| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justin Buck, Matthew T C Manion, Wenyu Zhang, Erica R Glasper, Kuan Hong Wan. Comparative anatomical analysis of dopamine systems in Mus musculus and Peromyscus californicus. Brain structure & function. 2022-05-02. PMID:35501609. |
in contrast, major interspecies differences from m. musculus are found in the ventral midbrain and striatum of p. californicus, including the expansion of midbrain dopamine neurons into the ventral substantia nigra and the presence of an internal capsule-like white matter tract that demarcates a dorsomedial area from the rest of the striatum. |
2022-05-02 |
2023-08-13 |
mouse |
| Md Zainul Ali, Pankaj Singh Dholaniy. Oxidative phosphorylation mediated pathogenesis of Parkinson's disease and its implication via Akt signaling. Neurochemistry international. 2022-04-28. PMID:35483538. |
substantia nigra pars-compacta (snpc), in the basal ganglion region, is a primary source of dopamine release. |
2022-04-28 |
2023-08-13 |
Not clear |
| Balachandar Vellingiri, Atchaya Suriyanarayanan, Priyanka Selvaraj, Kripa Susan Abraham, Md Younus Pasha, Harysh Winster, Abilash Valsala Gopalakrishnan, Singaravelu G, Janardhana Kumar Reddy, Niraikulam Ayyadurai, Nandha Kumar, Bupesh Giridharan, Sivaprakash P, K R S Sambasiva Rao, Senthil Kumar Nachimuthu, Arul Narayanasamy, Iyer Mahalaxmi, Dhivya Venkatesa. Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity. Chemosphere. 2022-04-19. PMID:35439490. |
parkinson's disease (pd) is a neurodegenerative condition characterized by the dopamine (da) neuronal loss in the substantia nigra. |
2022-04-19 |
2023-08-13 |
Not clear |
| Evgeniya V Efimova, Saveliy R Kuvarzin, Mikael S Mor, Nataliia V Katolikova, Taisiia S Shemiakova, Valeria Razenkova, Maria Ptukha, Alena A Kozlova, Ramilya Z Murtazina, Daria Smirnova, Aleksandr A Veshchitskii, Natalia S Merkulyeva, Anna B Volnova, Pavel E Musienko, Dmitrii E Korzhevskii, Evgeny A Budygin, Raul R Gainetdino. Trace Amine-Associated Receptor 2 Is Expressed in the Limbic Brain Areas and Is Involved in Dopamine Regulation and Adult Neurogenesis. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431833. |
taar2-ko mice also had elevated tissue dopamine levels in the striatum and an increased dopaminergic neuron number in the substantia nigra. |
2022-04-18 |
2023-08-13 |
mouse |
| Clarissa Catale, Luisa Lo Iacono, Alessandro Martini, Constantin Heil, Ezia Guatteo, Nicola Biagio Mercuri, Maria Teresa Viscomi, Daniela Palacios, Valeria Carol. Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline. Molecular neurobiology. 2022-04-18. PMID:35435618. |
we found that social stress in early life altered da neurons morphology, reduced dopamine transporter (dat) and tyrosine hydroxylase expression, and lowered dat-mediated currents in the ventral tegmental area but not substantia nigra of male mice only. |
2022-04-18 |
2023-08-13 |
mouse |
| Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamot. Motor progression and nigrostriatal neurodegeneration in Parkinson's disease. Annals of neurology. 2022-04-16. PMID:35428994. |
meanwhile, neuromelanin-laden dopamine neuron loss in the substantia nigra (sn) elucidated a variability at early stages and gradual loss with less variability 10 years post-diagnosis. |
2022-04-16 |
2023-08-13 |
Not clear |
| Amanda R Burmeister, Juozas Gordevicius, Emmanuel N Paul, Christina Houck, Sonia George, Martha L Escobar Galvis, Qiong Sha, Patrik Brundin, J Andrew Pospisilik, Karen Racicot, Lena Brundi. Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. Neurobiology of disease. 2022-04-13. PMID:35417751. |
motor symptoms of parkinson's disease (pd) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated. |
2022-04-13 |
2023-08-13 |
mouse |
| Elodie C Kip, Louise C Parr-Brownli. Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease.Prevention of neuroinflammation in Parkinson's disease. Ageing research reviews. 2022-04-08. PMID:35395416. |
