| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Tahajjul Taufique, Vinod Kuma. Differential activation and tyrosine hydroxylase distribution in the hippocampal, pallial and midbrain brain regions in response to cognitive performance in Indian house crows exposed to abrupt light environment. Behavioural brain research. vol 314. 2018-01-18. PMID:27478138. |
further, under ll, th- immunoreactive neurons were reduced in number in midbrain dopamine synthesis sites, the venteral tegmental area (vta) and substantia nigra (sn), with a negative correlation of co-localized zenk/th- immunoreactive cells on errors during the association tasks. |
2018-01-18 |
2023-08-13 |
Not clear |
| Thomas M Jeitner, Mike Kalogiannis, Boris F Krasnikov, Irving Gomolin, Morgan R Peltier, Graham R Mora. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 2. 2018-01-16. PMID:27026709. |
overall, our findings suggest that chlorination of dopamine by hocl generates toxins that selectively kill dopaminergic neurons in the substantia nigra in a manner comparable to mpp+. |
2018-01-16 |
2023-08-13 |
mouse |
| María-José Sánchez-Catalán, Fanny Faivre, Ipek Yalcin, Marc-Antoine Muller, Dominique Massotte, Monique Majchrzak, Michel Barro. Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27468916. |
the gabaergic tail of the ventral tegmental area (tvta), also named rostromedial tegmental nucleus (rmtg), exerts an inhibitory control on dopamine neurons of the vta and substantia nigra. |
2018-01-16 |
2023-08-13 |
rat |
| Bernardo F C Lima, Daniele C Ramos, Janaína K Barbiero, Laura Pulido, Peter Redgrave, Donita L Robinson, Alexander Gómez-A, Claudio Da Cunh. Partial lesion of dopamine neurons of rat substantia nigra impairs conditioned place aversion but spares conditioned place preference. Neuroscience. vol 349. 2018-01-16. PMID:28279753. |
partial lesion of dopamine neurons of rat substantia nigra impairs conditioned place aversion but spares conditioned place preference. |
2018-01-16 |
2023-08-13 |
rat |
| Ting Xu, Junjun Zhou, Jie Zhu, Shuai Zhang, Ning Zhang, Yan Zhao, Chunchun Ding, Xue Shi, Jihong Ya. Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:27957651. |
furthermore, ca treated-animals displayed an increase in the contents of dopamine (da) and its metabolites 3,4-dihydroxyphenylacelic acid (dopac) and elevated the expressions of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) as well as the th protein in the striatum. |
2018-01-12 |
2023-08-13 |
rat |
| Tian Wang, Lijie Wang, Cuiting Li, Bing Han, Zhenhua Wang, Ji Li, Yan Lv, Shuyun Wang, Fenghua F. Hydroxysafflor Yellow A Improves Motor Dysfunction in the Rotenone-Induced Mice Model of Parkinson's Disease. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28097465. |
hsya treatment increased not only the number of th-containing dopaminergic neurons in substantia nigra, but also the dopamine content in the striatum in pd mice. |
2018-01-09 |
2023-08-13 |
mouse |
| Alpana Singh, Poonam Verma, Gillela Balaji, Supriti Samantaray, Kochupurackal P Mohanakuma. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochemistry international. vol 99. 2018-01-03. PMID:27395789. |
it attenuated mptp-induced loss of dopaminergic tyrosine hydroxylase positive neurons in substantia nigra, improved mitochondrial oxygen consumption and inhibited reactive oxygen species production in the striatal mitochondria measured using dichlorodihydrofluorescein fluorescence, but failed to block striatal dopamine depletion. |
2018-01-03 |
2023-08-13 |
mouse |
| Mohd Sami Ur Rasheed, Manish Kumar Tripathi, Abhishek Kumar Mishra, Saurabh Shukla, Mahendra Pratap Sing. Resveratrol Protects from Toxin-Induced Parkinsonism: Plethora of Proofs Hitherto Petty Translational Value. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25691456. |
parkinson's disease (pd) is a mysterious, chronic, multi-factorial and progressive disorder of the nervous system that is characterized by the selective loss of dopamine-producing cells of the substantia nigra leading to dopamine deficiency in the striatum. |
2017-12-22 |
2023-08-13 |
Not clear |
| Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmon. Protection of cultured dopamine neurons from MPP(+) requires a combination of neurotrophic factors. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27098376. |
parkinson's disease is a progressive neurodegenerative disorder, caused in part by the loss of dopamine (da) neurons in the substantia nigra (sn). |
2017-12-22 |
2023-08-13 |
rat |
| Natalie Landeck, Kerstin Buck, Deniz Kiri. Toxic effects of human and rodent variants of alpha-synuclein in vivo. The European journal of neuroscience. vol 45. issue 4. 2017-12-22. PMID:27893183. |
by quantifying the neurodegeneration of rat substantia nigra dopamine neurons here we show that h-asyn, h-bsyn, and h-asyn(d70-83) display comparable neurotoxicity across the vector doses tested. |
2017-12-22 |
2023-08-13 |
mouse |
