| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
to explore further the relationship between the mesencephalic dopaminergic neurons and pfc gabaergic neurons, we investigated the effects of nicotine and passive exposure to cigarette smoke on the regulation of tyrosine hydroxylase (th) in vta and substantia nigra (snc) and dopamine (da) d1 receptor levels in nucleus accumbens (nac) and caudate-putamen (cpu). |
2005-03-07 |
2023-08-12 |
rat |
| Sheila M Fleming, Yvon Delville, Timothy Schaller. An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. Behavioural brain research. vol 156. issue 2. 2005-03-07. PMID:15582106. |
an immunocytochemical assay for tyrosine hydroxylase, a dopamine cell marker, revealed a partial loss of immunoreactive cells in the substantia nigra. |
2005-03-07 |
2023-08-12 |
Not clear |
| Marten P Smidt, Simone M Smits, J Peter H Burbac. Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15300495. |
homeobox gene pitx3 and its role in the development of dopamine neurons of the substantia nigra. |
2005-03-04 |
2023-08-12 |
mouse |
| Robert E Burk. Ontogenic cell death in the nigrostriatal system. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15349767. |
like most neural systems, dopamine neurons of the substantia nigra undergo apoptotic natural cell death during development. |
2005-03-04 |
2023-08-12 |
mouse |
| Andreas Schobe. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15503155. |
pd is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. |
2005-03-04 |
2023-08-12 |
human |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |
| F Fornai, P Lenzi, M Gesi, M Ferrucci, G Lazzeri, L Capobianco, A de Blasi, G Battaglia, F Nicoletti, S Ruggieri, A Paparell. Similarities between methamphetamine toxicity and proteasome inhibition. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542714. |
in fact, meth-induced striatal dopamine (da) loss is accompanied by damage to striatal nerve endings arising from the substantia nigra. |
2005-02-18 |
2023-08-12 |
mouse |
| A C Riegel, S F Ali, S Torinese, E D Frenc. Repeated exposure to the abused inhalant toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542760. |
here we examined the effects of seven daily intraperitoneal injections of 600 mg/kg toluene on the content of serotonin and dopamine in the caudate nucleus (cn) and nucleus accumbens (nac), substantia nigra, and ventral tegmental area at 2, 4, and 24 h after the last injection. |
2005-02-18 |
2023-08-12 |
rat |
| Joana Gomes-da-Silva, Rosario de Miguel, Javier Fernández-Ruiz, Teresa Summavielle, M Amélia Tavare. Effects of neonatal exposure to methamphetamine: catecholamine levels in brain areas of the developing rat. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542769. |
norepinephrine, dopamine, and dihydroxyphenylacetic acid levels were measured in target areas of methamphetamine: the substantia nigra, ventral tegmental area, caudate-putamen, nucleus accumbens, and medial prefrontal cortex. |
2005-02-18 |
2023-08-12 |
rat |
| Matthew G Quinlan, Ruth Sharf, David Y Lee, Roy A Wise, Robert Ranald. Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology. vol 175. issue 1. 2005-02-08. PMID:14767633. |
blockade of substantia nigra dopamine d1 receptors reduces intravenous cocaine reward in rats. |
2005-02-08 |
2023-08-12 |
rat |
| Matthew G Quinlan, Ruth Sharf, David Y Lee, Roy A Wise, Robert Ranald. Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology. vol 175. issue 1. 2005-02-08. PMID:14767633. |
we have recently found that blockade of dopamine d1-type receptors in the ventral tegmental area reduces the rewarding effects of intravenous cocaine; here, we explored the possibility that blockade of d1 receptors in the adjacent substantia nigra (sn)--not usually considered part of reward circuitry--might have similar effects. |
2005-02-08 |
2023-08-12 |
rat |
| David M Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B Seroog. Supranigral injection of neuregulin1-beta induces striatal dopamine overflow. Brain research. vol 1028. issue 1. 2005-01-25. PMID:15518649. |
previous studies have provided anatomical evidence that the functional neuregulin receptor, erbb4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. |
2005-01-25 |
2023-08-12 |
Not clear |
| David M Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B Seroog. Supranigral injection of neuregulin1-beta induces striatal dopamine overflow. Brain research. vol 1028. issue 1. 2005-01-25. PMID:15518649. |
heregulin1-beta), a neuregulin-1 gene isoform that preferentially binds to and activates the erbb4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. |
2005-01-25 |
2023-08-12 |
Not clear |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, Y Imai, H Kato, T Arak. Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice. Neurological research. vol 26. issue 6. 2005-01-07. PMID:15327754. |
in our immunohistochemical studies with antibodies against tyrosine hydroxylase (th), microtubule-associated protein 2a, b (map2), dopamine transporter (dat), parvalbumin (pv), glial fibrillary acidic protein (gfap) and cu/zn-superoxide dismutase (cu/zn-sod), the administration of perindopril significantly attenuated mptp-induced substantia nigra and striatal damage. |
2005-01-07 |
2023-08-12 |
mouse |
| Vandana Zaman, Matthew E Nelson, Greg A Gerhardt, Baerbel Rohre. Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530873. |
to further evaluate the role of trkb in the nigrostriatal pathway, we studied neurotrophin levels, dopamine metabolism, and morphology of dopaminergic neurons of the substantia nigra (sn-da) in young adult hypomorphic trkb mice (trkbfbz/fbz), which express only approximately 25% of wild type levels of trkb. |
2004-12-29 |
2023-08-12 |
mouse |
| Paul J Shughru. Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta). Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530885. |
estrogen attenuates the loss of dopamine from striatum and dopamine neurons from the substantia nigra (snc) in animal models of parkinson's disease. |
2004-12-29 |
2023-08-12 |
mouse |
| Bala V Manyam, Muralikrishnan Dhanasekaran, Theodore A Har. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytotherapy research : PTR. vol 18. issue 9. 2004-12-23. PMID:15478206. |
unlike synthetic levodopa treatment, mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. |
2004-12-23 |
2023-08-12 |
rat |
| JinWhan Cho, Olga Yarygina, Tinmarla Frances Oo, Nikolai G Kholodilov, Robert E Burk. Glial cell line-derived neurotrophic factor receptor GFRalpha1 is expressed in the rat striatum during postnatal development. Brain research. Molecular brain research. vol 127. issue 1-2. 2004-12-22. PMID:15306125. |
dopamine neurons of the substantia nigra (sn) undergo a natural cell death event which is biphasic, with peaks at postnatal days (pnds) 2 and 14. |
2004-12-22 |
2023-08-12 |
rat |
| Stephanie J Cragg, Jérôme Baufreton, Yi Xue, J Paul Bolam, Mark D Beva. Synaptic release of dopamine in the subthalamic nucleus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15380000. |
the direct modulation of subthalamic nucleus (stn) neurons by dopamine (da) neurons of the substantia nigra (sn) is controversial owing to the thick caliber and low density of da axons in the stn. |
2004-12-22 |
2023-08-12 |
rat |