| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Hong, S Sha, L Zhou, C Wang, J Yin, L Che. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell death & disease. vol 6. 2016-04-12. PMID:26203861. |
the pharmacological or genetic inactivation of σ1r suppressed the expression of dopamine transporter (dat) in substantia nigra, which was corrected by nmda. |
2016-04-12 |
2023-08-13 |
mouse |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Xuejing Wang, Mingming Ma, Junfang Teng, Jiewen Zhang, Shuang Zhou, Ying Zhang, Erxi Wu, Xuebing Din. Chronic exposure to cerebrospinal fluid of multiple system atrophy in neuroblastoma and glioblastoma cells induces cytotoxicity via ER stress and autophagy activation. Oncotarget. vol 6. issue 15. 2016-04-07. PMID:25965819. |
specifically, dopamine neurons in substantia nigra and purkinje cells in cerebellum cortex were degenerated in msa-csf-injected mice. |
2016-04-07 |
2023-08-13 |
mouse |
| Richa Pahuja, Kavita Seth, Anshi Shukla, Rajendra Kumar Shukla, Priyanka Bhatnagar, Lalit Kumar Singh Chauhan, Prem Narain Saxena, Jharna Arun, Bhushan Pradosh Chaudhari, Devendra Kumar Patel, Sheelendra Pratap Singh, Rakesh Shukla, Vinay Kumar Khanna, Pradeep Kumar, Rajnish Kumar Chaturvedi, Kailash Chand Gupt. Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats. ACS nano. vol 9. issue 5. 2016-04-05. PMID:25825926. |
dopamine delivered through nps did not cause additional generation of ros, dopaminergic neuron degeneration, and ultrastructural changes in the striatum and substantia nigra as compared to 6-ohda-lesioned rats. |
2016-04-05 |
2023-08-13 |
rat |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
parkinson's disease (pd) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. |
2016-04-05 |
2023-08-13 |
mouse |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
the results showed that compound-23 inhibited mptp-induced reduction of retention time on the rotor rod bar, neuronal cell death in the substantia nigra and striatum and dopamine content in wild-type mice but not in dj-1-knockout mice, indicating a dj-1-dependent effect of compound-23. |
2016-04-05 |
2023-08-13 |
mouse |
| Satoshi Ikemoto, Chen Yang, Aaron Ta. Basal ganglia circuit loops, dopamine and motivation: A review and enquiry. Behavioural brain research. vol 290. 2016-04-04. PMID:25907747. |
accumulating evidence suggests that such motivational role of dopamine neurons is not limited to those located in the ventral tegmental area, but also in the substantia nigra. |
2016-04-04 |
2023-08-13 |
Not clear |
| Jin Yong Chung, Ji Won Lee, Choon Ho Ryu, Hye Kyung Min, Yeo Jin Yoon, Mi Jung Lim, Cheol Hyoung Par. 1-[2-(4-Benzyloxyphenoxy)Ethyl]Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease. Journal of neuroscience research. vol 93. issue 8. 2016-04-01. PMID:25711470. |
significantly reversed the behavioral impairments, dopamine levels in the striatum, and neuronal loss in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated mice compared with the mptp-alone-treated group. |
2016-04-01 |
2023-08-13 |
mouse |
| S-J Hong, D Zhang, L-H Zhang, P Yang, J Wan, Y Yu, T-H Wang, Z-T Feng, L-H Li, D T W Ye. Expression of dopamine transporter in the different cerebral regions of methamphetamine-dependent rats. Human & experimental toxicology. vol 34. issue 7. 2016-03-30. PMID:25504685. |
to observe the expression of the dopamine transporter (dat) in six cerebral regions of a methamphetamine (ma)-dependent rat, which were frontal cortex, nucleus accumbens septi, striatum, hippocampus, substantia nigra and ventral tegmental area. |
2016-03-30 |
2023-08-13 |
rat |
| Mélanie Bourque, Marc Morissette, Thérèse Di Paol. Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1. Neuropharmacology. vol 95. 2016-03-24. PMID:25892506. |
the erα/β antagonist, ici 182,780, blocked the protective effects of 17β-estradiol, but not those of gper1 agonist g1, on dopamine concentration as well as dopamine transporter and vesicular monoamine transporter 2 specific binding in both the striatum and the substantia nigra. |
