| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Oeckl, Annika Scheffold, André Lechel, K Lenhard Rudolph, Boris Ferge. Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion. Neuroreport. vol 25. issue 5. 2014-11-21. PMID:24525820. |
substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to mptp-induced dopamine depletion. |
2014-11-21 |
2023-08-12 |
mouse |
| Mrudang Shah, Subramanian Rajagopalan, Liping Xu, Chandrashekhar Voshavar, Yevgeniya Shurubor, Flint Beal, Julie K Andersen, Aloke K Dutt. The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24848702. |
in vivo, pre-treatment with 0.5 mg/kg d-512 was protective against neurodegenerative phenotypes associated with systemic administration of mptp, including losses in striatal dopamine, reductions in numbers of daergic neurons in the substantia nigra (sn), and locomotor dysfunction. |
2014-11-21 |
2023-08-13 |
mouse |
| Begoña Villar-Cheda, Antonio Dominguez-Meijide, Rita Valenzuela, Noelia Granado, Rosario Moratalla, Jose L Labandeira-Garci. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiology of aging. vol 35. issue 7. 2014-11-17. PMID:24529758. |
we observed overexpression of at1 receptors in the striatum and substantia nigra of young adult dopamine d1 and d2 receptor-deficient mice and young dopamine-depleted rats, together with compensatory overexpression of at2 receptors or compensatory downregulation of angiotensinogen and/or angiotensin. |
2014-11-17 |
2023-08-12 |
mouse |
| Begoña Villar-Cheda, Antonio Dominguez-Meijide, Rita Valenzuela, Noelia Granado, Rosario Moratalla, Jose L Labandeira-Garci. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiology of aging. vol 35. issue 7. 2014-11-17. PMID:24529758. |
the results suggest that dopamine may play an important role in modulating oxidative stress and inflammation in the substantia nigra and striatum via the ras, which is impaired by aging. |
2014-11-17 |
2023-08-12 |
mouse |
| Maxime Assous, Laurence Had-Aissouni, Paolo Gubellini, Christophe Melon, Imane Nafia, Pascal Salin, Lydia Kerkerian-Le-Goff, Philippe Kachidia. Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra. Neurobiology of disease. vol 65. 2014-11-13. PMID:24480091. |
parkinson's disease (pd) is characterized by the progressive degeneration of substantia nigra (sn) dopamine neurons, involving a multifactorial cascade of pathogenic events. |
2014-11-13 |
2023-08-12 |
rat |
| José R L P Cavalcanti, Joacil G Soares, Francisco G Oliveira, Fausto P Guzen, André L B Pontes, Twyla B Sousa, Jeferson S Cavalcante, Expedito S Nascimento, Judney C Cavalcante, Miriam S M O Cost. A cytoarchitectonic and TH-immunohistochemistry characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in the rock cavy (Kerodon rupestris). Journal of chemical neuroanatomy. vol 55. 2014-11-06. PMID:24444614. |
a cytoarchitectonic and th-immunohistochemistry characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in the rock cavy (kerodon rupestris). |
2014-11-06 |
2023-08-12 |
Not clear |
| Christina E Khodr, Amanda Becerra, Ye Han, Martha C Boh. Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain research. vol 1550. 2014-11-03. PMID:24463035. |
previously we showed that human (h)snca gene silencing using a short hairpin (sh)rna in rat substantia nigra (sn) protects against a hsnca-induced forelimb deficit, but not dopamine (da) neuron loss. |
2014-11-03 |
2023-08-12 |
human |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Dhanraj Vijayraja, Nataraj Ashokkumar, Srinivasagam Rajasankar, Thamilarasan Manivasaga. Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice. Annals of neurosciences. vol 17. issue 3. 2014-10-24. PMID:25205886. |
parkinson's disease (pd) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure. |
2014-10-24 |
2023-08-13 |
mouse |
