| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| Aliaa Ghoneim, Christopher Pollard, Alok Tyagi, Ravi Jampan. Substantia nigra micro-haemorrhage causing ipsilateral unilateral Parkinsonism and abnormal dopamine transporter scan uptake. BJR case reports. vol 7. issue 1. 2021-02-23. PMID:33614119. |
substantia nigra micro-haemorrhage causing ipsilateral unilateral parkinsonism and abnormal dopamine transporter scan uptake. |
2021-02-23 |
2023-08-13 |
Not clear |
| Mahalakshmi Somayaji, Stefano Cataldi, Se Joon Choi, Robert H Edwards, Eugene V Mosharov, David Sulze. A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 51. 2021-02-19. PMID:33273122. |
a dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo. |
2021-02-19 |
2023-08-13 |
Not clear |
| Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo Horg. Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses. NeuroImage. vol 208. 2021-02-17. PMID:31841683. |
neuromelanin-sensitive mri (nm-mri) provides a noninvasive measure of the content of neuromelanin (nm), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (sn). |
2021-02-17 |
2023-08-13 |
Not clear |
| Wei Yang, Adam C Munhall, Steven W Johnso. Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons. Neuroscience. vol 427. 2021-02-01. PMID:31883822. |
dopamine evokes a trace amine receptor-dependent inward current that is regulated by amp kinase in substantia nigra dopamine neurons. |
2021-02-01 |
2023-08-13 |
rat |
| Willemieke M Kouwenhoven, Guillaume Fortin, Anna-Maija Penttinen, Clélia Florence, Benoît Delignat-Lavaud, Marie-Josée Bourque, Thorsten Trimbuch, Milagros Pereira Luppi, Alix Salvail-Lacoste, Pascale Legault, Jean-François Poulin, Christian Rosenmund, Raj Awatramani, Louis-Éric Trudea. VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 43. 2021-02-01. PMID:32928885. |
a subset of adult ventral tegmental area dopamine (da) neurons expresses vesicular glutamate transporter 2 (vglut2) and releases glutamate as a second neurotransmitter in the striatum, while only few adult substantia nigra da neurons have this capacity. |
2021-02-01 |
2023-08-13 |
Not clear |
| Jeffrey Landrigan, Zach Dwyer, Sheryl Beauchamp, Ruth Rodriguez, Teresa Fortin, Shawn Hayle. Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration. Neurotoxicology. vol 76. 2021-01-20. PMID:31738977. |
parkinson's disease (pd) is characterized by profound microglial driven inflammatory processes and the loss of dopamine neurons of the substantia nigra (snc). |
2021-01-20 |
2023-08-13 |
Not clear |
| Tian Xu, Xiaoxiao Lu, Danhong Peng, Gongdao Wang, Chen Chen, Wen Liu, Wei Wu, Timothy J Maso. Ultrasonic stimulation of the brain to enhance the release of dopamine - A potential novel treatment for Parkinson's disease. Ultrasonics sonochemistry. vol 63. 2021-01-19. PMID:31945561. |
parkinson's disease (pd) is characterized by the decrease of dopamine (da) production and release in the substantia nigra and striatum regions of the brain. |
2021-01-19 |
2023-08-13 |
Not clear |
| Hemraj B Dodiya, Christopher B Forsyth, Robin M Voigt, Phillip A Engen, Jinal Patel, Maliha Shaikh, Stefan J Green, Ankur Naqib, Avik Roy, Jeffrey H Kordower, Kalipada Pahan, Kathleen M Shannon, Ali Keshavarzia. Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease. Neurobiology of disease. vol 135. 2021-01-15. PMID:30579705. |
in addition, rs promoted a number of rotenone-induced effects in the brain including: 1) reduced number of resting microglia and a higher number of dystrophic/phagocytic microglia as well as (fj-c+) dying cells in the substantia nigra (sn), 2) increased lipopolysaccharide (lps) reactivity in the sn, and 3) reduced dopamine (da) and da metabolites (dopac, hva) in the striatum compared to control mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Bianca L B Marino, Lucilene R de Souza, Kessia P A Sousa, Jaderson V Ferreira, Elias C Padilha, Carlos H T P da Silva, Carlton A Taft, Lorane I S Hage-Meli. Parkinson's Disease: A Review from Pathophysiology to Treatment. Mini reviews in medicinal chemistry. vol 20. issue 9. 2021-01-15. PMID:31686637. |
pd is caused by the necrosis of dopaminergic neurons in the substantia nigra, which is the brain region responsible for the synthesis of the neurotransmitter dopamine (da), resulting in its decrease in the synaptic cleft. |
2021-01-15 |
2023-08-13 |
Not clear |
| Fabin Han, Baoyang H. Stem Cell Therapy for Parkinson's Disease. Advances in experimental medicine and biology. vol 1266. 2021-01-08. PMID:33105493. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases caused by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain. |
2021-01-08 |
2023-08-13 |
human |
| Nikita Katila, Sunil Bhurtel, Pil-Hoon Park, Jin Tae Hong, Dong-Young Cho. Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine. Biochemical pharmacology. vol 180. 2020-12-31. PMID:32800853. |
parkinson's disease (pd) is the second most common neurodegenerative disease, which is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to a decrease in striatal dopamine. |
2020-12-31 |
2023-08-13 |
mouse |
| Xiao-Wen Wang, Liang-Jie Yuan, Ye Yang, Mei Zhang, Wen-Fang Che. IGF-1 inhibits MPTP/MPP American journal of physiology. Endocrinology and metabolism. vol 319. issue 4. 2020-12-31. PMID:32865008. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treatment significantly induced mouse movement disorder and decreased the protein level of tyrosine hydroxylase (th) in the substantia nigra (sn) and dopamine (da) content in striatum. |
2020-12-31 |
2023-08-13 |
mouse |
| David M Hedges, Jordan T Yorgason, Andrew W Perez, Nathan D Schilaty, Benjamin M Williams, Richard K Watt, Scott C Steffense. Spontaneous Formation of Melanin from Dopamine in the Presence of Iron. Antioxidants (Basel, Switzerland). vol 9. issue 12. 2020-12-29. PMID:33339254. |
parkinson's disease is associated with degeneration of neuromelanin (nm)-containing substantia nigra dopamine (da) neurons and subsequent decreases in striatal da transmission. |
2020-12-29 |
2023-08-13 |
Not clear |
| Rajesh Pahwa, Stuart H Isaacso. Pathophysiology, Patient Burden, and Recognition of OFF Episodes of Parkinson Disease. The Journal of clinical psychiatry. vol 81. issue 6. 2020-12-21. PMID:33113598. |
the pathophysiology of pd has been elusive, but the motor symptoms of the disease are believed to result from a dopamine deficiency in the substantia nigra. |
2020-12-21 |
2023-08-13 |
Not clear |
| Kobra Foroughi, Mehdi Khaksari, Asghar Shayanni. Molecular Docking Studies of Methamphetamine and Amphetamine- Related Derivatives as an Inhibitor against Dopamine Receptor. Current computer-aided drug design. vol 16. issue 2. 2020-12-17. PMID:30514192. |
some evidence suggests that the degeneration of dopamine neurons in the substantia nigra contributes to parkinson's disease (pd), which is a neurodegenerative disorder and it is responsible for the major symptoms of pd. |
2020-12-17 |
2023-08-13 |
Not clear |
| Xuran Li, Weiwei Yang, Xin Li, Min Chen, Chengwei Liu, Jie Li, Shun Y. Alpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys. Neuroscience letters. vol 716. 2020-12-14. PMID:31759083. |
here, in mptp-intoxicated cynomolgus monkeys, we showed a parallel daergic degeneration in the colon as well as in the substantia nigra and striatum (sn/str), as indicated by reduced expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2020-12-14 |
2023-08-13 |
human |
| Clifford M Cassidy, Kenneth M Carpenter, Anna B Konova, Victoria Cheung, Alexander Grassetti, Luigi Zecca, Anissa Abi-Dargham, Diana Martinez, Guillermo Horg. Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI. The American journal of psychiatry. vol 177. issue 11. 2020-12-14. PMID:32854531. |
evidence for dopamine abnormalities in the substantia nigra in cocaine addiction revealed by neuromelanin-sensitive mri. |
2020-12-14 |
2023-08-13 |
human |
| Seunghyi Kook, Xuanzhi Zhan, Kimberly Thibeault, Mohamed R Ahmed, Vsevolod V Gurevich, Eugenia V Gurevic. Mdm2 enhances ligase activity of parkin and facilitates mitophagy. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32193420. |
loss-of-function mutations in the e3 ubiquitin ligase parkin have been implicated in the death of dopaminergic neurons in the substantia nigra, which is the root cause of dopamine deficit in the striatum in parkinson's disease. |
2020-12-10 |
2023-08-13 |
Not clear |
| Kyle Farmer, Khaled S Abd-Elrahman, Alexa Derksen, Elyn M Rowe, Ashley M Thompson, Christopher A Rudyk, Natalie A Prowse, Zachary Dwyer, Samantha C Bureau, Teresa Fortin, Stephen S G Ferguson, Shawn Hayle. mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson's Disease. Molecular neurobiology. vol 57. issue 3. 2020-12-04. PMID:31754998. |
parkinson's disease is a neurodegenerative disease characterized by a loss of dopaminergic substantia nigra neurons and depletion of dopamine. |
2020-12-04 |
2023-08-13 |
mouse |