| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Poonam Thakur, Ludivine S Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C Luk, Virginia M Y Lee, John Q Trojanowski, Anders Björklun. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 39. 2018-06-05. PMID:28900002. |
this study was designed to generate a more faithful model of parkinson's disease by injecting human α-syn fibril seeds into the rat substantia nigra (sn), in combination with adenoassociated virus (aav)-mediated overexpression of human α-syn, at levels that, by themselves, are unable to induce acute dopamine (da) neurodegeneration. |
2018-06-05 |
2023-08-13 |
human |
| Sonia Olmedo-Díaz, Héctor Estévez-Silva, Greger Orädd, Sara Af Bjerkén, Daniel Marcellino, Ana Vire. An altered blood-brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson's disease. Neuroscience. vol 362. 2018-06-04. PMID:28842186. |
presence of iron following dopamine cell degeneration was studied by mri, which revealed hypointense signals in the substantia nigra. |
2018-06-04 |
2023-08-13 |
rat |
| Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhar. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D NeuroImage. vol 158. 2018-06-01. PMID:28655632. |
normative data of dopaminergic neurotransmission functions in substantia nigra measured with mri and pet: neuromelanin, dopamine synthesis, dopamine transporters, and dopamine d the central dopaminergic system is of major importance in the pathophysiology of parkinson's disease, schizophrenia, and other neuropsychiatric disorders. |
2018-06-01 |
2023-08-13 |
Not clear |
| Maribel Pérez-Rodríguez, Esperanza García-Mendoza, Eunice D Farfán-García, Bhaskar C Das, Fabiola J Ciprés-Flores, José G Trujillo-Ferrara, Feliciano Tamay-Cach, Marvin A Soriano-Ursú. Not all boronic acids with a five-membered cycle induce tremor, neuronal damage and decreased dopamine. Neurotoxicology. vol 62. 2018-05-30. PMID:28595910. |
data was collected through acute toxicity evaluations, motor behavior tests, necropsies, determination of neuronal survival by immunohistochemistry, raman spectroscopic analysis of brain tissue, and hplc measurement of dopamine in substantia nigra and striatum tissue. |
2018-05-30 |
2023-08-13 |
mouse |
| Athanasios D Spathis, Xenophon Asvos, Despina Ziavra, Theodoros Karampelas, Stavros Topouzis, Zoe Cournia, Xiaobing Qing, Pavlos Alexakos, Lisa M Smits, Christina Dalla, Hardy J Rideout, Jens Christian Schwamborn, Constantin Tamvakopoulos, Demosthenes Fokas, Demetrios K Vassilati. Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 15. 2018-05-22. PMID:28348207. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (daergic) neurons in the substantia nigra and the gradual depletion of dopamine (da). |
2018-05-22 |
2023-08-13 |
mouse |
| Ziyue Yuan, Dongfang Li, Peng Feng, Guofang Xue, Chenhui Ji, Guanglai Li, Christian Hölsche. A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease. European journal of pharmacology. vol 812. 2018-05-15. PMID:28666800. |
dopamine synthesis as indicated by levels of tyrosine hydroxylase was much reduced by mptp in the substantia nigra and striatum, and da3-ch reversed this while liragutide only partially reversed this. |
2018-05-15 |
2023-08-13 |
mouse |
| Oliver T Phillipso. Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management. Ageing research reviews. vol 40. 2018-05-15. PMID:28986235. |
the motor deficits which characterise the sporadic form of parkinson's disease arise from age-related loss of a subset of dopamine neurons in the substantia nigra. |
2018-05-15 |
2023-08-13 |
Not clear |
| Jaung-Geng Lin, Chao-Jung Chen, Han-Bin Yang, Yi-Hung Chen, Shih-Ya Hun. Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28837077. |
the pathological hallmark of pd is a progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta in the brain, ultimately resulting in severe striatal dopamine deficiency and the development of primary motor symptoms (e.g., resting tremor, bradykinesia) in pd. |
2018-05-03 |
2023-08-13 |
mouse |
| Elizabeth S Smith, Madeline E Clark, Gwendolyn A Hardy, David J Kraan, Elisa Biondo, F Gonzalez-Lima, Lawrence K Cormack, Marie Monfils, Hongjoo J Le. Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. Neuroscience. vol 359. 2018-04-30. PMID:28694175. |
