| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte Amalie Navntoft, Jakob Kisbye Dreye. How compensation breaks down in Parkinson's disease: Insights from modeling of denervated striatum. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 3. 2016-12-15. PMID:26890687. |
the bradykinesia and other motor signs of parkinson's disease (pd) are linked to progressive loss of substantia nigra dopamine (da) neurons innervating the striatum. |
2016-12-15 |
2023-08-13 |
Not clear |
| Shuai Zhang, Si-Yuan Shao, Xiu-Yun Song, Cong-Yuan Xia, Ya-Nan Yang, Pei-Cheng Zhang, Nai-Hong Che. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology. vol 52. 2016-12-13. PMID:26408940. |
gavage administration of fs8 (50 and 200mg/kg, but not 10mg/kg) for 25 days significantly improved the behavior function, decreased the loss of dopaminergic neurons in substantia nigra (sn), and maintained the level of dopamine in striatum after unilateral infusion of rotenone in sn. |
2016-12-13 |
2023-08-13 |
Not clear |
| Hugo Juárez Olguín, David Calderón Guzmán, Ernestina Hernández García, Gerardo Barragán Mejí. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxidative medicine and cellular longevity. vol 2016. 2016-12-13. PMID:26770661. |
dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T Zaveri, Girolamo Calò, Erwan Bezard, Michele Morar. Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease. Neurobiology of disease. vol 89. 2016-12-13. PMID:26804029. |
stereological unbiased methods were used to estimate the total number of dopamine neurons in the substantia nigra of i) nop(-/-) mice acutely treated with the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (mptp), ii) naïve mice subacutely treated with mptp, alone or in combination with sb-612111, iii) rats injected with a recombinant adeno-associated viral (aav) vector overexpressing human mutant p.a53t α-synuclein, treated with vehicle or sb-612111. |
2016-12-13 |
2023-08-13 |
mouse |
| Juan Camilo Jurado-Coronel, Marco Avila-Rodriguez, Francisco Capani, Janneth Gonzalez, Valentina Echeverria Moran, George E Barret. Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease. Current pharmaceutical design. vol 22. issue 10. 2016-12-13. PMID:26972289. |
parkinson's disease (pd) is a relatively common disorder of the central nervous system (cns), whose etiology is characterized by a selective and progressive degeneration of dopaminergic neurons, and the presence of lewy bodies in the pars compacta of the substantia nigra, and gaping dopamine depletion in the striatum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yunlong Zhang, Feng Tan, Pingyi Xu, Shaogang Q. Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson's Disease. Neural plasticity. vol 2016. 2016-12-13. PMID:26981287. |
drugs or treatments promoting the expression and function of eaats are shown to attenuate dopamine neurons death in the substantia nigra and striatum, ameliorate the behavior disorder, and improve cognitive abilities in pd animal models. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jon B Toledo, Pallavi Gopal, Kevin Raible, David J Irwin, Johannes Brettschneider, Samantha Sedor, Kayla Waits, Susana Boluda, Murray Grossman, Vivianna M Van Deerlin, Edward B Lee, Steven E Arnold, John E Duda, Howard Hurtig, Virginia M-Y Lee, Charles H Adler, Thomas G Beach, John Q Trojanowsk. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26721587. |
the dem-ad-lb individuals showed relative preservation of substantia nigra cells and dopamine active transporter in putamen. |
2016-11-08 |
2023-08-13 |
human |
| Milena Pinto, Nadee Nissanka, Susana Peralta, Roberta Brambilla, Francisca Diaz, Carlos T Morae. Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:27038906. |
the cause of the motor symptoms is the loss of dopaminergic neurons in the substantia nigra with consequent depletion of dopamine in the striatum. |
2016-11-08 |
2023-08-13 |
mouse |
| Shosuke Ito, Yuta Yamanaka, Makoto Ojika, Kazumasa Wakamats. The Metabolic Fate of ortho-Quinones Derived from Catecholamine Metabolites. International journal of molecular sciences. vol 17. issue 2. 2016-10-20. PMID:26828480. |
neuromelanin, a dark pigment present in the substantia nigra and locus coeruleus of the brain, is produced from dopamine (da) and norepinephrine (ne) via an interaction with cysteine, but it also incorporates their alcoholic and acidic metabolites. |
2016-10-20 |
2023-08-13 |
Not clear |
| Sarah J Stednitz, Briana Freshner, Samantha Shelton, Tori Shen, Donovan Black, Ethan Gahta. Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae. Neurotoxicology and teratology. vol 52. issue Pt A. 2016-10-12. PMID:26546233. |
the primary neuropathology in pd involves the death of dopaminergic cells in the substantia nigra (sn), an anatomical region of the brain implicated in dopamine production and voluntary motor control. |
2016-10-12 |
