| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashim. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25627674. |
the globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. |
2015-12-31 |
2023-08-13 |
human |
| Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huan. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-12-15. PMID:26664824. |
levels in the redox system, dopamine (da) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (sn) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of gsh + tet (or gsh) and/or l-3,4-dihydroxyphenylalanine (l-dopa) to pd rats. |
2015-12-15 |
2023-08-13 |
rat |
| Yan-Na Wu, Steven W Johnso. Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons. Brain research. vol 1603. 2015-12-07. PMID:25656790. |
memantine selectively blocks extrasynaptic nmda receptors in rat substantia nigra dopamine neurons. |
2015-12-07 |
2023-08-13 |
rat |
| Yan-Na Wu, Steven W Johnso. Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons. Brain research. vol 1603. 2015-12-07. PMID:25656790. |
we recorded whole-cell currents with patch pipettes to characterize the ability of memantine, a low-affinity nmda channel blocker, to block synaptic and extrasynaptic nmda receptors in substantia nigra zona compacta (snc) dopamine neurons in slices of rat brain. |
2015-12-07 |
2023-08-13 |
rat |
| Hongyan Gou, Di Wen, Chunling Ma, Ming Li, Yingmin Li, Wenfang Zhang, Li Liu, Bin Con. Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice. Behavioural brain research. vol 283. 2015-12-02. PMID:25629941. |
cck-8 pretreatment attenuated meth (10mg/kg)-induced hyperthermia, the decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum, and th in the substantia nigra. |
2015-12-02 |
2023-08-13 |
mouse |
| Hong Guo, Fang Shi, Meijiao Li, Qingqing Liu, Bin Yu, Limin H. Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system. BMC complementary and alternative medicine. vol 15. 2015-11-30. PMID:25994206. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2015-11-30 |
2023-08-13 |
Not clear |
| Edyta Możdżeń, Małgorzata Kajta, Agnieszka Wąsik, Tomasz Lenda, Lucyna Antkiewicz-Michalu. Salsolinol, an endogenous compound triggers a two-phase opposing action in the central nervous system. Neurotoxicity research. vol 27. issue 3. 2015-11-25. PMID:25537852. |
ex vivo studies indicated that both acute and chronic administration of salsolinol did not affect the dopamine metabolism, its striatal concentration or α-synuclein and tyrosine hydroxylase protein level in the rat substantia nigra and striatum. |
2015-11-25 |
2023-08-13 |
mouse |
| Shengyuan Ding, Li Li, Fu-Ming Zho. Nigral dopamine loss induces a global upregulation of presynaptic dopamine D1 receptor facilitation of the striatonigral GABAergic output. Journal of neurophysiology. vol 113. issue 6. 2015-11-25. PMID:25552639. |
in parkinson's disease (pd), the dopamine (da) neuron loss in the substantia nigra and the da axon loss in the dorsal striatum are severe, but da neurons in the ventral tegmental area and da axons in middle and ventral striatal subregions are less affected. |
2015-11-25 |
2023-08-13 |
mouse |
| Norifumi Shioda, Masahiro Sawai, Yuta Ishizuka, Tomoaki Shirao, Kohji Fukunag. Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26163515. |
in support of this idea, chronic administration of the dopamine d2 receptor partial agonist aripiprazole increased pp1 activity and promoted nuclear camkiiδ3 translocation and bdnf expression in the rat brain substantia nigra. |
2015-11-20 |
2023-08-13 |
rat |
| Benjamin H M Hunn, Stephanie J Cragg, J Paul Bolam, Maria-Grazia Spillantini, Richard Wade-Martin. Impaired intracellular trafficking defines early Parkinson's disease. Trends in neurosciences. vol 38. issue 3. 2015-11-17. PMID:25639775. |
it is defined at post-mortem by the loss of dopamine neurons in the substantia nigra together with the presence of lewy bodies and lewy neurites. |
2015-11-17 |
2023-08-13 |
human |
| Ying Dai, Joanne Clark, Kangni Zheng, Gregory C Kujoth, Tomas A Prolla, David K Simo. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicology and teratology. vol 46. 2015-11-16. PMID:25450660. |
