| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judy Cheng, Ellen T Koch, Daniel Ramandi, James P Mackay, Timothy P O'Leary, William Rees-Jones, Lynn A Raymon. Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease. Neurobiology of disease. 2024-12-24. PMID:39716682. |
d2 receptors are also expressed on glutamatergic cortical terminals, cholinergic interneurons, and dopaminergic terminals from substantia nigra where they suppress release of glutamate, acetylcholine and dopamine, respectively, and these cell types may contribute to early striatal dysfunction in hd. |
2024-12-24 |
2024-12-26 |
mouse |
| Yuying Liu, Lijiao Cao, Junlan Zhou, Chuqi Li, Jinchang Du, Yifei Xue, Xianchan Li, Lanqun Ma. Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine. Journal of the American Chemical Society. 2024-12-20. PMID:39705330. |
utilizing this methodology, we investigated a pd animal model, which demonstrated a significant reduction in both vesicular dopamine (da) storage and exocytotic release in da neurons in the substantia nigra. |
2024-12-20 |
2024-12-23 |
Not clear |
| José L Lanciego, José A Obes. Functional Neuroanatomy of the Normal and Pathological Basal Ganglia. Cold Spring Harbor perspectives in medicine. 2024-12-18. PMID:39694693. |
dopamine released from the substantia nigra is the underlying driving force keeping the basal ganglia network under proper equilibrium and, indeed, reduction of dopamine levels triggers basal ganglia dysfunction, setting the groundwork for several movement disorders. |
2024-12-18 |
2024-12-21 |
Not clear |
| Fa-Li Zhang, Ai-Ying Li, Yi-Lin Niu, Kai Zhang, Ming-Hui Zhao, Jiao-Jiao Huang, Wei She. Identification of biomarkers in Parkinson's disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells. Frontiers in aging neuroscience. vol 16. 2024-12-05. PMID:39634657. |
parkinson's disease (pd) is an age-related neurodegenerative disease characterized by the death of dopamine neurons in the substantia nigra. |
2024-12-05 |
2024-12-07 |
Not clear |
| Natalie Lipari, Ashley Galfano, Shruti Venkatesh, Han Grezenko, Ivette M Sandoval, Fredric P Manfredsson, Christopher Bisho. The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson's disease. Frontiers in neural circuits. vol 18. 2024-12-05. PMID:39634948. |
parkinson's disease (pd) is commonly characterized by severe dopamine (da) depletion within the substantia nigra (sn) leading to a myriad of motor and non-motor symptoms. |
2024-12-05 |
2024-12-07 |
rat |
| Chanchal Sharma, Sehwan Kim, Hyemi Eo, Sang Ryong Ki. Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson's disease. Neural regeneration research. vol 20. issue 10. 2024-11-29. PMID:39610091. |
intriguingly, at diagnosis, many dopamine neurons remain in the substantia nigra, offering a potential window for recovery and survival. |
2024-11-29 |
2024-12-01 |
Not clear |
| Chanchal Sharma, Sehwan Kim, Hyemi Eo, Sang Ryong Ki. Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson's disease. Neural regeneration research. vol 20. issue 10. 2024-11-29. PMID:39610091. |
we propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future research. |
2024-11-29 |
2024-12-01 |
Not clear |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
it is characterized by the progressive loss of dopaminergic (danergic) neurons in the substantia nigra and decreased dopamine (da) levels, which lead to both motor and non-motor symptoms. |
2024-11-27 |
2024-11-29 |
Not clear |
| Muhammad Khalid Iqbal, Bakhtawar Khan, Hifsa, Ge YuXuan, Muhammad Mujahid, Mubin Mustafa Kiyani, Hamid Khan, Shahid Bashi. The Impact of the Blood-Brain Barrier and Its Dysfunction in Parkinson's Disease: Contributions to Pathogenesis and Progression. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583664. |
parkinson's disease (pd) is a brain disorder in which neuronal cells responsible for the release of dopamine, a neurotransmitter that controls movement, are degenerated or impaired in the substantia nigra and basal ganglia. |
2024-11-25 |
2024-11-27 |
Not clear |
| Shobha Kumari, Sakshi Gupta, Rajesh Sukhija, Shaifali Gurjar, Sunil Kumar Dubey, Rajeev Taliya. Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease. European journal of pharmacology. vol 985. 2024-11-15. PMID:39536854. |
the progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain leads to a deficiency of dopamine and, ultimately, the onset of parkinson's disease (pd). |
2024-11-15 |
2024-11-17 |
Not clear |
| Neha Rana, Parul Grove. Parkinson's Disease: Unravelling the Medicinal Perspectives and Recent Developments of Heterocyclic Monoamine Oxidase-B Inhibitors. CNS & neurological disorders drug targets. 2024-11-06. PMID:39501950. |
