| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Ae Lee, Hyo Jin Son, Ki Duk Park, Se Hee Han, Nari Shin, Ji Hyun Kim, Hye Ri Kim, Dong Jin Kim, Onyou Hwan. A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson's Disease Models. Neurotoxicity research. vol 28. issue 4. 2016-07-21. PMID:26233727. |
parkinson's disease (pd) is a progressive neurodegenerative disorder accompanied by a selective loss of the dopamine(da)ergic neurons residing in the substantia nigra. |
2016-07-21 |
2023-08-13 |
Not clear |
| Jacqueline A Bayliss, Moyra B Lemus, Romana Stark, Vanessa V Santos, Aiysha Thompson, Daniel J Rees, Sandra Galic, John D Elsworth, Bruce E Kemp, Jeffrey S Davies, Zane B Andrew. Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961958. |
cr attenuated the mptp-induced loss of substantia nigra (sn) dopamine neurons and striatal dopamine turnover in ghrelin wt but not ko mice, demonstrating that ghrelin mediates cr's neuroprotective effect. |
2016-07-19 |
2023-08-13 |
mouse |
| M B Youdim, N Zamir, S Yehud. The Involvement of Enkephalin System in Analgesia Induced by Brain Iron Deficiency. Nutritional neuroscience. vol 3. issue 5. 2016-07-16. PMID:27414134. |
furthermore, the levels of dynorphin b and met-enkephalin are significantly increased in dopamine opiate-rich brain areas (caudate nucleus, substantia nigra, nucleus accumbens and globus pallidus) during id. |
2016-07-16 |
2023-08-13 |
rat |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| B K Binukumar, Harish C Pan. TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease. Neural regeneration research. vol 11. issue 5. 2016-06-23. PMID:27335538. |
pd is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2016-06-23 |
2023-08-13 |
mouse |
| Omidreza Jafarieh, Shadab Md, Mushir Ali, Sanjula Baboota, J K Sahni, Bhavna Kumari, Aseem Bhatnagar, Javed Al. Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting. Drug development and industrial pharmacy. vol 41. issue 10. 2016-06-15. PMID:25496439. |
parkinson disease (pd) is a common, progressive neurodegenerative disorder, characterized by marked depletion of striatal dopamine and degeneration of dopaminergic neurons in the substantia nigra. |
2016-06-15 |
2023-08-13 |
Not clear |
| Yan Liu, Jian-Dong Sun, Lian-Kun Song, Jing Li, Shi-Feng Chu, Yu-He Yuan, Nai-Hong Che. Environment-contact administration of rotenone: A new rodent model of Parkinson's disease. Behavioural brain research. vol 294. 2016-06-14. PMID:26239001. |
accordingly, rotenone caused significant dopamine depletion from the striatum (hplc analysis), nigrostriatal degeneration (quantitative tyrosine hydroxylase immunohistochemistry and western blot), and accumulation of α-synuclein in the substantia nigra and striatum (α-synuclein immunohistochemistry) in a time-dependent manner. |
2016-06-14 |
2023-08-13 |
mouse |
| YanFang Zhang, YiMei Chen, Lin Li, Christian Hölsche. Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model. Behavioural brain research. vol 293. 2016-06-02. PMID:26187689. |
(val8)glp-1-glu-pal showed good effects in preventing the mptp-induced motor impairment (rotarod, open field locomotion, swim test), reduction in tyrosine hydroxylase levels (dopamine synthesis) in the substantia nigra, a reduction of activated caspase 3 levels, of tunel positive cell numbers, of the pro-apoptotic signaling molecule bax and an increase in the growth signaling molecule bcl-2. |
2016-06-02 |
2023-08-13 |
mouse |
| Stephanie C Gantz, Erica S Levitt, Nerea Llamosas, Kim A Neve, John T William. Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA. Cell reports. vol 12. issue 6. 2016-05-27. PMID:26235617. |
application of l-dopa augmented the d2-receptor-mediated inhibitory postsynaptic current (ipsc) in dopamine neurons of the substantia nigra. |
2016-05-27 |
2023-08-13 |
mouse |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Lalitha Madhavan, Brian F Daley, Beverly L Davidson, Ryan L Boudreau, Jack W Lipton, Allyson Cole-Strauss, Kathy Steece-Collier, Timothy J Collie. Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PloS one. vol 10. issue 9. 2016-05-20. PMID:26340267. |
