| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esteban A Fridman, Joseph R Osborne, Paul D Mozley, Jonathan D Victor, Nicholas D Schif. Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. Brain : a journal of neurology. vol 142. issue 7. 2020-05-18. PMID:31505542. |
however, administration of the dopamine precursor l-dopa reversed the presynaptic deficit by restoring the biosynthesis of dopamine from both ventral tegmentum and substantia nigra. |
2020-05-18 |
2023-08-13 |
human |
| Birgit Liss, Jörg Striessni. The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease. Annual review of pharmacology and toxicology. vol 59. 2020-05-14. PMID:30625283. |
the motor symptoms of parkinson's disease (pd) mainly arise from degeneration of dopamine neurons within the substantia nigra. |
2020-05-14 |
2023-08-13 |
Not clear |
| Emilie Puginier, Rahul Bharatiya, Abdeslam Chagraoui, Julien Manem, Yoon H Cho, Maurice Garret, Philippe De Deurwaerdèr. Early neurochemical modifications of monoaminergic systems in the R6/1 mouse model of Huntington's disease. Neurochemistry international. vol 128. 2020-04-24. PMID:31054882. |
using tissue measurement of dopamine (da), serotonin (5-ht), noradrenaline, and some metabolites, we observed that da and/or its metabolite 3,4-dihydroxyphenylacetic acid (dopac), but not 5-ht or noradrenaline tissue content was reduced in an age-dependent manner (from two to six months) in the striatum, substantia nigra and globus pallidus of r6/1 mice. |
2020-04-24 |
2023-08-13 |
mouse |
| Ana Virel, Ilona Dudka, Rutger Laterveer, Sara Af Bjerké. Molecular and cellular neurosciences. vol 98. 2020-04-21. PMID:31200101. |
parkinson's disease is the second most common neurodegenerative disease caused by degeneration of dopamine neurons in the substantia nigra. |
2020-04-21 |
2023-08-13 |
Not clear |
| Bernardo Stutz, Carole Nasrallah, Mariana Nigro, Daniel Curry, Zhong-Wu Liu, Xiao-Bing Gao, John D Elsworth, Liat Mintz, Tamas L Horvat. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular metabolism. vol 24. 2020-04-15. PMID:30833218. |
dopamine neuronal protection in the mouse substantia nigra by ghsr is independent of electric activity. |
2020-04-15 |
2023-08-13 |
mouse |
| Bernardo Stutz, Carole Nasrallah, Mariana Nigro, Daniel Curry, Zhong-Wu Liu, Xiao-Bing Gao, John D Elsworth, Liat Mintz, Tamas L Horvat. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular metabolism. vol 24. 2020-04-15. PMID:30833218. |
dopamine neurons in the substantia nigra (sn) play crucial roles in control of voluntary movement. |
2020-04-15 |
2023-08-13 |
mouse |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the reduction of dopamine levels in the striatum. |
2020-04-07 |
2023-08-13 |
mouse |
| Ruru Li, Jianzong Che. Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxidative medicine and cellular longevity. vol 2019. 2020-03-20. PMID:31583052. |
moreover, sal diminished mptp-induced degeneration of nigrostriatal da neurons as evidenced by upregulated th-positive neurons in the substantia nigra, increased dat expression, and high dopamine and metabolite levels in the striatum. |
2020-03-20 |
2023-08-13 |
Not clear |
| Mi-Yoon Chang, Boram Oh, Jang-Eun Choi, Yanuar Alan Sulistio, Hye-Ji Woo, Ayoung Jo, Jinil Kim, Eun-Hee Kim, Seung Won Kim, Jungwook Hwang, Jungyun Park, Jae-Jin Song, Oh-Chan Kwon, Hyongbum Henry Kim, Young-Hoon Kim, Joo Yeon Ko, Jun Young Heo, Min Joung Lee, Moses Lee, Murim Choi, Sun Ju Chung, Hyun-Seob Lee, Sang-Hun Le. LIN28A loss of function is associated with Parkinson's disease pathogenesis. The EMBO journal. vol 38. issue 24. 2020-03-20. PMID:31750563. |
parkinson's disease (pd) is neurodegenerative movement disorder characterized by degeneration of midbrain-type dopamine (mda) neurons in the substantia nigra (sn). |
