| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Tang, Li Meng, Chang-Min Wan, Zhen-Hua Liu, Wei-Hua Liao, Xin-Xiang Yan, Xiao-Yu Wang, Bei-Sha Tang, Ji-Feng Gu. Identifying the presence of Parkinson's disease using low-frequency fluctuations in BOLD signals. Neuroscience letters. vol 645. 2017-10-10. PMID:28249785. |
parkinson's disease (pd) is a chronic, progressive, and degenerative neurological disorder that is characterized by the degeneration of dopamine neurons in the substantia nigra and the formation of intracellular lewy inclusion bodies. |
2017-10-10 |
2023-08-13 |
human |
| Chen Wang, Mengxi Niu, Zehua Zhou, Xiaoyuan Zheng, Lingzhi Zhang, Ye Tian, Xiaojun Yu, Guojun Bu, Huaxi Xu, Qilin Ma, Yun-Wu Zhan. VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460146. |
mutations or dysfunction of vps35 have been linked to parkinson's disease (pd), which is pathologically characterized by the loss of dopamine neurons in brain substantia nigra region. |
2017-09-28 |
2023-08-13 |
Not clear |
| Maowen Ba, Guozhao Ma, Chao Ren, Xuwen Sun, Min Kon. Repetitive transcranial magnetic stimulation for treatment of lactacystin-induced Parkinsonian rat model. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881616. |
rtms could significantly alleviate the loss of tyrosine hydroxylase-positive dopaminergic neurons in lactacystin-lesioned substantia nigra and prevent the loss of striatal dopamine levels. |
2017-09-25 |
2023-08-13 |
rat |
| Alexandre Charlet, Valery Grinevic. Oxytocin Mobilizes Midbrain Dopamine toward Sociality. Neuron. vol 95. issue 2. 2017-09-14. PMID:28728017. |
(2017) show that the activity of dopamine neurons of the ventral tegmental area and the substantia nigra is finely tuned by axonal release of oxytocin. |
2017-09-14 |
2023-08-13 |
Not clear |
| Kristal R Tucker, Samantha L Cavolo, Edwin S Levita. Elevated mitochondria-coupled NAD(P)H in endoplasmic reticulum of dopamine neurons. Molecular biology of the cell. vol 27. issue 21. 2017-09-05. PMID:27582392. |
here we use brain slice multiphoton microscopy to show that substantia nigra dopamine neurons, which are sensitive to stress in mitochondria and the endoplasmic reticulum (er), display elevated combined nadh and nadph (i.e., nad(p)h) autofluorescence. |
2017-09-05 |
2023-08-13 |
Not clear |
| Peng Zhao, Xiaoxia Yang, Liu Yang, Minshu Li, Kristofer Wood, Qiang Liu, Xiaodong Zh. Neuroprotective effects of fingolimod in mouse models of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 1. 2017-08-29. PMID:27671228. |
we found that fty720 significantly reduced the deficit of motor function, diminished the loss of tyrosine hydroxylase-positive neurons in the substantia nigra, and attenuated the decrease of striatal dopamine and metabolite levels in mice receiving 6-hydroxydopamine (6-ohda) or rotenone to simulate pd. |
2017-08-29 |
2023-08-13 |
mouse |
| Elisa Mariani, Flavia Frabetti, Andrea Tarozzi, Maria Chiara Pelleri, Fabrizio Pizzetti, Raffaella Casade. Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression. PloS one. vol 11. issue 9. 2017-08-25. PMID:27611585. |
meta-analysis of parkinson's disease transcriptome data using tram software: whole substantia nigra tissue and single dopamine neuron differential gene expression. |
2017-08-25 |
2023-08-13 |
Not clear |
| Andrea Herrera, Patricia Muñoz, Irmgard Paris, Gabriela Díaz-Veliz, Sergio Mora, Jose Inzunza, Kjell Hultenby, Cesar Cardenas, Fabián Jaña, Rita Raisman-Vozari, Katia Gysling, Jorge Abarca, Harry W M Steinbusch, Juan Segura-Aguila. Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 73. issue 18. 2017-08-23. PMID:27001668. |
the unilateral injection of aminochrome into rat striatum resulted in (1) contralateral rotation when the animals are stimulated with apomorphine; (2) absence of significant loss of tyrosine hydroxylase-positive neuronal elements both in substantia nigra and striatum; (3) cell shrinkage; (4) significant reduction of dopamine release; (5) significant increase in gaba release; (6) significant decrease in the number of monoaminergic presynaptic vesicles; (7) significant increase of dopamine concentration inside of monoaminergic vesicles; (8) significant increase of damaged mitochondria; (9) significant decrease of atp level in the striatum (10) significant decrease in basal and maximal mitochondrial respiration. |