using rna silencing, the current study investigated the roles of two donor npc molecules, namely glial cell-line derived neurotrophic factor (gdnf) and sonic hedgehog (shh), in the protection of substantia nigra dopamine neurons in rats treated with 6-hydroxydopamine (6-ohda). |
2016-05-20 |
2023-08-13 |
rat |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mechanisms of ageing and development. vol 149. 2016-05-10. PMID:26065381. |
age-related gene expression changes in substantia nigra dopamine neurons of the rat. |
2016-05-10 |
2023-08-13 |
rat |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mechanisms of ageing and development. vol 149. 2016-05-10. PMID:26065381. |
however, while the dopamine deficit in pd is due to degeneration of substantia nigra (sn) dopamine (da) neurons, it is unclear whether there is sufficient loss of sn da neurons with ageing to explain observed motor impairments. |
2016-05-10 |
2023-08-13 |
rat |
| Paul F Kramer, John T William. Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25829143. |
the present study examines cocaine-induced plasticity of mglur-dependent currents in dopamine neurons in the substantia nigra. |
2016-05-09 |
2023-08-13 |
Not clear |
| W Liu, J Jalewa, M Sharma, G Li, L Li, C Hölsche. Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience. vol 303. 2016-05-06. PMID:26141845. |
both liraglutide and lixisenatide showed effects in preventing the mptp-induced motor impairment (rotarod, open-field locomotion, catalepsy test), reduction in tyrosine hydroxylase (th) levels (dopamine synthesis) in the substantia nigra and basal ganglia, a reduction of the pro-apoptotic signaling molecule bax and an increase in the anti-apoptotic signaling molecule b-cell lymphoma-2. |
2016-05-06 |
2023-08-13 |
mouse |
| Jin H Nam, Eun S Park, So-Yoon Won, Yu A Lee, Kyoung I Kim, Jae Y Jeong, Jeong Y Baek, Eun J Cho, Minyoung Jin, Young C Chung, Byoung D Lee, Sung Hyun Kim, Eung-Gook Kim, Kyunghee Byun, Bonghee Lee, Dong Ho Woo, C Justin Lee, Sang R Kim, Eugene Bok, Yoon-Seong Kim, Tae-Beom Ahn, Hyuk Wan Ko, Saurav Brahmachari, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson, Byung K Ji. TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain : a journal of neurology. vol 138. issue Pt 12. 2016-05-04. PMID:26490328. |
western blot and immunohistochemical analysis of human post-mortem substantia nigra from parkinson's disease suggests that this endogenous neuroprotective system (trpv1 and cntf on astrocytes, and cntfrα on dopamine neurons) might have relevance to human parkinson's disease. |
2016-05-04 |
2023-08-13 |
human |
| LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutte. Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model. PloS one. vol 10. issue 7. 2016-05-03. PMID:26135399. |
among all the cortical regions assessed, forward step-wise regression analyses indicated that only stereologic cell counts in vta, and not counts in the substantia nigra (sn), predict dopamine transporter changes in ic. |
2016-05-03 |
2023-08-13 |
monkey |
| Merja H Voutilainen, Urmas Arumäe, Mikko Airavaara, Mart Saarm. Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease. FEBS letters. vol 589. issue 24 Pt A. 2016-04-29. PMID:26450777. |
parkinson's disease (pd) is a progressive neurodegenerative disorder where dopamine (da) neurons in the substantia nigra degenerate and die. |
2016-04-29 |
2023-08-13 |
Not clear |
| Christine E Briggs, Yulei Wang, Benjamin Kong, Tsung-Ung W Woo, Lakshmanan K Iyer, Kai C Sonnta. Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network. Brain research. vol 1618. 2016-04-25. PMID:26047984. |
the degeneration of substantia nigra (sn) dopamine (da) neurons in sporadic parkinson׳s disease (pd) is characterized by disturbed gene expression networks. |
2016-04-25 |
2023-08-13 |
Not clear |
| Krystyna Stepień, Anna Dzierzega-Lecznar, Irena Ta. [The role of neuromelanin in Parkinson's disease--new concepts]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 11-12. 2016-04-23. PMID:18540183. |
progressive degeneration of dopaminergic neurons of the substantia nigra and the resulting dopamine deficiency in the striatum are neuropathological basis of the movement disorders in parkinson's disease (pd). |
2016-04-23 |
2023-08-12 |
Not clear |