| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Zhang, Jian Lu, Ji-Guo Zhang, Jun-Xia Xi. Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson's disease model in C57BL/6J mice. Neural regeneration research. vol 10. issue 2. 2015-04-17. PMID:25883632. |
the results showed that the immunoreactive staining and mrna expression of the dopamine transporter and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra, were significantly increased in mice pretreated with 800 mg/kg of the polysaccharide compared with those in mptp-treated mice. |
2015-04-17 |
2023-08-13 |
mouse |
| Penelope J Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacso. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell reports. vol 7. issue 6. 2015-04-16. PMID:24910427. |
labeling of the mitochondrial outer membrane protein tom20 and α-synuclein showed a typical cellular pathology in the patients' own substantia nigra, which was not observed in transplanted dopamine neurons. |
2015-04-16 |
2023-08-13 |
human |
| Eduard Bentea, Anke Van der Perren, Joeri Van Liefferinge, Anissa El Arfani, Giulia Albertini, Thomas Demuyser, Ellen Merckx, Yvette Michotte, Ilse Smolders, Veerle Baekelandt, Ann Massi. Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein. Frontiers in behavioral neuroscience. vol 9. 2015-04-15. PMID:25873870. |
we report that unilateral administration of 3 μg lactacystin to the substantia nigra of mice leads to partial (~40%) dopaminergic cell loss and concurrent striatal dopamine depletion, accompanied by increased expression of ser129-phosphorylated α-synuclein. |
2015-04-15 |
2023-08-13 |
mouse |
| Yong Ye, Fei Fang, Yue L. Isolation of the sapogenin from defatted seeds of Camellia oleifera and its neuroprotective effects on dopaminergic neurons. Journal of agricultural and food chemistry. vol 62. issue 26. 2015-04-13. PMID:24909656. |
the results showed that the sapogenin and its derivative increased dopamine content in striatum and tyrosine hydroxylase (th) positive cells in substantia nigra and relieved inflammation and behavioral disorder, but the effect on movement was reversed by dopamine receptor antagonist haloperidol and was not intervened by adenosine receptor antagonist cgs 15943. |
2015-04-13 |
2023-08-13 |
mouse |
| Guoshuai Feng, Zhijian Zhang, Qingqing Bao, Zaijun Zhang, Libing Zhou, Jie Jiang, Sha L. Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24871044. |
consistently, chinonin reduced loss of dopaminergic neurons in the substantia nigra and prevented depletion of dopamine and its metabolites 3-methoxy-4-hydroxy-phenylacetic acid and homovanillic acid in the striatum of mice. |
2015-04-06 |
2023-08-13 |
mouse |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
moreover, the content of dopamine in the culture medium of subventricular zone neurons was significantly increased at 48 hours after induction with the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor. |
2015-03-06 |
2023-08-13 |
rat |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
experimental findings indicate that the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons in the substantia nigra with the ability to secrete dopamine. |
2015-03-06 |
2023-08-13 |
rat |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of x-box-binding protein 1-transfected neural stem cells. |
2015-03-04 |
2023-08-13 |
rat |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
these results indicate that transplantation of x-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of parkinson's disease in rats. |
2015-03-04 |
2023-08-13 |
rat |
| Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklun. Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons. PloS one. vol 9. issue 7. 2015-02-27. PMID:24999658. |
while the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to parkinson's disease, is well studied, animal models recapitulating the cortical degeneration in dementia with lewy-bodies (dlb) are much less mature. |
2015-02-27 |
2023-08-13 |
human |
| Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, Xiao-Ping P. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PloS one. vol 8. issue 10. 2015-02-23. PMID:24205164. |
meanwhile, in an mptp mouse model, pal prevented a decrease of the contents of dopamine (da) and its metabolites in the striatum and th-positive dopaminergic neuron loss in the substantia nigra (sn). |
2015-02-23 |
2023-08-12 |
mouse |
| Meghan R Hennis, Katherine W Seamans, Marian A Marvin, Bradford H Casey, Matthew S Goldber. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386432. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by loss of neurons in the substantia nigra that project to the striatum and release dopamine. |
2015-02-23 |
2023-08-12 |
mouse |
| A Ninh Pham, T David Wait. Cu(II)-catalyzed oxidation of dopamine in aqueous solutions: mechanism and kinetics. Journal of inorganic biochemistry. vol 137. 2015-02-12. PMID:24815905. |
spontaneous oxidation of dopamine (da) and the resultant formation of free radical species within dopamine neurons of the substantia nigra (sn) is thought to bestow a considerable oxidative load upon these neurons and may contribute to their vulnerability to degeneration in parkinson's disease (pd). |
2015-02-12 |
2023-08-13 |
Not clear |
| Han Sam Cho, Dae Jung Baek, Seung Soo Bae. Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats. Journal of exercise nutrition & biochemistry. vol 18. issue 4. 2015-02-11. PMID:25671205. |
effect of exercise on hyperactivity, impulsivity and dopamine d2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats. |
2015-02-11 |
2023-08-13 |
rat |
| Falk Schlaudraff, Jan Gründemann, Michael Fauler, Elena Dragicevic, John Hardy, Birgit Lis. Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24742361. |
progressive loss of substantia nigra dopamine neurons (sn da) is a hallmark of aging and of parkinson's disease (pd). |
2015-02-09 |
2023-08-13 |
human |
| Kauê M Cost. The effects of aging on substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 46. 2015-02-09. PMID:25392480. |
the effects of aging on substantia nigra dopamine neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Kunio Doi, Koji Uetsuk. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. International journal of molecular sciences. vol 12. issue 8. 2015-01-29. PMID:21954354. |
ota causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neuronal cell apoptosis in the substantia nigra, striatum and hippocampus. |
2015-01-29 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
in the brain, neonatal estradiol valerate administration led to a significant increase in dopamine content in striatum, substantia nigra and ventral tegmental area. |
2015-01-26 |
2023-08-12 |
rat |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
with respect to the contents of dopamine metabolites, only 3-methoxytyramine content increased in substantia nigra and ventral tegmental area. |
2015-01-26 |
2023-08-12 |
rat |