| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Patrick P Michel, Etienne C Hirsch, Stéphane Huno. Understanding Dopaminergic Cell Death Pathways in Parkinson Disease. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196972. |
progressive impairment of voluntary motor control, which represents the primary clinical feature of the disease, is caused by a loss of midbrain substantia nigra dopamine (da) neurons. |
2017-08-03 |
2023-08-13 |
Not clear |
| Na Hyea Kang, Candace H Carriere, Sarra G Bahna, Lennard P Nile. Altered melatonin MT Brain research. vol 1652. 2017-07-28. PMID:27693415. |
a loss of tyrosine hydroxylase immunoreactivity and/or immunofluorescence in the striatum and substantia nigra was seen in animals lesioned in either the striatum or medial forebrain bundle, indicating degeneration of dopamine neurons. |
2017-07-28 |
2023-08-13 |
rat |
| Ke-Zhong Shen, Yan-Na Wu, Adam C Munhall, Steven W Johnso. AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons. Neuroscience. vol 330. 2017-07-11. PMID:27267246. |
amp kinase regulates ligand-gated k-atp channels in substantia nigra dopamine neurons. |
2017-07-11 |
2023-08-13 |
rat |
| E Faggiani, A Benazzou. Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: From history to the interaction with the monoaminergic systems. Progress in neurobiology. vol 151. 2017-07-11. PMID:27412110. |
parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. |
2017-07-11 |
2023-08-13 |
Not clear |
| K Krajnak, K Sriram, C Johnson, J R Roberts, R Mercer, G R Miller, O Wirth, J M Antonin. Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity. Journal of toxicology and environmental health. Part A. vol 80. issue 5. 2017-07-07. PMID:28598268. |
in welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (da) neurons in the substantia nigra. |
2017-07-07 |
2023-08-13 |
Not clear |
| James B Koprich, Tom H Johnston, Gabriela Reyes, Vanessa Omana, Jonathan M Brotchi. Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque. PloS one. vol 11. issue 11. 2017-07-06. PMID:27902767. |
when injected into 4 sites within each substantia nigra (7 μl per site, 1.7 x 1012 gp/ml), this vector provided expression lasting at least 4 months, and a 50% loss of nigral dopaminergic neurons and a 60% reduction in striatal dopamine. |
2017-07-06 |
2023-08-13 |
human |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
the hedlund mutation increased noradrenaline level in the hypothalamus and substantia nigra, serotonin level in the substantia nigra and striatum and decreased dopamine concentration in the hypothalamus and striatum. |
2017-06-28 |
2023-08-13 |
Not clear |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
significant interaction effects were found between the hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (p < 0.001), dopamine level in the midbrain (p < 0.01) and its metabolism in the striatum (p < 0.05). |
2017-06-28 |
2023-08-13 |
Not clear |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
it was found that the occurrence of α-syn-positive neurons proceeded topologically based on the midbrain dopamine pathways arising from the substantia nigra and the ventral tegmental area where they were primarily observed. |
2017-06-26 |
2023-08-13 |
human |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
concerning the nigrostriatal pathway, a mediolateral or rostrocaudal gradient was seen in the substantia nigra or the striatum, respectively, and a compensatory increase in dopamine transporter occurred in the striatum regardless of the decreased dopamine level. |
2017-06-26 |
2023-08-13 |
human |
| Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Gianni Pezzoli, Fabio A Zucca, Luigi Zecca, Ulrich Schraermeye. Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27121280. |
neuromelanin-containing organelles of dopamine neurons in normal human substantia nigra were investigated by analytical electron mircoscopy and secondary ion mass spectroscopy (nanosims) yielding the ultrastructure and elemental composition. |
2017-06-23 |
2023-08-13 |
human |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The astrocytic response to the dopaminergic denervation of the striatum. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27230040. |
increasing evidence suggests that the dopaminergic degeneration which characterizes parkinson's disease starts in the striatal dopamine terminals and progresses retrogradely to the body of dopamine cells in the substantia nigra. |
2017-06-09 |
2023-08-13 |
rat |
| Amira M Soliman, Ahmed M Fathalla, Ahmed A Moustaf. Dose-dependent neuroprotective effect of caffeine on a rotenone-induced rat model of parkinsonism: A histological study. Neuroscience letters. vol 623. 2017-05-24. PMID:27132082. |
our study showed that the treatment with caffeine improved histopathological degeneration in the substantia nigra parts compacta (snpc) neurons and hindered the reduction in dopamine concentration caused by rotenone. |
2017-05-24 |
2023-08-13 |
rat |
| S Nicole Fearnbach, Laural K English, Marlou Lasschuijt, Stephen J Wilson, Jennifer S Savage, Jennifer O Fisher, Barbara J Rolls, Kathleen L Kelle. Brain response to images of food varying in energy density is associated with body composition in 7- to 10-year-old children: Results of an exploratory study. Physiology & behavior. vol 162. 2017-05-16. PMID:26973134. |
our findings support literature on ffm as an appetitive driver, such that greater amounts of lean mass were associated with greater activation for high ed foods in an area of the brain associated with dopamine signaling and reward (substantia nigra). |
2017-05-16 |
2023-08-13 |
Not clear |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
in the subset of 12 patients, who also had a (123)i-fp-cit scan, the mean total striatal dopamine transporter signal was decreased by 45% and the mean total (18)f-av-1451 substantia nigra volume of distribution was decreased by 33% after median disease duration of 4.7 years (0.5-12.4 years). |
2017-05-10 |
2023-08-13 |
human |
| Asuka Morizane, Jun Takahash. Cell Therapy for Parkinson's Disease. Neurologia medico-chirurgica. vol 56. issue 3. 2017-05-01. PMID:26912295. |
in parkinson's disease (pd), dopamine neurons in the substantia nigra are degenerated and lost. |
2017-05-01 |
2023-08-13 |
Not clear |
| Silvia Paola Caminiti, Luca Presotto, Damiano Baroncini, Valentina Garibotto, Rosa Maria Moresco, Luigi Gianolli, Maria Antonietta Volonté, Angelo Antonini, Daniela Peran. Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease. NeuroImage. Clinical. vol 14. 2017-04-20. PMID:28409113. |
a progressive loss of dopamine neurons in the substantia nigra (sn) is considered the main feature of idiopathic parkinson's disease (pd). |
2017-04-20 |
2023-08-13 |
Not clear |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |