deepal K Rai, Okezie I Aruoma, David T Dexte. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free radical research. vol 39. issue 10. 2006-01-10. PMID:16298737. |
unilateral infusion of 6-ohda into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) as well as a decreased of dopamine (da) content in the striata in the vehicle-treated animals. |
2006-01-10 |
2023-08-12 |
rat |
| Renee M Miller, Howard J Federof. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 11. issue 6. 2006-01-05. PMID:16282595. |
these include exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), which selectively kills dopamine neurons in the substantia nigra, and genetic models incorporating mutations in the alpha-synuclein gene that cause disease in human patients. |
2006-01-05 |
2023-08-12 |
human |
| S Jourdain, M Morissette, N Morin, T Di Paol. Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Journal of neuroendocrinology. vol 17. issue 8. 2005-12-23. PMID:16011487. |
oestrogens prevent loss of dopamine transporter (dat) and vesicular monoamine transporter (vmat2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. |
2005-12-23 |
2023-08-12 |
mouse |
| Ronald L Klein, Robert D Dayton, Wen-Lang Lin, Dennis W Dickso. Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiology of disease. vol 20. issue 1. 2005-12-19. PMID:16137567. |
both tau and alpha-synuclein are important for substantia nigra neurodegeneration models in rats, further indicating their potential as therapeutic targets for human diseases involving loss of dopamine neurons. |
2005-12-19 |
2023-08-12 |
human |
| Jordi Bové, Jordi Serrats, Guadalupe Mengod, Roser Cortés, Eduardo Tolosa, Concepció Mari. Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways. Experimental brain research. vol 165. issue 3. 2005-12-01. PMID:15968457. |
in parkinson's disease (pd), the striatal dopamine depletion and the following overactivation of the indirect pathway of the basal ganglia leads to very early disinhibition of the subthalamic nucleus (stn) that may contribute to the progression of pd by glutamatergic overstimulation of the dopaminergic neurons in the substantia nigra. |
2005-12-01 |
2023-08-12 |
rat |
| Juan C Mayo, Rosa M Sainz, Dun-Xian Tan, Isaac Antolín, Carmen Rodríguez, Russel J Reite. Melatonin and Parkinson's disease. Endocrine. vol 27. issue 2. 2005-12-01. PMID:16217130. |
it is characterized by a progressive loss of dopamine in the substantia nigra and striatum. |
2005-12-01 |
2023-08-12 |
Not clear |
| Abdullah Shafique Ahmad, Mubeen Ahmad Ansari, Muzamil Ahmad, Sofiyan Saleem, Seema Yousuf, Md Nasrul Hoda, Fakhrul Isla. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacology, biochemistry, and behavior. vol 81. issue 4. 2005-11-28. PMID:16005057. |
activity of antioxidant enzymes and content of dopamine (da) and its metabolites were estimated in striatum, whereas glutathione (gsh) content and thiobarbituric acid reactive substance (tbars) were evaluated in substantia nigra. |
2005-11-28 |
2023-08-12 |
rat |
| Carolyn F Orr, Dominic B Rowe, Yoshikuni Mizuno, Hideo Mori, Glenda M Hallida. A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain : a journal of neurology. vol 128. issue Pt 11. 2005-11-28. PMID:16219675. |
a mean 30 +/- 12% of dopamine nigral neurons were immunoreactive for igg in parkinson's disease with the proportion of igg immunopositive neurons negatively correlating with the degree of cell loss in the substantia nigra (r = -0.67, p < 0.0001) and positively correlating with the number of hla immunopositive microglia (r = 0.51, p = 0.01). |
2005-11-28 |
2023-08-12 |
Not clear |
| Yan Chen, Yi Ai, John R Slevin, Bruce E Maley, Don M Gas. Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16112112. |
there was no evidence of neurogenesis in the substantia nigra, with new cells displaying glial features and none of the 1549 brdu-positive cells co-labeled for the dopamine neuronal marker tyrosine hydroxylase (th). |
2005-11-22 |
2023-08-12 |
rat |
| Pao-Chi Liao, Yu-Min Kuo, Hen-Chia Hsu, Chienfang G Cherng, Lung Y. Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicity. Journal of neurochemistry. vol 95. issue 1. 2005-11-08. PMID:16181420. |
infusion of anisomycin into striatum and substantia nigra both abolished the ma-induced striatal dopamine (da) and dihydroxyphenylacetic acid (dopac) depletions, indicating a critical role of local protein synthesis in determining such dopaminergic toxicity. |
2005-11-08 |
2023-08-12 |
Not clear |