| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel Perez de la Mora, Carlos Hernandez-Mondragon, Minerva Crespo-Ramirez, José Rejon-Orantes, Dasiel O Borroto-Escuela, Kjell Fux. Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson's Disease and Schizophrenia. Neuroscience. vol 439. 2021-05-14. PMID:31349007. |
particularly important for this task are the mesencephalic dopamine neurons, which from the substantia nigra and ventral tegmental area project to the dorsal striatum and the cortical/subcortical limbic systems, respectively. |
2021-05-14 |
2023-08-13 |
Not clear |
| Nian-Ting Yao, Qian Zheng, Zi-Qian Xu, Jian-Hong Yin, Lin-Guang Lu, Qi Zuo, Su Yang, Chun-Lin Zhang, Ling Jia. Positron emission computed tomography/single photon emission computed tomography in Parkinson disease. Chinese medical journal. vol 133. issue 12. 2021-05-14. PMID:32404694. |
its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a lewy body, leading to a decreased dopamine level. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
this study examined the impact of curtailing neurogenesis in early gestation on neuron number in the midbrain dopamine group, i.e., the substantia nigra and contiguous ventral tegmental area. |
2021-05-14 |
2023-08-13 |
monkey |
| Marieke van der Pluijm, Clifford Cassidy, Melissa Zandstra, Elon Wallert, Kora de Bruin, Jan Booij, Lieuwe de Haan, Guillermo Horga, Elsmarieke van de Giesse. Reliability and Reproducibility of Neuromelanin-Sensitive Imaging of the Substantia Nigra: A Comparison of Three Different Sequences. Journal of magnetic resonance imaging : JMRI. vol 53. issue 3. 2021-05-14. PMID:33037730. |
neuromelanin-sensitive mri (nm-mri) of the substantia nigra provides a noninvasive way to acquire an indirect measure of dopamine functioning. |
2021-05-14 |
2023-08-13 |
Not clear |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Yingjuan Liu, Weihua Jin, Zhenzhen Deng, Jing Wang, Quanbin Zhan. Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson's Model. Marine drugs. vol 18. issue 9. 2021-05-11. PMID:32842556. |
parkinson's disease (pd), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. |
2021-05-11 |
2023-08-13 |
Not clear |
| Maham Sanawar, Uzma Saleem, Fareeha Anwar, Samra Nazir, Muhammad Furqan Akhtar, Bashir Ahmad, Tariq Ismai. Investigation of anti-Parkinson activity of dicyclomine. The International journal of neuroscience. 2021-05-10. PMID:32847457. |
the major causative factors that progress the pd are age, genetic abnormalities, environmental factors and degeneration of dopamine neurons in substantia nigra. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hunday Govindasamy, Sivanandam Magudeeswaran, Saravanan Kandasamy, Kumaradhas Pooman. Binding mechanism of naringenin with monoamine oxidase - B enzyme: QM/MM and molecular dynamics perspective. Heliyon. vol 7. issue 4. 2021-04-28. PMID:33898820. |
the reduced level of dopamine at midbrain (substantia nigra) leads to parkinson disease by the influence of monoamine oxidation process of monoamine oxidase b (mao-b) enzyme. |
2021-04-28 |
2023-08-13 |
Not clear |
| Ricardo Leitão, Carla Guerreiro, Rita G Nunes, Nilza Gonçalves, Giulia Galati, Madalena Rosário, Leonor Correia Guedes, Joaquim J Ferreira, Sofia Reimã. Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in Huntington's Disease. Journal of Huntington's disease. vol 9. issue 2. 2021-04-27. PMID:32065802. |
pathological changes in the extra-striatal structures, such as the substantia nigra (sn), and abnormalities in pre-synaptic striatal dopamine neurotransmission are also known to occur. |
2021-04-27 |
2023-08-13 |
Not clear |
| Daniela Mercatelli, Erwan Bezard, Roberto Eleopra, Nurulain T Zaveri, Michele Morar. Managing Parkinson's disease: moving ON with NOP. British journal of pharmacology. vol 177. issue 1. 2021-04-07. PMID:31648371. |
