Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Aqilah M McCane, Meredyth A Wegener, Mojdeh Faraji, Maria T Rivera-Garcia, Kathryn G Wallin-Miller, Vincent D Costa, Bita Moghadda. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-14. PMID:34611024. |
both forms of learning, when associated with a rewarding outcome, rely on midbrain dopamine neurons in the ventral tegmental area (vta) and substantia nigra (sn). |
2021-11-14 |
2023-08-13 |
rat |
Jingqi Wang, Ruihong Shang, Le He, Rongsong Zhou, Zhensen Chen, Yu Ma, Xuesong L. Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With Connectome Based on Hemispheric Asymmetry. Frontiers in neuroscience. vol 15. 2021-11-13. PMID:34764846. |
parkinson's disease (pd) is a neurodegenerative disease that is associated with motor and non-motor symptoms and caused by lack of dopamine in the substantia nigra of the brain. |
2021-11-13 |
2023-08-13 |
Not clear |
Amandine Isenbrandt, Marc Morissette, Mélanie Bourque, Jérôme Lamontagne-Proulx, Katherine Coulombe, Denis Soulet, Thérèse Di Paol. Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice. Neuropharmacology. vol 201. 2021-11-09. PMID:34555366. |
the main neuropathological feature of parkinson's disease (pd) is degeneration of dopamine (da) neurons in the substantia nigra (sn); pd prevalence is higher in men, suggesting a role of sex hormones in neuroprotection. |
2021-11-09 |
2023-08-13 |
mouse |
Agata Casado-Sainz, Frederik Gudmundsen, Simone L Baerentzen, Denise Lange, Annemette Ringsted, Isabel Martinez-Tejada, Siria Medina, Hedok Lee, Claus Svarer, Sune H Keller, Martin Schain, Celia Kjaerby, Patrick M Fisher, Paul Cumming, Mikael Palne. Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-05. PMID:34725486. |
in this study, we developed a chemogenetic method for selective activation of dopamine neurons in the substantia nigra, which innervates the dorsal striatum in the rat. |
2021-11-05 |
2023-08-13 |
rat |
Omid Tavassoly, Esther Del Cid Pellitero, Frederique Larroquette, Eddie Cai, Rhalena A Thomas, Vincent Soubannier, Wen Luo, Thomas M Durcan, Edward A Fo. Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 2. 2021-11-02. PMID:33713002. |
aggregation and deposition of α-synuclein (α-syn) in lewy bodies within dopamine neurons of substantia nigra (sn) is the pathological hallmark of parkinson's disease (pd). |
2021-11-02 |
2023-08-13 |
mouse |
K Ushna S Islam, Norisa Meli, Sandra Blaes. The Development of the Mesoprefrontal Dopaminergic System in Health and Disease. Frontiers in neural circuits. vol 15. 2021-10-30. PMID:34712123. |
midbrain dopaminergic neurons located in the substantia nigra and the ventral tegmental area are the main source of dopamine in the brain. |
2021-10-30 |
2023-08-13 |
Not clear |
Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dav. Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. PloS one. vol 16. issue 6. 2021-10-26. PMID:34106956. |
while no changes in the number of dopamine neurons in the substantia nigra were noted, subtle changes in striatal neurotransmitters were observed in gba1 d409v ki mice. |
2021-10-26 |
2023-08-13 |
mouse |
Juan Pérez-Fernández, Marta Barandela, Cecilia Jiménez-Lópe. The Dopaminergic Control of Movement-Evolutionary Considerations. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681941. |
dopamine is likely the most studied modulatory neurotransmitter, in great part due to characteristic motor deficits in parkinson's disease that arise after the degeneration of the dopaminergic neurons in the substantia nigra |
2021-10-26 |
2023-08-13 |
Not clear |
Philip R Baldwin, Raul Alanis, Ramiro Sala. The Role of the Habenula in Nicotine Addiction. Journal of addiction research & therapy. vol S1. issue 2. 2021-10-21. PMID:22493758. |
to learn from success, the brain relies on signals originating in the ventral tegmental area and substantia nigra that result in increased release of dopamine in the striatum. |
2021-10-21 |
2023-08-12 |
mouse |
Dongjun Dai, Yunliang Wang, Lingyan Wang, Jinfeng Li, Qingqing Ma, Jianmin Tao, Xingyu Zhou, Hanlin Zhou, Yi Jiang, Guanghui Pan, Limin Xu, Ping Ru, Danfeng Lin, Jun Pan, Leiting Xu, Meng Ye, Shiwei Dua. Polymorphisms of Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649110. |
