| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Artur Dawid Surowka, Pawel Wrobel, Dariusz Adamek, Edyta Radwanska, Magdalena Szczerbowska-Boruchowsk. Synchrotron radiation based X-ray fluorescence shows changes in the elemental composition of the human substantia nigra in aged brains. Metallomics : integrated biometal science. vol 7. issue 11. 2016-08-23. PMID:26440290. |
in particular, it is thought that the human substantia nigra might play a pivotal role in age-associated dopamine depletion which could be responsible for neuronal demise and subsequent emergence of different neurological alterations. |
2016-08-23 |
2023-08-13 |
human |
| Christina Poetschke, Elena Dragicevic, Johanna Duda, Julia Benkert, Antonios Dougalis, Roberta DeZio, Terrance P Snutch, Joerg Striessnig, Birgit Lis. Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports. vol 5. 2016-08-19. PMID:26381090. |
compensatory t-type ca2+ channel activity alters d2-autoreceptor responses of substantia nigra dopamine neurons from cav1.3 l-type ca2+ channel ko mice. |
2016-08-19 |
2023-08-13 |
mouse |
| Christina Poetschke, Elena Dragicevic, Johanna Duda, Julia Benkert, Antonios Dougalis, Roberta DeZio, Terrance P Snutch, Joerg Striessnig, Birgit Lis. Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports. vol 5. 2016-08-19. PMID:26381090. |
the preferential degeneration of substantia nigra dopamine midbrain neurons (sn da) causes the motor-symptoms of parkinson's disease (pd). |
2016-08-19 |
2023-08-13 |
mouse |
| Miae Jang, Ki Bum Um, Jinyoung Jang, Hyun Jin Kim, Hana Cho, Sungkwon Chung, Myoung Kyu Par. Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. Scientific reports. vol 5. 2016-08-15. PMID:26435058. |
coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. |
2016-08-15 |
2023-08-13 |
mouse |
| Miae Jang, Ki Bum Um, Jinyoung Jang, Hyun Jin Kim, Hana Cho, Sungkwon Chung, Myoung Kyu Par. Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. Scientific reports. vol 5. 2016-08-15. PMID:26435058. |
dopamine neurons of the substantia nigra have long been believed to have multiple aspiny dendrites which receive many glutamatergic synaptic inputs from several regions of the brain. |
2016-08-15 |
2023-08-13 |
mouse |
| WeiZhen Liu, Yanwei Li, Jaishree Jalewa, Taylor Saunders-Wood, Lin Li, Christian Hölsche. Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. European journal of pharmacology. vol 765. 2016-08-12. PMID:26302060. |
oxy treatment prevented or reversed the mptp- induced motor impairment (rotarod, spontaneous locomotion, swim activity, muscle strength test), the mptp-induced reduction in tyrosine hydroxylase (th) levels (dopamine synthesis) in the substantia nigra and basal ganglia, the reduction of the synaptic marker synapstophysin, the inactivation of the growth factor kinase akt/pkb and of the anti-apoptotic signaling molecule bcl-2, and the increase of levels of the pro-inflammatory cytokine tnf-α. |
2016-08-12 |
2023-08-13 |
mouse |
| Jun-Jun Zhou, Shen-Yu Zhai, Hui-Nan Zhang, Yue-Hua Wang, Xiao-Ping P. Neuroprotective effects of 3-O-demethylswertipunicoside against MPTP-induced Parkinson's disease in vivo and its antioxidant properties in vitro. Brain research. vol 1624. 2016-08-04. PMID:26210618. |
in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp)-treated mouse model of parkinson's disease (pd), 3-ods dose-dependently improved motor coordination (as shown by rotarod test), increased the contents of dopamine (da) and its metabolites in the striatum, and increased the number of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn). |
2016-08-04 |
2023-08-13 |
mouse |
| R W Morris, T D Purves-Tyson, C Shannon Weickert, D Rothmond, R Lenroot, T W Weicker. Testosterone and reward prediction-errors in healthy men and men with schizophrenia. Schizophrenia research. vol 168. issue 3. 2016-08-03. PMID:26232868. |
we also identified midbrain dopamine neurons that were androgen receptor immunoreactive, and found that androgen receptor (ar) mrna was positively correlated with tyrosine hydroxylase (th) mrna in human male substantia nigra. |
2016-08-03 |
2023-08-13 |
human |
| Kun Ma, Hao-Yu Wu, Bo Zhang, Xi He, Bai-Xiang L. Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation. Molecular bioSystems. vol 11. issue 11. 2016-08-01. PMID:26256823. |
however, atr is neurotoxic; it reduces dopamine levels in the substantia nigra and corpus striatum in the midbrain, affects the absorption of synaptic vesicles and synaptic bodies, and interferes with dopamine storage and uptake in synaptic vesicles, leading to neurodegenerative disorders. |
2016-08-01 |
2023-08-13 |
human |
| A R Wild, M Bollands, P G Morris, S Jone. Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons. The European journal of neuroscience. vol 42. issue 9. 2016-07-27. PMID:26370007. |
