| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in parkinson's disease. |
2014-09-23 |
2023-08-13 |
mouse |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
furthermore, we detected elevated substantia nigra dopamine messenger rna levels of ncs-1 (but not cav1.2 or cav1.3) after cocaine in mice, as well as in remaining human sn da neurons in parkinson's disease. |
2014-09-23 |
2023-08-13 |
mouse |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
as it is accessible to pharmacological modulation, it provides a novel promising target for tuning substantia nigra dopamine neuron activity, and their vulnerability to degeneration. |
2014-09-23 |
2023-08-13 |
mouse |
| Ali Chaari, Jessica Hoarau-Véchot, Moncef Ladjim. Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease. International journal of biological macromolecules. vol 60. 2014-09-12. PMID:23748003. |
this accumulation is also due to insufficient formation and activity of dopamine produced in certain neurons within the substantia nigra. |
2014-09-12 |
2023-08-12 |
human |
| Kwang Taek Kim, Kyung Jin Chung, Han Sae Lee, Il Gyu Ko, Chang Ju Kim, Yong Gil Na, Khae Hawn Ki. Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia. Neural regeneration research. vol 8. issue 8. 2014-09-10. PMID:25206715. |
a decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine d2 receptor expression in the striatum and substantia nigra region. |
2014-09-10 |
2023-08-13 |
Not clear |
| Kwang Taek Kim, Kyung Jin Chung, Han Sae Lee, Il Gyu Ko, Chang Ju Kim, Yong Gil Na, Khae Hawn Ki. Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia. Neural regeneration research. vol 8. issue 8. 2014-09-10. PMID:25206715. |
however, treatment with tadalafil increased cyclic guanosine monophosphate expression, suppressed thyrosine hydroxylase expression and increased dopamine d2 receptor expression in the striatum and substantia nigra region in a dose-dependent manner. |
2014-09-10 |
2023-08-13 |
Not clear |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
aging decreases l-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. |
2014-09-09 |
2023-08-13 |
mouse |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. |
2014-09-09 |
2023-08-13 |
mouse |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
previous studies suggest that the unique set of ion conductances that drive spontaneous, rhythmic firing of action potentials could predispose substantia nigra dopamine neurons to selective neurodegeneration. |
2014-09-09 |
2023-08-13 |
mouse |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
here we show, using patch-clamp electrophysiological recordings in brain slices, that substantia nigra dopamine neurons from mice 25-30 months of age (old) have comparable membrane capacitance and input resistance to neurons from mice 2-7 months of age (young). |
2014-09-09 |
2023-08-13 |
mouse |
| Adriane Gröger, Rupert Kolb, Rita Schäfer, Uwe Klos. Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416192. |
dopamine reduction in the substantia nigra of parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. |
2014-09-08 |
2023-08-12 |
Not clear |
| Chi L L Pham, Roberto Cappa. The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding. Bioscience reports. vol 33. issue 5. 2014-09-03. PMID:24066973. |
the deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of da (dopamine) containing neurons in the substantia nigra are two key features of pd (parkinson's disease). |
2014-09-03 |
2023-08-12 |
Not clear |
| Fabio A Zucca, Emy Basso, Francesca A Cupaioli, Emanuele Ferrari, David Sulzer, Luigi Casella, Luigi Zecc. Neuromelanin of the human substantia nigra: an update. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24155156. |
the high concentration of neuromelanin in substantia nigra neurons seems to be linked to the presence of considerable amounts of cytosolic dopamine that have not been sequestered into synaptic vesicles. |
2014-08-28 |
2023-08-12 |
human |
| J A Teske, C J Billington, C M Kot. Mechanisms underlying obesity resistance associated with high spontaneous physical activity. Neuroscience. vol 256. 2014-08-27. PMID:24161277. |
we further tested whether orexin action on dopamine one receptors (da1r) in the substantia nigra (sn) plays an important role in the generation of spa. |
2014-08-27 |
2023-08-12 |
rat |
| Jun Ming Wan. Allopregnanolone and neurogenesis in the nigrostriatal tract. Frontiers in cellular neuroscience. vol 8. 2014-08-27. PMID:25161608. |
loss of dopamine neurons in the substantia nigra (sn) is one of the main pathological features of parkinson's and also in, at least, a subset of alzheimer's patients. |
2014-08-27 |
2023-08-13 |
mouse |
| Biswarup Ghosh, Chen Zhang, George M Smit. Bridging between transplantation therapy and neurotrophic factors in Parkinson's disease. Frontiers in bioscience (Elite edition). vol 6. 2014-08-25. PMID:24896204. |
with increased understanding of growth and guidance molecule effecting dopaminergic neurons, it may be feasible to place transplants in the damaged substantia nigra and direct the growth of axons into target regions to reconstruction of midbrain dopamine (da) circuitry. |
2014-08-25 |
2023-08-13 |
Not clear |
| May-Jywan Tsai, Ching-Feng Weng, Nien-Chu Yu, Dann-Ying Liou, Fu-San Kuo, Ming-Chao Huang, Wen-Cheng Huang, Kabik Tam, Song-Kun Shyue, Henrich Chen. Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23691265. |
in vivo, adenoviral gene transfer of bicistronic cox-1/pgis to substantia nigra protected 6-ohda- induced dopamine depletion and ameliorated behavioral deficits. |
2014-08-13 |
2023-08-12 |
rat |
| Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato, Hiroshi Maita, Takeshi Niki, Sanae M M Iguchi-Arig. Neuroprotective function of DJ-1 in Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766857. |
parkinson's disease (pd) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. |
2014-08-13 |
2023-08-12 |
Not clear |
| Kai-Hsiang Kang, Horng-Hui Liou, Mann-Jen Hour, Houng-Chi Liou, Wen-Mei F. Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. Neuropharmacology. vol 73. 2014-08-13. PMID:23800665. |
mk-886 administration increased the number of tyrosine hydroxylase-positive neurons in the substantia nigra and the dopamine content in the striatum in mptp-induced parkinsonian mice. |
2014-08-13 |
2023-08-12 |
mouse |
| Patrick Oeckl, Bastian Hengerer, Boris Ferge. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology. vol 257. 2014-08-13. PMID:24747358. |
western blot analyses revealed no alteration in the expression and subcellular localisation of the dopamine d2 receptor in the striatum of gpr6(-/-) mice, and the number of tyrosine hydroxylase positive neurons in the substantia nigra was unchanged. |
2014-08-13 |
2023-08-13 |
mouse |