the results show that mb could preserve some dopamine neurons in the substantia nigra par compacta when 6-ohda was infused into the medial forebrain bundle. |
2018-04-30 |
2023-08-13 |
rat |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
isradipine attenuates mptp-induced dopamine neuron degeneration by inhibiting up-regulation of l-type calcium channels and iron accumulation in the substantia nigra of mice. |
2018-04-23 |
2023-08-13 |
mouse |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
the aim of this study is to investigate the effects of l-type calcium channels (ltccs) on mptp-induced dopamine (da) neuron degeneration and iron accumulation in the substantia nigra (sn) of mice. |
2018-04-23 |
2023-08-13 |
mouse |
| James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devo. Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28592304. |
the primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron content. |
2018-04-17 |
2023-08-13 |
Not clear |
| Timothy J Collier, Nicholas M Kanaan, Jeffrey H Kordowe. Aging and Parkinson's disease: Different sides of the same coin? Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 7. 2018-04-16. PMID:28520211. |
we present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in pd, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in pd. |
2018-04-16 |
2023-08-13 |
Not clear |
| Fabio A Zucca, Juan Segura-Aguilar, Emanuele Ferrari, Patricia Muñoz, Irmgard Paris, David Sulzer, Tadeusz Sarna, Luigi Casella, Luigi Zecc. Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease. Progress in neurobiology. vol 155. 2018-04-11. PMID:26455458. |
neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia nigra and norepinephrine neurons of the locus coeruleus, the two neuronal populations most targeted in parkinson's disease. |
2018-04-11 |
2023-08-13 |
Not clear |
| V V Pavshintsev, L S Podshivalova, O Y Frolova, M V Belopolskaya, O A Averina, E A Kushnir, N V Marmiy, M L Lova. Effects of Mitochondrial Antioxidant SkQ1 on Biochemical and Behavioral Parameters in a Parkinsonism Model in Mice. Biochemistry. Biokhimiia. vol 82. issue 12. 2018-03-23. PMID:29486701. |
skq1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the parkinson-like condition. |
2018-03-23 |
2023-08-13 |
mouse |
| Mari H Savolainen, Katrina Albert, Mikko Airavaara, Timo T Myöhäne. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse. Experimental brain research. vol 235. issue 7. 2018-03-22. PMID:28439627. |
we found that lactacystin induced a parkinson's disease-like motor phenotype 5-7 days after injection in young and adult mice, and this was associated with widespread neuroinflammation based on glial cell markers, asyn accumulation in substantia nigra, striatal dopamine decrease, and loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2018-03-22 |
2023-08-13 |
mouse |
| Yukari Suda, Naoko Kuzumaki, Michiko Narita, Yusuke Hamada, Masahiro Shibasaki, Kenichi Tanaka, Hideki Tamura, Takashi Kawamura, Takashige Kondo, Akihiro Yamanaka, Minoru Narit. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29378186. |
this receptor has recently been found in the substantia nigra (sn) to control dopamine (da)-related physiological functions. |
2018-03-22 |
2023-08-13 |
Not clear |
| Charlotte Caine, Meytal Shohat, Jeong-Ki Kim, Koki Nakanishi, Shunichi Homma, Eugene V Mosharov, Umrao R Monan. A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency. Human molecular genetics. vol 26. issue 22. 2018-03-21. PMID:28973165. |
the striatum as well as substantia nigra appeared normal and no loss of dopamine expressing cells in the latter was detected. |
2018-03-21 |
2023-08-13 |
mouse |
| Margaret I Davis, Jill R Crittenden, Austin Y Feng, David A Kupferschmidt, Alipi Naydenov, Nephi Stella, Ann M Graybiel, David M Lovinge. The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. PloS one. vol 13. issue 2. 2018-03-13. PMID:29466446. |
these data suggest a role for cb1-rs in caudal dorsolateral striosome collaterals and striosome-dendron bouquet projections to lateral substantia nigra, where they are anatomically poised to mediate presynaptic disinhibition of both striosomal msns and midbrain dopamine neurons in response to endocannabinoids and cannabinomimetics. |
2018-03-13 |
2023-08-13 |
mouse |