| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Huo, Qu Cui, Wei Yang, Wei Gu. LPS induces dopamine depletion and iron accumulation in substantia nigra in rat models of Parkinson's disease. International journal of clinical and experimental pathology. vol 11. issue 10. 2020-01-21. PMID:31949570. |
lps induces dopamine depletion and iron accumulation in substantia nigra in rat models of parkinson's disease. |
2020-01-21 |
2023-08-13 |
rat |
| Jianzhong Zhu, Shan Wang, Weiwei Qi, Xue Xu, Yingyin Lian. Overexpression of miR-153 promotes oxidative stress in MPP International journal of clinical and experimental pathology. vol 11. issue 8. 2020-01-21. PMID:31949812. |
overexpression of mir-153 promotes oxidative stress in mpp increasing evidence points to oxidative stress as a chief mediator of parkinson's disease (pd) characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra. |
2020-01-21 |
2023-08-13 |
Not clear |
| Sunil Bhurtel, Nikita Katila, Sunil Srivastav, Sabita Neupane, Dong-Young Cho. Mechanistic comparison between MPTP and rotenone neurotoxicity in mice. Neurotoxicology. vol 71. 2020-01-09. PMID:30605763. |
mptp clearly produced dopaminergic lesions in both the substantia nigra and the striatum as shown by loss of dopaminergic neurons, depletion of striatal dopamine, activation of glial cells in the nigrostriatal pathway and behavioral impairment. |
2020-01-09 |
2023-08-13 |
mouse |
| Rose B Creed, Liliana Menalled, Bradford Casey, Kuldip D Dave, Holden B Janssens, Isaac Veinbergs, Marieke van der Hart, Arash Rassoulpour, Matthew S Goldber. Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum. Neuroscience. vol 409. 2020-01-09. PMID:31029729. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder and is characterized by the loss of neurons in the substantia nigra that project to the striatum and release dopamine (da), which is required for normal movement. |
2020-01-09 |
2023-08-13 |
rat |
| Ruonan Wang, Min Li, Meng Zhao, Dahua Yu, Yu Hu, Corinde E Wiers, Gene-Jack Wang, Nora D Volkow, Kai Yua. Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway. Brain imaging and behavior. vol 13. issue 4. 2020-01-07. PMID:30054871. |
dopamine projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) and from the substantia nigra (sn) to the dorsal striatum are involved in addiction. |
2020-01-07 |
2023-08-13 |
human |
| Yun Li, Yue Zhang, Xiao-Li Zhang, Xiao-Yan Feng, Chen-Zhe Liu, Xiu-Neng Zhang, Zhu-Sheng Quan, Jing-Ting Yan, Jin-Xia Zh. Dopamine promotes colonic mucus secretion through dopamine D American journal of physiology. Cell physiology. vol 316. issue 3. 2020-01-06. PMID:30624983. |
mice injected intraperitoneally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) destroying enteric dopamine (da) neurons, rats microinjected with 6-hydroxydopamine (6-ohda) into the bilateral substantia nigra damaging central dopaminergic neurons, and dopamine d |
2020-01-06 |
2023-08-13 |
mouse |
| Reiho Tsutsumi, Yuria Hori, Takahiro Seki, Yuki Kurauchi, Masahiro Sato, Mutsumi Oshima, Akinori Hisatsune, Hiroshi Katsuk. Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30803759. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive degeneration of dopamine neurons in the substantia nigra. |
2019-12-16 |
2023-08-13 |
Not clear |
| Anna-Maija Penttinen, Ilmari Parkkinen, Sami Blom, Jaakko Kopra, Jaan-Olle Andressoo, Kari Pitkänen, Merja H Voutilainen, Mart Saarma, Mikko Airavaar. Implementation of deep neural networks to count dopamine neurons in substantia nigra. The European journal of neuroscience. vol 48. issue 6. 2019-12-12. PMID:30144349. |
implementation of deep neural networks to count dopamine neurons in substantia nigra. |
2019-12-12 |
2023-08-13 |
mouse |
| Anna-Maija Penttinen, Ilmari Parkkinen, Sami Blom, Jaakko Kopra, Jaan-Olle Andressoo, Kari Pitkänen, Merja H Voutilainen, Mart Saarma, Mikko Airavaar. Implementation of deep neural networks to count dopamine neurons in substantia nigra. The European journal of neuroscience. vol 48. issue 6. 2019-12-12. PMID:30144349. |
we implemented whole-slide digital imaging and deep convolutional neural networks (cnn) to count substantia nigra dopamine neurons. |
2019-12-12 |
2023-08-13 |
mouse |
| Anna-Maija Penttinen, Ilmari Parkkinen, Sami Blom, Jaakko Kopra, Jaan-Olle Andressoo, Kari Pitkänen, Merja H Voutilainen, Mart Saarma, Mikko Airavaar. Implementation of deep neural networks to count dopamine neurons in substantia nigra. The European journal of neuroscience. vol 48. issue 6. 2019-12-12. PMID:30144349. |
the developed cnn algorithm and fully cloud-embedded aiforia™ platform provide robust and fast analysis of dopamine neurons in rat and mouse substantia nigra. |
2019-12-12 |
2023-08-13 |
mouse |
| Poonam Zham, Dinesh Kumar, Rekha Viswanthan, Kit Wong, Kanae J Nagao, Sridhar Poosapadi Arjunan, Sanjay Raghav, Peter Kempste. Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study. Journal of neurology. vol 266. issue 6. 2019-12-09. PMID:30877380. |