2017-08-23 |
2023-08-13 |
rat |
| Rebekah C Evans, Manhua Zhu, Zayd M Khali. Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 13. 2017-08-18. PMID:28264982. |
dopamine inhibition differentially controls excitability of substantia nigra dopamine neuron subpopulations through t-type calcium channels. |
2017-08-18 |
2023-08-13 |
mouse |
| D Luke Fischer, Christopher J Kemp, Allyson Cole-Strauss, Nicole K Polinski, Katrina L Paumier, Jack W Lipton, Kathy Steece-Collier, Timothy J Collier, Daniel J Buhlinger, Caryl E Sortwel. Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 28. 2017-08-18. PMID:28607168. |
in preclinical models, stn dbs provides neuroprotection for substantia nigra (sn) dopamine neurons and increases bdnf in the nigrostriatal system and primary motor cortex. |
2017-08-18 |
2023-08-13 |
rat |
| Sandy Stayte, Peggy Rentsch, Anna R Tröscher, Maximilian Bamberger, Kong M Li, Bryce Visse. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PloS one. vol 12. issue 1. 2017-08-10. PMID:28121982. |
furthermore, activin a failed to protect against loss of striatal dopamine transporter expression in the striatum, suggesting the neuroprotective action of activin a may be localized to the substantia nigra. |
2017-08-10 |
2023-08-13 |
mouse |
| Zhen-Nian Zhang, Jing-Si Zhang, Jun Xiang, Zhong-Hai Yu, Wen Zhang, Min Cai, Xiang-Ting Li, Ting Wu, Wen-Wei Li, Ding-Fang Ca. Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study. Brain research. vol 1655. 2017-08-08. PMID:27876560. |
furthermore, at 2 and 2.5mg/kg, rotenone caused a significant decrease in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra, and dopamine in the striatum. |
2017-08-08 |
2023-08-13 |
rat |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Patrick P Michel, Etienne C Hirsch, Stéphane Huno. Understanding Dopaminergic Cell Death Pathways in Parkinson Disease. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196972. |
progressive impairment of voluntary motor control, which represents the primary clinical feature of the disease, is caused by a loss of midbrain substantia nigra dopamine (da) neurons. |
2017-08-03 |
2023-08-13 |
Not clear |
| Na Hyea Kang, Candace H Carriere, Sarra G Bahna, Lennard P Nile. Altered melatonin MT Brain research. vol 1652. 2017-07-28. PMID:27693415. |
a loss of tyrosine hydroxylase immunoreactivity and/or immunofluorescence in the striatum and substantia nigra was seen in animals lesioned in either the striatum or medial forebrain bundle, indicating degeneration of dopamine neurons. |
2017-07-28 |
2023-08-13 |
rat |
| Ke-Zhong Shen, Yan-Na Wu, Adam C Munhall, Steven W Johnso. AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons. Neuroscience. vol 330. 2017-07-11. PMID:27267246. |
amp kinase regulates ligand-gated k-atp channels in substantia nigra dopamine neurons. |
2017-07-11 |
2023-08-13 |
rat |
| E Faggiani, A Benazzou. Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: From history to the interaction with the monoaminergic systems. Progress in neurobiology. vol 151. 2017-07-11. PMID:27412110. |
parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. |
2017-07-11 |
2023-08-13 |
Not clear |
| K Krajnak, K Sriram, C Johnson, J R Roberts, R Mercer, G R Miller, O Wirth, J M Antonin. Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity. Journal of toxicology and environmental health. Part A. vol 80. issue 5. 2017-07-07. PMID:28598268. |
in welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (da) neurons in the substantia nigra. |
2017-07-07 |
2023-08-13 |
Not clear |
| James B Koprich, Tom H Johnston, Gabriela Reyes, Vanessa Omana, Jonathan M Brotchi. Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque. PloS one. vol 11. issue 11. 2017-07-06. PMID:27902767. |
when injected into 4 sites within each substantia nigra (7 μl per site, 1.7 x 1012 gp/ml), this vector provided expression lasting at least 4 months, and a 50% loss of nigral dopaminergic neurons and a 60% reduction in striatal dopamine. |
2017-07-06 |
2023-08-13 |
human |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
the hedlund mutation increased noradrenaline level in the hypothalamus and substantia nigra, serotonin level in the substantia nigra and striatum and decreased dopamine concentration in the hypothalamus and striatum. |
2017-06-28 |
2023-08-13 |
Not clear |