| Guangwei Du, Mechelle M Lewis, Nicholas W Sterling, Lan Kong, Honglei Chen, Richard B Mailman, Xuemei Huan. Microstructural changes in the substantia nigra of asymptomatic agricultural workers. Neurotoxicology and teratology. vol 41. 2014-10-22. PMID:24334261. |
parkinson's disease (pd) is marked by the loss of dopamine neurons in the substantia nigra (sn). |
2014-10-22 |
2023-08-12 |
human |
| Satyndra Kumar Yadav, Jay Prakash, Shikha Chouhan, Susan Westfall, Mradul Verma, Tryambak Deo Singh, Surya Pratap Sing. Comparison of the neuroprotective potential of Mucuna pruriens seed extract with estrogen in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Neurochemistry international. vol 65. 2014-10-20. PMID:24333323. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by tyrosine hydroxylase (th), immunostaining. |
2014-10-20 |
2023-08-12 |
mouse |
| Victor Tapias, Jason R Cannon, J Timothy Greenamyr. Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24315037. |
numerous factors contribute to the death of substantia nigra (sn) dopamine (da) neurons in parkinson's disease (pd). |
2014-10-06 |
2023-08-12 |
rat |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
cav1.3 channels control d2-autoreceptor responses via ncs-1 in substantia nigra dopamine neurons. |
2014-09-23 |
2023-08-13 |
mouse |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in parkinson's disease. |
2014-09-23 |
2023-08-13 |
mouse |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
furthermore, we detected elevated substantia nigra dopamine messenger rna levels of ncs-1 (but not cav1.2 or cav1.3) after cocaine in mice, as well as in remaining human sn da neurons in parkinson's disease. |
2014-09-23 |
2023-08-13 |
mouse |
| Elena Dragicevic, Christina Poetschke, Johanna Duda, Falk Schlaudraff, Stephan Lammel, Julia Schiemann, Michael Fauler, Andrea Hetzel, Masahiko Watanabe, Rafael Lujan, Robert C Malenka, Joerg Striessnig, Birgit Lis. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology. vol 137. issue Pt 8. 2014-09-23. PMID:24934288. |
as it is accessible to pharmacological modulation, it provides a novel promising target for tuning substantia nigra dopamine neuron activity, and their vulnerability to degeneration. |
2014-09-23 |
2023-08-13 |
mouse |
| Ali Chaari, Jessica Hoarau-Véchot, Moncef Ladjim. Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease. International journal of biological macromolecules. vol 60. 2014-09-12. PMID:23748003. |
this accumulation is also due to insufficient formation and activity of dopamine produced in certain neurons within the substantia nigra. |
2014-09-12 |
2023-08-12 |
human |
| Kwang Taek Kim, Kyung Jin Chung, Han Sae Lee, Il Gyu Ko, Chang Ju Kim, Yong Gil Na, Khae Hawn Ki. Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia. Neural regeneration research. vol 8. issue 8. 2014-09-10. PMID:25206715. |
a decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine d2 receptor expression in the striatum and substantia nigra region. |
2014-09-10 |
2023-08-13 |
Not clear |
| Kwang Taek Kim, Kyung Jin Chung, Han Sae Lee, Il Gyu Ko, Chang Ju Kim, Yong Gil Na, Khae Hawn Ki. Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia. Neural regeneration research. vol 8. issue 8. 2014-09-10. PMID:25206715. |
however, treatment with tadalafil increased cyclic guanosine monophosphate expression, suppressed thyrosine hydroxylase expression and increased dopamine d2 receptor expression in the striatum and substantia nigra region in a dose-dependent manner. |
2014-09-10 |
2023-08-13 |
Not clear |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
aging decreases l-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. |
2014-09-09 |
2023-08-13 |
mouse |
| Sarah Y Branch, Ramaswamy Sharma, Michael J Beckstea. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009264. |
substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. |
2014-09-09 |
2023-08-13 |
mouse |