| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rafael Gonzalo-Gobernado, Lucía Calatrava-Ferreras, Diana Reimers, Antonio Sánchez Herranz, Macarena Rodríguez-Serrano, Cristina Miranda, Adriano Jiménez-Escrig, Juan José Díaz-Gil, Eulalia Bazá. Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson's disease. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861803. |
because lgf partially protects dopamine neurons from 6-ohda neurotoxicity in the substantia nigra, and reduces motor deficits in these animals, we propose lgf as a novel factor that may be useful in the treatment of parkinson's disease. |
2014-02-03 |
2023-08-12 |
rat |
| Alexander X Tai, Robert M Cassidy, Lawrence F Krome. EphA7 expression identifies a unique neuronal compartment in the rat striatum. The Journal of comparative neurology. vol 521. issue 12. 2014-01-29. PMID:23348681. |
epha7+ axons avoid regions containing dopamine neurons within the substantia nigra and preferentially innervate areas near the rostral and caudal margins of the nucleus. |
2014-01-29 |
2023-08-12 |
rat |
| Meredith A Reid, Nina V Kraguljac, Kathy B Avsar, David M White, Jan A den Hollander, Adrienne C Laht. Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia. Schizophrenia research. vol 147. issue 2-3. 2014-01-17. PMID:23706412. |
dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. |
2014-01-17 |
2023-08-12 |
Not clear |
| Mark A Rossi, Tatyana Sukharnikova, Volodya Y Hayrapetyan, Lucie Yang, Henry H Yi. Operant self-stimulation of dopamine neurons in the substantia nigra. PloS one. vol 8. issue 6. 2014-01-14. PMID:23755282. |
operant self-stimulation of dopamine neurons in the substantia nigra. |
2014-01-14 |
2023-08-12 |
mouse |
| Keon Sung Shin, Hyun Sook Choi, Ting Ting Zhao, Kwang Hoon Suh, Ik Hyun Kwon, Soon Ok Choi, Myung Koo Le. Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Archives of pharmacal research. vol 36. issue 6. 2014-01-13. PMID:23539311. |
treatments with either concentration of berberine (5 and 15 mg/kg) in 6-ohda-lesioned groups decreased the numbers of tyrosine hydroxylase (th)-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum as compared to 6-ohda-lesioned groups. |
2014-01-13 |
2023-08-12 |
rat |
| Keon Sung Shin, Hyun Sook Choi, Ting Ting Zhao, Kwang Hoon Suh, Ik Hyun Kwon, Soon Ok Choi, Myung Koo Le. Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Archives of pharmacal research. vol 36. issue 6. 2014-01-13. PMID:23539311. |
however, both concentrations of berberine in 6-ohda-lesioned groups treated with l-dopa aggravated the numbers of th-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, dopac and hva in the striatum as compared to rats not treated with berberine. |
2014-01-13 |
2023-08-12 |
rat |
| Makoto Naoi, Wakako Maruyama, Keiko Inaba-Hasegaw. Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms. Expert review of neurotherapeutics. vol 13. issue 6. 2014-01-09. PMID:23739004. |
in parkinson's disease, cell death of dopamine neurons in the substantia nigra progresses and neuroprotective therapy is required to halt neuronal loss. |
2014-01-09 |
2023-08-12 |
Not clear |
| Michelle Healy-Stoffel, S Omar Ahmad, John A Stanford, Beth Levan. Altered nucleolar morphology in substantia nigra dopamine neurons following 6-hydroxydopamine lesion in rats. Neuroscience letters. vol 546. 2014-01-08. PMID:23643997. |
altered nucleolar morphology in substantia nigra dopamine neurons following 6-hydroxydopamine lesion in rats. |
2014-01-08 |
2023-08-12 |
rat |
| Akane Hayashi, Naoya Matsunaga, Hiroyuki Okazaki, Keisuke Kakimoto, Yoshinori Kimura, Hiroki Azuma, Eriko Ikeda, Takeshi Shiba, Mayumi Yamato, Ken-Ichi Yamada, Satoru Koyanagi, Shigehiro Ohd. A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease. Neuromolecular medicine. vol 15. issue 2. 2014-01-03. PMID:23292542. |
parkinson's disease (pd) is a common neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in the substantia nigra and dopamine depletion in the striatum. |
2014-01-03 |
2023-08-12 |
mouse |
| Jian Yu Wang, Jing Yu Yang, Fang Wang, Shi Yuan Fu, Yue Hou, Bo Jiang, Jie Ma, Cui Song, Chun Fu W. Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2014-01-03. PMID:24386001. |
