| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John N J Reynolds, Brian I Hyland, Jeff R Wicken. Modulation of an afterhyperpolarization by the substantia nigra induces pauses in the tonic firing of striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 44. 2005-06-09. PMID:15525771. |
the conditioned pause is dependent on dopamine from the substantia nigra, but its underlying cellular mechanism is unknown. |
2005-06-09 |
2023-08-12 |
Not clear |
| Jarosław Maciaczyk, Cyprian Swietaszczyk, Heliodor A Kasprza. [Surgical treatment of Parkinson's disease]. Przeglad lekarski. vol 61. issue 12. 2005-06-09. PMID:15850334. |
its pathogenesis is based on diminution of neurons in substantia nigra, that under normal conditions acts as the source of dopamine in nigrostriatal circuit. |
2005-06-09 |
2023-08-12 |
Not clear |
| P B Osborne, G M Halliday, H M Cooper, J R Keas. Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience. vol 131. issue 3. 2005-06-06. PMID:15730872. |
significant dcc-immunoreactivity was detected in midbrain, where it was localized to ventrally displaced a9 dopamine neurons in the substantia nigra, and ventromedial a10 dopamine neurons predominantly situated in and around the interfascicular nucleus. |
2005-06-06 |
2023-08-12 |
Not clear |
| Raymond H Kim, Patrice D Smith, Hossein Aleyasin, Shawn Hayley, Matthew P Mount, Scott Pownall, Andrew Wakeham, Annick J You-Ten, Suneil K Kalia, Patrick Horne, David Westaway, Andres M Lozano, Hymie Anisman, David S Park, Tak W Ma. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 14. 2005-05-25. PMID:15784737. |
dopaminergic neuron numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal. |
2005-05-25 |
2023-08-12 |
mouse |
| Zao C Xu, Guangyi Ling, Robert N Sahr, Bethany S Neal-Belivea. Asymmetrical changes of dopamine receptors in the striatum after unilateral dopamine depletion. Brain research. vol 1038. issue 2. 2005-05-24. PMID:15757632. |
degeneration of dopamine neurons in the substantia nigra (sn) is the major cause of many neurological disorders, and the reduction of dopamine innervation results in alterations of dopamine receptors in the striatum. |
2005-05-24 |
2023-08-12 |
rat |
| Bruce G Jenkins, Rosario Sanchez-Pernaute, Anna-Liisa Brownell, Yin-Ching Iris Chen, Ole Isacso. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509742. |
there was a significant correlation between rcbv loss in the substantia nigra and both pet imaging of dopamine transporters and behavioral measures. |
2005-05-19 |
2023-08-12 |
monkey |
| Yu Koike, M A Frey, F Sahiar, R Dodge, S Mohle. Effects of HZE particle on the nigrostriatal dopaminergic system in a future Mars mission. Acta astronautica. vol 56. issue 3. 2005-05-18. PMID:15754475. |
in addition, studies of the pathophysiology of parkinson's disease demonstrated that excess iron cause a reduction in the dopamine content in the substantia nigra. |
2005-05-18 |
2023-08-12 |
human |
| James G Greene, Raymond Dingledine, J Timothy Greenamyr. Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649693. |
as a group, energy metabolism transcripts are more highly expressed in substantia nigra (sn) dopamine neurons, an intriguing result considering previous evidence for a mitochondrial defect in idiopathic pd and the greater susceptibility of sn dopamine neurons to damage by mitochondrial poisons. |
2005-05-16 |
2023-08-12 |
rat |
| Matteo Marti, Massimiliano Manzalini, Martina Fantin, Clementina Bianchi, Laura Della Corte, Michele Morar. Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine. Journal of neurochemistry. vol 93. issue 1. 2005-05-16. PMID:15773919. |
striatal glutamate release evoked in vivo by nmda is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance p and dopamine. |
2005-05-16 |
2023-08-12 |
Not clear |
| R M Miller, L L Chen, G L Kiser, T L Giesler, T M Kaysser-Kranich, C Palaniappan, H J Federof. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of aging. vol 26. issue 5. 2005-05-09. PMID:15708451. |
the gradual loss of striatal dopamine and dopaminergic neurons residing in the substantia nigra (sn) causes parkinsonism characterized by slow, halting movements, rigidity, and resting tremor when neuronal loss exceeds a threshold of approximately 80%. |
2005-05-09 |
2023-08-12 |
mouse |
| Jennifer T Trevitt, Joseph Morrow, John F Marshal. Dopamine manipulation alters immediate-early gene response of striatal parvalbumin interneurons to cortical stimulation. Brain research. vol 1035. issue 1. 2005-05-09. PMID:15713275. |
