| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asha K Lahiri, Mark D Beva. Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons. Neuron. vol 106. issue 2. 2020-08-11. PMID:32075716. |
substantia nigra dopamine neurons have been implicated in the initiation and invigoration of movement, presumably through their modulation of striatal projection neuron (spn) activity. |
2020-08-11 |
2023-08-13 |
Not clear |
| Mohammad Raziya Banu, Muhammed Ibrahim, K Prabhu, Srinivasagam Rajasanka. Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. Cells, tissues, organs. vol 208. issue 1-2. 2020-08-05. PMID:31982873. |
withaferin-a (wa) was evaluated for its neuroprotective efficacy on the dopamine (da) neurons of the substantia nigra (sn) and striatum (st) in aged rats. |
2020-08-05 |
2023-08-13 |
rat |
| David Matuskey, Sule Tinaz, Kyle C Wilcox, Mika Naganawa, Takuya Toyonaga, Mark Dias, Shannan Henry, Brian Pittman, Jim Ropchan, Nabeel Nabulsi, Ivonne Suridjan, Robert A Comley, Yiyun Huang, Sjoerd J Finnema, Richard E Carso. Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging. Annals of neurology. vol 87. issue 3. 2020-08-03. PMID:31953875. |
parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. |
2020-08-03 |
2023-08-13 |
Not clear |
| Włodzimierz Mrówczyńsk. Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor-A Systematic Review. Neural plasticity. vol 2019. 2020-07-29. PMID:31341469. |
this review suggests that the increase of posttraining levels of bdnf and its trkb receptors causes simultaneous changes in the activity of the spinal cord, the substantia nigra, and the hypothalamic nuclei neurons, which are responsible for the alteration of the functional properties of motoneurons innervating the skeletal muscles, for the enhancement of dopamine release in the brain, and for the modulation of hormone levels involved in regulating the metabolic processes, responsively. |
2020-07-29 |
2023-08-13 |
human |
| Lena F Burbulla, Dimitri Krain. The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. Neurobiology of disease. vol 132. 2020-07-27. PMID:31351996. |
our understanding of the molecular mechanisms underlying differential vulnerability of substantia nigra dopamine neurons in parkinson's disease (pd) remains limited, and previous therapeutic efforts targeting rodent nigral neurons have not been successfully translated to humans. |
2020-07-27 |
2023-08-13 |
human |
| Tomasz Brude. Inflammatory Bowel Diseases and Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue s2. 2020-07-27. PMID:31609699. |
widespread aggregation of the α-synuclein protein in the form of lewy bodies and lewy neurites, and degeneration of substantia nigra dopamine neurons are the pathological hallmarks of pd. |
2020-07-27 |
2023-08-13 |
Not clear |
| Edward J Robinson, Sebastian Aguiar, Marten P Smidt, Lars P van der Heid. MCL1 as a Therapeutic Target in Parkinson's Disease? Trends in molecular medicine. vol 25. issue 12. 2020-07-21. PMID:31706839. |
dopamine neurons in the substantia nigra (sn) pars compacta are selectively lost during the progression of parkinson's disease (pd). |
2020-07-21 |
2023-08-13 |
Not clear |
| Rosa Anna M Marino, Ross A McDevitt, Stephanie C Gantz, Hui Shen, Marco Pignatelli, Wendy Xin, Roy A Wise, Antonello Bonc. Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 15. 2020-07-21. PMID:32229573. |
moreover, direct stimulation of vta or substantia nigra dopamine cell bodies failed to induce food approach or eating. |
2020-07-21 |
2023-08-13 |
mouse |
| Basma Radwan, He Liu, Dipesh Chaudhur. The role of dopamine in mood disorders and the associated changes in circadian rhythms and sleep-wake cycle. Brain research. vol 1713. 2020-07-20. PMID:30481503. |
dopamine is primarily produced in the substantia nigra (sn) and the ventral tegmentum area (vta) in the brain. |
2020-07-20 |
2023-08-13 |
Not clear |
| Wei Yang, Adam C Munhall, Steven W Johnso. AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in substantia nigra neurons. Neuropharmacology. vol 158. 2020-07-20. PMID:31301335. |
amp-activated protein kinase slows d2 dopamine autoreceptor desensitization in substantia nigra neurons. |
2020-07-20 |
2023-08-13 |
Not clear |
| Wei Yang, Adam C Munhall, Steven W Johnso. AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in substantia nigra neurons. Neuropharmacology. vol 158. 2020-07-20. PMID:31301335. |
dopamine neurons in the substantia nigra zona compacta (snc) are well known to express d2 receptors. |
2020-07-20 |
2023-08-13 |
Not clear |
| Marianna A Pagida, Anastasia E Konstantinidou, Margarita A Chrysanthou-Piterou, Efstratios S Patsouris, Maria T Panayotacopoulo. Apoptotic Markers in the Midbrain of the Human Neonate After Perinatal Hypoxic/Ischemic Injury. Journal of neuropathology and experimental neurology. vol 79. issue 1. 2020-07-20. PMID:31803912. |
our previous postmortem studies on neonates with neuropathological injury of perinatal hypoxia/ischemia (phi) showed a dramatic reduction of tyrosine hydroxylase expression (dopamine synthesis enzyme) in substantia nigra (sn) neurons, with reduction of their cellular size. |
2020-07-20 |
2023-08-13 |
human |
| D M Bortz, K L Gazo, A A Grac. The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:31261368. |
the medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons. |
2020-07-08 |
2023-08-13 |
rat |
| D M Bortz, K L Gazo, A A Grac. The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:31261368. |
intra-ventral subiculum cno enhanced reversal learning in the same manner as systemic cno and also significantly increased ventral tegmental area and decreased substantia nigra dopamine neuron population activity. |
2020-07-08 |
2023-08-13 |
rat |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Huifangjie Li, Pengfei Yang, William Knight, Yingqiu Guo, Joel S Perlmutter, Tammie L S Benzinger, John C Morris, Jinbin X. The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases. Journal of neurochemistry. vol 152. issue 2. 2020-06-25. PMID:31613384. |
the striatum with a number of dopamine containing neurons, receiving projections from the substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative diseases of motor and memory function. |
2020-06-25 |
2023-08-13 |
Not clear |
| Dongping Huang, Qing Li, Yi Wang, Zhaolin Liu, Zishan Wang, Heng Li, Jinghui Wang, Jing Su, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Huan. Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson's disease. Aging. vol 11. issue 10. 2020-06-17. PMID:31147527. |
degeneration of the dopaminergic neurons in the substantia nigra and the resultant dopamine depletion from the striatum are the hallmarks of parkinson's disease (pd) and are responsible for the disease's cardinal motor symptoms. |
2020-06-17 |
2023-08-13 |
mouse |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Ru Zeng, Xueting Wang, Qian Zhou, Xiaolong Fu, Qin Wu, Yuanfu Lu, Jingshan Shi, James E Klaunig, Shaoyu Zho. Icariin protects rotenone-induced neurotoxicity through induction of SIRT3. Toxicology and applied pharmacology. vol 379. 2020-06-01. PMID:31251943. |
rats treated with rot exhibited a marked loss of dopamine (da) neurons and a decline in motor function, along with a decrease in protein expressions of sirt3 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α) in the substantia nigra (sn). |
2020-06-01 |
2023-08-13 |
rat |
| Ke-Zhong Shen, Adam C Munhall, Steven W Johnso. Phosphoinositol metabolism affects AMP kinase-dependent K-ATP currents in rat substantia nigra dopamine neurons. Brain research. vol 1706. 2020-05-29. PMID:30722976. |
phosphoinositol metabolism affects amp kinase-dependent k-atp currents in rat substantia nigra dopamine neurons. |
2020-05-29 |
2023-08-13 |
rat |