| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Yong Chung, Ji Won Lee, Choon Ho Ryu, Hye Kyung Min, Yeo Jin Yoon, Mi Jung Lim, Cheol Hyoung Par. 1-[2-(4-Benzyloxyphenoxy)Ethyl]Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease. Journal of neuroscience research. vol 93. issue 8. 2016-04-01. PMID:25711470. |
significantly reversed the behavioral impairments, dopamine levels in the striatum, and neuronal loss in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated mice compared with the mptp-alone-treated group. |
2016-04-01 |
2023-08-13 |
mouse |
| S-J Hong, D Zhang, L-H Zhang, P Yang, J Wan, Y Yu, T-H Wang, Z-T Feng, L-H Li, D T W Ye. Expression of dopamine transporter in the different cerebral regions of methamphetamine-dependent rats. Human & experimental toxicology. vol 34. issue 7. 2016-03-30. PMID:25504685. |
to observe the expression of the dopamine transporter (dat) in six cerebral regions of a methamphetamine (ma)-dependent rat, which were frontal cortex, nucleus accumbens septi, striatum, hippocampus, substantia nigra and ventral tegmental area. |
2016-03-30 |
2023-08-13 |
rat |
| Mélanie Bourque, Marc Morissette, Thérèse Di Paol. Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1. Neuropharmacology. vol 95. 2016-03-24. PMID:25892506. |
the erα/β antagonist, ici 182,780, blocked the protective effects of 17β-estradiol, but not those of gper1 agonist g1, on dopamine concentration as well as dopamine transporter and vesicular monoamine transporter 2 specific binding in both the striatum and the substantia nigra. |
2016-03-24 |
2023-08-13 |
mouse |
| Cristian Follmer, Eduardo Coelho-Cerqueira, Danilo Y Yatabe-Franco, Gabriel D T Araujo, Anderson S Pinheiro, Gilberto B Domont, David Elieze. Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL). The Journal of biological chemistry. vol 290. issue 46. 2016-03-07. PMID:26381411. |
when injected into the substantia nigra of rat brains, dopal causes the loss of dopaminergic neurons accompanied by the accumulation of potentially toxic oligomers of the presynaptic protein α-synuclein (as), potentially explaining the synergistic toxicity described for dopamine metabolism and as aggregation. |
2016-03-07 |
2023-08-13 |
rat |
| Tsung-Hsun Hsieh, Ying-Zu Huang, Alexander Rotenberg, Alvaro Pascual-Leone, Yung-Hsiao Chiang, Jia-Yi Wang, Jia-Jin J Che. Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 7. 2016-02-19. PMID:24451657. |
here, we have established a tms model in rat and applied this model to study the impact of substantia nigra dopamine neuron on tbs-induced motor plasticity in pd rats. |
2016-02-19 |
2023-08-12 |
human |
| Kazumasa Wakamatsu, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26156066. |
using the chemical degradation methods for the determination of catechols in neuromelanin (nm), we have shown that dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), 3,4-dihydroxyphenylethanol (dope), and 3,4-dihydroxyphenylalanine (dopa) are mainly responsible for the structure of nm from substantia nigra (sn), while norepinephrine (ne), 3,4-dihydroxymandelic acid (doma), and 3,4-dihydroxyphenylethylene glycol (dopeg) are additionally responsible for the structure of nm from locus coeruleus (lc). |
2016-02-16 |
2023-08-13 |
Not clear |
| Omar Mamad, Claire Delaville, Wail Benjelloun, Abdelhamid Benazzou. Dopaminergic control of the globus pallidus through activation of D2 receptors and its impact on the electrical activity of subthalamic nucleus and substantia nigra reticulata neurons. PloS one. vol 10. issue 3. 2016-01-28. PMID:25742005. |
the globus pallidus (gp) receives dopaminergic afferents from the pars compacta of substantia nigra and several studies suggested that dopamine exerts its action in the gp through presynaptic d2 receptors (d2rs). |
2016-01-28 |
2023-08-13 |
rat |
| Xiao-Feng Yin, Hua-Min Xu, Yun-Xia Jiang, Yun-Lai Zhi, Yu-Xiu Liu, Heng-Wei Xiang, Kai Liu, Xiao-Dong Ding, Peng Su. Lentivirus-mediated Persephin over-expression in Parkinson's disease rats. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807117. |
results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with persephin gene. |
2016-01-25 |
2023-08-13 |
rat |
| Shengli Xu, Piu Cha. Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease. Biomolecules. vol 5. issue 2. 2016-01-18. PMID:26057626. |
