| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| İsmail Ünal, Ebru Emekli-Alturfa. Fishing for Parkinson's Disease: A review of the literature. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 62. 2019-04-24. PMID:30660479. |
parkinson's disease (pd), the second most common neurodegenerative disorder in the world, is due to the damage or death of cells that produce dopamine in the region called the substantia nigra (sn). |
2019-04-24 |
2023-08-13 |
human |
| Zhiguo Lu, Yongchang Zheng, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Xin Zhan. Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System. Journal of biomedical nanotechnology. vol 14. issue 10. 2019-04-22. PMID:30041715. |
and the mechanisms of these effects maybe lie in the increases of neural activity in hippocampus, hypothalamus and olfactory bulb regions, the enhances of the abilities of nerve regeneration in olfactory bulb, corpus striatum and substantia nigra and the increases of the expressions of dopamine, acetylcholine, γ-aminobutyric acid and n-methyl-d-aspartic acid. |
2019-04-22 |
2023-08-13 |
mouse |
| Ekaterina Zhurakovskaya, Juuso Leikas, Tiina Pirttimäki, Francesc Casas Mon, Mikko Gynther, Rubin Aliev, Tomi Rantamäki, Heikki Tanila, Markus M Forsberg, Olli Gröhn, Jaakko Paasonen, Aaro J Jalkane. Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease. eNeuro. vol 6. issue 1. 2019-04-18. PMID:30838323. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to striatal dopamine depletion. |
2019-04-18 |
2023-08-13 |
rat |
| Ming-Chung Chou, Ping-Hong Lai, Jie-Yuan L. Early white matter injuries associated with dopamine transporter dysfunction in patients with acute CO intoxication: A diffusion kurtosis imaging and Tc-99m TRODAT-1 SPECT study. European radiology. vol 29. issue 3. 2019-04-03. PMID:30143836. |
patients with co intoxication were demonstrated to exhibit white matter (wm) injuries, changes in substantia nigra, dopamine transporter dysfunctions of striatum and parkinsonism symptoms. |
2019-04-03 |
2023-08-13 |
Not clear |
| Saima Malik, Mark Jacobs, Sang-Soo Cho, Isabelle Boileau, Daniel Blumberger, Markus Heilig, Alan Wilson, Zafiris J Daskalakis, Antonio P Strafella, Abraham Zangen, Bernard Le Fol. Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [ Brain imaging and behavior. vol 12. issue 5. 2019-04-01. PMID:29170944. |
low frequency rtms (1 hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum. |
2019-04-01 |
2023-08-13 |
human |
| Christopher Knowlton, Sylvie Kutterer, Jochen Roeper, Carmen C Canavie. Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. Journal of neurophysiology. vol 119. issue 1. 2019-03-15. PMID:28978764. |
calcium dynamics control k-atp channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. |
2019-03-15 |
2023-08-13 |
mouse |
| Christopher Knowlton, Sylvie Kutterer, Jochen Roeper, Carmen C Canavie. Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. Journal of neurophysiology. vol 119. issue 1. 2019-03-15. PMID:28978764. |
burst firing in medial substantia nigra (msn) dopamine (da) neurons has been selectively linked to novelty-induced exploration behavior in mice. |
2019-03-15 |
2023-08-13 |
mouse |
| Roy A Wise, Ross A McDevit. Drive and Reinforcement Circuitry in the Brain: Origins, Neurotransmitters, and Projection Fields. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 4. 2019-03-11. PMID:28984293. |
from this work a dispersed but synaptically interconnected network of reinforcement circuitry is emerging: it includes afferents to the ventral tegmental area and substantia nigra; the dopamine systems themselves; glutamatergic afferents to the striatum; and one of two dopamine-receptor-expressing efferent pathways of the striatum. |
2019-03-11 |
2023-08-13 |
Not clear |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
re-expression of voltage-gated sodium channel subtype nav1.3 in the substantia nigra after dopamine depletion. |
2019-03-07 |
2023-08-13 |
rat |
| Eduard R Mingazov, Gulnara R Khakimova, Elena A Kozina, Alexei E Medvedev, Olga A Buneeva, Ara S Bazyan, Michael V Ugrumo. MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28456940. |
in this study, we showed that despite the progressive loss of neurons in the substantia nigra at the presymptomatic and symptomatic stage, almost no change was observed in the main functional characteristics of this brain region, including dopamine (da) uptake and release, dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) expression, and activity of mao-a and mao-b. |
