| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael F Salvator. Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function-Not a New Concept, but Neglected Reality. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256204. |
dopamine signaling in substantia nigra and its impact on locomotor function-not a new concept, but neglected reality. |
2024-01-23 |
2024-01-25 |
human |
| Irene Fasciani, Francesco Petragnano, Federica Bono, Gabriella Aloisi, Veronica Mutti, Carla Pardini, Marco Carli, Marco Scarselli, Francesca Vaglini, Adriano Angelucci, Chiara Fiorentini, Luca Lozzi, Cristina Missale, Roberto Maggio, Mario Ross. In-vitro approaches to investigate the detrimental effect of light on dopaminergic neurons. Neuroscience. 2024-01-20. PMID:38244669. |
our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to the development of typical histological characteristics associated with parkinson's disease such as the loss of dopamine neurons in the substantia nigra. |
2024-01-20 |
2024-01-23 |
mouse |
| Yunha Hwang, Abul Kasem Mohammad Mydul Islam, Seongmin Park, Hyun Goo Kang, Chaemin Lee, Mi Hee Lim, Seung Jae Le. Decoding the Parkinson's Symphony: PARIS, Maestro of Transcriptional Regulation and Metal Coordination for Dopamine Release. ACS chemical neuroscience. 2024-01-19. PMID:38241020. |
notably, the binding of paris to insulin response sequences (irss) triggers a cascade of events that results in the functional loss in the substantia nigra, which impairs dopamine release and, subsequently, exacerbates the relentless neurodegeneration. |
2024-01-19 |
2024-01-21 |
Not clear |
| Bodil Fornstedt Walli. Oxidation of dopamine and related catechols in dopaminergic brain regions in Parkinson's disease and during ageing in non-Parkinsonian subjects. Journal of neural transmission (Vienna, Austria : 1996). 2024-01-18. PMID:38238531. |
based on 5-s-cysteinyl-da/da ratios, dopamine oxidation was found to increase statistically significantly with age in the caudate nucleus, and non-significantly in the substantia nigra. |
2024-01-18 |
2024-01-21 |
human |
| Yanhua Shen, Xueting Wang, Nan Nan, Xiaolong Fu, Ru Zeng, Yonggang Yang, Siting Xian, Jingshan Shi, Qin Wu, Shaoyu Zho. SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contributing to Neuroprotection in Rotenone-Induced PD Models. Molecular neurobiology. 2023-12-12. PMID:38087172. |
mitochondrial dysfunction is critically involved in the degeneration of dopamine (da) neurons in the substantia nigra, a common pathological feature of parkinson's disease (pd). |
2023-12-12 |
2023-12-17 |
Not clear |
| Natalia Kulesskaya, Arnab Bhattacharjee, Kira M Holmström, Päivi Vuorio, Alexandre Henriques, Noëlle Callizot, Henri J Huttune. HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson's disease. Cell chemical biology. 2023-12-01. PMID:38039968. |
subcutaneously administered her-096 modulated upr pathway activity, protected dopamine neurons, and reduced α-synuclein aggregates and neuroinflammation in substantia nigra of aged mice with synucleinopathy. |
2023-12-01 |
2023-12-10 |
mouse |
| John Woulfe, David G Munoz, Douglas A Gray, Hyder A Jinnah, Alyona Ivanov. Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra. Neurobiology of aging. vol 134. 2023-11-22. PMID:37992544. |
we explored mechanisms involved in the age-dependent degeneration of human substantia nigra (sn) dopamine (da) neurons. |
2023-11-22 |
2023-11-29 |
human |
| Mohamed R Ahmed, Chen Zheng, Jeffery L Dunning, Mohamed S Ahmed, Connie Ge, F Sanders Pair, Vsevolod V Gurevich, Eugenia V Gurevic. Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961199. |
in rodents with unilateral ablation of the substantia nigra neurons supplying dopamine to the striatum, chronic treatment with the dopamine precursor l-dopa or dopamine agonists induces a progressive increase of behavioral responses, a process known as behavioral sensitization. |
2023-11-14 |
2023-11-20 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