the degeneration of dopamine neurons in the substantia nigra contributes to the pathogenesis of pd. |
2021-10-21 |
2023-08-12 |
Not clear |
Zengxun Liu, Zhenchun Shi, Jintong Liu, Yang Wan. HIV transactivator of transcription enhances methamphetamine-induced Parkinson's-like behavior in the rats. Neuroreport. vol 25. issue 11. 2021-10-21. PMID:24911386. |
the present study aims to study the synergistic effect of ma and tat on cytokine synthesis in substantia nigra, striatal dopamine content, and behavioral performance in the rats. |
2021-10-21 |
2023-08-13 |
rat |
Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Naga. Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors. Journal of neural transmission (Vienna, Austria : 1996). 2021-10-16. PMID:34654977. |
parkinson's disease is characterized by typical motor symptoms, loss of dopamine neurons in the substantia nigra, and accumulation of lewy body composed of mutated α-synuclein. |
2021-10-16 |
2023-08-13 |
Not clear |
Garrett Salzman, Jocelyn Kim, Guillermo Horga, Kenneth Wengle. Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra. Journal of visualized experiments : JoVE. issue 175. 2021-10-15. PMID:34570093. |
neuromelanin is a byproduct of dopamine synthesis that accumulates in dopaminergic neurons of the substantia nigra. |
2021-10-15 |
2023-08-13 |
Not clear |
Garrett Salzman, Jocelyn Kim, Guillermo Horga, Kenneth Wengle. Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra. Journal of visualized experiments : JoVE. issue 175. 2021-10-15. PMID:34570093. |
neuromelanin-sensitive magnetic resonance imaging (nm-mri) is a noninvasive method for measuring neuromelanin in those dopaminergic neurons, providing a direct measure of dopaminergic cell loss in the substantia nigra and a proxy measure of dopamine function. |
2021-10-15 |
2023-08-13 |
Not clear |
Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
the dopamine level in the striatum is preserved because of the innervation of the substantia nigra (sn) dopaminergic neurons into it. |
2021-10-12 |
2023-08-13 |
Not clear |
Takuya Hikima, Christian R Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E Ric. Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron. Cell reports. vol 35. issue 1. 2021-10-06. PMID:33826884. |
activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron. |
2021-10-06 |
2023-08-13 |
Not clear |
Li Zuo, Chunfang Dai, Lilin Yi, Zhifang Don. 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease. Cell death discovery. vol 7. issue 1. 2021-10-06. PMID:34545064. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and diminished dopamine content in the striatum. |
2021-10-06 |
2023-08-13 |
mouse |
Mélissa Jasmin, Eun Hee Ahn, Merja H Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-Ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Y. Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. The EMBO journal. vol 40. issue 3. 2021-10-04. PMID:33351190. |
here, we show that silencing netrin-1 in the adult substantia nigra of mice induces dcc cleavage and a significant loss of dopamine neurons, resulting in motor deficits. |
2021-10-04 |
2023-08-13 |
mouse |
Michael J Beckstead, Rebecca D Howel. Progressive parkinsonism due to mitochondrial impairment: Lessons from the MitoPark mouse model. Experimental neurology. vol 341. 2021-10-04. PMID:33753138. |
the cardinal pathophysiological finding of parkinson's disease (pd) is a chronic, progressive degeneration of dopamine (da) neurons in the substantia nigra, which is responsible for the motor and some of the non-motor symptomatology. |
2021-10-04 |
2023-08-13 |
mouse |
Saad Latif, Muhammad Jahangeer, Dure Maknoon Razia, Mehvish Ashiq, Abdul Ghaffar, Muhammad Akram, Aicha El Allam, Abdelhakim Bouyahya, Larisa Garipova, Mohammad Ali Shariati, Muthu Thiruvengadam, Mohammad Azam Ansar. Dopamine in Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 522. 2021-09-28. PMID:34389279. |
the production of dopamine (a monoamine neurotransmitter) occurs in the ventral tegmental area (vta) of the substantia nigra, specifically in the hypothalamic nucleus and midbrain. |
2021-09-28 |
2023-08-13 |
Not clear |