| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gonzalo Sanchez, Rafael K Varaschin, Hansruedi Büeler, Paul C Marcogliese, David S Park, Louis-Eric Trudea. Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733019. |
parkinson's disease (pd) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (da) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. |
2015-05-28 |
2023-08-13 |
mouse |
| Lia Panman, Maria Papathanou, Ariadna Laguna, Tony Oosterveen, Nikolaos Volakakis, Dario Acampora, Idha Kurtsdotter, Takashi Yoshitake, Jan Kehr, Eliza Joodmardi, Jonas Muhr, Antonio Simeone, Johan Ericson, Thomas Perlman. Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. Cell reports. vol 8. issue 4. 2015-05-26. PMID:25127144. |
sox6 and otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. |
2015-05-26 |
2023-08-13 |
Not clear |
| Xiao-Xi Zhuan. Aberrant plasticity and "learned" motor inhibition in Parkinson's disease. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 5. 2015-05-16. PMID:23090495. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder characterized by severe loss of substantia nigra dopamine (da) neurons. |
2015-05-16 |
2023-08-12 |
Not clear |
| Juliann D Jaumotte, Michael J Zigmon. Comparison of GDF5 and GDNF as neuroprotective factors for postnatal dopamine neurons in ventral mesencephalic cultures. Journal of neuroscience research. vol 92. issue 11. 2015-05-11. PMID:24916473. |
we report that both gdnf (10-500 ng/ml) and gdf5 (100-500 ng/ml) promoted the survival of dopamine neurons from the substantia nigra of postnatal rats, although gdnf was considerably more potent than gdf5. |
2015-05-11 |
2023-08-13 |
rat |
| Juliann D Jaumotte, Michael J Zigmon. Comparison of GDF5 and GDNF as neuroprotective factors for postnatal dopamine neurons in ventral mesencephalic cultures. Journal of neuroscience research. vol 92. issue 11. 2015-05-11. PMID:24916473. |
using organotypic co-cultures, we also compared gdf5 with gdnf as chemoattractants for the innervation of the striatum and the neocortex by dopamine neurons from the substantia nigra. |
2015-05-11 |
2023-08-13 |
rat |
| Matthew F Lazenka, Bethany G David, Aron H Lichtman, Eric J Nestler, Dana E Selley, Laura J Sim-Selle. Delta FosB and AP-1-mediated transcription modulate cannabinoid CB₁ receptor signaling and desensitization in striatal and limbic brain regions. Biochemical pharmacology. vol 91. issue 3. 2015-04-28. PMID:25093286. |
overexpression of Δfosb in striatal dopamine type 1 receptor-containing (d1r) medium spiny neurons (msns) attenuated cb₁r desensitization in the substantia nigra, ventral tegmental area (vta) and amygdala. |
2015-04-28 |
2023-08-13 |
mouse |
| Laurie H Sanders, Jennifer McCoy, Xiaoping Hu, Pier G Mastroberardino, Bryan C Dickinson, Christopher J Chang, Charleen T Chu, Bennett Van Houten, J T Greenamyr. Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24981012. |
we identified the molecular identity of mtdna damage to be apurinic/apyrimidinic (abasic) sites in substantia nigra dopamine neurons, but not in cortical neurons from postmortem pd specimens. |
2015-04-21 |
2023-08-13 |
human |
| Hui-Kang Tao, Qin Tang, Jin-Jin Dai, Yuan-Yuan Li, Ming-Yan He. [Impact of dopamine receptor modulation on reduced anxiety-like behavior in neonatal rats after hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 16. issue 10. 2015-04-17. PMID:25344189. |
to observe the long-term changes in anxiety-like behavior and tyrosine hydroxylase (th) expression in the substantia nigra (sn) after hypoxic-ischemic brain damage (hibd) in a neonatal rat model and to further explore the relationship between dopamine (da) level and long-term anxiety-like behavior using the da receptor (dar) antagonist. |
2015-04-17 |
2023-08-13 |
rat |
| Fang Zhang, Jian Lu, Ji-Guo Zhang, Jun-Xia Xi. Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson's disease model in C57BL/6J mice. Neural regeneration research. vol 10. issue 2. 2015-04-17. PMID:25883632. |
the results showed that the immunoreactive staining and mrna expression of the dopamine transporter and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra, were significantly increased in mice pretreated with 800 mg/kg of the polysaccharide compared with those in mptp-treated mice. |