2016-03-24 |
2023-08-13 |
mouse |
| Cristian Follmer, Eduardo Coelho-Cerqueira, Danilo Y Yatabe-Franco, Gabriel D T Araujo, Anderson S Pinheiro, Gilberto B Domont, David Elieze. Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL). The Journal of biological chemistry. vol 290. issue 46. 2016-03-07. PMID:26381411. |
when injected into the substantia nigra of rat brains, dopal causes the loss of dopaminergic neurons accompanied by the accumulation of potentially toxic oligomers of the presynaptic protein α-synuclein (as), potentially explaining the synergistic toxicity described for dopamine metabolism and as aggregation. |
2016-03-07 |
2023-08-13 |
rat |
| Tsung-Hsun Hsieh, Ying-Zu Huang, Alexander Rotenberg, Alvaro Pascual-Leone, Yung-Hsiao Chiang, Jia-Yi Wang, Jia-Jin J Che. Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 7. 2016-02-19. PMID:24451657. |
here, we have established a tms model in rat and applied this model to study the impact of substantia nigra dopamine neuron on tbs-induced motor plasticity in pd rats. |
2016-02-19 |
2023-08-12 |
human |
| Kazumasa Wakamatsu, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26156066. |
using the chemical degradation methods for the determination of catechols in neuromelanin (nm), we have shown that dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), 3,4-dihydroxyphenylethanol (dope), and 3,4-dihydroxyphenylalanine (dopa) are mainly responsible for the structure of nm from substantia nigra (sn), while norepinephrine (ne), 3,4-dihydroxymandelic acid (doma), and 3,4-dihydroxyphenylethylene glycol (dopeg) are additionally responsible for the structure of nm from locus coeruleus (lc). |
2016-02-16 |
2023-08-13 |
Not clear |
| Omar Mamad, Claire Delaville, Wail Benjelloun, Abdelhamid Benazzou. Dopaminergic control of the globus pallidus through activation of D2 receptors and its impact on the electrical activity of subthalamic nucleus and substantia nigra reticulata neurons. PloS one. vol 10. issue 3. 2016-01-28. PMID:25742005. |
the globus pallidus (gp) receives dopaminergic afferents from the pars compacta of substantia nigra and several studies suggested that dopamine exerts its action in the gp through presynaptic d2 receptors (d2rs). |
2016-01-28 |
2023-08-13 |
rat |
| Xiao-Feng Yin, Hua-Min Xu, Yun-Xia Jiang, Yun-Lai Zhi, Yu-Xiu Liu, Heng-Wei Xiang, Kai Liu, Xiao-Dong Ding, Peng Su. Lentivirus-mediated Persephin over-expression in Parkinson's disease rats. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807117. |
results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with persephin gene. |
2016-01-25 |
2023-08-13 |
rat |
| Shengli Xu, Piu Cha. Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease. Biomolecules. vol 5. issue 2. 2016-01-18. PMID:26057626. |
parkinson's disease (pd) is a very common neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) into lewy body (lb) inclusions and the loss of neuronmelanin (nm) containing dopamine (da) neurons in the substantia nigra (sn). |
2016-01-18 |
2023-08-13 |
Not clear |
| Jennifer T Lamberts, Erin N Hildebrandt, Patrik Brundi. Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis. Neurobiology of disease. vol 77. 2016-01-06. PMID:25046996. |
parkinson's disease (pd) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. |
2016-01-06 |
2023-08-13 |
Not clear |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Jazmin E Hawes, Dijana Tesic, Andrew J Whitehouse, Graeme R Zosky, Jeremy T Smith, Caitlin S Wyrwol. Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse. Behavioural brain research. vol 286. 2016-01-04. PMID:25753408. |
at e17.5, brain tyrosine hydroxylase (th) gene expression was reduced in females, as was th protein localization (to identify dopamine neurons) in the substantia nigra of vitamin d-deficient female foetuses. |
2016-01-04 |
2023-08-13 |
mouse |
| Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashim. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25627674. |
the globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. |
2015-12-31 |
2023-08-13 |
human |