| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie C Gantz, Erica S Levitt, Nerea Llamosas, Kim A Neve, John T William. Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA. Cell reports. vol 12. issue 6. 2016-05-27. PMID:26235617. |
application of l-dopa augmented the d2-receptor-mediated inhibitory postsynaptic current (ipsc) in dopamine neurons of the substantia nigra. |
2016-05-27 |
2023-08-13 |
mouse |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Lalitha Madhavan, Brian F Daley, Beverly L Davidson, Ryan L Boudreau, Jack W Lipton, Allyson Cole-Strauss, Kathy Steece-Collier, Timothy J Collie. Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PloS one. vol 10. issue 9. 2016-05-20. PMID:26340267. |
using rna silencing, the current study investigated the roles of two donor npc molecules, namely glial cell-line derived neurotrophic factor (gdnf) and sonic hedgehog (shh), in the protection of substantia nigra dopamine neurons in rats treated with 6-hydroxydopamine (6-ohda). |
2016-05-20 |
2023-08-13 |
rat |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mechanisms of ageing and development. vol 149. 2016-05-10. PMID:26065381. |
age-related gene expression changes in substantia nigra dopamine neurons of the rat. |
2016-05-10 |
2023-08-13 |
rat |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mechanisms of ageing and development. vol 149. 2016-05-10. PMID:26065381. |
however, while the dopamine deficit in pd is due to degeneration of substantia nigra (sn) dopamine (da) neurons, it is unclear whether there is sufficient loss of sn da neurons with ageing to explain observed motor impairments. |
2016-05-10 |
2023-08-13 |
rat |
| Paul F Kramer, John T William. Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25829143. |
the present study examines cocaine-induced plasticity of mglur-dependent currents in dopamine neurons in the substantia nigra. |
2016-05-09 |
2023-08-13 |
Not clear |
| W Liu, J Jalewa, M Sharma, G Li, L Li, C Hölsche. Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience. vol 303. 2016-05-06. PMID:26141845. |
both liraglutide and lixisenatide showed effects in preventing the mptp-induced motor impairment (rotarod, open-field locomotion, catalepsy test), reduction in tyrosine hydroxylase (th) levels (dopamine synthesis) in the substantia nigra and basal ganglia, a reduction of the pro-apoptotic signaling molecule bax and an increase in the anti-apoptotic signaling molecule b-cell lymphoma-2. |
2016-05-06 |
2023-08-13 |
mouse |
| Jin H Nam, Eun S Park, So-Yoon Won, Yu A Lee, Kyoung I Kim, Jae Y Jeong, Jeong Y Baek, Eun J Cho, Minyoung Jin, Young C Chung, Byoung D Lee, Sung Hyun Kim, Eung-Gook Kim, Kyunghee Byun, Bonghee Lee, Dong Ho Woo, C Justin Lee, Sang R Kim, Eugene Bok, Yoon-Seong Kim, Tae-Beom Ahn, Hyuk Wan Ko, Saurav Brahmachari, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson, Byung K Ji. TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain : a journal of neurology. vol 138. issue Pt 12. 2016-05-04. PMID:26490328. |
western blot and immunohistochemical analysis of human post-mortem substantia nigra from parkinson's disease suggests that this endogenous neuroprotective system (trpv1 and cntf on astrocytes, and cntfrα on dopamine neurons) might have relevance to human parkinson's disease. |
2016-05-04 |
2023-08-13 |
human |
| LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutte. Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model. PloS one. vol 10. issue 7. 2016-05-03. PMID:26135399. |
among all the cortical regions assessed, forward step-wise regression analyses indicated that only stereologic cell counts in vta, and not counts in the substantia nigra (sn), predict dopamine transporter changes in ic. |
2016-05-03 |
2023-08-13 |
monkey |
| Merja H Voutilainen, Urmas Arumäe, Mikko Airavaara, Mart Saarm. Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease. FEBS letters. vol 589. issue 24 Pt A. 2016-04-29. PMID:26450777. |
parkinson's disease (pd) is a progressive neurodegenerative disorder where dopamine (da) neurons in the substantia nigra degenerate and die. |