serial testing of handwriting in patients known to be at risk for developing pd might prove to be an effective biomarker for cell loss in the substantia nigra and the associated dopamine deficiency. |
2019-12-09 |
2023-08-13 |
human |
| Bo Pan, Chao Den. Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain. Psychopharmacology. vol 236. issue 9. 2019-12-02. PMID:31053935. |
the ventral midbrain, mainly containing the ventral tegmental area (vta) and substantia nigra (sn), are the nuclei with dopamine origins in the brain, which are also involved in the actions of antipsychotics. |
2019-12-02 |
2023-08-13 |
rat |
| F. Artaud, P. Baruch, J. M. Stutzmann, M. Saffroy, G. Godeheu, L. Barbeito, D. Hervé, J. M. Studler, J. Glowinski, A. Chéram. Cholecystokinin: Corelease with dopamine from nigrostriatal neurons in the cat. The European journal of neuroscience. vol 1. issue 2. 2019-11-20. PMID:12106166. |
the activation of dopaminergic cells induced by the nigral application of alpha-methyl-para-tyrosine (10-4 m) stimulated the release of cck-li and dopamine in the ipsilateral caudate nucleus, whilst opposite effects were seen in the substantia nigra. |
2019-11-20 |
2023-08-12 |
cat |
| S. Morgan, D. Baker, J.P. Husto. Relationship between Behavioral Recovery from Unilateral 6-OHDA Lesion of the Substania Nigra and Changes in the Tuberomammillary-Striatal Projection as Measured by HRP-Labelling. Restorative neurology and neuroscience. vol 12. issue 4. 2019-11-20. PMID:12671291. |
a unilateral lesion of dopamine cells in the substantia nigra (sn) results in asymmetrical behavior, and recovery from this asymmetry was previously found to be associated with asymmetrical changes in the nigro-striatal projection as determined by anatomical tracing technique. |
2019-11-20 |
2023-08-12 |
rat |
| F. Viallet, T. Witja. [Neuroplasticity and Parkinson's disease] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690314. |
after a brief survey of some general aspects of plasticity in the cns, the present tutorial review illustrates with recent data from the literature the modes of plastic changes during the course of ipd, either resulting from dopaminergic denervation (hyperactivity of remaining dopaminergic neurons with increase of their excitatory cholinergic innervation in the substantia nigra, enhancement of the corticostriatal glutamatergic synaptic activity at the striatal level) or due to dopaminergic treatment (change in phosphorylation state of the striatal glutamate receptors, internalization of d1 dopamine receptors). |
2019-11-20 |
2023-08-12 |
Not clear |
| J Andrés Abin-Carriquiry, Ronald McGregor-Armas, Gustavo Costa, Jessika Urbanavicius, Federico Daja. Presynaptic involvement in the nicotine prevention of the dopamine loss provoked by 6-OHDA administration in the substantia nigra. Neurotoxicity research. vol 4. issue 2. 2019-11-20. PMID:12829413. |
presynaptic involvement in the nicotine prevention of the dopamine loss provoked by 6-ohda administration in the substantia nigra. |
2019-11-20 |
2023-08-12 |
Not clear |
| J Andrés Abin-Carriquiry, Ronald McGregor-Armas, Gustavo Costa, Jessika Urbanavicius, Federico Daja. Presynaptic involvement in the nicotine prevention of the dopamine loss provoked by 6-OHDA administration in the substantia nigra. Neurotoxicity research. vol 4. issue 2. 2019-11-20. PMID:12829413. |
in a previous paper we have shown that in the 6-hydroxydopamine (6-ohda) model of experimental parkinsonism, an intermittent administration schedule of nicotine (4 h before and 20, 44 and 68 h after 6-ohda) was able to prevent the decrease of dopamine (da) concentration in the corpus striatum (cs) provoked by the partial lesion of the substantia nigra (50% neuronal death after 6 micro g of 6-ohda). |
2019-11-20 |
2023-08-12 |
Not clear |
| John P Kostrzewa, Rose Anna Kostrzewa, Richard M Kostrzewa, Ryszard Brus, Przemysław Nowa. Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson's Disease. Current topics in behavioral neurosciences. vol 29. 2019-11-20. PMID:26475156. |
the classic rodent model of parkinson's disease (pd) is produced by unilateral lesioning of pars compacta substantia nigra (snpc) in adult rats, producing unilateral motor deficits which can be assessed by dopamine (da) d |
2019-11-20 |
2023-08-13 |
rat |
| YuHong Fu, George Paxinos, Charles Watson, Glenda M Hallida. The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration. Journal of chemical neuroanatomy. vol 76. issue Pt B. 2019-11-20. PMID:26859066. |
the pathology of parkinson's disease (pd) is characterised by the loss of neurons in the substantia nigra parcompacta (a9), which results in the insufficient release of dopamine, and the appearance of motor symptoms. |
2019-11-20 |
2023-08-13 |
human |
| Kamla Pathak, Nida Akhta. Nose to Brain Delivery of Nanoformulations for Neurotherapeutics in Parkinson`s disease: Defining the Preclinical, Clinical and toxicity issues. Current drug delivery. 2019-11-20. PMID:27280392. |
pd is featured by severe dropping of dopamine related neurons present in substantia nigra as well as cytoplasmic inclusions. |
2019-11-20 |
2023-08-13 |
Not clear |