| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang-Youl Park, Shin-Ho Lee, Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Hong Ki. Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. Journal of exercise rehabilitation. vol 9. issue 4. 2013-11-26. PMID:24278893. |
in this study, hypoxic ischemia injury caused loss of dopamine neurons in the substantia nigra and dopaminergic fibers in the striatum. |
2013-11-26 |
2023-08-12 |
rat |
| Patrik Brundin, Jeffrey H Kordowe. Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy. Progress in brain research. vol 200. 2013-11-15. PMID:23195421. |
additionally, the grafted cells placed in the parkinson's disease brain eventually downregulate the expression of dopamine transporter and tyrosine hydroxylase in a manner similar to what is seen in the substantia nigra dopamine neurons that are degenerating due to the disease. |
2013-11-15 |
2023-08-12 |
Not clear |
| Brandon S Pruett, Michael F Salvator. Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Molecular neurobiology. vol 47. issue 3. 2013-11-11. PMID:23321789. |
delivery of exogenous glial cell line-derived neurotrophic factor (gdnf) increases locomotor activity in rodent models of aging and parkinson's disease in conjunction with increased dopamine (da) tissue content in substantia nigra (sn). |
2013-11-11 |
2023-08-12 |
rat |
| Patrick J Schultheis, Sheila M Fleming, Amy K Clippinger, Jada Lewis, Taiji Tsunemi, Benoit Giasson, Dennis W Dickson, Joseph R Mazzulli, Mark E Bardgett, Kristi L Haik, Osunde Ekhator, Anil Kumar Chava, John Howard, Matt Gannon, Elizabeth Hoffman, Yinhuai Chen, Vikram Prasad, Stephen C Linn, Rafael J Tamargo, Wendy Westbroek, Ellen Sidransky, Dimitri Krainc, Gary E Shul. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human molecular genetics. vol 22. issue 10. 2013-11-01. PMID:23393156. |
there was no change in the number of dopaminergic neurons in the substantia nigra or in striatal dopamine levels in aged atp13a2(-/-) mice. |
2013-11-01 |
2023-08-12 |
mouse |
| Sarah Y Branch, R Brandon Goertz, Amanda L Sharpe, Janie Pierce, Sudip Roy, Daijin Ko, Carlos A Paladini, Michael J Beckstea. Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 34. 2013-10-28. PMID:23966705. |
here we show that chronic mild food restriction increases the burst firing of dopamine neurons in the substantia nigra. |
2013-10-28 |
2023-08-12 |
mouse |
| Sarah Y Branch, R Brandon Goertz, Amanda L Sharpe, Janie Pierce, Sudip Roy, Daijin Ko, Carlos A Paladini, Michael J Beckstea. Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 34. 2013-10-28. PMID:23966705. |
these results identify dopamine neurons in the substantia nigra as a convergence point for the interactions between feeding state and drugs of abuse. |
2013-10-28 |
2023-08-12 |
mouse |
| Marina Spanos, Julie Gras-Najjar, Jeremy M Letchworth, Audrey L Sanford, J Vincent Toups, Leslie A Somber. Quantitation of hydrogen peroxide fluctuations and their modulation of dopamine dynamics in the rat dorsal striatum using fast-scan cyclic voltammetry. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23556461. |
the dopaminergic neurons of the nigrostriatal dopamine (da) projection from the substantia nigra to the dorsal striatum become dysfunctional and slowly degenerate in parkinson's disease, a neurodegenerative disorder that afflicts more than one million americans. |
2013-10-22 |
2023-08-12 |
rat |
| Li Xie, Li-Fang Hu, Xing Qi Teo, Chi Xin Tiong, Valerio Tazzari, Anna Sparatore, Piero Del Soldato, Gavin Stewart Dawe, Jin-Song Bia. Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model. PloS one. vol 8. issue 4. 2013-10-22. PMID:23573240. |
immunofluorescence staining and high-performance liquid chromatography analysis showed that acs84 alleviated the loss of tyrosine-hydroxylase positive neurons in the substantia nigra and the declined dopamine concentration in the injured striatums of the 6-ohda-induced pd model. |
2013-10-22 |
2023-08-12 |
rat |
| Maria Aguirregomozcorta, Maria Stamelou, Angelo Antonini, Petra Schwingenschuh, Liz Prvulovich, Mark J Edwards, John C Dickson, Kailash P Bhati. Patients with rest-tremor and scans with ipsilateral dopaminergic deficit. Journal of neurology. vol 260. issue 4. 2013-09-26. PMID:23196338. |
an explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. |
2013-09-26 |
2023-08-12 |
Not clear |
| Yoshikazu Isomura, Takashi Takekawa, Rie Harukuni, Takashi Handa, Hidenori Aizawa, Masahiko Takada, Tomoki Fuka. Reward-modulated motor information in identified striatum neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785137. |
