| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J K Marcario, K F Manaye, K S SantaCruz, P R Mouton, N E J Berman, P D Chene. Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus. Journal of neurovirology. vol 10. issue 6. 2005-04-19. PMID:15765810. |
to investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (gp) and for dopamine (da)-containing neurons in the substantia nigra (sn) in eight macaques inoculated with macrophage-tropic, neurovirulent siv (sivmac r71/17e), and five control animals. |
2005-04-19 |
2023-08-12 |
human |
| Mahboubeh Tavakoli-Nezhad, David K Pitt. Postnatal inorganic lead exposure reduces midbrain dopaminergic impulse flow and decreases dopamine D1 receptor sensitivity in nucleus accumbens neurons. The Journal of pharmacology and experimental therapeutics. vol 312. issue 3. 2005-04-05. PMID:15550573. |
lead treatment via drinking water for 3 to 6 weeks at 250 ppm was found to significantly decrease the number of spontaneously active dopamine (da) neurons in both the substantia nigra and ventral tegmental area that were recorded using standard extracellular electrophysiological recording techniques. |
2005-04-05 |
2023-08-12 |
Not clear |
| V I Mel'nikov, A V Lavrent'eva, V S Kudrin, K S Raevskiĭ, M V Ugriumo. [Dopamine synthesis by non-dopaminergic neurons of the rat fetus arquate nucleus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 7. 2005-04-01. PMID:15462205. |
moreover, l-tyrosine provoked an increase of dopamine synthesis in substantia nigra and a decrease in the mediobasal hypothalamus. |
2005-04-01 |
2023-08-12 |
rat |
| Allison D Ebert, Feng Chen, Xiaolong He, Vincent L Cryns, Martha C Boh. A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. Experimental neurology. vol 191 Suppl 1. 2005-03-29. PMID:15629764. |
caspase-9 is a critical downstream effector molecule involved in apoptosis, a cell death process thought to be involved in the demise of dopamine (da) neurons in the substantia nigra (sn) affected by parkinson's disease (pd). |
2005-03-29 |
2023-08-12 |
rat |
| Biljana Georgievska, Deniz Kirik, Anders Björklun. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 29. 2005-03-21. PMID:15269253. |
the effects of continuous glial cell line-derived neurotrophic factor (gdnf) overexpression in the intact nigrostriatal dopamine (da) system was studied using recombinant lentiviral (rlv) vector delivery of gdnf to the striatum or substantia nigra (sn) in the rat. |
2005-03-21 |
2023-08-12 |
rat |
| Gonzalo Bustos, Jorge Abarca, Jorge Campusano, Victor Bustos, Viviana Noriega, Esteban Aliag. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572168. |
dopaminergic nigrostriatal neurons may be considered as bipolar functional entities since they are endowed with the ability to synthesize, store and release the transmitter dopamine (da) at the somatodendritic level in the substantia nigra (sn). |
2005-03-15 |
2023-08-12 |
Not clear |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
to explore further the relationship between the mesencephalic dopaminergic neurons and pfc gabaergic neurons, we investigated the effects of nicotine and passive exposure to cigarette smoke on the regulation of tyrosine hydroxylase (th) in vta and substantia nigra (snc) and dopamine (da) d1 receptor levels in nucleus accumbens (nac) and caudate-putamen (cpu). |
2005-03-07 |
2023-08-12 |
rat |
| Sheila M Fleming, Yvon Delville, Timothy Schaller. An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. Behavioural brain research. vol 156. issue 2. 2005-03-07. PMID:15582106. |
an immunocytochemical assay for tyrosine hydroxylase, a dopamine cell marker, revealed a partial loss of immunoreactive cells in the substantia nigra. |
2005-03-07 |
2023-08-12 |
Not clear |
| Marten P Smidt, Simone M Smits, J Peter H Burbac. Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15300495. |
homeobox gene pitx3 and its role in the development of dopamine neurons of the substantia nigra. |
2005-03-04 |
2023-08-12 |
mouse |
| Robert E Burk. Ontogenic cell death in the nigrostriatal system. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15349767. |
like most neural systems, dopamine neurons of the substantia nigra undergo apoptotic natural cell death during development. |
2005-03-04 |
2023-08-12 |
mouse |
| Andreas Schobe. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15503155. |
pd is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. |
2005-03-04 |
2023-08-12 |
human |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |
| F Fornai, P Lenzi, M Gesi, M Ferrucci, G Lazzeri, L Capobianco, A de Blasi, G Battaglia, F Nicoletti, S Ruggieri, A Paparell. Similarities between methamphetamine toxicity and proteasome inhibition. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542714. |
in fact, meth-induced striatal dopamine (da) loss is accompanied by damage to striatal nerve endings arising from the substantia nigra. |
2005-02-18 |
2023-08-12 |
mouse |
| A C Riegel, S F Ali, S Torinese, E D Frenc. Repeated exposure to the abused inhalant toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542760. |
here we examined the effects of seven daily intraperitoneal injections of 600 mg/kg toluene on the content of serotonin and dopamine in the caudate nucleus (cn) and nucleus accumbens (nac), substantia nigra, and ventral tegmental area at 2, 4, and 24 h after the last injection. |
2005-02-18 |
2023-08-12 |
rat |
| Joana Gomes-da-Silva, Rosario de Miguel, Javier Fernández-Ruiz, Teresa Summavielle, M Amélia Tavare. Effects of neonatal exposure to methamphetamine: catecholamine levels in brain areas of the developing rat. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542769. |
norepinephrine, dopamine, and dihydroxyphenylacetic acid levels were measured in target areas of methamphetamine: the substantia nigra, ventral tegmental area, caudate-putamen, nucleus accumbens, and medial prefrontal cortex. |
2005-02-18 |
2023-08-12 |
rat |
| Matthew G Quinlan, Ruth Sharf, David Y Lee, Roy A Wise, Robert Ranald. Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology. vol 175. issue 1. 2005-02-08. PMID:14767633. |
blockade of substantia nigra dopamine d1 receptors reduces intravenous cocaine reward in rats. |
2005-02-08 |
2023-08-12 |
rat |
| Matthew G Quinlan, Ruth Sharf, David Y Lee, Roy A Wise, Robert Ranald. Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology. vol 175. issue 1. 2005-02-08. PMID:14767633. |
we have recently found that blockade of dopamine d1-type receptors in the ventral tegmental area reduces the rewarding effects of intravenous cocaine; here, we explored the possibility that blockade of d1 receptors in the adjacent substantia nigra (sn)--not usually considered part of reward circuitry--might have similar effects. |
2005-02-08 |
2023-08-12 |
rat |
| David M Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B Seroog. Supranigral injection of neuregulin1-beta induces striatal dopamine overflow. Brain research. vol 1028. issue 1. 2005-01-25. PMID:15518649. |
previous studies have provided anatomical evidence that the functional neuregulin receptor, erbb4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. |
2005-01-25 |
2023-08-12 |
Not clear |
| David M Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B Seroog. Supranigral injection of neuregulin1-beta induces striatal dopamine overflow. Brain research. vol 1028. issue 1. 2005-01-25. PMID:15518649. |
heregulin1-beta), a neuregulin-1 gene isoform that preferentially binds to and activates the erbb4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. |
2005-01-25 |
2023-08-12 |
Not clear |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |