| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| René A J Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M Massari, Víctor Fernández-Dueñas, Christophe P Stove, Francisco Ciruel. Striatal Dopamine D Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32231561. |
striatal dopamine d parkinson's disease (pd) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. |
2020-09-28 |
2023-08-13 |
Not clear |
| Geiza Fernanda Antunes, Flavia Venetucci Gouveia, Fabiana Strambio Rezende, Midiã Dias de Jesus Seno, Milene Cristina de Carvalho, Caroline Cruz de Oliveira, Lennon Cardoso Tosati Dos Santos, Marina Correia de Castro, Mayra Akemi Kuroki, Manoel Jacobsen Teixeira, José Pinhata Otoch, Marcus Lira Brandao, Erich Talamoni Fonoff, Raquel Chacon Ruiz Martine. Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation. Neurobiology of stress. vol 12. 2020-09-28. PMID:32435668. |
furthermore, we quantified the contents of dopamine and metabolites (3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva)) in the amygdala, evaluated the basal levels of tyrosine hydroxylase expression (catecholamine synthesis enzyme) and measured the volume of the substantia nigra, ventral tegmental area and locus coeruleus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rafael Gonzalo-Gobernado, Diana Reimers, María José Casarejos, Lucía Calatrava Ferreras, Manuela Vallejo-Muñoz, Adriano Jiménez-Escrig, Juan José Diaz-Gil, Gonzalo M Ulzurrun de Asanza, Eulalia Bazá. Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease. Brain sciences. vol 10. issue 5. 2020-09-28. PMID:32455921. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive death of dopaminergic (da) neurons in the substantia nigra (sn), which leads to a loss of the neurotransmitter dopamine in the basal ganglia. |
2020-09-28 |
2023-08-13 |
rat |
| Yao Lin, Lanfang Tang, Peizhen Huang, Ting Liu, Jianan Zhong, Qian Xu, Xiyu Li, Youning Lin, Shaojian Xiao, Jing Ca. Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32508943. |
the numbers of tyrosine hydroxylase- (th-) positive cells and the dopamine levels in the substantia nigra were assessed using immunohistochemistry and high-performance liquid chromatography, respectively. |
2020-09-28 |
2023-08-13 |
rat |
| Sabah H El-Ghaiesh, Hoda I Bahr, Afaf T Ibrahiem, Doaa Ghorab, Suliman Y Alomar, Noha E Farag, Sawsan A Zaiton. Metformin Protects From Rotenone-Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32625061. |
parkinson's disease (pd) is a neurodegenerative disease that affects substantia nigra dopamine neurons. |
2020-09-28 |
2023-08-13 |
mouse |
| Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Son. Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study. Parkinson's disease. vol 2020. 2020-09-28. PMID:32765825. |
systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. |
2020-09-28 |
2023-08-13 |
Not clear |
| Analu A Fonteles, Julliana C S Neves, Ana Paula F Menezes, Juliana F Pereira, Ana Thais A Silva, Rodrigo A Cunha, Geanne M Andrad. ATP Signaling Controlling Dyskinesia Through P2X7 Receptors. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32848592. |
in parallel, bbg treatment rebalanced the altered dopamine d1 and d2 receptor density and signaling as well as some neuroinflammation-associated parameters in the striatum and substantia nigra. |
2020-09-28 |
2023-08-13 |
rat |
| Fariha Jama. Immunotherapies Targeting α-Synuclein in Parkinson Disease. Federal practitioner : for the health care professionals of the VA, DoD, and PHS. vol 37. issue 8. 2020-09-28. PMID:32908345. |
pathologic diagnosis of pd relies on loss of dopamine neurons in the substantia nigra and accumulation of the abnormal protein α-synuclein in the form of lewy bodies and lewy neurites. |
2020-09-28 |
2023-08-13 |
Not clear |
| Raghunandan Kumar Yadav, Mudasir Ahmad Khanday, Birendra Nath Mallic. Interplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats. Behavioural brain research. vol 376. 2020-09-17. PMID:31442548. |
interplay of dopamine and gaba in substantia nigra for the regulation of rapid eye movement sleep in rats. |
2020-09-17 |
2023-08-13 |
rat |
| Raghunandan Kumar Yadav, Mudasir Ahmad Khanday, Birendra Nath Mallic. Interplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats. Behavioural brain research. vol 376. 2020-09-17. PMID:31442548. |
substantia nigra (sn) is rich in dopamine (da)-ergic and gaba-ergic neurons, which project to and receive inputs from locus coeruleus (lc) and pedunculo-pontine tegmentum (ppt) possessing rem-off and rem-on neurons, respectively. |
2020-09-17 |
2023-08-13 |
rat |
| Deanna L Benson, George W Huntle. Are we listening to everything the PARK genes are telling us? The Journal of comparative neurology. vol 527. issue 9. 2020-09-16. PMID:30680728. |