2016-04-29 |
2023-08-13 |
Not clear |
| Christine E Briggs, Yulei Wang, Benjamin Kong, Tsung-Ung W Woo, Lakshmanan K Iyer, Kai C Sonnta. Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network. Brain research. vol 1618. 2016-04-25. PMID:26047984. |
the degeneration of substantia nigra (sn) dopamine (da) neurons in sporadic parkinson׳s disease (pd) is characterized by disturbed gene expression networks. |
2016-04-25 |
2023-08-13 |
Not clear |
| Krystyna Stepień, Anna Dzierzega-Lecznar, Irena Ta. [The role of neuromelanin in Parkinson's disease--new concepts]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 11-12. 2016-04-23. PMID:18540183. |
progressive degeneration of dopaminergic neurons of the substantia nigra and the resulting dopamine deficiency in the striatum are neuropathological basis of the movement disorders in parkinson's disease (pd). |
2016-04-23 |
2023-08-12 |
Not clear |
| Bo Zhang, Kun Ma, Baixiang L. Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra. The Journal of toxicological sciences. vol 40. issue 4. 2016-04-19. PMID:26165640. |
increasing evidence indicates that atr plays a critical role in inducing physiological changes to the endocrine and reproductive systems, and further may affect the nigrostriatal dopaminergic system in the diencephalon, resulting in altered dopamine (da) levels in the striatum, transport and storage-related protein abnormalities in the synaptic terminals, motor function deficits, and degeneration of da neurons in the substantia nigra (sn). |
2016-04-19 |
2023-08-13 |
rat |
| J Hong, S Sha, L Zhou, C Wang, J Yin, L Che. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell death & disease. vol 6. 2016-04-12. PMID:26203861. |
the pharmacological or genetic inactivation of σ1r suppressed the expression of dopamine transporter (dat) in substantia nigra, which was corrected by nmda. |
2016-04-12 |
2023-08-13 |
mouse |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Xuejing Wang, Mingming Ma, Junfang Teng, Jiewen Zhang, Shuang Zhou, Ying Zhang, Erxi Wu, Xuebing Din. Chronic exposure to cerebrospinal fluid of multiple system atrophy in neuroblastoma and glioblastoma cells induces cytotoxicity via ER stress and autophagy activation. Oncotarget. vol 6. issue 15. 2016-04-07. PMID:25965819. |
specifically, dopamine neurons in substantia nigra and purkinje cells in cerebellum cortex were degenerated in msa-csf-injected mice. |
2016-04-07 |
2023-08-13 |
mouse |
| Richa Pahuja, Kavita Seth, Anshi Shukla, Rajendra Kumar Shukla, Priyanka Bhatnagar, Lalit Kumar Singh Chauhan, Prem Narain Saxena, Jharna Arun, Bhushan Pradosh Chaudhari, Devendra Kumar Patel, Sheelendra Pratap Singh, Rakesh Shukla, Vinay Kumar Khanna, Pradeep Kumar, Rajnish Kumar Chaturvedi, Kailash Chand Gupt. Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats. ACS nano. vol 9. issue 5. 2016-04-05. PMID:25825926. |
dopamine delivered through nps did not cause additional generation of ros, dopaminergic neuron degeneration, and ultrastructural changes in the striatum and substantia nigra as compared to 6-ohda-lesioned rats. |
2016-04-05 |
2023-08-13 |
rat |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
parkinson's disease (pd) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. |
2016-04-05 |
2023-08-13 |
mouse |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
the results showed that compound-23 inhibited mptp-induced reduction of retention time on the rotor rod bar, neuronal cell death in the substantia nigra and striatum and dopamine content in wild-type mice but not in dj-1-knockout mice, indicating a dj-1-dependent effect of compound-23. |
2016-04-05 |
2023-08-13 |
mouse |
| Satoshi Ikemoto, Chen Yang, Aaron Ta. Basal ganglia circuit loops, dopamine and motivation: A review and enquiry. Behavioural brain research. vol 290. 2016-04-04. PMID:25907747. |
accumulating evidence suggests that such motivational role of dopamine neurons is not limited to those located in the ventral tegmental area, but also in the substantia nigra. |
2016-04-04 |
2023-08-13 |
Not clear |