| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norifumi Shioda, Masahiro Sawai, Yuta Ishizuka, Tomoaki Shirao, Kohji Fukunag. Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26163515. |
in support of this idea, chronic administration of the dopamine d2 receptor partial agonist aripiprazole increased pp1 activity and promoted nuclear camkiiδ3 translocation and bdnf expression in the rat brain substantia nigra. |
2015-11-20 |
2023-08-13 |
rat |
| Benjamin H M Hunn, Stephanie J Cragg, J Paul Bolam, Maria-Grazia Spillantini, Richard Wade-Martin. Impaired intracellular trafficking defines early Parkinson's disease. Trends in neurosciences. vol 38. issue 3. 2015-11-17. PMID:25639775. |
it is defined at post-mortem by the loss of dopamine neurons in the substantia nigra together with the presence of lewy bodies and lewy neurites. |
2015-11-17 |
2023-08-13 |
human |
| Ying Dai, Joanne Clark, Kangni Zheng, Gregory C Kujoth, Tomas A Prolla, David K Simo. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicology and teratology. vol 46. 2015-11-16. PMID:25450660. |
in contrast, we find that susceptibility to mptp in both heterozygous and homozygous polg mutator mice at this young age is not different from that of wild type littermate controls as measured by levels of tyrosine hydroxylase positive (th+) striatal terminals, striatal dopamine and its metabolites, a marker of oxidative damage, or stereological counts of th+ and total substantia nigra neurons. |
2015-11-16 |
2023-08-13 |
mouse |
| Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Rui. The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease. PloS one. vol 10. issue 2. 2015-11-16. PMID:25693197. |
the progressive degeneration of the dopamine neurons of the pars compacta of substantia nigra and the consequent loss of the dopamine innervation of the striatum leads to the impairment of motor behavior in parkinson's disease. |
2015-11-16 |
2023-08-13 |
rat |
| Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Rui. The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease. PloS one. vol 10. issue 2. 2015-11-16. PMID:25693197. |
accordingly, an efficient therapy of the disease should protect and regenerate the dopamine neurons of the substantia nigra and the dopamine innervation of the striatum. |
2015-11-16 |
2023-08-13 |
rat |
| L Zhao, L X He, S N Huang, L J Gong, L Li, Y Y Lv, Z M Qia. Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease. Physiological research. vol 63. issue 5. 2015-11-09. PMID:24908088. |
here, we investigated the effects of longer duration (4 weeks) of low amplitude vibration (lav) training on the numbers of dopaminergic neurons in the substantia nigra by immunostaining and the levels of dopamine (da) and brain-derived neurotrophic factor (bdnf) in the striatum by hplc and elisa in the chronic mptp lesion mouse. |
2015-11-09 |
2023-08-13 |
mouse |
| Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayam. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology. vol 28. issue 4. 2015-11-05. PMID:26538809. |
treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). |
2015-11-05 |
2023-08-13 |
mouse |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat. Current aging science. vol 7. issue 3. 2015-10-26. PMID:25612740. |
increased mitochondrial dna deletions in substantia nigra dopamine neurons of the aged rat. |
2015-10-26 |
2023-08-13 |
human |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
regulation of dopamine d₃ receptor in the striatal regions and substantia nigra in diffuse lewy body disease. |
2015-10-20 |
2023-08-12 |
Not clear |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
in this study, a novel d₃-preferring radioligand [(3)h]wc-10 and a d₂-preferring radioligand [(3)h]raclopride were used and the absolute densities of the dopamine d₃ and d₂ receptors were determined in the striatal regions and substantia nigra (sn) from postmortem brains from five cases of dlbd, which included dementia with lewy bodies (dlb, n=4) and parkinson disease dementia (pdd, n=1). |
2015-10-20 |
2023-08-12 |
Not clear |
| Guanghui Zhu, Ganping Chen, Lu Shi, Jenny Feng, Yan Wang, Chaohui Ye, Wenke Feng, Jianlou Niu, Zhifeng Huan. PEGylated rhFGF-2 conveys long-term neuroprotection and improves neuronal function in a rat model of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24930088. |
