| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaung-Geng Lin, Chao-Jung Chen, Han-Bin Yang, Yi-Hung Chen, Shih-Ya Hun. Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28837077. |
the pathological hallmark of pd is a progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta in the brain, ultimately resulting in severe striatal dopamine deficiency and the development of primary motor symptoms (e.g., resting tremor, bradykinesia) in pd. |
2018-05-03 |
2023-08-13 |
mouse |
| Elizabeth S Smith, Madeline E Clark, Gwendolyn A Hardy, David J Kraan, Elisa Biondo, F Gonzalez-Lima, Lawrence K Cormack, Marie Monfils, Hongjoo J Le. Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. Neuroscience. vol 359. 2018-04-30. PMID:28694175. |
the results show that mb could preserve some dopamine neurons in the substantia nigra par compacta when 6-ohda was infused into the medial forebrain bundle. |
2018-04-30 |
2023-08-13 |
rat |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
isradipine attenuates mptp-induced dopamine neuron degeneration by inhibiting up-regulation of l-type calcium channels and iron accumulation in the substantia nigra of mice. |
2018-04-23 |
2023-08-13 |
mouse |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
the aim of this study is to investigate the effects of l-type calcium channels (ltccs) on mptp-induced dopamine (da) neuron degeneration and iron accumulation in the substantia nigra (sn) of mice. |
2018-04-23 |
2023-08-13 |
mouse |
| James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devo. Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28592304. |
the primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron content. |
2018-04-17 |
2023-08-13 |
Not clear |
| Timothy J Collier, Nicholas M Kanaan, Jeffrey H Kordowe. Aging and Parkinson's disease: Different sides of the same coin? Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 7. 2018-04-16. PMID:28520211. |
we present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in pd, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in pd. |
2018-04-16 |
2023-08-13 |
Not clear |
| Fabio A Zucca, Juan Segura-Aguilar, Emanuele Ferrari, Patricia Muñoz, Irmgard Paris, David Sulzer, Tadeusz Sarna, Luigi Casella, Luigi Zecc. Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease. Progress in neurobiology. vol 155. 2018-04-11. PMID:26455458. |
neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia nigra and norepinephrine neurons of the locus coeruleus, the two neuronal populations most targeted in parkinson's disease. |
2018-04-11 |
2023-08-13 |
Not clear |
| V V Pavshintsev, L S Podshivalova, O Y Frolova, M V Belopolskaya, O A Averina, E A Kushnir, N V Marmiy, M L Lova. Effects of Mitochondrial Antioxidant SkQ1 on Biochemical and Behavioral Parameters in a Parkinsonism Model in Mice. Biochemistry. Biokhimiia. vol 82. issue 12. 2018-03-23. PMID:29486701. |
skq1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the parkinson-like condition. |
2018-03-23 |
2023-08-13 |
mouse |
| Mari H Savolainen, Katrina Albert, Mikko Airavaara, Timo T Myöhäne. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse. Experimental brain research. vol 235. issue 7. 2018-03-22. PMID:28439627. |
we found that lactacystin induced a parkinson's disease-like motor phenotype 5-7 days after injection in young and adult mice, and this was associated with widespread neuroinflammation based on glial cell markers, asyn accumulation in substantia nigra, striatal dopamine decrease, and loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2018-03-22 |
2023-08-13 |
mouse |
| Yukari Suda, Naoko Kuzumaki, Michiko Narita, Yusuke Hamada, Masahiro Shibasaki, Kenichi Tanaka, Hideki Tamura, Takashi Kawamura, Takashige Kondo, Akihiro Yamanaka, Minoru Narit. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29378186. |
this receptor has recently been found in the substantia nigra (sn) to control dopamine (da)-related physiological functions. |
2018-03-22 |
2023-08-13 |
Not clear |
| Charlotte Caine, Meytal Shohat, Jeong-Ki Kim, Koki Nakanishi, Shunichi Homma, Eugene V Mosharov, Umrao R Monan. A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency. Human molecular genetics. vol 26. issue 22. 2018-03-21. PMID:28973165. |
