| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
previous studies suggest that the unique set of ion conductances that drive spontaneous, rhythmic firing of action potentials could predispose substantia nigra dopamine neurons to selective neurodegeneration. |
2014-09-09 |
2023-08-13 |
mouse |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
here we show, using patch-clamp electrophysiological recordings in brain slices, that substantia nigra dopamine neurons from mice 25-30 months of age (old) have comparable membrane capacitance and input resistance to neurons from mice 2-7 months of age (young). |
2014-09-09 |
2023-08-13 |
mouse |
| Adriane Gröger, Rupert Kolb, Rita Schäfer, Uwe Klos. Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416192. |
dopamine reduction in the substantia nigra of parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. |
2014-09-08 |
2023-08-12 |
Not clear |
| Chi L L Pham, Roberto Cappa. The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding. Bioscience reports. vol 33. issue 5. 2014-09-03. PMID:24066973. |
the deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of da (dopamine) containing neurons in the substantia nigra are two key features of pd (parkinson's disease). |
2014-09-03 |
2023-08-12 |
Not clear |
| Fabio A Zucca, Emy Basso, Francesca A Cupaioli, Emanuele Ferrari, David Sulzer, Luigi Casella, Luigi Zecc. Neuromelanin of the human substantia nigra: an update. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24155156. |
the high concentration of neuromelanin in substantia nigra neurons seems to be linked to the presence of considerable amounts of cytosolic dopamine that have not been sequestered into synaptic vesicles. |
2014-08-28 |
2023-08-12 |
human |
| J A Teske, C J Billington, C M Kot. Mechanisms underlying obesity resistance associated with high spontaneous physical activity. Neuroscience. vol 256. 2014-08-27. PMID:24161277. |
we further tested whether orexin action on dopamine one receptors (da1r) in the substantia nigra (sn) plays an important role in the generation of spa. |
2014-08-27 |
2023-08-12 |
rat |
| Jun Ming Wan. Allopregnanolone and neurogenesis in the nigrostriatal tract. Frontiers in cellular neuroscience. vol 8. 2014-08-27. PMID:25161608. |
loss of dopamine neurons in the substantia nigra (sn) is one of the main pathological features of parkinson's and also in, at least, a subset of alzheimer's patients. |
2014-08-27 |
2023-08-13 |
mouse |
| Biswarup Ghosh, Chen Zhang, George M Smit. Bridging between transplantation therapy and neurotrophic factors in Parkinson's disease. Frontiers in bioscience (Elite edition). vol 6. 2014-08-25. PMID:24896204. |
with increased understanding of growth and guidance molecule effecting dopaminergic neurons, it may be feasible to place transplants in the damaged substantia nigra and direct the growth of axons into target regions to reconstruction of midbrain dopamine (da) circuitry. |
2014-08-25 |
2023-08-13 |
Not clear |
| May-Jywan Tsai, Ching-Feng Weng, Nien-Chu Yu, Dann-Ying Liou, Fu-San Kuo, Ming-Chao Huang, Wen-Cheng Huang, Kabik Tam, Song-Kun Shyue, Henrich Chen. Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23691265. |
in vivo, adenoviral gene transfer of bicistronic cox-1/pgis to substantia nigra protected 6-ohda- induced dopamine depletion and ameliorated behavioral deficits. |
2014-08-13 |
2023-08-12 |
rat |
| Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato, Hiroshi Maita, Takeshi Niki, Sanae M M Iguchi-Arig. Neuroprotective function of DJ-1 in Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766857. |
parkinson's disease (pd) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. |
2014-08-13 |
2023-08-12 |
Not clear |
| Kai-Hsiang Kang, Horng-Hui Liou, Mann-Jen Hour, Houng-Chi Liou, Wen-Mei F. Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. Neuropharmacology. vol 73. 2014-08-13. PMID:23800665. |
mk-886 administration increased the number of tyrosine hydroxylase-positive neurons in the substantia nigra and the dopamine content in the striatum in mptp-induced parkinsonian mice. |
2014-08-13 |
2023-08-12 |
mouse |