using dlap, we identified a small subpopulation of th-positive neurons (~5%), mainly located in the very lateral substantia nigra (sn), that was immunofluorescence-negative for the plasmalemmal dopamine transporter (dat), with ~40% smaller cell bodies. |
2023-11-10 |
2023-11-20 |
mouse |
| Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Priyadarshi Prajjwal, Herson S Flores Sanga, Kirtish Acharya, Tamara Tango, Jobby John, Rene S C Rodriguez, Mohammed Dheyaa Marsool Marsool, Mukhamed Sulaimanov, Aneeqa Ahmed, Omniat A Hussi. Parkinson's disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment. Annals of medicine and surgery (2012). vol 85. issue 10. 2023-10-09. PMID:37811009. |
a deficiency of dopamine in the substantia nigra of the brainstem is the main pathology. |
2023-10-09 |
2023-10-15 |
Not clear |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
dopamine (da), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (sn) pars compacta of the midbrain. |
2023-10-03 |
2023-10-07 |
Not clear |
| Sirin Zhang, Juan Mena-Segovia, Nadine K Gu. Inhibitory Pedunculopontine Neurons Gate Dopamine-Mediated Motor Actions of Unsigned Valence. Current neuropharmacology. 2023-09-13. PMID:37702175. |
we recently revealed the existence of a monosynaptic gabaergic input from the ppn that inhibits dopamine neurons of the substantia nigra. |
2023-09-13 |
2023-10-07 |
Not clear |
| Nadine J Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Joerg Striessni. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI insight. 2023-09-12. PMID:37698939. |
the a749g mutation induced aberrant excitability of dorsomedial striatum-projecting substantia nigra dopamine neurons and medium spiny neurons in the dorsal striatum. |
2023-09-12 |
2023-10-07 |
mouse |
| Jia-Xin Shi, Ke-Zhong Zhan. Advancements in autologous stem cell transplantation for Parkinson's Disease. Current stem cell research & therapy. 2023-09-11. PMID:37691194. |
parkinson's disease (pd) is a progressive neurodegenerative disease marked by comparatively focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the striatum, which causes motor and non-motor symptoms. |
2023-09-11 |
2023-10-07 |
Not clear |
| Liaqat Hussain, Ina Masood, Matloob Ahmad, Muhammad Yasir Ali, Uzma Saleem, Musaddique Hussain, Syed Haroon Khalid, Zunera Chauhdar. Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies. Toxicology and applied pharmacology. 2023-09-08. PMID:37683697. |
in parkinson's disease (pd), degradation of dopaminergic neurons in substantia nigra causes striatal deficiency of dopamine, which results in tremors, bradykinesia with instability in posture, rigidity and shuffled gait. |
2023-09-08 |
2023-10-07 |
mouse |
| Kailin Yang, Liuting Zeng, Jinsong Zeng, Ying Deng, Shanshan Wang, Hao Xu, Qi He, Mengxia Yuan, Yanfang Luo, Anqi Ge, Jinwen G. Research Progress in the Molecular Mechanism of Ferroptosis in Parkinson's Disease and Regulation by Natural Plant Products. Ageing research reviews. 2023-09-06. PMID:37673132. |
the current understanding of pd focuses mainly on the loss of dopamine neurons in the substantia nigra region of the midbrain, which is attributed to factors such as oxidative stress, alpha-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction. |
2023-09-06 |
2023-10-07 |
Not clear |
| Yinying Wang, Qian Wen, Rongsha Chen, Zhichao Gan, Xinwei Huang, Pengfei Wang, Xia Cao, Ninghui Zhao, Zhongshan Yang, Jinyuan Ya. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. Journal of cellular and molecular medicine. 2023-09-05. PMID:37668106. |
in the present study, it was shown that pd mice had significant motor dysfunction, increased iron content, less dopamine neurons and more α-synuclein accumulation in the substantia nigra. |
2023-09-05 |
2023-09-07 |
mouse |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
in parkinson's disease (pd), the activities and levels of mrna and protein of all catecholamine-synthesizing enzymes are decreased, especially in dopamine neurons in the substantia nigra. |
2023-08-28 |
2023-09-07 |
human |