parkinson's disease (pd) is the second most common age-associated neurodegenerative disorder and is characterized by progressive loss of dopamine neurons in the substantia nigra. |
2022-04-08 |
2023-08-13 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
the pathology of parkinson's disease (pd) is characterized by α-synuclein aggregation, microglia-mediated neuroinflammation, and dopaminergic neurodegeneration in the substantia nigra with collateral striatal dopamine signaling deficiency. |
2022-03-25 |
2023-08-13 |
Not clear |
| Sandra L Castro, Victor Tapias, Ronald Gathagan, Alexandra Emes, Taylor E Brandon, Amanda D Smit. Blueberry juice augments exercise-induced neuroprotection in a Parkinson's disease model through modulation of GDNF levels. IBRO neuroscience reports. vol 12. 2022-03-24. PMID:35321527. |
four weeks of running before and after intrastriatal 6-ohda reduced amphetamine-induced rotational behavior and loss of substantia nigra dopamine (da) neurons. |
2022-03-24 |
2023-08-13 |
Not clear |
| Chung-Yin Lin, Ching-Yun Huang, Chiung-Mei Chen, Hao-Li Li. Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson's Disease. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214176. |
gradual accumulation of αsnca aggregates in substantia nigra (sn) diminishes the normal functioning of soluble αsnca, leading to a loss of dopamine (da) neurons. |
2022-02-26 |
2023-08-13 |
mouse |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Silu Li, Guorong Bi, Shunchang Han, Rui Huan. MicroRNAs Play a Role in Parkinson's Disease by Regulating Microglia Function: From Pathogenetic Involvement to Therapeutic Potential. Frontiers in molecular neuroscience. vol 14. 2022-02-07. PMID:35126050. |
parkinson's disease (pd) is a clinically common neurodegenerative disease of the central nervous system (cns) characterized by loss of dopamine neurons in the substantia nigra. |
2022-02-07 |
2023-08-13 |
Not clear |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Siva Prasad Panda, Urvashi Son. A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities. Ageing research reviews. 2022-01-15. PMID:35031512. |
pdd is caused by decreased or absent dopamine secretion from nerve cells in the substantia nigra, as well as prkn gene deletion/duplication mutations, and shift in the prkn-pacrg organisation, all of which are linked to ageing. |
2022-01-15 |
2023-08-13 |
Not clear |
| Ehraz Anis, Aoji Xie, Lena Brundin, Patrik Brundi. Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease. Trends in endocrinology and metabolism: TEM. 2021-12-24. PMID:34949514. |
two hallmarks of parkinson's disease (pd) are the widespread deposition of misfolded alpha-synuclein (αsyn) protein in the nervous system and loss of substantia nigra dopamine neurons. |
2021-12-24 |
2023-08-13 |
Not clear |
| Tian Zhang, Tan Wang, Xinxu Chen, Zhenqiang Zhao, Zhibin Che. Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and therapeutic medicine. vol 23. issue 1. 2021-12-22. PMID:34934429. |
gut microbiota relieves inflammation in the substantia nigra of chronic parkinson's disease by protecting the function of dopamine neurons. |
2021-12-22 |
2023-08-13 |
mouse |
| Fumiaki Sato, Yoki Nakamura, Simeng Ma, Takahiro Kochi, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Moriok. Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 145. 2021-12-17. PMID:34915668. |
the 6ohda-administered mice displayed unilateral loss of dopamine neurons in the substantia nigra and mechanical hypersensitivity in both hind paws. |
2021-12-17 |
2023-08-13 |
mouse |
| Takaya Ogasawara, Fatih Sogukpinar, Kaining Zhang, Yang-Yang Feng, Julia Pai, Ahmad Jezzini, Ilya E Monoso. A primate temporal cortex-zona incerta pathway for novelty seeking. Nature neuroscience. 2021-12-14. PMID:34903880. |
zi-dependent novelty seeking was not regulated by neurons in the lateral habenula or by many dopamine neurons in the substantia nigra, traditionally associated with reward seeking. |
2021-12-14 |
2023-08-13 |
monkey |