| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
such in vivo astrocyte reprogramming in the mouse model of pd has successfully added new dopaminergic neurons to the substantia nigra and increased dopamine levels associated with axonal projections into the striatum. |
2021-07-02 |
2023-08-13 |
mouse |
| Khadga Raj, G D Gupta, Shamsher Sing. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. Drug and chemical toxicology. 2021-07-02. PMID:34210222. |
parkinson's disease (pd) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra, with deficiency of dopamine in the striatum. |
2021-07-02 |
2023-08-13 |
rat |
| Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Cour. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell death and differentiation. vol 27. issue 4. 2021-06-29. PMID:31591470. |
parkinson's disease (pd) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. |
2021-06-29 |
2023-08-13 |
mouse |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Fang Luo, Sushan Luo, Wenjing Qian, Lin Zhang, Chen Chen, Meimei Xu, Guangling Wang, Zhongfeng Wang, Jian Wang, Wenyuan Wan. Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons. Stem cell research. vol 49. 2021-06-21. PMID:33059129. |
parkinson's disease (pd) is the second most common neurodegenerative disease affecting millions of elder people due to the degeneration of dopamine neurons in the striatum and substantia nigra. |
2021-06-21 |
2023-08-13 |
human |
| Emmi Pakarinen, Tatiana Danilova, Vootele Võikar, Piotr Chmielarz, Petteri Piepponen, Mikko Airavaara, Mart Saarma, Maria Lindah. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. eNeuro. vol 7. issue 1. 2021-06-18. PMID:32005751. |
in our mouse model, increased upr activation did not lead to neuronal cell loss in the substantia nigra (sn), decrease of striatal dopamine or behavioral changes of manf-deficient mice. |
2021-06-18 |
2023-08-13 |
mouse |
| E Hill, R Gowers, M J E Richardson, M J Wal. α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33229413. |
α-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the katp channel inhibitor glibenclamide. |
2021-06-18 |
2023-08-13 |
Not clear |
| Maria Regoni, Letizia Zanetti, Stefano Comai, Daniela Mercatelli, Salvatore Novello, Federica Albanese, Laura Croci, Gian Giacomo Consalez, Andrea Ciammola, Flavia Valtorta, Michele Morari, Jenny Sasson. Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse. Biomedicines. vol 9. issue 5. 2021-06-15. PMID:34063112. |
early dysfunction of substantia nigra dopamine neurons in the parkinq311x mouse. |
2021-06-15 |
2023-08-13 |
mouse |
| Lorena Jiménez-Sánchez, Javier Blesa, Natalia L Del Rey, Mariana H G Monje, José A Obeso, Carmen Cavad. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. vol 170. 2021-06-03. PMID:31589886. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra and dopamine depletion in the striatum. |
2021-06-03 |
2023-08-13 |
monkey |
| J Mašková, D Školoudík, P Štofaniková, V Ibarburu, D Kemlink, D Zogala, J Trnka, R Krupička, K Šonka, E Růžička, P Duše. Comparative study of the substantia nigra echogenicity and Sleep medicine. vol 70. 2021-05-31. PMID:32403038. |
comparative study of the substantia nigra echogenicity and hyperechogenicity of the substantia nigra (sn) and abnormal dopamine transporter-single-photon emission computed tomography (dat-spect) are biomarkers commonly used in the assessment of prodromal synucleinopathy. |
2021-05-31 |
2023-08-13 |
human |
| Jingyi He, Guofu Zhu, Guoqing Wang, Feng Zhan. Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration. Oxidative medicine and cellular longevity. vol 2020. 2021-05-28. PMID:32714488. |
progressive loss of dopamine (da) neurons in midbrain substantia nigra is considered to be the main cause of pd. |
2021-05-28 |
2023-08-13 |
Not clear |
| V N Salkov, R M Khudoerko. [The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases]. Arkhiv patologii. vol 83. issue 3. 2021-05-28. PMID:34041898. |
the accumulation of ions of these metals in the brain structures leads to chronic intoxication that is manifested by the morphological signs that are typical for alzheimer's disease, such as deposits of β-amyloid and τ-protein mainly in the frontal and temporal regions of the cortex, and for parkinson's disease, such as degeneration of dopamine neurons in the substantia nigra and their accumulation of α-synuclein. |
2021-05-28 |
2023-08-13 |
human |
| Hunday Govindasamy, Sivanandam Magudeeswaran, Kumaradhas Pooman. Identification of novel flavonoid inhibitor of Catechol-O-Methyltransferase enzyme by molecular screening, quantum mechanics/molecular mechanics and molecular dynamics simulations. Journal of biomolecular structure & dynamics. vol 38. issue 18. 2021-05-25. PMID:31779524. |
the low level of dopamine at substantia nigra (mid-brain) has been considered to be one of the reasons for parkinson's disease (pd). |
2021-05-25 |
2023-08-13 |
Not clear |
| Anthony N van den Pol, Xue Zhang, Stephen E Maher, Alfred L M Bothwel. Immune cells enhance Zika virus-mediated neurologic dysfunction in brain of mice with humanized immune systems. Developmental neurobiology. vol 81. issue 4. 2021-05-24. PMID:33811750. |
infection was also found in cortex, striatum, the dopamine neurons of the substantia nigra, and other brain loci. |
2021-05-24 |
2023-08-13 |
mouse |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
the pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: a neurochemical, immunohistochemical and behavioral study. |
2021-05-20 |
2023-08-13 |
rat |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
sixteen days after fipronil or dmso injection into the substantia nigra, rats were sacrificed, and either striatal dopamine content or substantia nigra tyrosine hydroxylase (th) immunoreactivity were measured. |
2021-05-20 |
2023-08-13 |
rat |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
the results confirm that the unilateral injection of fipronil into the substantia nigra caused the degeneration of nigrostriatal dopaminergic neurons, which leads to a decrease around 50 % in striatal dopamine content and substantia nigra th imunoreactivity. |
2021-05-20 |
2023-08-13 |
rat |
| Yingjuan Liu, Weihua Jin, Zhenzhen Deng, Quanbin Zhang, Jing Wan. Glucuronomannan GM2 from Marine drugs. vol 19. issue 2. 2021-05-20. PMID:33503975. |
glucuronomannan gm2 from parkinson's disease (pd), one of the most common neurodegenerative disorders, is caused by dopamine depletion in the striatum and dopaminergic neuron degeneration in the substantia nigra. |
2021-05-20 |
2023-08-13 |
Not clear |
| Man Xiong, Yezheng Tao, Qinqin Gao, Ban Feng, Wei Yan, Yingying Zhou, Thomas A Kotsonis, Tingli Yuan, Zhiwen You, Ziyan Wu, Jiajie Xi, Alexander Haberman, Julia Graham, Jasper Block, Wenhao Zhou, Yuejun Chen, Su-Chun Zhan. Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function. Cell stem cell. vol 28. issue 1. 2021-05-19. PMID:32966778. |
we transplanted hesc-derived midbrain dopamine (mda) or cortical glutamate neurons into the substantia nigra or striatum of a mouse pd model and found extensive graft integration with host circuitry. |
2021-05-19 |
2023-08-13 |
mouse |
| Patricia García-Sanz, Johannes M F G Aerts, Rosario Moratall. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33219714. |
parkinson's disease (pd) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. |
2021-05-19 |
2023-08-13 |
Not clear |