2023-08-13 |
zebrafish |
| B K Binukumar, Varsha Shukla, Niranjana D Amin, Philip Grant, M Bhaskar, Susan Skuntz, Joseph Steiner, Harish C Pan. Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease. Molecular biology of the cell. vol 26. issue 24. 2016-10-11. PMID:26399293. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2016-10-11 |
2023-08-13 |
mouse |
| S K Franke, R E van Kesteren, J A M Wubben, S Hofman, I Paliukhovich, R C van der Schors, P van Nierop, A B Smit, I H C H M Philippen. Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage. Neuroscience. vol 312. 2016-09-29. PMID:26431624. |
postmortem analyses, after the recovery period, revealed no alteration of the number and sizes of tyrosine hydroxylase (th)-positive dopamine (da) neurons in the substantia nigra. |
2016-09-29 |
2023-08-13 |
monkey |
| Michael F Salvatore, Jennifer Terrebonne, Victoria Fields, Danielle Nodurft, Cori Runfalo, Brian Latimer, Donald K Ingra. Initiation of calorie restriction in middle-aged male rats attenuates aging-related motoric decline and bradykinesia without increased striatal dopamine. Neurobiology of aging. vol 37. 2016-09-26. PMID:26610387. |
we hypothesized that nigrostriatal dopamine tissue content would be greater in the cr group and observed a modest increase only in substantia nigra with no group differences in striatum, nucleus accumbens, or ventral tegmental area. |
2016-09-26 |
2023-08-13 |
human |
| Cheng-You Zheng, Bao-Jian Guo, Wei Cai, Wei Cui, Shing-Hung Mak, Yu-Qiang Wang, Simon Ming-Yuen Lee, Yi-Fan Han, Zai-Jun Zhan. No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice. Neural regeneration research. vol 11. issue 8. 2016-09-21. PMID:27651784. |
by using neurobehavioural tests, high-performance liquid chromatography and western blot assay, we showed that b3c at 0.3 mg/kg, rasagiline at 0.02 mg/kg, as well as co-treatment with b3c and rasagiline prevented mptp-induced behavioural abnormities, increased the concentrations of dopamine and its metabolites in the striatum, and up-regulated the expression of tyrosine hydroxylase in the substantia nigra. |
2016-09-21 |
2023-08-13 |
mouse |
| J Belin, J L Houéto, T Constans, C Hommet, B de Toffol, K Mondo. [Geriatric particularities of Parkinson's disease: Clinical and therapeutic aspects]. Revue neurologique. vol 171. issue 12. 2016-09-19. PMID:26573332. |
although historically pd has been characterized by the presence of progressive dopaminergic neuronal loss of the substantia nigra, the disease process also involves neurotransmitters other that dopamine and regions of the nervous system outside the basal ganglia. |
2016-09-19 |
2023-08-13 |
human |
| Dominique Engel, Vincent Seuti. High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons. The Journal of physiology. vol 593. issue 22. 2016-09-12. PMID:26350173. |
the hyperpolarization-activated cation current ih is expressed in dopamine neurons of the substantia nigra, but the subcellular distribution of the current and its role in synaptic integration remain unknown. |
2016-09-12 |
2023-08-13 |
rat |
| Tim D Auman. Environment- and activity-dependent dopamine neurotransmitter plasticity in the adult substantia nigra. Journal of chemical neuroanatomy. vol 73. 2016-09-06. PMID:26718607. |
environment- and activity-dependent dopamine neurotransmitter plasticity in the adult substantia nigra. |
2016-09-06 |
2023-08-13 |
mouse |
| Sonal Agrawal, Anubhuti Dixit, Ashish Singh, Pratibha Tripathi, Dhirendra Singh, Devendra Kumar Patel, Mahendra Pratap Sing. Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25370934. |
the expression of α-synuclein, 3-nitrotyrosine (3-nt), 4-hydroxynonenal (4-hne)-modified proteins, mitochondrial dysfunction-dependent apoptotic proteins, nitrite content, lipid peroxidation (lpo) and number of tyrosine hydroxylase (th)-positive neurons were estimated in the substantia nigra and dopamine content in the striatum of control and treated rats employing standard procedures. |
2016-08-30 |
2023-08-13 |
rat |
| Shuke Nie, Yan Xu, Guiqin Chen, Kai Ma, Chao Han, Zhenli Guo, Zhentao Zhang, Keqiang Ye, Xuebing Ca. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. vol 99. 2016-08-30. PMID:26282118. |
dopaminergic neurons loss in the substantia nigra (sn) and dopamine (da) content loss in the striatum correlate well with disease severity in parkinson's disease (pd). |
2016-08-30 |
2023-08-13 |
mouse |
| Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A Hayes, Jonathan Beagan, Jesse R McLean, Sarah C Izen, Eduardo Perez-Torres, Penelope J Hallett, Ole Isacso. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of disease. vol 82. 2016-08-24. PMID:26392287. |
in rats, co-injection of aav-gba1 with aav-a53t α-synuclein into the substantia nigra prevented α-synuclein-mediated degeneration of nigrostriatal dopamine neurons by 6 months. |
2016-08-24 |
2023-08-13 |
mouse |