the striatum as well as substantia nigra appeared normal and no loss of dopamine expressing cells in the latter was detected. |
2018-03-21 |
2023-08-13 |
mouse |
| Margaret I Davis, Jill R Crittenden, Austin Y Feng, David A Kupferschmidt, Alipi Naydenov, Nephi Stella, Ann M Graybiel, David M Lovinge. The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. PloS one. vol 13. issue 2. 2018-03-13. PMID:29466446. |
these data suggest a role for cb1-rs in caudal dorsolateral striosome collaterals and striosome-dendron bouquet projections to lateral substantia nigra, where they are anatomically poised to mediate presynaptic disinhibition of both striosomal msns and midbrain dopamine neurons in response to endocannabinoids and cannabinomimetics. |
2018-03-13 |
2023-08-13 |
mouse |
| Richard P Allen, Nathan C Donelson, Byron C Jones, Yuqing Li, Mauro Manconi, David B Rye, Subhabrata Sanyal, Juliane Winkelman. Animal models of RLS phenotypes. Sleep medicine. vol 31. 2018-03-05. PMID:27839945. |
the major pathophysiology of rls is low iron concentration in the substantia nigra containing the cell bodies of dopamine neurons that project to the striatum, an area that is crucial for modulating movement. |
2018-03-05 |
2023-08-13 |
mouse |
| Eleanor Loh, Dharshan Kumaran, Raphael Koster, David Berron, Ray Dolan, Emrah Duze. Context-specific activation of hippocampus and SN/VTA by reward is related to enhanced long-term memory for embedded objects. Neurobiology of learning and memory. vol 134 Pt A. 2018-02-09. PMID:26708279. |
animal studies indicate that hippocampal representations of environmental context modulate reward-related processing in the substantia nigra and ventral tegmental area (sn/vta), a major origin of dopamine in the brain. |
2018-02-09 |
2023-08-13 |
Not clear |
| Hongliang Yi, Xiaohang Bao, Xiaotong Tang, Xiaotang Fan, Haiwei X. Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice. Journal of chemical neuroanatomy. vol 77. 2018-01-31. PMID:27211874. |
estrogen attenuates the loss of dopamine neurons from the substantia nigra in animal models of parkinson's disease (pd) and excitatory amino-acid induced neurotoxicity by interactions with brain-derived neurotrophic factor (bdnf), and calretinin (cr) containing dopaminergic (da) neurons. |
2018-01-31 |
2023-08-13 |
mouse |
| Yo Oishi, Yoshiaki Suzuki, Koji Takahashi, Toshiya Yonezawa, Takeshi Kanda, Yohko Takata, Yoan Cherasse, Michael Lazaru. Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28124114. |
we found that activation of dopamine neurons in the ventral tegmental area (vta), but not in the substantia nigra, strongly induced wakefulness, although both cell populations expressed the neuronal activity marker c-fos after chemogenetic stimulation. |
2018-01-30 |
2023-08-13 |
mouse |
| Pablo Garrido-Gil, Ana I Rodriguez-Perez, Patricia Fernandez-Rodriguez, Jose L Lanciego, Jose L Labandeira-Garci. Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28161727. |
in recent studies, we have demonstrated the presence of a local ras in the substantia nigra of rodents and primates that modulates dopamine release and dopamine receptor expression. |
2018-01-30 |
2023-08-13 |
rat |
| Yi-Ming Shao, Xiaohua Ma, Priyankar Paira, Aaron Tan, Deron Raymond Herr, Kah Leong Lim, Chee Hoe Ng, Gopalakrishnan Venkatesan, Karl-Norbert Klotz, Stephanie Federico, Giampiero Spalluto, Siew Lee Cheong, Yu Zong Chen, Giorgia Pastori. Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment. PloS one. vol 13. issue 1. 2018-01-29. PMID:29304113. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. |
2018-01-29 |
2023-08-13 |
human |
| M J Sanchez-Catalan, J Kaufling, F Georges, P Veinante, M Barro. The antero-posterior heterogeneity of the ventral tegmental area. Neuroscience. vol 282. 2018-01-26. PMID:25241061. |
it controls vta and substantia nigra dopamine cells, thus exerting a major influence on basal ganglia functions. |
2018-01-26 |
2023-08-13 |
Not clear |
| Linde Boekhoudt, Azar Omrani, Mieneke C M Luijendijk, Inge G Wolterink-Donselaar, Ellen C Wijbrans, Geoffrey van der Plasse, Roger A H Ada. Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 11. 2018-01-26. PMID:27712862. |
chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats. |
2018-01-26 |
2023-08-13 |
rat |