the expression of tyrosine hydroxylase (th) in substantia nigra (sn) and the content of extracellular dopamine (da) in striatum were also significantly increased after pf11 treatment. |
2014-01-03 |
2023-08-12 |
rat |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
however, it is not known if the dopaminergic dysfunction is limited to the striatal terminals of dopamine neurons, or is also evident in the dopamine neuron cell bodies, which mostly originate in the substantia nigra. |
2013-12-31 |
2023-08-12 |
human |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
the aim of our studies was therefore to determine whether dopamine synthesis capacity is altered in the substantia nigra of people with schizophrenia, and how this relates to symptoms. |
2013-12-31 |
2023-08-12 |
human |
| C Ortez, C Jou, E Cortès-Saladelafont, J Moreno, A Pérez, A Ormazábal, C Pérez-Cerdá, B Pérez, R Artuch, V Cusi, A García-Cazorl. Infantile parkinsonism and GABAergic hypotransmission in a patient with pyruvate carboxylase deficiency. Gene. vol 532. issue 2. 2013-12-24. PMID:23973720. |
both gamma-aminobutyric acid and dopamine markers were found coexisting in individual neurons of the substantia nigra. |
2013-12-24 |
2023-08-12 |
Not clear |
| Tim D Aumann, Doris Tomas, Malcolm K Horn. Environmental and behavioral modulation of the number of substantia nigra dopamine neurons in adult mice. Brain and behavior. vol 3. issue 6. 2013-12-23. PMID:24363965. |
environmental and behavioral modulation of the number of substantia nigra dopamine neurons in adult mice. |
2013-12-23 |
2023-08-12 |
mouse |
| Philip Seeman, Michele Tinazz. Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23454261. |
while an apparent reduction in dopamine transporters may result from reduced expression of the transporters secondary to antipsychotic treatment, the seemingly increased loss rate is consistent with the accumulation of antipsychotics in the neuromelanin of the substantia nigra, subsequent injury to the dopamine-containing neurons, and the development of extrapyramidal motor disturbances such as tardive dyskinesia or parkinson's disease. |
2013-12-18 |
2023-08-12 |
human |
| Flavia di Michele, Sabina Luchetti, Giorgio Bernardi, Elena Romeo, Patrizia Longon. Neurosteroid and neurotransmitter alterations in Parkinson's disease. Frontiers in neuroendocrinology. vol 34. issue 2. 2013-12-16. PMID:23563222. |
parkinson's disease (pd) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. |
2013-12-16 |
2023-08-12 |
human |
| P Giuliani, S Romano, P Ballerini, R Ciccarelli, N Petragnani, S Cicchitti, M Zuccarini, S Jiang, M P Rathbone, F Caciagli, P Di Iori. Protective activity of guanosine in an in vitro model of Parkinson's disease. Panminerva medica. vol 54. issue 1 Suppl 4. 2013-12-09. PMID:23241934. |
parkinson's disease (pd) is a pathological condition characterized by a progressive neurodegeneration of dopaminergic neurons with the consequent reduction of dopamine content in the substantia nigra. |
2013-12-09 |
2023-08-12 |
human |
| Scott Mackey, Yu Jing, Joseph Flores, Katie Dinelle, Doris J Doude. Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry. Experimental neurology. vol 247. 2013-11-26. PMID:23557600. |
in this study, a range of lactacystin doses (0.5, 1, 2, 10 and 20 μg) were injected into the right substantia nigra in rats to determine the ideal dose required to produce a robust and specific lesion of the dopamine nigro-striatal system and motor deficits. |
2013-11-26 |
2023-08-12 |
rat |
| Chang-Youl Park, Shin-Ho Lee, Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Hong Ki. Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. Journal of exercise rehabilitation. vol 9. issue 4. 2013-11-26. PMID:24278893. |
we determined the effects of treadmill exercise on survival of dopamine neurons in the substantia nigra and dopaminergic fibers in the striatum after hypoxic ischemia brain injury. |
2013-11-26 |
2023-08-12 |
rat |
| Chang-Youl Park, Shin-Ho Lee, Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Hong Ki. Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. Journal of exercise rehabilitation. vol 9. issue 4. 2013-11-26. PMID:24278893. |
the viability of dopamine neurons in the substantia nigra and dopamine fibers in the striatum were analyzed using immunohistochemistry. |
2013-11-26 |
2023-08-12 |
rat |