| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
re-expression of voltage-gated sodium channel subtype nav1.3 in the substantia nigra after dopamine depletion. |
2019-03-07 |
2023-08-13 |
rat |
| Eduard R Mingazov, Gulnara R Khakimova, Elena A Kozina, Alexei E Medvedev, Olga A Buneeva, Ara S Bazyan, Michael V Ugrumo. MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28456940. |
in this study, we showed that despite the progressive loss of neurons in the substantia nigra at the presymptomatic and symptomatic stage, almost no change was observed in the main functional characteristics of this brain region, including dopamine (da) uptake and release, dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) expression, and activity of mao-a and mao-b. |
2019-02-26 |
2023-08-13 |
mouse |
| Yunjin Lee, Hannah Kim, Ji-Eun Kim, Jin-Young Park, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Pyung-Lim Ha. Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:29027111. |
in the present study, we demonstrated that mice with increased dopamine functions in the dorsal striatum via the suppression of dopamine transporter expression in substantia nigra neurons or the optogenetic stimulation of the nigro-striatal circuitry exhibited sociability deficits and repetitive behaviors relevant to asd pathology in animal models, while these behavioral changes were blocked by a d1 receptor antagonist. |
2019-02-26 |
2023-08-13 |
mouse |
| David M Bortz, Anthony A Grac. Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 10. 2019-02-21. PMID:29654260. |
medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways. |
2019-02-21 |
2023-08-13 |
rat |
| Jerry Zhao, Michel Baudry, Susan Jone. Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons. Neuropharmacology. vol 137. 2019-02-20. PMID:29772491. |
calpain inhibition reduces nmda receptor rundown in rat substantia nigra dopamine neurons. |
2019-02-20 |
2023-08-13 |
rat |
| Benjamin Weismüller, Marta Ghio, Kazimierz Logmin, Christian Hartmann, Alfons Schnitzler, Bettina Pollok, Martin Südmeyer, Christian Bellebau. Effects of feedback delay on learning from positive and negative feedback in patients with Parkinson's disease off medication. Neuropsychologia. vol 117. 2019-02-07. PMID:29758227. |
phasic dopamine (da) signals conveyed from the substantia nigra to the striatum and the prefrontal cortex crucially affect learning from feedback, with da bursts facilitating learning from positive feedback and da dips facilitating learning from negative feedback. |
2019-02-07 |
2023-08-13 |
Not clear |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Nicolas Giguère, Consiglia Pacelli, Caroline Saumure, Marie-Josée Bourque, Diana Matheoud, Daniel Levesque, Ruth S Slack, David S Park, Louis-Éric Trudea. Comparative analysis of Parkinson's disease-associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons. The Journal of biological chemistry. vol 293. issue 25. 2019-01-22. PMID:29700116. |
however, little is known about the mechanisms explaining why alterations in such diverse cellular processes lead to the selective loss of dopamine (da) neurons in the substantia nigra (snc) in the brain of individuals with pd. |
2019-01-22 |
2023-08-13 |
mouse |
| Johanna Duda, Michael Fauler, Jan Gründemann, Birgit Lis. Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. Methods in molecular biology (Clifton, N.J.). vol 1723. 2019-01-16. PMID:29344870. |
all these issues were considered for comparative gene expression analysis in dopamine (da) midbrain neurons of the substantia nigra (sn) from controls and parkinson's disease (pd) specimens, as the preferential degeneration of sn da neurons in the pathological hallmark of pd. |
2019-01-16 |
2023-08-13 |
human |
| Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipe. Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease. International journal of molecular sciences. vol 19. issue 10. 2019-01-07. PMID:30274251. |
a shortage of dopamine, which is predominantly produced by the dopaminergic neurons within the substantia nigra, causes clinical symptoms such as reduction of muscle mass, impaired body balance, akinesia, bradykinesia, tremors, postural instability, etc. |
2019-01-07 |
2023-08-13 |
Not clear |
