| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
significant interaction effects were found between the hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (p < 0.001), dopamine level in the midbrain (p < 0.01) and its metabolism in the striatum (p < 0.05). |
2017-06-28 |
2023-08-13 |
Not clear |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
it was found that the occurrence of α-syn-positive neurons proceeded topologically based on the midbrain dopamine pathways arising from the substantia nigra and the ventral tegmental area where they were primarily observed. |
2017-06-26 |
2023-08-13 |
human |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
concerning the nigrostriatal pathway, a mediolateral or rostrocaudal gradient was seen in the substantia nigra or the striatum, respectively, and a compensatory increase in dopamine transporter occurred in the striatum regardless of the decreased dopamine level. |
2017-06-26 |
2023-08-13 |
human |
| Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Gianni Pezzoli, Fabio A Zucca, Luigi Zecca, Ulrich Schraermeye. Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27121280. |
neuromelanin-containing organelles of dopamine neurons in normal human substantia nigra were investigated by analytical electron mircoscopy and secondary ion mass spectroscopy (nanosims) yielding the ultrastructure and elemental composition. |
2017-06-23 |
2023-08-13 |
human |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The astrocytic response to the dopaminergic denervation of the striatum. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27230040. |
increasing evidence suggests that the dopaminergic degeneration which characterizes parkinson's disease starts in the striatal dopamine terminals and progresses retrogradely to the body of dopamine cells in the substantia nigra. |
2017-06-09 |
2023-08-13 |
rat |
| Amira M Soliman, Ahmed M Fathalla, Ahmed A Moustaf. Dose-dependent neuroprotective effect of caffeine on a rotenone-induced rat model of parkinsonism: A histological study. Neuroscience letters. vol 623. 2017-05-24. PMID:27132082. |
our study showed that the treatment with caffeine improved histopathological degeneration in the substantia nigra parts compacta (snpc) neurons and hindered the reduction in dopamine concentration caused by rotenone. |
2017-05-24 |
2023-08-13 |
rat |
| S Nicole Fearnbach, Laural K English, Marlou Lasschuijt, Stephen J Wilson, Jennifer S Savage, Jennifer O Fisher, Barbara J Rolls, Kathleen L Kelle. Brain response to images of food varying in energy density is associated with body composition in 7- to 10-year-old children: Results of an exploratory study. Physiology & behavior. vol 162. 2017-05-16. PMID:26973134. |
our findings support literature on ffm as an appetitive driver, such that greater amounts of lean mass were associated with greater activation for high ed foods in an area of the brain associated with dopamine signaling and reward (substantia nigra). |
2017-05-16 |
2023-08-13 |
Not clear |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
in the subset of 12 patients, who also had a (123)i-fp-cit scan, the mean total striatal dopamine transporter signal was decreased by 45% and the mean total (18)f-av-1451 substantia nigra volume of distribution was decreased by 33% after median disease duration of 4.7 years (0.5-12.4 years). |
2017-05-10 |
2023-08-13 |
human |
| Asuka Morizane, Jun Takahash. Cell Therapy for Parkinson's Disease. Neurologia medico-chirurgica. vol 56. issue 3. 2017-05-01. PMID:26912295. |
in parkinson's disease (pd), dopamine neurons in the substantia nigra are degenerated and lost. |
2017-05-01 |
2023-08-13 |
Not clear |
| Silvia Paola Caminiti, Luca Presotto, Damiano Baroncini, Valentina Garibotto, Rosa Maria Moresco, Luigi Gianolli, Maria Antonietta Volonté, Angelo Antonini, Daniela Peran. Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease. NeuroImage. Clinical. vol 14. 2017-04-20. PMID:28409113. |
a progressive loss of dopamine neurons in the substantia nigra (sn) is considered the main feature of idiopathic parkinson's disease (pd). |
2017-04-20 |
2023-08-13 |
Not clear |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |
| José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesino. Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs. Planta medica. vol 82. issue 11-12. 2017-03-16. PMID:27224274. |
the reduction of dopamine levels produces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| L M Birioukova, E Yu Sitnikova, M A Kulikov, V V Raevsk. Compensatory Changes in the Brain Dopaminergic System of WAG/Rij Rats Genetically Predisposed to Absence Epilepsy. Bulletin of experimental biology and medicine. vol 161. issue 5. 2017-02-14. PMID:27709379. |
we revealed reduced expression of dopamine receptors in various brain structures prior to first manifestations of the disease (at the age of 1-3 months), reduced density of neurons in the center of nigrostriatal system (substantia nigra pars compacta) in 10-month-old rats in comparison with 1-month-old rats, and positive correlation between neural density in the substantia nigra and intensity of epileptic activity in eeg. |
2017-02-14 |
2023-08-13 |
rat |
| E R Mingazov, M V Ugrumo. Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system. Doklady. Biochemistry and biophysics. vol 470. issue 1. 2017-01-25. PMID:27817030. |
degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. |
2017-01-25 |
2023-08-13 |
Not clear |
| J S McDowall, D R Brow. Alpha-synuclein: relating metals to structure, function and inhibition. Metallomics : integrated biometal science. vol 8. issue 4. 2017-01-02. PMID:26864076. |
high concentrations of both dopamine and metals are present in the substantia nigra making this an ideal location for both the structural alteration of alpha-synuclein and the production of toxic oxygen species. |
2017-01-02 |
2023-08-13 |
Not clear |
| Helder Henrique Alves Medeiros, Melquisedec Abiaré Dantas Santana, Mariana Dias Leite, Luisa Alves Pereira Aquino, Marília Abero Sá de Barros, Nayana Tânia Galvão, Fernando Vagner Lobo Ladd, Judney Cley Cavalcante, Miriam Stela Maris Oliveira Costa, Jeferson Souza Cavalcante, Expedito Silva Nasciment. The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris). Neuroscience research. vol 112. 2016-12-28. PMID:27349153. |
the cytoarchitectonic and th-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (artibeus planirostris). |
2016-12-28 |
2023-08-13 |
Not clear |
| Helder Henrique Alves Medeiros, Melquisedec Abiaré Dantas Santana, Mariana Dias Leite, Luisa Alves Pereira Aquino, Marília Abero Sá de Barros, Nayana Tânia Galvão, Fernando Vagner Lobo Ladd, Judney Cley Cavalcante, Miriam Stela Maris Oliveira Costa, Jeferson Souza Cavalcante, Expedito Silva Nasciment. The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris). Neuroscience research. vol 112. 2016-12-28. PMID:27349153. |
the dopamine (da) neurons of the retrorubral field (rrf - a8), the substantia nigra (sn - a9), and the ventral tegmental area (vta - a10) have been implicated in motor regulation, reward, aversion, cognition, and several neuropsychiatric disorders. |
2016-12-28 |
2023-08-13 |
Not clear |
| Candace H Carriere, Na Hyea Kang, Lennard P Nile. Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson's disease. Brain research. vol 1633. 2016-12-26. PMID:26740407. |
stereological cell counts indicated a significant (p<0.05) decrease in dopamine neurons in the substantia nigra of rotenone-lesioned animals, which was confirmed by nissl staining. |
2016-12-26 |
2023-08-13 |
rat |
| Gessynger Morais-Silva, Mariane Ferreira-Santos, Marcelo T Mari. Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice. Behavioural brain research. vol 305. 2016-12-16. PMID:26924015. |
the blockade of h3 receptors and ethanol seem to interact in the modulation of dopaminergic neurotransmission of nigrostriatal pathway, decreasing dopamine metabolites in substantia nigra. |
2016-12-16 |
2023-08-13 |
mouse |