2020-03-20 |
2023-08-13 |
mouse |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in dopamine transporter (dat)-cre mice, overexpression of comt, specifically in dopaminergic neurons of the substantia nigra, produced cataleptic behaviours associated with impaired motor coordination. |
2020-03-12 |
2023-08-13 |
mouse |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
aav vector-mediated gene delivery to substantia nigra dopamine neurons: implications for gene therapy and disease models. |
2020-03-06 |
2023-08-13 |
rat |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
dopamine neurons in the substantia nigra projecting to the striatum, comprising the nigrostriatal pathway, are involved in movement control and degenerate in parkinson's disease. |
2020-03-06 |
2023-08-13 |
rat |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
much less emphasis has been put on aav-based gene therapy targeting dopamine neurons in substantia nigra. |
2020-03-06 |
2023-08-13 |
rat |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
we will review the literature related to targeting striatum and/or substantia nigra dopamine neurons using aavs in order to express neuroprotective and neurorestorative molecules, as well as produce animal disease models of parkinson's disease. |
2020-03-06 |
2023-08-13 |
rat |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
we discuss difficulties in targeting substantia nigra dopamine neurons and their vulnerability to stress in general. |
2020-03-06 |
2023-08-13 |
rat |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, Mikko Airavaar. AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models. Genes. vol 8. issue 2. 2020-03-06. PMID:28208742. |
we also review studies using aav-a-synuclein (a-syn) to target substantia nigra dopamine neurons to produce an α-syn overexpression disease model in rats. |
2020-03-06 |
2023-08-13 |
rat |
| Wei-Wei Li, Ying-Ying Shen, Dong-Wan Chen, Hui-Yun Li, Qian-Qian Shi, Jing Mei, Heng Yang, Fa-Ying Zhou, An-Yu Shi, Tao Zhang, Xiu-Qing Yao, Zhi-Qiang Xu, Fan Zeng, Yan-Jiang Wan. Genetic Association Between NGFR, ADAM17 Gene Polymorphism, and Parkinson's Disease in the Chinese Han Population. Neurotoxicity research. vol 36. issue 3. 2020-02-10. PMID:30941646. |
the p75 neurotrophin receptor (p75ntr, encoded by ngfr) was found to play an important role in the selective neuronal death of dopamine neurons in the substantia nigra, as well as the pathogenesis and development of pd. |
2020-02-10 |
2023-08-13 |
Not clear |
| Yaofeng Zhu, Bingbing Liu, Xuefeng Zheng, Jiajia Wu, Si Chen, Zhi Chen, Tao Chen, Ziyun Huang, Wanlong Le. Partial decortication ameliorates dopamine depletion‑induced striatal neuron lesions in rats. International journal of molecular medicine. vol 44. issue 4. 2020-02-04. PMID:31364729. |
the balance between glutamate (cortex and thalamus) and dopamine (substantia nigra) inputs on striatal neurons is of vital importance. |
2020-02-04 |
2023-08-13 |
rat |
| Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V Lafuente, Cristina Miguelez, Luisa Uged. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia. International review of neurobiology. vol 146. 2020-02-03. PMID:31349930. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, the depletion of striatal dopamine and the presence of lewy aggregates containing alpha-synuclein. |
2020-02-03 |
2023-08-13 |
Not clear |
| Ronald Keiflin, Heather J Pribut, Nisha B Shah, Patricia H Jana. Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions. Current biology : CB. vol 29. issue 1. 2020-01-23. PMID:30581025. |
dopamine (da) neurons in the ventral tegmental area (vta) and substantia nigra (snc) encode reward prediction errors (rpes) and are proposed to mediate error-driven learning. |
2020-01-23 |
2023-08-13 |
Not clear |