| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Genesys Giraldo, Mieu Brooks, Benoit I Giasson, Christopher Janu. Locomotor differences in mice expressing wild-type human α-synuclein. Neurobiology of aging. vol 65. 2018-09-26. PMID:29477894. |
parkinson's disease manifests as a progressive movement disorder with underlying degeneration of dopaminergic neurons in the substantia nigra, consequent depletion of dopamine levels, and the accumulation of lewy bodies in the brain. |
2018-09-26 |
2023-08-13 |
mouse |
| Chun Huang, Fengqin Lin, Guoqing Wang, Disheng Lu, Qin Wu, Jie Liu, Jingshan Shi, Feng Zhan. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative medicine and cellular longevity. vol 2018. 2018-09-18. PMID:29576855. |
parkinson's disease (pd) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (da) neurons in the midbrain substantia nigra (sn). |
2018-09-18 |
2023-08-13 |
Not clear |
| Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısma. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical cellular pathology (Amsterdam). vol 2017. 2018-08-10. PMID:28458992. |
levels of dopamine, secreted from the substantia nigra, nerve growth factor (ngf) developed from the hippocampal neurons, and gfap, secreted from astrocyte cells, were detected to be significantly lower in the toluene-administration group than in the control group ( |
2018-08-10 |
2023-08-13 |
rabbit |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
acute and chronic administration of win55,212-2 decreased dopamine transporter (dat) binding and mrna levels, as well as tyrosine hydroxylase (th) mrna expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2018-07-27 |
2023-08-13 |
rat |
| Eric E Beier, Matthew Neal, Gelerah Alam, Melissa Edler, Long-Jun Wu, Jason R Richardso. Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide. Neurobiology of disease. vol 108. 2018-07-23. PMID:28823928. |
for 4days), we found that lps induced a 34% loss of dopamine neurons in the substantia nigra 19days after initiation of treatment, but no further cell loss was observed at 36days. |
2018-07-23 |
2023-08-13 |
mouse |
| Lesly Puspita, Sun Young Chung, Jae-Won Shi. Oxidative stress and cellular pathologies in Parkinson's disease. Molecular brain. vol 10. issue 1. 2018-07-23. PMID:29183391. |
parkinson's disease (pd) is a chronic and progressive neurodegeneration of dopamine neurons in the substantia nigra. |
2018-07-23 |
2023-08-13 |
Not clear |
| Hailong Li, Jessica M Illenberger, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booz. Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology. Journal of visualized experiments : JoVE. issue 133. 2018-07-13. PMID:29658920. |
using a novel rna in situ hybridization assay, the current study identified dopamine drd1α receptor and tyrosine hydroxylase (th) rna expression from da-related circuitry in the nucleus accumbens (nac) area and substantia nigra region (snr), respectively. |
2018-07-13 |
2023-08-13 |
rat |
| Werner Poewe, Klaus Seppi, Caroline M Tanner, Glenda M Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag, Anthony E Lan. Parkinson disease. Nature reviews. Disease primers. vol 3. 2018-07-10. PMID:28332488. |
neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological hallmarks of parkinson disease. |
2018-07-10 |
2023-08-13 |
Not clear |
| A A Kolacheva, M V Ugrumo. Dopamine Synthesis as a Mechanism of Brain Plasticity in Nigrostriatal System Pathology. Doklady. Biochemistry and biophysics. vol 479. issue 1. 2018-07-05. PMID:29779103. |
the enzyme activity and the dopamine content showed unidirectional changes in the substantia nigra, but not in the striatum, which is apparently due to triggering other compensatory mechanisms. |
2018-07-05 |
2023-08-13 |
mouse |
| Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxe. Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease. International review of neurobiology. vol 137. 2018-06-25. PMID:29132545. |
in addition to a remarkable depletion of dopamine in the nigrostriatal system, the administration of 6-ohda into mfb induces some other neuropathological changes such as an increase of glial fibrillary acidic protein (gfap) positive cells in substantia nigra (sn) as well as in striatum. |
2018-06-25 |
2023-08-13 |
rat |