dopamine depletion, as in rodent models of pd results in up-regulation of n/ofq transmission in the substantia nigra and down-regulation of n/ofq transmission in the striatum. |
2021-04-07 |
2023-08-13 |
Not clear |
| Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mende. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. Neuropharmacology. vol 166. 2021-04-02. PMID:31870855. |
here, our results suggest that the somatodendritic release of dopamine in the substantia nigra (sn) may stimulate gabaergic neurons that project their axons into the hippocampus. |
2021-04-02 |
2023-08-13 |
Not clear |
| Hong-Xu Chen, Fu-Chao Liang, Ping Gu, Bian-Ling Xu, Hong-Jun Xu, Wen-Ting Wang, Jia-Yang Hou, Dong-Xiao Xie, Xi-Qing Chai, Sheng-Jun A. Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32341347. |
furthermore, exos reached the substantia nigra through the blood-brain barrier (bbb) in vivo, relieved apomorphine-induced asymmetric rotation, reduced substantia nigra dopaminergic neuron loss and apoptosis, and upregulated the level of dopamine in the striatum. |
2021-03-31 |
2023-08-13 |
human |
| S Agosta, D Magnago, E Galante, F Ferraro, A Magherini, R Di Giacopo, G Miceli, L Battell. Lateralized cognitive functions in Parkinson's patients: A behavioral approach for the early detection of sustained attention deficits. Brain research. vol 1726. 2021-03-29. PMID:31580872. |
the lateralized motor onset of symptoms indicates asymmetrical dysregulation of the dopamine production in the substantia nigra, in the striatum and, in turns, a dysfunction of the basal ganglia and of the connected cortical areas. |
2021-03-29 |
2023-08-13 |
Not clear |
| Zhaohui Liu, Hoi-Hung Cheun. Stem Cell-Based Therapies for Parkinson Disease. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33137927. |
the pathway consists of neural populations in the substantia nigra that project to the striatum of the brain where they release dopamine. |
2021-03-29 |
2023-08-13 |
Not clear |
| Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Naga. Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 2. 2021-03-26. PMID:31993732. |
parkinson's disease has been considered as a motor neuron disease with dopamine (da) deficit caused by neuronal loss in the substantia nigra, but now proposed as a multi-system disorder associated with α-synuclein accumulation in neuronal and non-neuronal systems. |
2021-03-26 |
2023-08-13 |
Not clear |
| Yanan Zheng, Linlin Zhang, Junxia Xie, Limin Sh. The Emerging Role of Neuropeptides in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-03-26. PMID:33762925. |
parkinson's disease (pd), the second most common age-related neurodegenerative disease, results from the loss of dopamine neurons in the substantia nigra. |
2021-03-26 |
2023-08-13 |
Not clear |
| Bhumika Kumar, Mukesh Pandey, Faheem H Pottoo, Faizana Fayaz, Anjali Sharma, P K Saho. Liposomes: Novel Drug Delivery Approach for Targeting Parkinson's Disease. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32003666. |
the neural cells producing dopamine in the substantia nigra of the brain die out. |
2021-03-19 |
2023-08-13 |
Not clear |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
multi-electrode array analysis identifies complex dopamine responses and glucose sensing properties of substantia nigra neurons in mouse brain slices. |
2021-03-16 |
2023-08-13 |
mouse |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Qiang Li, Zihao Wang, Hao Xing, Yu Wang, Yi Gu. Exosomes derived from miR-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson's disease. Molecular therapy. Nucleic acids. vol 23. 2021-03-16. PMID:33717653. |
the most important pathological feature of pd is the irreversible damage of dopamine neurons, which is related to autophagy and neuroinflammation in the substantia nigra. |
2021-03-16 |
2023-08-13 |
mouse |