in contrast, we find that susceptibility to mptp in both heterozygous and homozygous polg mutator mice at this young age is not different from that of wild type littermate controls as measured by levels of tyrosine hydroxylase positive (th+) striatal terminals, striatal dopamine and its metabolites, a marker of oxidative damage, or stereological counts of th+ and total substantia nigra neurons. |
2015-11-16 |
2023-08-13 |
mouse |
| Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Rui. The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease. PloS one. vol 10. issue 2. 2015-11-16. PMID:25693197. |
the progressive degeneration of the dopamine neurons of the pars compacta of substantia nigra and the consequent loss of the dopamine innervation of the striatum leads to the impairment of motor behavior in parkinson's disease. |
2015-11-16 |
2023-08-13 |
rat |
| Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Rui. The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease. PloS one. vol 10. issue 2. 2015-11-16. PMID:25693197. |
accordingly, an efficient therapy of the disease should protect and regenerate the dopamine neurons of the substantia nigra and the dopamine innervation of the striatum. |
2015-11-16 |
2023-08-13 |
rat |
| L Zhao, L X He, S N Huang, L J Gong, L Li, Y Y Lv, Z M Qia. Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease. Physiological research. vol 63. issue 5. 2015-11-09. PMID:24908088. |
here, we investigated the effects of longer duration (4 weeks) of low amplitude vibration (lav) training on the numbers of dopaminergic neurons in the substantia nigra by immunostaining and the levels of dopamine (da) and brain-derived neurotrophic factor (bdnf) in the striatum by hplc and elisa in the chronic mptp lesion mouse. |
2015-11-09 |
2023-08-13 |
mouse |
| Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayam. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology. vol 28. issue 4. 2015-11-05. PMID:26538809. |
treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). |
2015-11-05 |
2023-08-13 |
mouse |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat. Current aging science. vol 7. issue 3. 2015-10-26. PMID:25612740. |
increased mitochondrial dna deletions in substantia nigra dopamine neurons of the aged rat. |
2015-10-26 |
2023-08-13 |
human |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
regulation of dopamine d₃ receptor in the striatal regions and substantia nigra in diffuse lewy body disease. |
2015-10-20 |
2023-08-12 |
Not clear |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
in this study, a novel d₃-preferring radioligand [(3)h]wc-10 and a d₂-preferring radioligand [(3)h]raclopride were used and the absolute densities of the dopamine d₃ and d₂ receptors were determined in the striatal regions and substantia nigra (sn) from postmortem brains from five cases of dlbd, which included dementia with lewy bodies (dlb, n=4) and parkinson disease dementia (pdd, n=1). |
2015-10-20 |
2023-08-12 |
Not clear |
| Guanghui Zhu, Ganping Chen, Lu Shi, Jenny Feng, Yan Wang, Chaohui Ye, Wenke Feng, Jianlou Niu, Zhifeng Huan. PEGylated rhFGF-2 conveys long-term neuroprotection and improves neuronal function in a rat model of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24930088. |
the in vivo data showed that, compared with native rhfgf-2, pegylated rhfgf-2 was more efficacious in preventing 6-ohda-induced lesion upon tyrosine hydroxylase-positive neurons in the substantia nigra (sn), improving the apomorphine-induced rotational behavior and the 6-ohda-induced decline in tissue concentration of dopamine (da) and its metabolites. |
2015-10-20 |
2023-08-13 |
human |
| Francesco Brigo, Roberto Erro, Antonio Marangi, Kailash Bhatia, Michele Tinazz. Differentiating drug-induced parkinsonism from Parkinson's disease: an update on non-motor symptoms and investigations. Parkinsonism & related disorders. vol 20. issue 8. 2015-10-16. PMID:24935237. |
we therefore performed a review to ascertain whether assessment of non-motor symptoms, or use of ancillary investigations, namely dopamine transporter imaging, transcranial sonography of the substantia nigra, and scintigraphy for myocardial sympathetic innervation, can be recommended to distinguish between these conditions. |
2015-10-16 |
2023-08-13 |
Not clear |