the in vivo data showed that, compared with native rhfgf-2, pegylated rhfgf-2 was more efficacious in preventing 6-ohda-induced lesion upon tyrosine hydroxylase-positive neurons in the substantia nigra (sn), improving the apomorphine-induced rotational behavior and the 6-ohda-induced decline in tissue concentration of dopamine (da) and its metabolites. |
2015-10-20 |
2023-08-13 |
human |
| Francesco Brigo, Roberto Erro, Antonio Marangi, Kailash Bhatia, Michele Tinazz. Differentiating drug-induced parkinsonism from Parkinson's disease: an update on non-motor symptoms and investigations. Parkinsonism & related disorders. vol 20. issue 8. 2015-10-16. PMID:24935237. |
we therefore performed a review to ascertain whether assessment of non-motor symptoms, or use of ancillary investigations, namely dopamine transporter imaging, transcranial sonography of the substantia nigra, and scintigraphy for myocardial sympathetic innervation, can be recommended to distinguish between these conditions. |
2015-10-16 |
2023-08-13 |
Not clear |
| Giulia Costa, Nicola Simola, Micaela Morell. MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex. Psychopharmacology. vol 231. issue 20. 2015-10-12. PMID:24687411. |
we have recently shown that chronic exposure to 3,4-methylenedioxymethamphetamine (mdma, "ecstasy") of adolescent mice exacerbates dopamine neurotoxicity and neuroinflammatory effects elicited by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in the substantia nigra and striatum at adulthood. |
2015-10-12 |
2023-08-12 |
mouse |
| M M Migliore, R Ortiz, S Dye, R B Campbell, M M Amiji, B L Waszcza. Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson's disease. Neuroscience. vol 274. 2015-10-07. PMID:24845869. |
glial cell line-derived neurotrophic factor (gdnf) exerts neurotrophic and neuroprotective effects on substantia nigra (sn) dopamine neurons and has great therapeutic potential for parkinson's disease (pd). |
2015-10-07 |
2023-08-13 |
rat |
| Carolina Cebrián, Fabio A Zucca, Pierluigi Mauri, Julius A Steinbeck, Lorenz Studer, Clemens R Scherzer, Ellen Kanter, Sadna Budhu, Jonathan Mandelbaum, Jean P Vonsattel, Luigi Zecca, John D Loike, David Sulze. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nature communications. vol 5. 2015-09-30. PMID:24736453. |
here we provide evidence from immunolabel, rna expression and mass spectrometry analysis of postmortem samples that human catecholaminergic substantia nigra and locus coeruleus neurons express mhc-i, and that this molecule is inducible in human stem cell-derived dopamine (da) neurons. |
2015-09-30 |
2023-08-13 |
human |
| Robert A McGovern, Andrew K Chan, Charles B Mikell, John P Sheehy, Vincent P Ferrera, Guy M McKhan. Human substantia nigra neurons encode decision outcome and are modulated by categorization uncertainty in an auditory categorization task. Physiological reports. vol 3. issue 9. 2015-09-29. PMID:26416969. |
to clarify the role of substantia nigra dopamine neurons in uncertain perceptual decision making, we investigated their behavior using single neuron extracellular recordings in patients with parkinson's disease undergoing deep brain stimulation. |
2015-09-29 |
2023-08-13 |
human |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. |
2015-09-21 |
2023-08-13 |
human |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (sn). |
2015-09-21 |
2023-08-13 |
human |
| Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Canno. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25174649. |
at ages of 4, 8, and 12 months, our characterization showed that expression of g2019s lrrk2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons. |
2015-09-21 |
2023-08-13 |
human |
| X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang, H Lo. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. vol 286. 2015-09-14. PMID:25449120. |
moreover, dmf ameliorated dopaminergic neurotoxicity in 6-ohda-induced pd animal models as evidenced by amelioration of locomotor dysfunction, loss in striatal dopamine, and reductions in dopaminergic neurons in the substantia nigra and striatum. |
2015-09-14 |
2023-08-13 |
mouse |