that these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last 50. |
2020-09-16 |
2023-08-13 |
Not clear |
| Marta Carmo, Francisco Q Gonçalves, Paula M Canas, Jean-Pierre Oses, Francisco D Fernandes, Filipe V Duarte, Carlos M Palmeira, Angelo R Tomé, Paula Agostinho, Geanne M Andrade, Rodrigo A Cunh. Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A British journal of pharmacology. vol 176. issue 18. 2020-09-14. PMID:31220343. |
enhanced atp release and cd73-mediated adenosine formation sustain adenosine a parkinson's disease (pd) involves an initial loss of striatal dopamine terminals evolving into degeneration of dopamine neurons in substantia nigra (sn), which can be modelled by 6-hydroxydopamine (6-ohda) administration. |
2020-09-14 |
2023-08-13 |
Not clear |
| Bin Song, Young Cha, Sanghyeok Ko, Jeha Jeon, Nayeon Lee, Hyemyung Seo, Kyung-Joon Park, In-Hee Lee, Claudia Lopes, Melissa Feitosa, María José Luna, Jin Hyuk Jung, Jisun Kim, Dabin Hwang, Bruce M Cohen, Martin H Teicher, Pierre Leblanc, Bob S Carter, Jeffrey H Kordower, Vadim Y Bolshakov, Sek Won Kong, Jeffrey S Schweitzer, Kwang-Soo Ki. Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models. The Journal of clinical investigation. vol 130. issue 2. 2020-09-14. PMID:31714896. |
parkinson's disease (pd) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mda) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. |
2020-09-14 |
2023-08-13 |
human |
| Ji-Eun Bae, Gil Myung Kang, Se Hee Min, Doo Sin Jo, Yong-Keun Jung, Keetae Kim, Min-Seon Kim, Dong-Hyung Ch. Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell death & disease. vol 10. issue 12. 2020-09-11. PMID:31844040. |
in mice, treatment with mitochondrial toxin, mptp elicits ciliary elongation and autophagy in the substantia nigra dopamine neurons. |
2020-09-11 |
2023-08-13 |
mouse |
| Justine A Fuller, Mark H Burrell, Andrew G Yee, Kavinda Liyanagama, Janusz Lipski, Jeffery R Wickens, Brian I Hylan. Role of homeostatic feedback mechanisms in modulating methylphenidate actions on phasic dopamine signaling in the striatum of awake behaving rats. Progress in neurobiology. vol 182. 2020-09-10. PMID:31412279. |
using brain slices of substantia nigra or striatum, we confirmed that methylphenidate effects on firing rate of nigral dopamine neurons and dopamine release from terminals are constrained by negative feedback. |
2020-09-10 |
2023-08-13 |
rat |
| Sara Af Bjerkén, Rasmus Stenmark Persson, Anna Barkander, Nina Karalija, Noelia Pelegrina-Hidalgo, Greg A Gerhardt, Ana Virel, Ingrid Strömber. Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance. Neurochemistry international. vol 131. 2020-09-03. PMID:31542295. |
the dopamine degeneration was confirmed by unbiased stereology, demonstrating significant loss of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra. |
2020-09-03 |
2023-08-13 |
rat |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Kai Zhang, Kenji Hashimot. Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain. Aging. vol 11. issue 17. 2020-09-02. PMID:31479418. |
mptp significantly decreased dopamine transporter (dat) immunoreactivity in the striatum and tyrosine hydroxylase (th) immunoreactivity in the substantia nigra of water-treated mice. |
2020-09-02 |
2023-08-13 |
mouse |
| Esraa A Kandil, Rabab H Sayed, Lamiaa A Ahmed, Mai A Abd El Fattah, Bahia M El-Saye. Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Clinical and experimental pharmacology & physiology. vol 46. issue 12. 2020-08-28. PMID:31408200. |
treatment of rats with abz markedly mitigated rotenone-induced histological alterations in substantia nigra (sn), restored striatal dopamine (da) level and motor functions and decreased the expression of α-synuclein (a disease marker protein). |
2020-08-28 |
2023-08-13 |
rat |
| Jia-Qi Liu, Shi-Feng Chu, Xin Zhou, Da-Yong Zhang, Nai-Hong Che. Role of chemokines in Parkinson's disease. Brain research bulletin. vol 152. 2020-08-14. PMID:31136787. |
the most common neuropathologic manifestation in patients with parkinson's disease is dopamine neurons degeneration and loss in substantia nigra of middle brain. |
2020-08-14 |
2023-08-13 |
Not clear |
| Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamot. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31228610. |
these effects preceded the activation of cleaved caspase-3 in dopamine cell bodies, as well as decreases in tyrosine hydroxylase (th) immunoreactivity in the substantia nigra and dopamine transporter (dat) immunoreactivity in the striatum measured at 7 days after meth. |
2020-08-14 |
2023-08-13 |
rat |