| Patrick Oeckl, Bastian Hengerer, Boris Ferge. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology. vol 257. 2014-08-13. PMID:24747358. |
western blot analyses revealed no alteration in the expression and subcellular localisation of the dopamine d2 receptor in the striatum of gpr6(-/-) mice, and the number of tyrosine hydroxylase positive neurons in the substantia nigra was unchanged. |
2014-08-13 |
2023-08-13 |
mouse |
| Kimberlee D'Ardenne, Terry Lohrenz, Krystle A Bartley, P Read Montagu. Computational heterogeneity in the human mesencephalic dopamine system. Cognitive, affective & behavioral neuroscience. vol 13. issue 4. 2014-08-11. PMID:23943512. |
blood oxygenation level dependent responses in regions of substantia nigra (sn) and ventral tegmental area (vta), where dopamine neurons are located, coded for td and fictive errors, and additionally were related to the motivational salience signal. |
2014-08-11 |
2023-08-12 |
human |
| David Lindenbach, Christopher Bisho. Critical involvement of the motor cortex in the pathophysiology and treatment of Parkinson's disease. Neuroscience and biobehavioral reviews. vol 37. issue 10 Pt 2. 2014-08-06. PMID:24113323. |
this review examines the involvement of the motor cortex in parkinson's disease (pd), a debilitating movement disorder typified by degeneration of dopamine cells of the substantia nigra. |
2014-08-06 |
2023-08-12 |
Not clear |
| Takuya Yamane, Sayaka Suzui, Hirotake Kitaura, Kazuko Takahashi-Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice. PloS one. vol 8. issue 11. 2014-07-29. PMID:24348900. |
cck is co-localized with dopamine in the substantia nigra to regulate release of dopamine. |
2014-07-29 |
2023-08-12 |
mouse |
| Weidong L. Role of iron in UPS impairment model of Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262171. |
our studies have shown that injection of the proteasome inhibitor lactacystin in the substantia nigra (sn) of rodents causes significant loss of dopamine (da) neurons and induces intracellular inclusion body formation, which is accompanied by excessive iron accumulation in the midbrain. |
2014-07-11 |
2023-08-12 |
Not clear |
| Simone A van den Berge, Miriam E van Strien, Elly M Ho. Resident adult neural stem cells in Parkinson's disease--the brain's own repair system? European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872414. |
one important pathological process in the brain of parkinson disease (pd) patients is the degeneration of the dopaminergic neurons in the substantia nigra, which leads to a decline in striatal dopamine levels and motor dysfunction. |
2014-07-02 |
2023-08-12 |
human |
| M Jaber, M Benoit-Marand, L Prestoz, A Gaillar. Cell transplantation in the damaged adult brain. Revue neurologique. vol 169. issue 11. 2014-07-01. PMID:24112517. |
to date, cell replacement trials in pd aiming at replacing lost dopamine neurons were mainly focused on placing the transplanted cells within the target site, the striatum, and not within the lesioned site, the substantia nigra (sn). |
2014-07-01 |
2023-08-12 |
Not clear |
| Abdelhamid Benazzouz, Omar Mamad, Pamphyle Abedi, Rabia Bouali-Benazzouz, Jonathan Chetri. Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson's disease. Frontiers in aging neuroscience. vol 6. 2014-06-24. PMID:24860498. |
these symptoms are classically attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra (snc), which results in a marked dopamine depletion in the striatum. |
2014-06-24 |
2023-08-13 |
Not clear |
| Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarrí. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease. Toxicology. vol 319. 2014-06-10. PMID:24607817. |
in order to explore whether silymarin has a neuroprotective effects in a mouse model of pd we determined the concentration of striatal dopamine by hplc, the number of apoptotic cells by in situ tunel assay and the number of tyrosine hydroxylase positive neurons by immunohistochemistry in substantia nigra of vehicle-treated, silymarin-treated, mptp-intoxicated and mptp-silymarin treated c57bl/6j male mice. |
2014-06-10 |
2023-08-12 |
mouse |