these symptoms occur due to the degeneration of dopamine- producing neurons in the substantia nigra region of the brain, leading to reduced dopamine levels. |
2024-11-06 |
2024-11-08 |
Not clear |
| Cong Chen, Tong Wang, Tong-Yao Gao, Ya-Ling Chen, Yun-Bi Lu, Wei-Ping Zhan. Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse. Brain research bulletin. 2024-11-03. PMID:39489186. |
using conditional knockout of the nampt gene in dopaminergic neurons and utilizing a nampt inhibitor in the substantia nigra of mice, we found that the nampt deficiency triggered the time-dependent loss of dopaminergic neurons, the impairment of the dopamine nigrostriatal pathway, and the development of pd-like motor dysfunction. |
2024-11-03 |
2024-11-06 |
mouse |
| Sabrina Haas, Fernando Bravo, Tudor M Ionescu, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Gina Dunkel, Laura Kuebler, Andreas Hahn, Rupert Lanzenberger, Bettina Weigelin, Gerald Reischl, Bernd J Pichler, Kristina Herfer. Functional PET/MRI reveals active inhibition of neuronal activity during optogenetic activation of the nigrostriatal pathway. Science advances. vol 10. issue 43. 2024-10-25. PMID:39454014. |
within this complex network, the nigrostriatal pathway represents a critical circuit for dopamine neurotransmission from the substantia nigra to the striatum. |
2024-10-25 |
2024-10-28 |
Not clear |
| Cindy Moore, Melinda L Helms, Michelle A Nipper, Lila C Winfrey, Deborah A Finn, Charles K Meshu. Dopamine loss alters glutamate synapses and transporters in the medial prefrontal cortex and anxiety-related behaviour in a male MPTP rodent model of Parkinson's disease. The European journal of neuroscience. 2024-10-21. PMID:39431445. |
using a rodent model of pd, we reported alterations in glutamate synapses in the striatum and substantia nigra following dopamine (da) loss. |
2024-10-21 |
2024-10-23 |
mouse |
| Augusta Giglio, Cinzia Valeria Russo, Gabriele Riccio, Simone Braca, Gennaro Cretella, Antonio Stornaiuolo, Luigi Baratto, Enrico Marano, Giuseppe De Michele, Anna De Ros. Prevalence and features of headache in Parkinson's disease: the role of dopamine. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-10-21. PMID:39432180. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, but dopamine also plays a role in the pathophysiology of migraine. |
2024-10-21 |
2024-10-23 |
Not clear |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to erk2. |
2024-10-16 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. |
2024-10-16 |
2024-10-19 |
mouse |
| Edward Wilson, Jacob Umans, Michelle Swarovski, Paras Minhas, Øivind Midttun, Arve Arve Ulvik, Marian Shahid-Besanti, Patricia Linortner, Siddhita Mhatre, Qian Wang, Divya Channappa, Nicole Corso, Lu Tian, Carolyn Fredericks, Geoffrey Kerchner, Edward Plowey, Brenna Cholerton, Per Ueland, Cyrus Zabetian, Nora Gray, Joseph Quinn, Thomas Montine, Sharon Sha, Frank Longo, David Wolk, Alice Chen-Plotkin, Victor Henderson, Tony Wyss-Coray, Anthony Wagner, Elizabeth Mormino, Nima Aghaeepour, Kathleen Poston, Katrin Andreasso. Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction. Research square. 2024-10-14. PMID:39399688. |
pathologically, pd involves neuronal loss in the substantia nigra, striatal dopamine deficiency, and accumulation of intracellular inclusions containing aggregates of α-synuclein. |
2024-10-14 |
2024-10-16 |
human |
| Elżbieta Lorenc-Koci, Kinga Kamińska, Tomasz Lenda, Jolanta Konieczn. The Effect of Chronic Treatment with the Inhibitor of Phosphodiesterase 5 (PDE5), Sildenafil, in Combination with L-DOPA on Asymmetric Behavior and Monoamine Catabolism in the Striatum and Substantia Nigra of Unilaterally 6-OHDA-Lesioned Rats. Molecules (Basel, Switzerland). vol 29. issue 18. 2024-09-28. PMID:39339313. |
the study aimed to investigate the impact of acute and chronic treatment with the phosphodiesterase 5 inhibitor, sildenafil, at low and moderate doses of 2 mg/kg and 6 mg/kg, and l-dopa (12.5 mg/kg), alone or in combination, on asymmetric behavior and dopamine (da) and serotonin metabolism in the striatum and substantia nigra of unilaterally 6-ohda-lesioned rats. |
2024-09-28 |
2024-10-01 |
rat |
| Raj Patel, Aaron Gomes, Shane K Maloney, Jeremy T Smit. Reduced voluntary wheel running behaviour in Kiss1r knockout mice. Physiology & behavior. 2024-09-24. PMID:39317294. |
no difference in immunohistochemistry expression was seen in lateral hypothalamic orexin neurons or dopamine neurons in the ventral tegmental area / substantia nigra. |
2024-09-24 |
2024-09-27 |
mouse |