the striatum also receives dopaminergic projections from the substantia nigra, but it has been challenging to study the impact of dopamine (da) cell injury on corticostriatal activity in vivo due to limitations in the methods used to induce cortical activity. |
2005-05-09 |
2023-08-12 |
rat |
| Vânia Gomide, Theo Bibancos, Gerson Chad. Dopamine cell morphology and glial cell hypertrophy and process branching in the nigrostriatal system after striatal 6-OHDA analyzed by specific sterological tools. The International journal of neuroscience. vol 115. issue 4. 2005-05-04. PMID:15804725. |
the optical disector detected decreases in the estimated total number of dopamine cells in the entire ipsilateral pars compacta of the substantia nigra (snc) and the ventral tegmental area (vta) as well as in the estimated total number of varicosity profiles in the entire ipsilateral neostriatum. |
2005-05-04 |
2023-08-12 |
rat |
| Gabriella Gardian, Lichuan Yang, Carine Cleren, Noel Y Calingasan, Peter Klivenyi, M Flint Bea. Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity. Neuromolecular medicine. vol 5. issue 3. 2005-05-03. PMID:15626823. |
administration of phenylbutyrate significantly attenuated mptp-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. |
2005-05-03 |
2023-08-12 |
Not clear |
| K Sonka, D Kemlin. Restless legs syndrome in 2004. Prague medical report. vol 105. issue 4. 2005-05-03. PMID:15822631. |
the pathophysiology of rls is related to dopamine transmission insufficiency, low iron storage in substantia nigra neurons, and spinal cord dysfunction. |
2005-05-03 |
2023-08-12 |
Not clear |
| V C Gomide, G A Silveira, G Chad. Transient and widespread astroglial activation in the brain after a striatal 6-OHDA-induced partial lesion of the nigrostriatal system. The International journal of neuroscience. vol 115. issue 1. 2005-05-02. PMID:15768855. |
th immunoreactive terminals disappeared in the striatum close to the injection site and a disappearance of a small number of a defined population of dopamine cell bodies was observed in the ipsilateral pars compacta of the substantia nigra (snc). |
2005-05-02 |
2023-08-12 |
rat |
| Taco R Werkman, Johanna E Olijslagers, Benny Perlstein, Antonius H J Jansen, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. Quetiapine increases the firing rate of rat substantia nigra and ventral tegmental area dopamine neurons in vitro. European journal of pharmacology. vol 506. issue 1. 2005-04-28. PMID:15588623. |
quetiapine increases the firing rate of rat substantia nigra and ventral tegmental area dopamine neurons in vitro. |
2005-04-28 |
2023-08-12 |
rat |
| Taco R Werkman, Johanna E Olijslagers, Benny Perlstein, Antonius H J Jansen, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. Quetiapine increases the firing rate of rat substantia nigra and ventral tegmental area dopamine neurons in vitro. European journal of pharmacology. vol 506. issue 1. 2005-04-28. PMID:15588623. |
the antipsychotic drug quetiapine increases the firing rate of dopamine neurons in the substantia nigra and the ventral tegmental area of the rat. |
2005-04-28 |
2023-08-12 |
rat |
| Michael Hsu, Bharath Srinivas, Jyothi Kumar, Rajagopalan Subramanian, Julie Anderse. Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715660. |
an early biochemical change in the parkinsonian substantia nigra (sn) is reduction in total glutathione (gsh + gssg) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex i activity, dopamine loss, and cell death. |
2005-04-28 |
2023-08-12 |
Not clear |
| Matthew S Goldberg, Antonio Pisani, Marian Haburcak, Timothy A Vortherms, Tohru Kitada, Cinzia Costa, Youren Tong, Giuseppina Martella, Anne Tscherter, Andrea Martins, Giorgio Bernardi, Bryan L Roth, Emmanuel N Pothos, Paolo Calabresi, Jie She. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. vol 45. issue 4. 2005-04-25. PMID:15721235. |
although dj-1(-/-) mice had normal numbers of dopaminergic neurons in the substantia nigra, evoked dopamine overflow in the striatum was markedly reduced, primarily as a result of increased reuptake. |
2005-04-25 |
2023-08-12 |
mouse |
| J K Marcario, K F Manaye, K S SantaCruz, P R Mouton, N E J Berman, P D Chene. Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus. Journal of neurovirology. vol 10. issue 6. 2005-04-19. PMID:15765810. |
to investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (gp) and for dopamine (da)-containing neurons in the substantia nigra (sn) in eight macaques inoculated with macrophage-tropic, neurovirulent siv (sivmac r71/17e), and five control animals. |
2005-04-19 |
2023-08-12 |
human |