the d1- and d2-expressing neurons are activated and inactivated, respectively, by dopamine released from substantia nigra neurons encoding reward expectation. |
2013-08-30 |
2023-08-12 |
rat |
| Nicolas Aznavour, Christophe Cendres-Bozzi, Laetitia Lemoine, Colette Buda, Jean-Pierre Sastre, Zoïa Mincheva, Luc Zimmer, Jian-Sheng Li. MPTP animal model of Parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? A study using PET imaging, autoradiography, and immunohistochemistry in the cat. CNS neuroscience & therapeutics. vol 18. issue 11. 2013-08-27. PMID:23106974. |
it is believed to cause a selective destruction of substantia nigra dopamine neurons, mainly based on a large reduction of tyrosine hydroxylase (th), the catecholamine's synthesizing enzyme. |
2013-08-27 |
2023-08-12 |
cat |
| X Cui, M Pelekanos, P-Y Liu, T H J Burne, J J McGrath, D W Eyle. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. vol 236. 2013-08-26. PMID:23352937. |
the vitamin d receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. |
2013-08-26 |
2023-08-12 |
human |
| P M Abedi, C Delaville, P De Deurwaerdère, W Benjelloun, A Benazzou. Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat. Neuroscience. vol 236. 2013-08-26. PMID:23376117. |
in addition to gaba and glutamate innervations, the globus pallidus (gp) receives dopamine afferents from the pars compacta of the substantia nigra (snc), and in turn, sends inhibitory gabaergic efferents to the subthalamic nucleus (stn) and the pars reticulata of the substantia nigra (snr). |
2013-08-26 |
2023-08-12 |
rat |
| Stefania Romeo, Cristina Viaggi, Daniela Di Camillo, Allison W Willis, Luca Lozzi, Cristina Rocchi, Marta Capannolo, Gabriella Aloisi, Francesca Vaglini, Rita Maccarone, Matteo Caleo, Cristina Missale, Brad A Racette, Giovanni U Corsini, Roberto Maggi. Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology. Scientific reports. vol 3. 2013-08-22. PMID:23462874. |
this study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. |
2013-08-22 |
2023-08-12 |
rat |
| Dawn Béraud, Hannah A Hathaway, Jordan Trecki, Sergey Chasovskikh, Delinda A Johnson, Jeffrey A Johnson, Howard J Federoff, Mika Shimoji, Timothy R Mhyre, Kathleen A Maguire-Zeis. Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:23054368. |
the pathologic features of this disorder include the loss of substantia nigra dopamine neurons and attendant striatal terminals, the presence of large protein-rich neuronal inclusions containing fibrillar α-synuclein and increased numbers of activated microglia. |
2013-08-16 |
2023-08-12 |
mouse |
| Mechelle M Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L Shaffer, Richard B Mailman, Xuemei Huan. Higher iron in the red nucleus marks Parkinson's dyskinesia. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23177595. |
dopamine cell loss and increased iron in the substantia nigra (sn) characterize parkinson's disease (pd), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (lid) development. |
2013-08-13 |
2023-08-12 |
human |
| Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay J Bhatt, Lir-Wan Fa. Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. vol 308. 2013-08-13. PMID:23567316. |
neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. |
2013-08-13 |
2023-08-12 |
rat |
| Samuel S Shin, James W Bales, Hong Q Yan, Anthony E Kline, Amy K Wagner, James Lyons-Weiler, C Edward Dixo. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. Journal of neurotrauma. vol 30. issue 4. 2013-08-12. PMID:23094804. |
to better understand the role of dopamine in chronic tbi pathophysiology and the effect of ee, we examined the mrna expression profile within the substantia nigra and vta at 4 weeks post-injury. |
2013-08-12 |
2023-08-12 |
rat |
| Samuel S Shin, James W Bales, Hong Q Yan, Anthony E Kline, Amy K Wagner, James Lyons-Weiler, C Edward Dixo. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. Journal of neurotrauma. vol 30. issue 4. 2013-08-12. PMID:23094804. |
elucidation of these alterations in gene expression within the substantia nigra and vta provides new insights into chronic changes in dopamine signaling post-tbi, and the potential role of ee in tbi rehabilitation. |
2013-08-12 |
2023-08-12 |
rat |
| Fernando Cardozo-Pelaez, Monica Sanchez-Contreras, Andrew B C Nevi. Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP. Neurochemistry international. vol 61. issue 5. 2013-07-29. PMID:22743193. |
aged ogg1 knock-out (ogg1 ko) mice show a decreased spontaneous locomotor behavior and evidence a decrease in striatal dopamine levels, a loss of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn), and an increase in ubiquitin-positive inclusions in their remaining sn neurons. |
2013-07-29 |
2023-08-12 |
mouse |