| Caroline Calice da Silva, Bárbara Nunes Azevedo, Denise Cantarelli Machado, Eduardo R Zimmer, Leo Anderson Meira Martins, Jaderson Costa da Cost. Dissociation between dopaminergic response and motor behavior following intrastriatal, but not intravenous, transplant of bone marrow mononuclear stem cells in a mouse model of Parkinson's disease. Behavioural brain research. vol 324. 2017-12-13. PMID:28167338. |
parkinson's disease is characterized by the progressive loss of dopaminergic neurons from the substantia nigra, a process that leads to a dopamine deficiency in the striatum. |
2017-12-13 |
2023-08-13 |
mouse |
| David Reyes-Corona, Nallely Vázquez-Hernández, Lourdes Escobedo, Carlos E Orozco-Barrios, Jose Ayala-Davila, Mario Gil Moreno, Miriam E Amaro-Lara, Yazmin M Flores-Martinez, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan A Gonzalez-Barrios, M E Gutierrez-Castillo, Ignacio González-Burgos, Daniel Martinez-Fon. Neurturin overexpression in dopaminergic neurons induces presynaptic and postsynaptic structural changes in rats with chronic 6-hydroxydopamine lesion. PloS one. vol 12. issue 11. 2017-12-11. PMID:29176874. |
dopamine recovery was 70 ± 4% in the striatum and complete in the substantia nigra. |
2017-12-11 |
2023-08-13 |
rat |
| Dhiman Ghosh, Surabhi Mehra, Shruti Sahay, Pradeep K Singh, Samir K Maj. α-synuclein aggregation and its modulation. International journal of biological macromolecules. vol 100. 2017-11-27. PMID:27737778. |
parkinson's disease (pd) is a neurological disorder marked by the presence of cytoplasmic inclusions, lewy bodies (lbs) and lewy neurites (lns) as well as the degeneration of dopamine producing neurons in the substantia nigra region of the brain. |
2017-11-27 |
2023-08-13 |
Not clear |
| Sun Young Chung, Sarah Kishinevsky, Joseph R Mazzulli, John Graziotto, Ana Mrejeru, Eugene V Mosharov, Lesly Puspita, Parvin Valiulahi, David Sulzer, Teresa A Milner, Tony Taldone, Dimitri Krainc, Lorenz Studer, Jae-Won Shi. Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation. Stem cell reports. vol 7. issue 4. 2017-11-21. PMID:27641647. |
parkinson's disease (pd) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in pd remains unclear. |
2017-11-21 |
2023-08-13 |
Not clear |
| Young C Chung, Won-Ho Shin, Jeong Y Baek, Eun J Cho, Hyung H Baik, Sang R Kim, So-Yoon Won, Byung K Ji. CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease. Experimental & molecular medicine. vol 48. issue 1. 2017-11-20. PMID:27534533. |
the mechanisms underlying cb2 receptor-mediated neuroprotection of dopamine neurons in the substantia nigra (sn) were evaluated in the mptp mouse model of parkinson's disease (pd) by immunohistochemical staining (tyrosine hydroxylase, macrophage ag complex-1, glial fibrillary acidic protein, myeloperoxidase (mpo), and cd3 and cd68), real-time pcr and a fluorescein isothiocyanate-labeled albumin assay. |
2017-11-20 |
2023-08-13 |
mouse |
| Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cummin. Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408789. |
contrary to expectation, comparison of on- and off-sifrol results did not reveal any discernible occupancy in nucleus accumbens, or elsewhere in the extended striatum; present methods should be sensitive to a 10% change in dopamine d2/3 receptor availability in striatum; the significant findings elsewhere in the basal ganglia and in cerebral cortex are consistent with a predominance of d3 receptors in those structures, especially in substantia nigra, and imply that therapeutic effects of pramipexole may be obtained at sites outside the extended striatum. |
2017-11-17 |
2023-08-13 |
Not clear |
| Anne-Sophie Rolland, Tatyana Kareva, Nikolai Kholodilov, Robert E Burk. A quantitative evaluation of a 2.5-kb rat tyrosine hydroxylase promoter to target expression in ventral mesencephalic dopamine neurons in vivo. Neuroscience. vol 346. 2017-11-09. PMID:28108256. |
we conclude that rthp(2.5) does preferentially label dopamine neurons but its specificity is not complete within the substantia nigra and caution must be used. |
2017-11-09 |
2023-08-13 |
human |
| Junchao Tong, Gausiha Rathitharan, Jeffrey H Meyer, Yoshiaki Furukawa, Lee-Cyn Ang, Isabelle Boileau, Mark Guttman, Oleh Hornykiewicz, Stephen J Kis. Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders. Brain : a journal of neurology. vol 140. issue 9. 2017-10-30. PMID:29050386. |
despite suggestions that maoa (versus maob) is primarily responsible for metabolism of dopamine in dopamine neurons, there was no loss of the enzyme in the parkinsonian substantia nigra; instead, increased nigral levels of a maoa fragment and 'turnover' of the enzyme were observed in the conditions. |
2017-10-30 |
2023-08-13 |
human |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| Mayela Rodríguez-Violante, Rosalía Zerón-Martínez, Amin Cervantes-Arriaga, Teresa Coron. Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms. Archives of medical research. vol 48. issue 3. 2017-10-23. PMID:28882322. |
almost one hundred years later, degeneration of neurons in the substantia nigra and low levels of dopamine were identified as the putative cause of the disease, thus the disease remained as a pure neurological disorder. |
2017-10-23 |
2023-08-13 |
human |