in substantia nigra dopamine neurons, activation of nmdars beyond the synapse during different frequencies of presynaptic stimulation has not been explored, even though excitatory afferents from the subthalamic nucleus show a range of firing frequencies, and these frequencies change in human and experimental parkinson's disease. |
2016-07-27 |
2023-08-13 |
mouse |
| A R Wild, M Bollands, P G Morris, S Jone. Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons. The European journal of neuroscience. vol 42. issue 9. 2016-07-27. PMID:26370007. |
these regulatory mechanisms may be essential in the substantia nigra for restricting glutamate diffusion from synaptic sites and keeping nmdar-epscs in dopamine neurons relatively small and fast. |
2016-07-27 |
2023-08-13 |
mouse |
| Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Rajamani Barathidasan, Chidambaram SaravanaBabu, Gilles J Guillemin, Mohammed A S Kha. Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice. PloS one. vol 11. issue 1. 2016-07-26. PMID:26765842. |
injections (once in 3.5 days for 5 weeks) of mptp/p or exposure to cms for 4 weeks, the behavioural (motor and non-motor) impairments, levels and expressions of dopamine (da), serotonin (5-ht), daergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporters-2 (vmat 2) and α-synuclein in nigrostriatal (striatum (st) and substantia nigra (sn)) and extra-nigrostriatal (hippocampus, cortex and cerebellum) tissues were analysed. |
2016-07-26 |
2023-08-13 |
mouse |
| Ji Ae Lee, Hyo Jin Son, Ki Duk Park, Se Hee Han, Nari Shin, Ji Hyun Kim, Hye Ri Kim, Dong Jin Kim, Onyou Hwan. A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson's Disease Models. Neurotoxicity research. vol 28. issue 4. 2016-07-21. PMID:26233727. |
parkinson's disease (pd) is a progressive neurodegenerative disorder accompanied by a selective loss of the dopamine(da)ergic neurons residing in the substantia nigra. |
2016-07-21 |
2023-08-13 |
Not clear |
| Jacqueline A Bayliss, Moyra B Lemus, Romana Stark, Vanessa V Santos, Aiysha Thompson, Daniel J Rees, Sandra Galic, John D Elsworth, Bruce E Kemp, Jeffrey S Davies, Zane B Andrew. Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961958. |
cr attenuated the mptp-induced loss of substantia nigra (sn) dopamine neurons and striatal dopamine turnover in ghrelin wt but not ko mice, demonstrating that ghrelin mediates cr's neuroprotective effect. |
2016-07-19 |
2023-08-13 |
mouse |
| M B Youdim, N Zamir, S Yehud. The Involvement of Enkephalin System in Analgesia Induced by Brain Iron Deficiency. Nutritional neuroscience. vol 3. issue 5. 2016-07-16. PMID:27414134. |
furthermore, the levels of dynorphin b and met-enkephalin are significantly increased in dopamine opiate-rich brain areas (caudate nucleus, substantia nigra, nucleus accumbens and globus pallidus) during id. |
2016-07-16 |
2023-08-13 |
rat |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| B K Binukumar, Harish C Pan. TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease. Neural regeneration research. vol 11. issue 5. 2016-06-23. PMID:27335538. |
pd is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2016-06-23 |
2023-08-13 |
mouse |
| Omidreza Jafarieh, Shadab Md, Mushir Ali, Sanjula Baboota, J K Sahni, Bhavna Kumari, Aseem Bhatnagar, Javed Al. Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting. Drug development and industrial pharmacy. vol 41. issue 10. 2016-06-15. PMID:25496439. |
parkinson disease (pd) is a common, progressive neurodegenerative disorder, characterized by marked depletion of striatal dopamine and degeneration of dopaminergic neurons in the substantia nigra. |
2016-06-15 |
2023-08-13 |
Not clear |
| Yan Liu, Jian-Dong Sun, Lian-Kun Song, Jing Li, Shi-Feng Chu, Yu-He Yuan, Nai-Hong Che. Environment-contact administration of rotenone: A new rodent model of Parkinson's disease. Behavioural brain research. vol 294. 2016-06-14. PMID:26239001. |
accordingly, rotenone caused significant dopamine depletion from the striatum (hplc analysis), nigrostriatal degeneration (quantitative tyrosine hydroxylase immunohistochemistry and western blot), and accumulation of α-synuclein in the substantia nigra and striatum (α-synuclein immunohistochemistry) in a time-dependent manner. |
2016-06-14 |
2023-08-13 |
mouse |
| YanFang Zhang, YiMei Chen, Lin Li, Christian Hölsche. Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model. Behavioural brain research. vol 293. 2016-06-02. PMID:26187689. |
(val8)glp-1-glu-pal showed good effects in preventing the mptp-induced motor impairment (rotarod, open field locomotion, swim test), reduction in tyrosine hydroxylase levels (dopamine synthesis) in the substantia nigra, a reduction of activated caspase 3 levels, of tunel positive cell numbers, of the pro-apoptotic signaling molecule bax and an increase in the growth signaling molecule bcl-2. |
2016-06-02 |
2023-08-13 |
mouse |