| Abdul Qayyum Rana, Danial Qureshi, Walid Sabeh, Abdullah Mosabbir, Eraad Rahman, Zainab Sarfraz, Ruqqiyah Ran. Pharmacological therapies for pain in Parkinson's disease - a review paper. Expert review of neurotherapeutics. vol 17. issue 12. 2019-01-03. PMID:28949252. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the loss of dopamine containing cells in the substantia nigra, with pain being one of the most common, yet frequently misunderstood symptoms. |
2019-01-03 |
2023-08-13 |
Not clear |
| Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocre. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29552727. |
pretreatment with peam ameliorated behavioral deficits and the reductions in expression of tyrosine hydroxylase and dopamine transporter, while blunting the upregulation of α-synuclein and β3-tubulin in the substantia nigra after mptp induction. |
2018-12-17 |
2023-08-13 |
mouse |
| Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N Trawick, Richard M Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vya. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nature communications. vol 9. issue 1. 2018-12-17. PMID:29934589. |
we examined the role of tlr9 and its regulation by glucocorticoid receptors (grs) in degeneration of substantia nigra dopamine neurons (dns). |
2018-12-17 |
2023-08-13 |
mouse |
| Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michalu. Multiple Administration of Endogenous Amines TIQ and 1MeTIQ Protects Against a 6-OHDA-Induced Essential Fall of Dopamine Release in the Rat Striatum: In Vivo Microdialysis Study. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29076060. |
a unilateral 6-ohda lesion in the substantia nigra produces a strong reduction in the release of dopamine (approx. |
2018-12-11 |
2023-08-13 |
rat |
| Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michalu. The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:30129004. |
unilateral lactacystin injection into the substantia nigra caused significant impairment of dopamine release (approx. |
2018-11-06 |
2023-08-13 |
rat |
| Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michalu. The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:30129004. |
the results obtained from the in vivo microdialysis study as well as from the ex vivo experiments suggest that multiple administration of 1metiq protects dopaminergic neurons against the lactacystin-induced decline in th concentration in the substantia nigra and prevents disturbances of dopamine release in the striatum. |
2018-11-06 |
2023-08-13 |
rat |
| Peng Feng, Xiangjian Zhang, Dongfang Li, Chenhui Ji, Ziyue Yuan, Ruifang Wang, Guofang Xue, Guanglai Li, Christian Hölsche. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 133. 2018-11-05. PMID:29462693. |
dopamine synthesis as indicated by levels of tyrosine hydroxylase was much reduced by mptp in the substantia nigra and striatum, and da-ch5 was the best drug to reverse this. |
2018-11-05 |
2023-08-13 |
mouse |
| Katherine Coulombe, Olivier Kerdiles, Cyntia Tremblay, Vincent Emond, Manon Lebel, Anne-Sophie Boulianne, Mélanie Plourde, Francesca Cicchetti, Frédéric Calo. Impact of DHA intake in a mouse model of synucleinopathy. Experimental neurology. vol 301. issue Pt A. 2018-10-24. PMID:29229294. |
thy1-αsyn mice displayed impaired motor skills, lower dopaminergic neuronal counts within the substantia nigra (-13%) in parallel to decreased levels of the striatal dopamine transporter (dat) (-24%), as well as reduced neun (-41%) and synaptic proteins psd-95 (-51%), synaptophysin (-80%) and vesicular acetylcholine transporter (vchat) (-40%) in the cerebral cortex compared to c57/bl6 mice. |
2018-10-24 |
2023-08-13 |
mouse |
| Ernest Dallé, Musa V Mabandl. Early Life Stress, Depression And Parkinson's Disease: A New Approach. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29551090. |
stimulation of regions contiguous to the substantia nigra as well as dopamine (da) agonists have been shown to be able to attenuate depression. |
2018-10-22 |
2023-08-13 |
Not clear |
| Ali Khodadadian, Mohsen Hemmati-Dinarvand, Ashkan Kalantary-Charvadeh, Amin Ghobadi, Mahta Mazaher. Candidate biomarkers for Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 104. 2018-10-05. PMID:29803930. |
the neuropathological dominant symptoms of pd include the destruction of neurons in the substantia nigra, thus causing striatal dopamine deficiency and the presence of intracellular inclusions that contain aggregates of α‑synuclein. |
2018-10-05 |
2023-08-13 |
Not clear |