2019-02-26 |
2023-08-13 |
mouse |
| Yunjin Lee, Hannah Kim, Ji-Eun Kim, Jin-Young Park, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Pyung-Lim Ha. Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:29027111. |
in the present study, we demonstrated that mice with increased dopamine functions in the dorsal striatum via the suppression of dopamine transporter expression in substantia nigra neurons or the optogenetic stimulation of the nigro-striatal circuitry exhibited sociability deficits and repetitive behaviors relevant to asd pathology in animal models, while these behavioral changes were blocked by a d1 receptor antagonist. |
2019-02-26 |
2023-08-13 |
mouse |
| David M Bortz, Anthony A Grac. Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 10. 2019-02-21. PMID:29654260. |
medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways. |
2019-02-21 |
2023-08-13 |
rat |
| Jerry Zhao, Michel Baudry, Susan Jone. Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons. Neuropharmacology. vol 137. 2019-02-20. PMID:29772491. |
calpain inhibition reduces nmda receptor rundown in rat substantia nigra dopamine neurons. |
2019-02-20 |
2023-08-13 |
rat |
| Benjamin Weismüller, Marta Ghio, Kazimierz Logmin, Christian Hartmann, Alfons Schnitzler, Bettina Pollok, Martin Südmeyer, Christian Bellebau. Effects of feedback delay on learning from positive and negative feedback in patients with Parkinson's disease off medication. Neuropsychologia. vol 117. 2019-02-07. PMID:29758227. |
phasic dopamine (da) signals conveyed from the substantia nigra to the striatum and the prefrontal cortex crucially affect learning from feedback, with da bursts facilitating learning from positive feedback and da dips facilitating learning from negative feedback. |
2019-02-07 |
2023-08-13 |
Not clear |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Nicolas Giguère, Consiglia Pacelli, Caroline Saumure, Marie-Josée Bourque, Diana Matheoud, Daniel Levesque, Ruth S Slack, David S Park, Louis-Éric Trudea. Comparative analysis of Parkinson's disease-associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons. The Journal of biological chemistry. vol 293. issue 25. 2019-01-22. PMID:29700116. |
however, little is known about the mechanisms explaining why alterations in such diverse cellular processes lead to the selective loss of dopamine (da) neurons in the substantia nigra (snc) in the brain of individuals with pd. |
2019-01-22 |
2023-08-13 |
mouse |
| Johanna Duda, Michael Fauler, Jan Gründemann, Birgit Lis. Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. Methods in molecular biology (Clifton, N.J.). vol 1723. 2019-01-16. PMID:29344870. |
all these issues were considered for comparative gene expression analysis in dopamine (da) midbrain neurons of the substantia nigra (sn) from controls and parkinson's disease (pd) specimens, as the preferential degeneration of sn da neurons in the pathological hallmark of pd. |
2019-01-16 |
2023-08-13 |
human |
| Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipe. Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease. International journal of molecular sciences. vol 19. issue 10. 2019-01-07. PMID:30274251. |
a shortage of dopamine, which is predominantly produced by the dopaminergic neurons within the substantia nigra, causes clinical symptoms such as reduction of muscle mass, impaired body balance, akinesia, bradykinesia, tremors, postural instability, etc. |
2019-01-07 |
2023-08-13 |
Not clear |
| Abdul Qayyum Rana, Danial Qureshi, Walid Sabeh, Abdullah Mosabbir, Eraad Rahman, Zainab Sarfraz, Ruqqiyah Ran. Pharmacological therapies for pain in Parkinson's disease - a review paper. Expert review of neurotherapeutics. vol 17. issue 12. 2019-01-03. PMID:28949252. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the loss of dopamine containing cells in the substantia nigra, with pain being one of the most common, yet frequently misunderstood symptoms. |
2019-01-03 |
2023-08-13 |
Not clear |
| Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocre. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29552727. |
pretreatment with peam ameliorated behavioral deficits and the reductions in expression of tyrosine hydroxylase and dopamine transporter, while blunting the upregulation of α-synuclein and β3-tubulin in the substantia nigra after mptp induction. |
2018-12-17 |
2023-08-13 |
mouse |