| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica Valencia, Marta Ferreira, J Francisco Merino-Torres, Antonio Marcilla, Jose M Sorian. The Potential Roles of Extracellular Vesicles as Biomarkers for Parkinson's Disease: A Systematic Review. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232833. |
the urge for an early diagnosis biomarker comes from the fact that clinical manifestations of pd are estimated to appear once the substantia nigra has deteriorated and there has been a reduction of the dopamine levels from the striatum. |
2022-10-14 |
2023-08-14 |
Not clear |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Srestha Mazumder, Anita Y Bahar, Claire E Shepherd, Asheeta A Prasa. Post-mortem brain histological examination in the substantia nigra and subthalamic nucleus in Parkinson's disease following deep brain stimulation. Frontiers in neuroscience. vol 16. 2022-10-03. PMID:36188463. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, pathologically hallmarked by the loss of dopamine neurons in the substantia nigra (sn) and alpha-synuclein aggregation. |
2022-10-03 |
2023-08-14 |
Not clear |
| Anders Björklund, Fredrik Nilsson, Bengt Mattsson, Deirdre B Hoban, Malin Parma. A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System. Journal of Parkinson's disease. 2022-10-03. PMID:36189605. |
injection of the aav/pff mixture into the substantia nigra makes it possible to target a larger proportion of the nigral dopamine neurons and obtain a level of dopamine cell loss (>60%) needed to induce significant impairments in drug-induced and spontaneous motor tests. |
2022-10-03 |
2023-08-14 |
mouse |
| Song-Yu Guo, Rong-Xiao Guan, Xiao-Dong Chi, Yue-Zhang, Ao-Ran Sui, Wei Zhao, Supratik Kundu, Jin-Yi Yang, Jie Zhao, Shao L. Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans. Brain research bulletin. 2022-10-03. PMID:36191729. |
the main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. |
2022-10-03 |
2023-08-14 |
caenorhabditis_elegans |
| Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Min. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-24. PMID:36152409. |
the mechanism of parkinson's disease still remains unknown, however, studies already proved that the damage or absence of dopaminergic neurons located in the substantia nigra and the decreased dopamine in the striatum are significantly related to parkinson's disease. |
2022-09-24 |
2023-08-14 |
Not clear |
| Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Le. Pyruvate Prevents Dopaminergic Neurodegeneration and Motor Deficits in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease. Molecular neurobiology. 2022-09-03. PMID:36057709. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the selective loss of dopamine(da)rgic neurons in the substantia nigra of the midbrain, and primarily causes motor symptoms. |
2022-09-03 |
2023-08-14 |
mouse |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| Shubhangini Tiwari, Parul Gupta, Abhishek Singh, Swati Chaturvedi, M Wahajuddin, Amit Mishra, Sarika Sing. 4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation. Neurochemical research. 2022-08-03. PMID:35922743. |
first, we observed the significant protective effects of 4pba on pd specific neuromuscular coordination, level of tyrosine hydroxylase, α-synuclein level and neurotransmitter dopamine in both substantia nigra and striatal regions of the experimental rat model of pd. |
2022-08-03 |
2023-08-14 |
rat |
| John A Razidlo, Skylar M L Fausner, Anna E Ingebretson, Liuchang C Wang, Christopher M Petersen, Salahudeen Mirza, Isabella N Swank, Veronica A Alvarez, Julia C Lemo. Chronic loss of muscarinic M5 receptor function manifests disparate impairments in exploratory behavior in male and female mice despite common dopamine regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-27. PMID:35896424. |
of these, the muscarinic type 5 receptor (m5) is the only one localized to dopamine neurons in the ventral tegmental area and substantia nigra. |
2022-07-27 |
2023-08-14 |
mouse |
| Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Sing. Role of Platelet in Parkinson's Disease: Insights into Pathophysiology & Theranostic Solutions. Ageing research reviews. 2022-07-07. PMID:35798236. |
gradual death and progressive loss of dopaminergic neurons in the pars compacta region of substantia nigra results in striatal dopamine deficiency in pd. |
2022-07-07 |
2023-08-14 |
Not clear |
| Christopher W Tschumi, Harris E Blankenship, Ramaswamy Sharma, William B Lynch, Michael J Beckstea. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-06. PMID:35794014. |
neurotensin release from dopamine neurons drives long-term depression of substantia nigra dopamine signaling. |
2022-07-06 |
2023-08-14 |
Not clear |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732806. |
striatal dopamine depletion caused by substantia nigra (sn) degeneration is a pathological hallmark of pd and is strongly associated with cardinal motor and non-motor symptoms. |
2022-06-22 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Qi Tian, Xiaoxia Yang, Juan Du, Huachen Huang, Wei Liu, Peng Zha. Translocator Protein Ligand Etifoxine Attenuates MPTP-Induced Neurotoxicity. Frontiers in molecular neuroscience. vol 15. 2022-06-10. PMID:35686060. |
we found that etifoxine significantly reduced motor function deficits, decreased the loss of tyrosine hydroxylase-positive neurons in the substantia nigra, and attenuated the decrease in striatal dopamine levels in mice that received mptp. |
2022-06-10 |
2023-08-14 |
mouse |
| Cláudia M Deus, José Teixeira, Nuno Raimundo, Paolo Tucci, Fernanda Borges, Luciano Saso, Paulo J Oliveir. Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's Disease. European journal of clinical investigation. 2022-05-31. PMID:35638352. |
pathologically, pd is characterized by dopaminergic cell neurodegeneration in the substantia nigra, resulting in decreased dopamine levels in the nigrostriatal pathway, triggering motor symptoms. |
2022-05-31 |
2023-08-13 |
Not clear |
| Cynthia Haidee Tran, Cynthia Shannon Weickert, Thomas Wesley Weickert, Duncan Sinclai. Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628144. |
therefore, we investigated gene expression following early life stress in adult brain regions containing dopamine neuron cell bodies (substantia nigra, ventral tegmental area (vta)) and terminals (dorsal/ventral striatum). |
2022-05-28 |
2023-08-13 |
rat |
| Massimiliano Mangone, Francesco Agostini, Alessandro de Sire, Angelo Cacchio, Angelo Chiaramonte, Giulia Butterini, Andrea Martano, Marco Paoloni, Andrea Bernetti, Teresa Paolucc. Effect of virtual reality rehabilitation on functional outcomes for return-to-work patients with Parkinson's disease: An umbrella review of systematic reviews. NeuroRehabilitation. 2022-05-23. PMID:35599505. |
parkinson's disease (pd) is a neurodegenerative disease characterized by loss of substantia nigra neurons with deficiency of dopamine. |
2022-05-23 |
2023-08-13 |
Not clear |
| Ami Sugiura, Misa Kitamura, Yasushi Hasegaw. Calcium carbonate supplementation causes motor dysfunction. Experimental animals. 2022-05-18. PMID:35584940. |
calcium carbonate supplementation decreased the dopamine content in the basal ganglia, including the striatum and substantia nigra, and the number of tyrosine hydroxylase-positive neurons in the substantia nigra. |
2022-05-18 |
2023-08-13 |
mouse |
| Alexander G Zestos, Harmain Rafi, Negar G Ardabil. Carbon Fiber Multielectrode Arrays for Multiplexing Neurotransmitter Detection in Heterogeneous Brain Regions. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556754. |
we mapped out endogenous levels of neurochemicals such as dopamine, serotonin, and adenosine in regions including the ventral tegmental area, caudate putamen, raphe nuclei, and substantia nigra. |
2022-05-13 |
2023-08-13 |
mouse |