2015-04-17 |
2023-08-13 |
mouse |
| Penelope J Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacso. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell reports. vol 7. issue 6. 2015-04-16. PMID:24910427. |
labeling of the mitochondrial outer membrane protein tom20 and α-synuclein showed a typical cellular pathology in the patients' own substantia nigra, which was not observed in transplanted dopamine neurons. |
2015-04-16 |
2023-08-13 |
human |
| Eduard Bentea, Anke Van der Perren, Joeri Van Liefferinge, Anissa El Arfani, Giulia Albertini, Thomas Demuyser, Ellen Merckx, Yvette Michotte, Ilse Smolders, Veerle Baekelandt, Ann Massi. Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein. Frontiers in behavioral neuroscience. vol 9. 2015-04-15. PMID:25873870. |
we report that unilateral administration of 3 μg lactacystin to the substantia nigra of mice leads to partial (~40%) dopaminergic cell loss and concurrent striatal dopamine depletion, accompanied by increased expression of ser129-phosphorylated α-synuclein. |
2015-04-15 |
2023-08-13 |
mouse |
| Yong Ye, Fei Fang, Yue L. Isolation of the sapogenin from defatted seeds of Camellia oleifera and its neuroprotective effects on dopaminergic neurons. Journal of agricultural and food chemistry. vol 62. issue 26. 2015-04-13. PMID:24909656. |
the results showed that the sapogenin and its derivative increased dopamine content in striatum and tyrosine hydroxylase (th) positive cells in substantia nigra and relieved inflammation and behavioral disorder, but the effect on movement was reversed by dopamine receptor antagonist haloperidol and was not intervened by adenosine receptor antagonist cgs 15943. |
2015-04-13 |
2023-08-13 |
mouse |
| Guoshuai Feng, Zhijian Zhang, Qingqing Bao, Zaijun Zhang, Libing Zhou, Jie Jiang, Sha L. Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24871044. |
consistently, chinonin reduced loss of dopaminergic neurons in the substantia nigra and prevented depletion of dopamine and its metabolites 3-methoxy-4-hydroxy-phenylacetic acid and homovanillic acid in the striatum of mice. |
2015-04-06 |
2023-08-13 |
mouse |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
moreover, the content of dopamine in the culture medium of subventricular zone neurons was significantly increased at 48 hours after induction with the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor. |
2015-03-06 |
2023-08-13 |
rat |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
experimental findings indicate that the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons in the substantia nigra with the ability to secrete dopamine. |
2015-03-06 |
2023-08-13 |
rat |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of x-box-binding protein 1-transfected neural stem cells. |
2015-03-04 |
2023-08-13 |
rat |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
these results indicate that transplantation of x-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of parkinson's disease in rats. |
2015-03-04 |
2023-08-13 |
rat |
| Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklun. Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons. PloS one. vol 9. issue 7. 2015-02-27. PMID:24999658. |
while the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to parkinson's disease, is well studied, animal models recapitulating the cortical degeneration in dementia with lewy-bodies (dlb) are much less mature. |
2015-02-27 |
2023-08-13 |
human |
| Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, Xiao-Ping P. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PloS one. vol 8. issue 10. 2015-02-23. PMID:24205164. |
meanwhile, in an mptp mouse model, pal prevented a decrease of the contents of dopamine (da) and its metabolites in the striatum and th-positive dopaminergic neuron loss in the substantia nigra (sn). |
2015-02-23 |
2023-08-12 |
mouse |
| Meghan R Hennis, Katherine W Seamans, Marian A Marvin, Bradford H Casey, Matthew S Goldber. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386432. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by loss of neurons in the substantia nigra that project to the striatum and release dopamine. |
2015-02-23 |
2023-08-12 |
mouse |