parkinson's disease (pd) is a very common neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) into lewy body (lb) inclusions and the loss of neuronmelanin (nm) containing dopamine (da) neurons in the substantia nigra (sn). |
2016-01-18 |
2023-08-13 |
Not clear |
| Jennifer T Lamberts, Erin N Hildebrandt, Patrik Brundi. Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis. Neurobiology of disease. vol 77. 2016-01-06. PMID:25046996. |
parkinson's disease (pd) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. |
2016-01-06 |
2023-08-13 |
Not clear |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Jazmin E Hawes, Dijana Tesic, Andrew J Whitehouse, Graeme R Zosky, Jeremy T Smith, Caitlin S Wyrwol. Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse. Behavioural brain research. vol 286. 2016-01-04. PMID:25753408. |
at e17.5, brain tyrosine hydroxylase (th) gene expression was reduced in females, as was th protein localization (to identify dopamine neurons) in the substantia nigra of vitamin d-deficient female foetuses. |
2016-01-04 |
2023-08-13 |
mouse |
| Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashim. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25627674. |
the globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. |
2015-12-31 |
2023-08-13 |
human |
| Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huan. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-12-15. PMID:26664824. |
levels in the redox system, dopamine (da) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (sn) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of gsh + tet (or gsh) and/or l-3,4-dihydroxyphenylalanine (l-dopa) to pd rats. |
2015-12-15 |
2023-08-13 |
rat |
| Yan-Na Wu, Steven W Johnso. Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons. Brain research. vol 1603. 2015-12-07. PMID:25656790. |
memantine selectively blocks extrasynaptic nmda receptors in rat substantia nigra dopamine neurons. |
2015-12-07 |
2023-08-13 |
rat |
| Yan-Na Wu, Steven W Johnso. Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons. Brain research. vol 1603. 2015-12-07. PMID:25656790. |
we recorded whole-cell currents with patch pipettes to characterize the ability of memantine, a low-affinity nmda channel blocker, to block synaptic and extrasynaptic nmda receptors in substantia nigra zona compacta (snc) dopamine neurons in slices of rat brain. |
2015-12-07 |
2023-08-13 |
rat |
| Hongyan Gou, Di Wen, Chunling Ma, Ming Li, Yingmin Li, Wenfang Zhang, Li Liu, Bin Con. Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice. Behavioural brain research. vol 283. 2015-12-02. PMID:25629941. |
cck-8 pretreatment attenuated meth (10mg/kg)-induced hyperthermia, the decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum, and th in the substantia nigra. |
2015-12-02 |
2023-08-13 |
mouse |
| Hong Guo, Fang Shi, Meijiao Li, Qingqing Liu, Bin Yu, Limin H. Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system. BMC complementary and alternative medicine. vol 15. 2015-11-30. PMID:25994206. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. |
2015-11-30 |
2023-08-13 |
Not clear |
| Edyta Możdżeń, Małgorzata Kajta, Agnieszka Wąsik, Tomasz Lenda, Lucyna Antkiewicz-Michalu. Salsolinol, an endogenous compound triggers a two-phase opposing action in the central nervous system. Neurotoxicity research. vol 27. issue 3. 2015-11-25. PMID:25537852. |
ex vivo studies indicated that both acute and chronic administration of salsolinol did not affect the dopamine metabolism, its striatal concentration or α-synuclein and tyrosine hydroxylase protein level in the rat substantia nigra and striatum. |
2015-11-25 |
2023-08-13 |
mouse |
| Shengyuan Ding, Li Li, Fu-Ming Zho. Nigral dopamine loss induces a global upregulation of presynaptic dopamine D1 receptor facilitation of the striatonigral GABAergic output. Journal of neurophysiology. vol 113. issue 6. 2015-11-25. PMID:25552639. |
in parkinson's disease (pd), the dopamine (da) neuron loss in the substantia nigra and the da axon loss in the dorsal striatum are severe, but da neurons in the ventral tegmental area and da axons in middle and ventral striatal subregions are less affected. |
2015-11-25 |
2023-08-13 |
mouse |