| Satyndra Kumar Yadav, Shivani Pandey, Babita Sing. Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A comparative study. Journal of chemical neuroanatomy. vol 85. 2018-06-22. PMID:28711564. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by immunostaining of tyrosine hydroxylase (th). |
2018-06-22 |
2023-08-13 |
mouse |
| Mechelle M Lewis, Nicholas W Sterling, Guangwei Du, Eun-Young Lee, Grace Shyu, Michael Goldenberg, Thomas Allen, Christy Stetter, Lan Kong, Shedra Amy Snipes, Byron C Jones, Honglei Chen, Richard B Mailman, Xuemei Huan. Lateralized Basal Ganglia Vulnerability to Pesticide Exposure in Asymptomatic Agricultural Workers. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28633499. |
pesticide exposure is linked to parkinson's disease, a neurodegenerative disorder marked by dopamine cell loss in the substantia nigra of the basal ganglia (bg) that often presents asymmetrically. |
2018-06-19 |
2023-08-13 |
Not clear |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Poonam Thakur, Ludivine S Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C Luk, Virginia M Y Lee, John Q Trojanowski, Anders Björklun. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 39. 2018-06-05. PMID:28900002. |
this study was designed to generate a more faithful model of parkinson's disease by injecting human α-syn fibril seeds into the rat substantia nigra (sn), in combination with adenoassociated virus (aav)-mediated overexpression of human α-syn, at levels that, by themselves, are unable to induce acute dopamine (da) neurodegeneration. |
2018-06-05 |
2023-08-13 |
human |
| Sonia Olmedo-Díaz, Héctor Estévez-Silva, Greger Orädd, Sara Af Bjerkén, Daniel Marcellino, Ana Vire. An altered blood-brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson's disease. Neuroscience. vol 362. 2018-06-04. PMID:28842186. |
presence of iron following dopamine cell degeneration was studied by mri, which revealed hypointense signals in the substantia nigra. |
2018-06-04 |
2023-08-13 |
rat |
| Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhar. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D NeuroImage. vol 158. 2018-06-01. PMID:28655632. |
normative data of dopaminergic neurotransmission functions in substantia nigra measured with mri and pet: neuromelanin, dopamine synthesis, dopamine transporters, and dopamine d the central dopaminergic system is of major importance in the pathophysiology of parkinson's disease, schizophrenia, and other neuropsychiatric disorders. |
2018-06-01 |
2023-08-13 |
Not clear |
| Maribel Pérez-Rodríguez, Esperanza García-Mendoza, Eunice D Farfán-García, Bhaskar C Das, Fabiola J Ciprés-Flores, José G Trujillo-Ferrara, Feliciano Tamay-Cach, Marvin A Soriano-Ursú. Not all boronic acids with a five-membered cycle induce tremor, neuronal damage and decreased dopamine. Neurotoxicology. vol 62. 2018-05-30. PMID:28595910. |
data was collected through acute toxicity evaluations, motor behavior tests, necropsies, determination of neuronal survival by immunohistochemistry, raman spectroscopic analysis of brain tissue, and hplc measurement of dopamine in substantia nigra and striatum tissue. |
2018-05-30 |
2023-08-13 |
mouse |
| Athanasios D Spathis, Xenophon Asvos, Despina Ziavra, Theodoros Karampelas, Stavros Topouzis, Zoe Cournia, Xiaobing Qing, Pavlos Alexakos, Lisa M Smits, Christina Dalla, Hardy J Rideout, Jens Christian Schwamborn, Constantin Tamvakopoulos, Demosthenes Fokas, Demetrios K Vassilati. Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 15. 2018-05-22. PMID:28348207. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (daergic) neurons in the substantia nigra and the gradual depletion of dopamine (da). |
2018-05-22 |
2023-08-13 |
mouse |
| Ziyue Yuan, Dongfang Li, Peng Feng, Guofang Xue, Chenhui Ji, Guanglai Li, Christian Hölsche. A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease. European journal of pharmacology. vol 812. 2018-05-15. PMID:28666800. |
dopamine synthesis as indicated by levels of tyrosine hydroxylase was much reduced by mptp in the substantia nigra and striatum, and da3-ch reversed this while liragutide only partially reversed this. |
2018-05-15 |
2023-08-13 |
mouse |
| Oliver T Phillipso. Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management. Ageing research reviews. vol 40. 2018-05-15. PMID:28986235. |
the motor deficits which characterise the sporadic form of parkinson's disease arise from age-related loss of a subset of dopamine neurons in the substantia nigra. |
2018-05-15 |
2023-08-13 |
Not clear |